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QRVHAFGDDALGDLDAVGLADAIRAGWVSRADVIEAAIVRTEAVNPALGGLAYEAFQWARQTASKAGSGF FSGVPTFIKDNIDVAGQPTMRGSDAWVPRNAFDDGEFTRLYLATGPVSLGKTQLSEFGFSASAEHMRLGP VRNPWDTDYTAGASSSGSGAFVAAGVVPMAHANDGGGSIRIPASCNGLVGLKPSRGRLPLDSELRRLPVG IVVNGVLTRSVRDTAAFYREAERIWHNPKLPPVGDVTQPGRQRLRIAVVTRSVQRECSPELRELTLKSAR LLEELGHRVERVAEPPVPPNFPDDFLLYWGLLAAMQVRTGRLAFGNTFDRTKLDSLTLGLDRHASRNMHR LPKAIMRLRRLRRRTADFFATYDVLLTPTVADETPRIGYLTPTDYQQVMDRLMGWVAFTPLQNVTGEPAI SLPLAQSADGMPVGMMFTADFGQEAQLLELAFELEEARPWARIQIGD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_01596 | - | - | 100% (468) | amidase |
| M. leprae Br4923 | MLBr_01702 | gatA | 3e-22 | 33.04% (227) | aspartyl/glutamyl-tRNA amidotransferase subunit A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2912c | amiC | 0.0 | 76.87% (467) | amidase |
| M. gilvum PYR-GCK | Mflv_4130 | - | 1e-176 | 65.95% (467) | amidase |
| M. tuberculosis H37Rv | Rv2888c | amiC | 0.0 | 76.87% (467) | amidase |
| M. abscessus ATCC 19977 | MAB_0724c | - | 1e-112 | 49.15% (470) | amidase |
| M. marinum M | MMAR_1821 | amiC | 0.0 | 70.85% (470) | amidase AmiC |
| M. avium 104 | MAV_0676 | - | 4e-66 | 37.34% (482) | 6-aminohexanoate-cyclic-dimer hydrolase |
| M. smegmatis MC2 155 | MSMEG_2521 | - | 1e-173 | 66.02% (465) | amidase |
| M. thermoresistible (build 8) | TH_2520 | - | 0.0 | 69.81% (467) | PUTATIVE Amidase |
| M. ulcerans Agy99 | MUL_2069 | amiC | 0.0 | 70.85% (470) | amidase |
| M. vanbaalenii PYR-1 | Mvan_2213 | - | 0.0 | 67.52% (468) | amidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2912c|M.bovis_AF2122/97 MSRVHAFVDDALGDLDAVALADAIRSGRVGRADVVEAAIARAEAVNPALN
Rv2888c|M.tuberculosis_H37Rv MSRVHAFVDDALGDLDAVALADAIRSGRVGRADVVEAAIARAEAVNPALN
MLBr_01596|M.leprae_Br4923 MQRVHAFGDDALGDLDAVGLADAIRAGWVSRADVIEAAIVRTEAVNPALG
MMAR_1821|M.marinum_M MVRVHAFGDDVLGDLDAVGLADAIRSGQLGAVEVVEAAVARTEAVNARLN
MUL_2069|M.ulcerans_Agy99 MVRVHAFGDDALGDLDAVGLADAIRSGQLGAVEVVEAAVARTEAVNARLN
Mflv_4130|M.gilvum_PYR-GCK MERIAAFGDDALADSDAVGLVEALRAGTVSPTELLDAAIARLEKVDPHLN
Mvan_2213|M.vanbaalenii_PYR-1 MDRVNAFGDDALGDLDAVGLVDELRRGAVSASELVEAAIARTEKANPALN
TH_2520|M.thermoresistible__bu MQRIHAFGDDALSDLDAVGLAAELRARRVSVPELIRAAIARTEAVNPALN
MSMEG_2521|M.smegmatis_MC2_155 --MVHAFSNDALGDHDAVGLVGELAAGRVSSADLIEAAIARVEAVNPTLK
MAB_0724c|M.abscessus_ATCC_199 MTRIHAFTEDALGDLDATGVAERIASGEVTAAECAEAAIVRLERVNPTLN
MAV_0676|M.avium_104 ------------MALDATALAGLVADKQVTPAELLALARQRADAVNPRLN
**..:. : : : * * : .:. *
Mb2912c|M.bovis_AF2122/97 ALAYAAFDVARDAAAMGTGQ---EAFFSGVPTFIKDN-VDVAGQPSMHGT
Rv2888c|M.tuberculosis_H37Rv ALAYAAFDVARDAAAMGTGQ---EAFFSGVPTFIKDN-VDVAGQPSMHGT
MLBr_01596|M.leprae_Br4923 GLAYEAFQWARQTASKAG-----SGFFSGVPTFIKDN-IDVAGQPTMRGS
MMAR_1821|M.marinum_M GVAHADFDRARDAAQQHGRG-SGRGFFGGVPSYIKDN-VDVSGLPTMRGT
MUL_2069|M.ulcerans_Agy99 GVAHADFDRARDAAQQHGRG-SGRGFFGGVPSYIKDN-VDVSGLPTMRDT
Mflv_4130|M.gilvum_PYR-GCK GLAHAAYDGARARAAQHR---RYGGFFDGVPSFLKDN-VAVAGMPTMNGT
Mvan_2213|M.vanbaalenii_PYR-1 GLTFEAYERARTRARLHR---PYGGFFDGVPSFVKDN-VAVAGMPAMNGT
TH_2520|M.thermoresistible__bu GLAYEAFDRALARAEAG----PVPGFFGGIPTYVKDN-AAVAGMPTMEGT
MSMEG_2521|M.smegmatis_MC2_155 GLAYAAFERAHARGAAPS---PYGGFFDGVPTFVKDN-VDVEGMPTMHGT
MAB_0724c|M.abscessus_ATCC_199 AVEFKDFPRARERAEQADAASSTSGTFRGVPTATKCN-IHVAGMPLTEGS
MAV_0676|M.avium_104 AIVCRLDDVADRQAADPN----LSGPFAGVPFLLKDLGQEYRGFPTSCGS
.: * . . * *:* * * * .:
Mb2912c|M.bovis_AF2122/97 DAWEPYAAVADSEITRVVLGTGLVSLGKTQLSEFGFSAVAEHPRLGPVRN
Rv2888c|M.tuberculosis_H37Rv DAWEPYAAVADSEITRVVLGTGLVSLGKTQLSEFGFSAVAEHPRLGPVRN
MLBr_01596|M.leprae_Br4923 DAWVPRNAFDDGEFTRLYLATGPVSLGKTQLSEFGFSASAEHMRLGPVRN
MMAR_1821|M.marinum_M DAWVPRRAGTDSEIARELLSTGLIALGKTQMSEFGFCAAAEHPRLGPVRN
MUL_2069|M.ulcerans_Agy99 DAWVPRRAGTDSEIARELLSTGLIALGKTQMSEFGFCAAAEHPRLGPVRN
Mflv_4130|M.gilvum_PYR-GCK DAWAPSPAAAHGDFARAYLATGLVPVGKTQMSEFGFSAAAEHPRLGAVRN
Mvan_2213|M.vanbaalenii_PYR-1 DAWEPVPAAHDGDFASAYLATGLVPVGRTRMSEFGFSAAAEHPRLGAVRN
TH_2520|M.thermoresistible__bu DAWDPRPQPAHGDFARLYLGTGVIPLGKTQMSEFGFSASAEHPRLGPVRN
MSMEG_2521|M.smegmatis_MC2_155 DAWEPRAVRAHGDFARAYLSTGLIALGKTRLSEYGFSASCEHPRLGPVRN
MAB_0724c|M.abscessus_ATCC_199 AAITPAPQTDDGPFARQFLSTGVIPIASTTMPEYGWSATTERAGGSATRN
MAV_0676|M.avium_104 RSLANDVADRHALVTQRFLDAGLVIFGKTNTPEFGAKGVTEPDYWGPARN
: .. .: * :* : .. * .*:* . * ...**
Mb2912c|M.bovis_AF2122/97 PWNTDYTAGASSSGSGALVAAGVVPIAHANDGGGSIRIPAACNGLVGLKP
Rv2888c|M.tuberculosis_H37Rv PWNTDYTAGASSSGSGALVAAGVVPIAHANDGGGSIRIPAACNGLVGLKP
MLBr_01596|M.leprae_Br4923 PWDTDYTAGASSSGSGAFVAAGVVPMAHANDGGGSIRIPASCNGLVGLKP
MMAR_1821|M.marinum_M PWNTDHTAGASSSGSGALVAAGVVPIAHANDGGGSIRIPASCNGLVGLKP
MUL_2069|M.ulcerans_Agy99 PWNTDHTAGASSSGSGALVAAGVVPIAHANDGGGSIRIPASCNGLVGLKP
Mflv_4130|M.gilvum_PYR-GCK PWNTDHTAGASSSGSGAFVAAGVVPIAHANDGGGSIRIPASCNGLVGLKP
Mvan_2213|M.vanbaalenii_PYR-1 PWHTDHTAGASSSGSGAFVAAGVVPIAHANDGGGSIRIPASCNGLVGLKP
TH_2520|M.thermoresistible__bu PWHPEHTAGASSSGSGAFVAAGVVPIAHANDGGGSIRIPAACNGLVGLKP
MSMEG_2521|M.smegmatis_MC2_155 PWNPEYTAGASSSGSAAFVAAGVVPIAHANDGGGSIRIPAACNGLVGLKP
MAB_0724c|M.abscessus_ATCC_199 PWHTDFSAGGSSGGSAALVAAGVVPIAHGNDGGGSIRIPAAACGLVGLKP
MAV_0676|M.avium_104 PWDTERTPGGSSGGSGAAVAAGIVPAAGANDGGGSIRIPAACNGLVGLKP
**..: :.*.**.**.* ****:** * .***********:. *******
Mb2912c|M.bovis_AF2122/97 SRGRLPLEPEYRRLPVGIVANGVLTRTVRDTAAFYR-------EAERLWR
Rv2888c|M.tuberculosis_H37Rv SRGRLPLEPEYRRLPVGIVANGVLTRTVRDTAAFYR-------EAERLWR
MLBr_01596|M.leprae_Br4923 SRGRLPLDSELRRLPVGIVVNGVLTRSVRDTAAFYR-------EAERIWH
MMAR_1821|M.marinum_M SRGRLPLNSQLRRLPLVIVANGVLTRSVRDTAAIYR-------EVERSWR
MUL_2069|M.ulcerans_Agy99 SRGRLPLNSQLRRLPLVIVANGVLTRSVRDTAAIYR-------EVERSWR
Mflv_4130|M.gilvum_PYR-GCK SRGRLPLDRDMRQMPLRIVANGVVTRSVRDTAAFYR-------EMEKISA
Mvan_2213|M.vanbaalenii_PYR-1 SRGRLPLDKDMRQMPLRIVANGVVTRSVRDTAAFYR-------EMEKVVA
TH_2520|M.thermoresistible__bu SRGRLPLDRHMRQMPLRIVANGVLTRSVRDTAAFYR-------EAELLTG
MSMEG_2521|M.smegmatis_MC2_155 SRGRLPQDKYFRAMPLRIVSDGVVTRSVRDTAAFYR-------EMERVYR
MAB_0724c|M.abscessus_ATCC_199 SRGRLLGDPSSSSAPVKIVAEGVLVRSVRDCARFFE-------SAELHYR
MAV_0676|M.avium_104 SRGLAPYGPQTGELMLGMATQGVVTRTVRDSAALLDAIIGHHPDASYRVA
*** : :. :**:.*:*** * : . .
Mb2912c|M.bovis_AF2122/97 NHQLPPVGDVTSPVKQRLRIAVVTRSVLREASP-EVRQLTLKLAGLLEEL
Rv2888c|M.tuberculosis_H37Rv NHQLPPVGDVTSPVKQRLRIAVVTRSVLREASP-EVRQLTLKLAGLLEEL
MLBr_01596|M.leprae_Br4923 NPKLPPVGDVTQPGRQRLRIAVVTRSVQRECSP-ELRELTLKSARLLEEL
MMAR_1821|M.marinum_M PSGLPPIGDVTRPGAERLKIAVVTRSVDGECGT-EMRELTLKTAGLLEEL
MUL_2069|M.ulcerans_Agy99 PSGLPPIGDVTRPGTERLKIAVVTRSVDGECGT-EMRELTLKTAGLLEEL
Mflv_4130|M.gilvum_PYR-GCK GPKLPPIGDVTGPGVRRLHIAVCTQSIIREASA-EVRDATLATAALLEGL
Mvan_2213|M.vanbaalenii_PYR-1 NPKLPPVGDVTGPGVQRLRIAVCTQSILHEASP-EVSELTLKTAALLEQL
TH_2520|M.thermoresistible__bu RTRLPPIGDITRPGAERLRIAVCTRSINRDASP-EVRELTLKTAALLEEL
MSMEG_2521|M.smegmatis_MC2_155 NPKLPPIGDVHRPGKQRLRIAVCTQSIVRDAAP-EVRDLTLKTAALLEEL
MAB_0724c|M.abscessus_ATCC_199 NPKLTPIGHVDRPVQRRLRIGLCMDSPFTPATDNPTRQAVNSAAELLESL
MAV_0676|M.avium_104 LPDKPFAQQITRP-PGPLTIGYSARSALNPRPDREAVAAVENSAALLSAL
. .: * * *. * . * **. *
Mb2912c|M.bovis_AF2122/97 GHRVEHVDHPPAPASFVDDFVLYWGFLALAQVRSGRRTFGRTFDPTRLDE
Rv2888c|M.tuberculosis_H37Rv GHRVEHVDHPPAPASFVDDFVLYWGFLALAQVRSGRRTFGRTFDPTRLDE
MLBr_01596|M.leprae_Br4923 GHRVERVAEPPVPPNFPDDFLLYWGLLAAMQVRTGRLAFGNTFDRTKLDS
MMAR_1821|M.marinum_M GHRVEYVEQVPVPESLPDDFILYWGFLATAQVLTGRYSFGKSFDRNRLDS
MUL_2069|M.ulcerans_Agy99 GHRVEYVEQVPVPESLPDDFILYWGFLATAQVLTGRYSFGKSFDRNRLDS
Mflv_4130|M.gilvum_PYR-GCK GHRITVIDN-PVPKNFIDDFVLYWSFLAFALVRGGRRTFGASFERTRLDN
Mvan_2213|M.vanbaalenii_PYR-1 GHRITVIDN-PVPQRFMDDFLLYWSFLAFALVRGGRRTFGPSFDRGRLDN
TH_2520|M.thermoresistible__bu GHHVTPIDN-PVPRQFQDDFLLYWAFLAMAVVRSGRRTFGPGFDRDRLDN
MSMEG_2521|M.smegmatis_MC2_155 GHRVTPIGN-PIPNHFKDDFLDYWAFLAFASVRGGRRTAGPSFDRDRLDN
MAB_0724c|M.abscessus_ATCC_199 GHTVEPYTP-AVLPSFKIDFEDYWAFLAFAVAKGGPRLFEG-FDPAKLDR
MAV_0676|M.avium_104 GHRVREVAPPYDDAALGRDFLTIWFAQLHQQVADIRRRTGARDNDFEADT
** : : ** * . : . *
Mb2912c|M.bovis_AF2122/97 LTLGLARHTGRNLHRLPLAIMRLRMLRRRSVR-FFGTYDVLLTPTVAEAT
Rv2888c|M.tuberculosis_H37Rv LTLGLARHTGRNLHRLPLAIMRLRMLRRRSVR-FFGTYDVLLTPTVAEAT
MLBr_01596|M.leprae_Br4923 LTLGLDRHASRNMHRLPKAIMRLRRLRRRTAD-FFATYDVLLTPTVADET
MMAR_1821|M.marinum_M LTLGLARHANRNVHRLPTAVARLRTLRRHTER-FFQRYDVVLTPTLADPP
MUL_2069|M.ulcerans_Agy99 LTLGLARHANRNVHRLPTAVARLRTLRRHTER-FFQRYDVVLTPTLADPP
Mflv_4130|M.gilvum_PYR-GCK LTLGLERHAARNLHRVPAATARLARTRRITAG-LYGTYDALLTPTLAETT
Mvan_2213|M.vanbaalenii_PYR-1 LSLGLEQHAARNLHRLPTAIARLARMRRVTSR-LQSTYDVVLTPTLADVP
TH_2520|M.thermoresistible__bu LTLGLDSHAARNLHRLPAAMVRLSRLRRVTAR-LTRDFDVVLTPTLADVP
MSMEG_2521|M.smegmatis_MC2_155 LTLGLDRRAARRLYRLPLAIARLARSGRITQR-LSNSYDVVLMPTLAEPT
MAB_0724c|M.abscessus_ATCC_199 LTLGLSRRFVRRSYRTPLFLARLAAAARVYERGFTTGIDAVLTPVLTHTT
MAV_0676|M.avium_104 LAISELGRSGGVLPVMSALENRNTYIQSLAAF--HEGYDFFLTPTLATPP
*::. : . * * .* *.:: .
Mb2912c|M.bovis_AF2122/97 PQVGYLAPT-DYQ------------------TVLDRLS----SWVVFTPV
Rv2888c|M.tuberculosis_H37Rv PQVGYLAPT-DYQ------------------TVLDRLS----SWVVFTPV
MLBr_01596|M.leprae_Br4923 PRIGYLTPT-DYQ------------------QVMDRLM----GWVAFTPL
MMAR_1821|M.marinum_M PQVGYLSPT-DYH------------------QVIERLR----KWVTFTPL
MUL_2069|M.ulcerans_Agy99 PQVGYLSPT-DYH------------------QVIERLR----KWVTFTPL
Mflv_4130|M.gilvum_PYR-GCK PPIGHLNPTAPYE------------------QIIDRLI----EWVAFTPL
Mvan_2213|M.vanbaalenii_PYR-1 PRVGHLDPTAPYE------------------QIIARLI----EWVAFTPL
TH_2520|M.thermoresistible__bu PRIGHLDPTADYQ------------------QIIDRLV----DWVAFTPL
MSMEG_2521|M.smegmatis_MC2_155 LPLGRLDPTADYE------------------QILQRLV----DWVAFTPL
MAB_0724c|M.abscessus_ATCC_199 PRIGYLTPDQDPD------------------VLLDKLS----SYVGFTPV
MAV_0676|M.avium_104 LVVGATSTSAALQRAARLVSRVRGGKLMRLSGILDDLIRESLGWVPYTQL
:* . . :: * :* :* :
Mb2912c|M.bovis_AF2122/97 QNVTGVPAISLPLAQSADGMPVGMMLSADTGREALLLELAYELEEARPWA
Rv2888c|M.tuberculosis_H37Rv QNVTGVPAISLPLAQSADGMPVGMMLSADTGREALLLELAYELEEARPWA
MLBr_01596|M.leprae_Br4923 QNVTGEPAISLPLAQSADGMPVGMMFTADFGQEAQLLELAFELEEARPWA
MMAR_1821|M.marinum_M QNVTGDPAISLPLAQSSDGLPVGMMLTADIGREARLLELAYELEEAQPFA
MUL_2069|M.ulcerans_Agy99 QNVTGDPAISLPLAQSSDGLPVGMMLTADIGREARLLELAYELEEAQPFA
Mflv_4130|M.gilvum_PYR-GCK QNATGEPAISLPLAQSATGLPIGLMFAAPVGHETRLLELAFELEAAQPWP
Mvan_2213|M.vanbaalenii_PYR-1 QNATGEPAISLPLGQSQSGLPVGMMFAAGVGEEARLLELAFELEQAQPWR
TH_2520|M.thermoresistible__bu HNVTGEPAVSLPLAQSRDGLPVGMMFAAALGEEARLLRLAYELEEARPWP
MSMEG_2521|M.smegmatis_MC2_155 QNATGDPAISLPLAQTTAGMPVGMMFSSTIGREARLLELAYELEEARPWA
MAB_0724c|M.abscessus_ATCC_199 HNASGAPAISLPLGQDPDGLPIGVMFSGRRGSERTLLELAMEIEEAQPFS
MAV_0676|M.avium_104 ANLTGRPAISVPLHWTDDGLPLGVQFVGKLGADGDLLQLAAQLEQARPWA
* :* **:*:** *:*:*: : . * : **.** ::* *:*:
Mb2912c|M.bovis_AF2122/97 RIHAPNIAE---------------
Rv2888c|M.tuberculosis_H37Rv RIHAPNIAE---------------
MLBr_01596|M.leprae_Br4923 RIQIGD------------------
MMAR_1821|M.marinum_M RIHVPG------------------
MUL_2069|M.ulcerans_Agy99 RIHVPG------------------
Mflv_4130|M.gilvum_PYR-GCK RLAA--------------------
Mvan_2213|M.vanbaalenii_PYR-1 RIQD--------------------
TH_2520|M.thermoresistible__bu RIDQRS------------------
MSMEG_2521|M.smegmatis_MC2_155 RIQDVTATKQPRKRAAKKATKTTE
MAB_0724c|M.abscessus_ATCC_199 ILG---------------------
MAV_0676|M.avium_104 QRHPAPVTPPN-------------