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VNCPAEDDPERELEPEPAHGFPARLWRTLERHPPPGVRRLAAFRSPLRGPWLTSVFGLVLLVAMPIVILT GLLSYIAYAPQFGQAIPADVGWLRLPGFDWPAHPSWLYRLTQGLHVGLGLVLIPVVVAKLWSVIPKLFVW PPARSIATLLERLSLLMLVGGVLFEIVTGVLNIQYDYIFGFSFYDGHYFGAWVFIAGFLMHIAVKMPKMI TGLRSFSIREVLRTNVTNTRPEPPDASGLVSADPAEPTVSRRGALALVGSGVLLLGVLTVGQTLGGPLRN IALLLPRGRPAQGNREFPVNKTAAVAGITPEAVGPAWRLVLRGGPNEVVLDRAALAGLPQHTARLPIACV EGWSTVQTWTGVRLSELARRAGVAAPRSARVTSLQRGGAFGEATLQGNQVGASDALLALRGNGEDLPLDH GYPARIIVPALPGVHNTKWVASINFEAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1110 | - | - | 100% (448) | hypothetical protein MUL_1110 |
| M. ulcerans Agy99 | MUL_2279 | - | 5e-10 | 40.70% (86) | membrane-bound oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0224 | - | 0.0 | 77.63% (438) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_4320 | - | 8e-11 | 40.70% (86) | oxidoreductase, molybdopterin binding |
| M. tuberculosis H37Rv | Rv0218 | - | 0.0 | 77.63% (438) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4441 | - | 1e-06 | 39.76% (83) | putative oxidoreductase |
| M. marinum M | MMAR_0461 | - | 0.0 | 98.88% (448) | hypothetical protein MMAR_0461 |
| M. avium 104 | MAV_2997 | - | 1e-167 | 67.83% (429) | oxidoreductase, molybdopterin binding |
| M. smegmatis MC2 155 | MSMEG_0998 | - | 5e-70 | 40.55% (397) | oxidoreductase, molybdopterin binding |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0889 | - | 1e-66 | 39.45% (398) | oxidoreductase, molybdopterin binding |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1110|M.ulcerans_Agy99 ---MNCPAEDDPERELEPEPAHGFPARLWRTLERHPPPGVRRLAAFRSPL
MMAR_0461|M.marinum_M ---MNCPAEDDPERELEPEPAHGFPARLWRTLERHPPPGVRRLAAFRSPL
Mb0224|M.bovis_AF2122/97 --------MSDPARGAEAEDAYGFPAGLWRWLQRHPPPALHRLTRFRSPL
Rv0218|M.tuberculosis_H37Rv --------MSDPARGAEAEDAYGFPAGLWRWLQRHPPPALHRLTRFRSPL
MAV_2997|M.avium_104 ---------MKPTR----TTGRSFPERLWR-----------------SPL
MSMEG_0998|M.smegmatis_MC2_155 -------------------------------------------------M
Mvan_0889|M.vanbaalenii_PYR-1 ---------------------------------------------MAASM
Mflv_4320|M.gilvum_PYR-GCK MTTPGVRAAGGVAAAAVAVGVASLVGAAFGPEADVRTAVGSSVIDLTPGP
MAB_4441|M.abscessus_ATCC_1997 MEHAARRIIAGLIAAAAALAVGQLAAAAVAPDSAPFYAVGNTVVDHTPAA
MUL_1110|M.ulcerans_Agy99 RGPWLTSVFGLVLLVAMPIVILTGLLSYIAYAPQFGQAIPADVGWLRLPG
MMAR_0461|M.marinum_M RGPWLTSVFGLVLLVAMPIVILTGLLSYIAYAPQFGQAIPADVGWLRLPG
Mb0224|M.bovis_AF2122/97 RGPWLTSVFGLVLLVALPFVIITGLLSYIAYAPQLGQAIPGDVGWLRLPA
Rv0218|M.tuberculosis_H37Rv RGPWLTSVFGLVLLVALPFVIITGLLSYIAYAPQLGQAIPGDVGWLRLPA
MAV_2997|M.avium_104 RGPWLTSVFGSILLVTLPVVIVTGLLSYIAYGPRFGQAVPAEVGWLRLPV
MSMEG_0998|M.smegmatis_MC2_155 RGTAITARVGLALGVAVAVCFVTGLISHFIQHPQ--------------PW
Mvan_0889|M.vanbaalenii_PYR-1 RGTAITARVGVALGVAIAVCLVTGLISHLIQHPQ--------------PW
Mflv_4320|M.gilvum_PYR-GCK VKEWAIATFGTADKLALAVMVLLTIAAIAAVAGLAETRRRPVCSIAIVIA
MAB_4441|M.abscessus_ATCC_1997 VREWVIGIFGTSDKAVLFACLTVIIALLAALAGLVEGERR-YGTVLIGLL
. .* .: . :
MUL_1110|M.ulcerans_Agy99 FDWPAHPSWLYRLTQGLHVGLGLVLIPVVVAKLWSVIPKLFVWPPARSIA
MMAR_0461|M.marinum_M FDWPAHPSWLYRLTQGLHVGLGLVLIPVVLAKLWSVIPKLFVWPPARSIA
Mb0224|M.bovis_AF2122/97 FTWPTRPSWLYRLTQGLHVGLGLVIIPVVLAKLWSVIPRLFVWPPARSIA
Rv0218|M.tuberculosis_H37Rv FTWPTRPSWLYRLTQGLHVGLGLVIIPVVLAKLWSVIPRLFVWPPARSIA
MAV_2997|M.avium_104 FDWPTDPSWLYRATQGLHVGLGLVLIPVVLAKLWSVIPRLFAWPPARSIA
MSMEG_0998|M.smegmatis_MC2_155 FFWPTRPVWLYRLTQGLHVISGIAAIPLIVVKLWSVWPKLFERPVIGGFV
Mvan_0889|M.vanbaalenii_PYR-1 FDWPTRPVWLYRFTQGLHVASGIAAIPLVVVKLWSVWPKLFDRPVIGGPV
Mflv_4320|M.gilvum_PYR-GCK GGIGCAAVLSRAGSTGADIIPTLIGTACGVAVLRILQSDRLDGPSSETGT
MAB_4441|M.abscessus_ATCC_1997 GVFGAVAAVTRPAGTFAWIWPSVIAAVAGALVLGTLVHR------AQSQA
. : : * : .
MUL_1110|M.ulcerans_Agy99 TLLERLSLLMLVGGVLFEIVTGVLNIQYDYIFGFSFYDGHYFGAWVFIAG
MMAR_0461|M.marinum_M TLLERLSLLMLVGGVLFEIVTGVLNIQYDYIFGFSFYDGHYFGAWVFIAG
Mb0224|M.bovis_AF2122/97 QVLERLSVLMLVGGILFQIVTGVLNIQYDYIFGFSFYTGHYFGAWVFIAG
Rv0218|M.tuberculosis_H37Rv QVLERLSVLMLVGGILFQIVTGVLNIQYDYIFGFSFYTGHYFGAWVFIAG
MAV_2997|M.avium_104 QLLERVSVLMLVGGILFEMVTGVLNIQYDYIFGFSFYTAHYFGAWVFVIG
MSMEG_0998|M.smegmatis_MC2_155 RQLERASILVLVGAMLFQLSTGIMNIAQWYAFEFFFTTSHYAMAYVAAGA
Mvan_0889|M.vanbaalenii_PYR-1 RALERMSILVLVASVLFQLSTGLLNIAQWYVFGFFFTTAHYAMAYVAVGA
Mflv_4320|M.gilvum_PYR-GCK DPGRRRSLLTIGLLAAGAVSGVAGVVISRLASSVAGDRDAFALPRIDTPA
MAB_4441|M.abscessus_ATCC_1997 VPDRRRFFGTAAVFALGSAGLYWLGTRWSKGTVVAAERREATVPAPVAPA
.* . . . .
MUL_1110|M.ulcerans_Agy99 FLMHIAVKMPKMITGLRSFSIREVLRTNVTNTRPEPPDASGLVSADPAEP
MMAR_0461|M.marinum_M FLMHIAVKMPKMITGLRSFSIREVLRTNVTDTRPEPPDASGLVSEDPAEP
Mb0224|M.bovis_AF2122/97 FLLHIVVKIPHMVTGLRSIPMREVLGTNVADTRAQPCDPDGLVSVNPGEA
Rv0218|M.tuberculosis_H37Rv FLLHIVVKIPHMVTGLRSIPMREVLGTNVADTRAQPCDPDGLVSVNPGEA
MAV_2997|M.avium_104 FLMHVTIKGRRMWAGLRSMSMRAVLRTPAADTEPEPWRPGGLAAAEPGPA
MSMEG_0998|M.smegmatis_MC2_155 VLVHIAVKLP---------VIRRALGEPLEQPSGE------LPGVPGLSR
Mvan_0889|M.vanbaalenii_PYR-1 VVVHIGVKLP---------VIRRALGEPLDDVAR------------SGSL
Mflv_4320|M.gilvum_PYR-GCK APIPESVQPKGVELPSWVTGNDDFYRIDTALSVPQLSRSEWRLRIHGMVD
MAB_4441|M.abscessus_ATCC_1997 PPLPEGIDVKGAVP--YITSNTDFYRIDTALRVPQVSTAEWQLNIHGMVD
: :.
MUL_1110|M.ulcerans_Agy99 T--VSRRGALALVGSGVLLLGVLTVGQTLGGPLRNIALLLPRGR-PAQGN
MMAR_0461|M.marinum_M T--VSRRGALALVGSGVLLLGVLTVGQTLGGPLRNIALLLPRGR-PAQGN
Mb0224|M.bovis_AF2122/97 T--LSRRGALGLVGAGVLLIGVLTVGQTLGGFTRKAALLLPRGR-VVSPG
Rv0218|M.tuberculosis_H37Rv T--LSRRGALGLVGAGVLLIGVLTVGQTLGGFTRKAALLLPRGR-VVSPG
MAV_2997|M.avium_104 T--MSRRGALALVGGGALFLALITAGQTLGGRTRPAALLLPHGRGRGSGA
MSMEG_0998|M.smegmatis_MC2_155 G--LTRRTVLRGTWLAVAVATVATAGQTVP-LLRKVSVLAPRTG---QGP
Mvan_0889|M.vanbaalenii_PYR-1 G--PSRRTVLRGTWLAVGLATLVTAGQTVP-LLRRVSVLAPRTG---EGP
Mflv_4320|M.gilvum_PYR-GCK REVTFTYEDLDRFEVVEKVITLTCVSNPVGGELISNAVWTGYRVKDLLAE
MAB_4441|M.abscessus_ATCC_1997 RPRTLMWADLNAMAATQRAVTLTCVSNEIGGNLIGNAVWTGFPIKPILES
* : ..: : ::
MUL_1110|M.ulcerans_Agy99 REFPVNKTAAVAGITPEAVGPAWRLVLRGGPNEVVLDRAALAGLPQHT--
MMAR_0461|M.marinum_M REFPVNKTAAVAGITPEAVGPAWRLVLRGGPNEVVLDRAALAGLPQHT--
Mb0224|M.bovis_AF2122/97 -DFPVNKTAAAAGITAEAIGPDWRLVLRGGPAEVVLDRATLAGLPQRT--
Rv0218|M.tuberculosis_H37Rv -DFPVNKTAAAAGITAEAIGPDWRLVLCGGPAEVVLDRATLAGLPQRT--
MAV_2997|M.avium_104 NDFDVNRTAAAAGIAAADIGARWRLTLGGGARPVVLDRASLLAMPQHT--
MSMEG_0998|M.smegmatis_MC2_155 QGVPVNRSAIAAGVLRTARSPQYRLTVTDGAVSRAFTLEDLQAMPQVT--
Mvan_0889|M.vanbaalenii_PYR-1 QGVPVNRTAVAAGVLGSARSADYRLTVINGDRAQEFTVDELRAMPQAT--
Mflv_4320|M.gilvum_PYR-GCK AGVRSGADMVLSMSVDGWTAGTPVEALT-GDDALLAIGMNGEPLPIEHGY
MAB_4441|M.abscessus_ATCC_1997 VGVHPDADMLLSKSVDGWTAGTPLQVLTDGRDAILAIAMNGTPLPVEHGY
. . : . .: * :*
MUL_1110|M.ulcerans_Agy99 -ARLPIACVEGWSTVQTWTG-------VRLSELARRAGVAAPRSARVTSL
MMAR_0461|M.marinum_M -ARLPIACVEGWSTVQTWTG-------VRLSELARRAGVAAPRSARVTSL
Mb0224|M.bovis_AF2122/97 -ARLPLACVEGWSAVRTWSG-------VPLAELALLAGVPAARSARVTSL
Rv0218|M.tuberculosis_H37Rv -ARLPLACVEGWSAVRTWSG-------VPLAELALLAGVPAARSARVTSL
MAV_2997|M.avium_104 -AVLPIACVEGWSTTQAWTG-------VRLADLARLAGVPAPRSARVSSV
MSMEG_0998|M.smegmatis_MC2_155 -HRLPIACVEGWSVDAEWTG-------AVLADLLATVGASPDSDVRMISL
Mvan_0889|M.vanbaalenii_PYR-1 -RRLPIVCVEGWSAEGQWSG-------VVLAHLVALVGASPDSDVRMISL
Mflv_4320|M.gilvum_PYR-GCK PARLVVPGLYGYVSATKWVTALELTRFDRAQAYWTRLGWSARGPIKTASR
MAB_4441|M.abscessus_ATCC_1997 PVRQVVPGLYGYVSATKWVVDWEITRFDKADAYWTIRGWSARGPIKTGCR
: : *: * * .. : .
MUL_1110|M.ulcerans_Agy99 QRGGAFGEATLQGNQVGASDALLALR-GNGEDLPLDHG-YPARIIVPALP
MMAR_0461|M.marinum_M QRGGAFGEATLQGNQVGAPDALLALR-VNGEDLPLDHG-YPARIIVPALP
Mb0224|M.bovis_AF2122/97 QRGGAFGEAKLAANQIADPDALLALR-VDGADLSLNHG-YPARIIVPALP
Rv0218|M.tuberculosis_H37Rv QRGGAFGEAKLAANQIADPDALLALR-VDGADLSLDHG-YPARIIVPALP
MAV_2997|M.avium_104 ERVGAFNAATLHGSQVLHPDALLALR-VNGAELSVDHG-FPARIVVPALP
MSMEG_0998|M.smegmatis_MC2_155 EPPGPYSRTTLPARHVRDSQTLIALR-LNGEALDLDHG-YPCRLIAPTRP
Mvan_0889|M.vanbaalenii_PYR-1 EPPGPYSRTVLPARHARDDMTLVALD-LNGEPLDLDHG-YPCRLIAPSRP
Mflv_4320|M.gilvum_PYR-GCK VDVPRSGQDVALGPVTFGGVAWAQNRGVRSVEVQMDDGPWEQATLGDSYS
MAB_4441|M.abscessus_ATCC_1997 IDTPRTGDRLGTGTQIVAGTAWAQHRGIATVEVQIDDGPWLPARLAPEYS
. . : : ::.* : : .
MUL_1110|M.ulcerans_Agy99 GVHNTKWVASINFEAG----------------------------------
MMAR_0461|M.marinum_M GVHNTKWVASINFEAG----------------------------------
Mb0224|M.bovis_AF2122/97 GVHNTKWVAGIEFHKR----------------------------------
Rv0218|M.tuberculosis_H37Rv GVHNTKWVAGIEFHKR----------------------------------
MAV_2997|M.avium_104 GVHNTKWVGAIDFRAGSDA-------------------------------
MSMEG_0998|M.smegmatis_MC2_155 GVLQTKWLSRIEVVP-----------------------------------
Mvan_0889|M.vanbaalenii_PYR-1 GVLQTKWLSRIEVVP-----------------------------------
Mflv_4320|M.gilvum_PYR-GCK GDTWRMWSYAWEARDTGFHTITVRATDDSGYTQTPDRADPVPDGATGWHS
MAB_4441|M.abscessus_ATCC_1997 VDTWRQWWFAWQA-TAGEHIITARATDGTGAVQTDQIASPVPDGATGYPK
* :
MUL_1110|M.ulcerans_Agy99 -------
MMAR_0461|M.marinum_M -------
Mb0224|M.bovis_AF2122/97 -------
Rv0218|M.tuberculosis_H37Rv -------
MAV_2997|M.avium_104 -------
MSMEG_0998|M.smegmatis_MC2_155 -------
Mvan_0889|M.vanbaalenii_PYR-1 -------
Mflv_4320|M.gilvum_PYR-GCK ITFAVK-
MAB_4441|M.abscessus_ATCC_1997 RLVTVAA