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M. ulcerans Agy99 MUL_1969 (leuD)

annotation: isopropylmalate isomerase small subunit
coordinates: 2176588 - 2177184
length: 198

MEAFDTHTGIGVPLRRSNVDTDQIIPAVFLKRVTRTGFEDGLFASWRSDPSFVLNLSPFDRGSVLVAGPD
FGTGSSREHAVWALMDYGFRVVISSRFGDIFRGNAGKAGLLAAEVDQDGVELLWKLIEQSPGLEITVNLQ
DRNVIAGTVVLPFRIDDHTAWRLLEGLDDIALTLRKLDEIEAYEAAYPAWKPRTLPTS
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_1969leuD-100% (198)isopropylmalate isomerase small subunit

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3011cleuD1e-10190.82% (196) isopropylmalate isomerase small subunit
M. gilvum PYR-GCKMflv_4226leuD4e-9685.71% (196) isopropylmalate isomerase small subunit
M. tuberculosis H37RvRv2987cleuD1e-10190.82% (196) isopropylmalate isomerase small subunit
M. leprae Br4923MLBr_01684leuD1e-10087.88% (198) isopropylmalate isomerase small subunit
M. abscessus ATCC 19977MAB_3293cleuD8e-9481.82% (198) isopropylmalate isomerase small subunit
M. marinum MMMAR_1727leuD1e-113100.00% (198) 3-isopropylmalate dehydratase (small subunit) LeuD
M. avium 104MAV_3837leuD1e-10692.93% (198) isopropylmalate isomerase small subunit
M. smegmatis MC2 155MSMEG_2388leuD1e-10190.31% (196) isopropylmalate isomerase small subunit
M. thermoresistible (build 8)TH_2044-2e-9886.73% (196) PROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (SMALL SUBUNIT) LEUD
M. vanbaalenii PYR-1Mvan_2136leuD6e-9685.71% (196) isopropylmalate isomerase small subunit

CLUSTAL 2.0.9 multiple sequence alignment


MUL_1969|M.ulcerans_Agy99           MEAFDTHTGIGVPLRRSNVDTDQIIPAVFLKRVTRTGFEDGLFASWRSDP
MMAR_1727|M.marinum_M               MEAFDTHTGIGVPLRRSNVDTDQIIPAVFLKRVTRTGFEDGLFASWRSDP
MAV_3837|M.avium_104                MEAFHTHTGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFASWRSDP
Mb3011c|M.bovis_AF2122/97           MEAFHTHSGIGVPLRRSNVDTDQIIPAVFLKRVTRTGFEDGLFAGWRSDP
Rv2987c|M.tuberculosis_H37Rv        MEAFHTHSGIGVPLRRSNVDTDQIIPAVFLKRVTRTGFEDGLFAGWRSDP
MLBr_01684|M.leprae_Br4923          MQAFRVHTGIGVPLRRSNVDTDQIIPAVFLKRVTRNGFEDGLFATWRVDP
Mflv_4226|M.gilvum_PYR-GCK          MEAFRTHTGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFAAWRNDP
Mvan_2136|M.vanbaalenii_PYR-1       MEAFRTHTGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFAAWRNDP
TH_2044|M.thermoresistible__bu      MQPFRTHTGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFAAWRTDP
MSMEG_2388|M.smegmatis_MC2_155      MEAFTTHTGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFAAWRNDP
MAB_3293c|M.abscessus_ATCC_199      MEAFDTHTGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFAGWRTDP
                                    *:.* .*:********************:******.******** ** **

MUL_1969|M.ulcerans_Agy99           SFVLNLSPFDRGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFGDI
MMAR_1727|M.marinum_M               SFVLNLSPFDRGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFGDI
MAV_3837|M.avium_104                SFVLNLSPFDRGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFGDI
Mb3011c|M.bovis_AF2122/97           AFVLNLSPFDRGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFGDI
Rv2987c|M.tuberculosis_H37Rv        AFVLNLSPFDRGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFGDI
MLBr_01684|M.leprae_Br4923          SFVLNLSPFDRGSVLVVGPDFGIGSSREHAVWALMDYGFRVVISSRFGDI
Mflv_4226|M.gilvum_PYR-GCK          SFVLNQPPFDQGSVLVTGPDFGTGSSREHAVWALMDFGFRVVISSRFADI
Mvan_2136|M.vanbaalenii_PYR-1       SFVLNLAPFDKGSVLVAGPDFGTGSSREHAVWALMDFGFRVVISSRFADI
TH_2044|M.thermoresistible__bu      SFVLNVPPYDKGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFADI
MSMEG_2388|M.smegmatis_MC2_155      SFILNLSPFDKGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFADI
MAB_3293c|M.abscessus_ATCC_199      SFILNLEPFNRGTVLVAGPEFGTGSSREHAVWALMDYGFRVVLSSRFGDI
                                    :*:**  *:::*:***.**:** *************:*****:****.**

MUL_1969|M.ulcerans_Agy99           FRGNAGKAGLLAAEVDQDGVELLWKLIEQSPGLEITVNLQDRNVIAGTVV
MMAR_1727|M.marinum_M               FRGNAGKAGLLAAEVDQDGVELLWKLIEQSPGLEITVNLQDRNVIAGTVV
MAV_3837|M.avium_104                FRGNAGKAGLLAAEVSQDGVELLWKLIEQSPGLEITANLQDRNITAGTTV
Mb3011c|M.bovis_AF2122/97           FRGNAGKAGLLAAEVAQDDVELLWKLIEQSPGLEITANLQDRIITAATVV
Rv2987c|M.tuberculosis_H37Rv        FRGNAGKAGLLAAEVAQDDVELLWKLIEQSPGLEITANLQDRIITAATVV
MLBr_01684|M.leprae_Br4923          FHGNAGKAGLLAAQVAQDDVEFLWKLIEQKPGLEITVNLQDRNINAATVV
Mflv_4226|M.gilvum_PYR-GCK          FRGNAGKAGLLAAEVTQDDVELLWKVIEQHPGTEITVNLQDRSVTAGTVM
Mvan_2136|M.vanbaalenii_PYR-1       FRGNAGKAGLLAAEVSQDDVELLWKLIEQHPGTEITVNLQDRTITAGTMM
TH_2044|M.thermoresistible__bu      FRGNAGKAGLLAAEVSQDDVELLWKALEQNPGLEITVNLQDRTVTAGTVV
MSMEG_2388|M.smegmatis_MC2_155      FRGNAGKAGLLAAEVAQDDVELLWKVIEQNPGLEITVNLQDRTVTAGTVV
MAB_3293c|M.abscessus_ATCC_199      FRGNAGKAGLVAGLVGQSDIELLWKLIEQNPGLELTVNLEDRTVTAGTAV
                                    *:********:*. * *..:*:*** :** ** *:*.**:** : *.* :

MUL_1969|M.ulcerans_Agy99           LPFRIDDHTAWRLLEGLDDIALTLRKLDEIEAYEAAYPAWKPRTLPTS-
MMAR_1727|M.marinum_M               LPFRIDDHTAWRLLEGLDDIALTLRKLDEIEAYEAAYPAWKPRTLPTS-
MAV_3837|M.avium_104                LPFKIDDHTAWRLLEGLDDIALTLRKLDRIESYEAAYPDWKPRTSPVA-
Mb3011c|M.bovis_AF2122/97           LPFKIDDHSAWRLLEGLDDIALTLRKLDEIEAFEGACAYWKPRTLPAP-
Rv2987c|M.tuberculosis_H37Rv        LPFKIDDHSAWRLLEGLDDIALTLRKLDEIEAFEGACAYWKPRTLPAP-
MLBr_01684|M.leprae_Br4923          LPFKIDDYTAWRLLEGLDDIALNLRKLDEIEAFESARPAWKPRTLPTT-
Mflv_4226|M.gilvum_PYR-GCK          VPFTIDDYTAWRLLEGLDDIGLTLRKLDEIEDFETHRPSWKPRTLPA--
Mvan_2136|M.vanbaalenii_PYR-1       VLFNIDDYTAWRLLEGLDDIGLTLRKLDEIEDYERHRPEWKPHTLPA--
TH_2044|M.thermoresistible__bu      VPFKIDDYTAWRLLEGLDDIALTLRKQDQIEAYEARRPSWKPRTLPA--
MSMEG_2388|M.smegmatis_MC2_155      VPFRIDDYTRWRLLEGLDDIGLTLRKLDQIEAYEAARPAWKPRTLPA--
MAB_3293c|M.abscessus_ATCC_199      VPFEIDDYTRWRLLEGLDDIGLTLRKVDEIAAFEAARPEFKPRTLEPSE
                                    : * ***:: **********.*.*** *.*  :*   . :**:*