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MEAFTTHTGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFAAWRNDPSFILNLSPFDKGSVLVAGPD FGTGSSREHAVWALMDYGFRVVISSRFADIFRGNAGKAGLLAAEVAQDDVELLWKVIEQNPGLEITVNLQ DRTVTAGTVVVPFRIDDYTRWRLLEGLDDIGLTLRKLDQIEAYEAARPAWKPRTLPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2388 | leuD | - | 100% (197) | isopropylmalate isomerase small subunit |
| M. smegmatis MC2 155 | MSMEG_1112 | - | 3e-08 | 29.50% (139) | aconitate hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3011c | leuD | 1e-98 | 86.29% (197) | isopropylmalate isomerase small subunit |
| M. gilvum PYR-GCK | Mflv_4226 | leuD | 1e-102 | 89.85% (197) | isopropylmalate isomerase small subunit |
| M. tuberculosis H37Rv | Rv2987c | leuD | 1e-98 | 86.29% (197) | isopropylmalate isomerase small subunit |
| M. leprae Br4923 | MLBr_01684 | leuD | 6e-98 | 85.20% (196) | isopropylmalate isomerase small subunit |
| M. abscessus ATCC 19977 | MAB_3293c | leuD | 2e-97 | 85.64% (195) | isopropylmalate isomerase small subunit |
| M. marinum M | MMAR_1727 | leuD | 1e-101 | 90.31% (196) | 3-isopropylmalate dehydratase (small subunit) LeuD |
| M. avium 104 | MAV_3837 | leuD | 1e-100 | 87.76% (196) | isopropylmalate isomerase small subunit |
| M. thermoresistible (build 8) | TH_2044 | - | 1e-104 | 91.37% (197) | PROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (SMALL SUBUNIT) LEUD |
| M. ulcerans Agy99 | MUL_1969 | leuD | 1e-102 | 90.31% (196) | isopropylmalate isomerase small subunit |
| M. vanbaalenii PYR-1 | Mvan_2136 | leuD | 1e-102 | 89.85% (197) | isopropylmalate isomerase small subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3011c|M.bovis_AF2122/97 MEAFHTHSGIGVPLRRSNVDTDQIIPAVFLKRVTRTGFEDGLFAGWRSDP
Rv2987c|M.tuberculosis_H37Rv MEAFHTHSGIGVPLRRSNVDTDQIIPAVFLKRVTRTGFEDGLFAGWRSDP
MLBr_01684|M.leprae_Br4923 MQAFRVHTGIGVPLRRSNVDTDQIIPAVFLKRVTRNGFEDGLFATWRVDP
MMAR_1727|M.marinum_M MEAFDTHTGIGVPLRRSNVDTDQIIPAVFLKRVTRTGFEDGLFASWRSDP
MUL_1969|M.ulcerans_Agy99 MEAFDTHTGIGVPLRRSNVDTDQIIPAVFLKRVTRTGFEDGLFASWRSDP
MAV_3837|M.avium_104 MEAFHTHTGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFASWRSDP
Mflv_4226|M.gilvum_PYR-GCK MEAFRTHTGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFAAWRNDP
Mvan_2136|M.vanbaalenii_PYR-1 MEAFRTHTGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFAAWRNDP
TH_2044|M.thermoresistible__bu MQPFRTHTGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFAAWRTDP
MSMEG_2388|M.smegmatis_MC2_155 MEAFTTHTGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFAAWRNDP
MAB_3293c|M.abscessus_ATCC_199 MEAFDTHTGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFAGWRTDP
*:.* .*:********************:******.******** ** **
Mb3011c|M.bovis_AF2122/97 AFVLNLSPFDRGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFGDI
Rv2987c|M.tuberculosis_H37Rv AFVLNLSPFDRGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFGDI
MLBr_01684|M.leprae_Br4923 SFVLNLSPFDRGSVLVVGPDFGIGSSREHAVWALMDYGFRVVISSRFGDI
MMAR_1727|M.marinum_M SFVLNLSPFDRGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFGDI
MUL_1969|M.ulcerans_Agy99 SFVLNLSPFDRGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFGDI
MAV_3837|M.avium_104 SFVLNLSPFDRGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFGDI
Mflv_4226|M.gilvum_PYR-GCK SFVLNQPPFDQGSVLVTGPDFGTGSSREHAVWALMDFGFRVVISSRFADI
Mvan_2136|M.vanbaalenii_PYR-1 SFVLNLAPFDKGSVLVAGPDFGTGSSREHAVWALMDFGFRVVISSRFADI
TH_2044|M.thermoresistible__bu SFVLNVPPYDKGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFADI
MSMEG_2388|M.smegmatis_MC2_155 SFILNLSPFDKGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFADI
MAB_3293c|M.abscessus_ATCC_199 SFILNLEPFNRGTVLVAGPEFGTGSSREHAVWALMDYGFRVVLSSRFGDI
:*:** *:::*:***.**:** *************:*****:****.**
Mb3011c|M.bovis_AF2122/97 FRGNAGKAGLLAAEVAQDDVELLWKLIEQSPGLEITANLQDRIITAATVV
Rv2987c|M.tuberculosis_H37Rv FRGNAGKAGLLAAEVAQDDVELLWKLIEQSPGLEITANLQDRIITAATVV
MLBr_01684|M.leprae_Br4923 FHGNAGKAGLLAAQVAQDDVEFLWKLIEQKPGLEITVNLQDRNINAATVV
MMAR_1727|M.marinum_M FRGNAGKAGLLAAEVDQDGVELLWKLIEQSPGLEITVNLQDRNVIAGTVV
MUL_1969|M.ulcerans_Agy99 FRGNAGKAGLLAAEVDQDGVELLWKLIEQSPGLEITVNLQDRNVIAGTVV
MAV_3837|M.avium_104 FRGNAGKAGLLAAEVSQDGVELLWKLIEQSPGLEITANLQDRNITAGTTV
Mflv_4226|M.gilvum_PYR-GCK FRGNAGKAGLLAAEVTQDDVELLWKVIEQHPGTEITVNLQDRSVTAGTVM
Mvan_2136|M.vanbaalenii_PYR-1 FRGNAGKAGLLAAEVSQDDVELLWKLIEQHPGTEITVNLQDRTITAGTMM
TH_2044|M.thermoresistible__bu FRGNAGKAGLLAAEVSQDDVELLWKALEQNPGLEITVNLQDRTVTAGTVV
MSMEG_2388|M.smegmatis_MC2_155 FRGNAGKAGLLAAEVAQDDVELLWKVIEQNPGLEITVNLQDRTVTAGTVV
MAB_3293c|M.abscessus_ATCC_199 FRGNAGKAGLVAGLVGQSDIELLWKLIEQNPGLELTVNLEDRTVTAGTAV
*:********:*. * *..:*:*** :** ** *:*.**:** : *.* :
Mb3011c|M.bovis_AF2122/97 LPFKIDDHSAWRLLEGLDDIALTLRKLDEIEAFEGACAYWKPRTLPAP-
Rv2987c|M.tuberculosis_H37Rv LPFKIDDHSAWRLLEGLDDIALTLRKLDEIEAFEGACAYWKPRTLPAP-
MLBr_01684|M.leprae_Br4923 LPFKIDDYTAWRLLEGLDDIALNLRKLDEIEAFESARPAWKPRTLPTT-
MMAR_1727|M.marinum_M LPFRIDDHTAWRLLEGLDDIALTLRKLDEIEAYEAAYPAWKPRTLPTS-
MUL_1969|M.ulcerans_Agy99 LPFRIDDHTAWRLLEGLDDIALTLRKLDEIEAYEAAYPAWKPRTLPTS-
MAV_3837|M.avium_104 LPFKIDDHTAWRLLEGLDDIALTLRKLDRIESYEAAYPDWKPRTSPVA-
Mflv_4226|M.gilvum_PYR-GCK VPFTIDDYTAWRLLEGLDDIGLTLRKLDEIEDFETHRPSWKPRTLPA--
Mvan_2136|M.vanbaalenii_PYR-1 VLFNIDDYTAWRLLEGLDDIGLTLRKLDEIEDYERHRPEWKPHTLPA--
TH_2044|M.thermoresistible__bu VPFKIDDYTAWRLLEGLDDIALTLRKQDQIEAYEARRPSWKPRTLPA--
MSMEG_2388|M.smegmatis_MC2_155 VPFRIDDYTRWRLLEGLDDIGLTLRKLDQIEAYEAARPAWKPRTLPA--
MAB_3293c|M.abscessus_ATCC_199 VPFEIDDYTRWRLLEGLDDIGLTLRKVDEIAAFEAARPEFKPRTLEPSE
: * ***:: **********.*.*** *.* :* . :**:*