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TLICAGSVVIDGELCRPGWIRTAGHKIADCGTGTAPLADFDFPDSIVVPGFVDIHVHGGAGASFADADAG GRALIQASEFHLRHGTTTMLASLVTAAPAQLLSAVAKLAEAISSGRSGTIAGIHLEGPWLSPARCGAHDH TQVRAPDPAEIDALLAAANGTIRMVTLAPELPGSADTIRRFLAAGVVVALGHSDATYEQTCQAIGHGATV ATHLFNAMAPLGHREPGPALALLKDPAVTLELIADGVHVHPAVVAAVIEAVGPDRVALVTDAIAAAGCGD GTYRLGSVPIEVESNVARVCGTPTIAGSTATMDRLFRAAFRAGAGAALDAGALAAAVQMTSATPARAVGL ARRGSLRAGFDANLVVLDRDLRVAAVMANGEWQAVED*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1443 | nagA | - | 100% (388) | n-acetylglucosamine-6-phosphate deacetylase NagA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3365 | nagA | 1e-147 | 69.85% (388) | N-acetylglucosamine-6-phosphate deacetylase |
| M. gilvum PYR-GCK | Mflv_2437 | - | 3e-05 | 27.64% (246) | amidohydrolase |
| M. tuberculosis H37Rv | Rv3332 | nagA | 1e-147 | 69.85% (388) | N-acetylglucosamine-6-phosphate deacetylase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0362c | - | 3e-83 | 56.35% (307) | N-acetylglucosamine-6-phosphate deacetylase NagA |
| M. marinum M | MMAR_1190 | nagA | 0.0 | 98.97% (388) | N-acetylglucosamine-6-phosphate deacetylase NagA |
| M. avium 104 | MAV_4307 | nagA | 1e-135 | 66.93% (384) | N-acetylglucosamine-6-phosphate deacetylase |
| M. smegmatis MC2 155 | MSMEG_2119 | nagA | 1e-100 | 52.36% (382) | N-acetylglucosamine-6-phosphate deacetylase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_4215 | - | 5e-05 | 28.23% (248) | amidohydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1443|M.ulcerans_Agy99 ---MTLICAGSVVIDG-ELCRPGWIRTAGHKIADCGTGTAPL-ADFDFPD
MMAR_1190|M.marinum_M ---MTLICAGSVVIDG-ELCRPGWIRTAGHKIADCGTGTAPL-ADFDFPD
Mb3365|M.bovis_AF2122/97 ---MTVLGADAVVIDG-RICRPGWVHTADGRILSGGAGAPPMPADAEFPD
Rv3332|M.tuberculosis_H37Rv ---MTVLGADAVVIDG-RICRPGWVHTADGRILSGGAGAPPMPADAEFPD
MAV_4307|M.avium_104 ---MGLIAAGTMVASG-RVHRPGWVETSGGHIAACGTGPPPRPADREFPD
MAB_0362c|M.abscessus_ATCC_199 -------------------------------------------------M
MSMEG_2119|M.smegmatis_MC2_155 ----MLLTADTVLTGT-ELLRPGWLEIASDRVVAVGAGAPPAQADRNLGA
Mflv_2437|M.gilvum_PYR-GCK MPLTTLKAAGLLDVDAGEIIRPGIVHVDGDRIVSIGGDAPPDAEVIDLGD
Mvan_4215|M.vanbaalenii_PYR-1 --MLTLKAAGLLDVVSGEIIRPGVVTVDGDRIVSLGGTPPPDVEVIDLGD
MUL_1443|M.ulcerans_Agy99 SIVVPGFVDIHVHGGAGASFADADAGGRALIQASEFHLRHG--TTTMLAS
MMAR_1190|M.marinum_M SIVVPGFVDIHVHGGAGASFADADAGGRALIQASEFHLRHG--TTTMLAS
Mb3365|M.bovis_AF2122/97 AIVVPGFVDMHVHGGGGASFADGNAAD--IARAAEFHLRHG--TTTTLAS
Rv3332|M.tuberculosis_H37Rv AIVVPGFVDMHVHGGGGASFADGNAAD--IARAAEFHLRHG--TTTTLAS
MAV_4307|M.avium_104 GTAVPGFVDMHVHGGGGASYTD--PDG--IAKAAAFHLRHG--TTTTMAS
MAB_0362c|M.abscessus_ATCC_199 SVTAPGFFDMHVHGGGGASFGRDAEAN---LVAATWHRSHG--TDGLLAS
MSMEG_2119|M.smegmatis_MC2_155 ATVVPGFVDTHLHGGGGGNFSAATDDET--ARAVALHRAHG--STTLVAS
Mflv_2437|M.gilvum_PYR-GCK AILMPGLMDMEVNLLMGGRGETPGLSQVQDDPATRVLRAVGNARRTLRAG
Mvan_4215|M.vanbaalenii_PYR-1 SILLPGLMDMEVNLLMGGRGENPGLSQVQDDPATRVLRAVGNARRTLRAG
. **:.* .:: *. * * *.
MUL_1443|M.ulcerans_Agy99 LVTAAPAQLLSAVAKLAEAISSGRSGTIAGIHLEGPWLSPA------RCG
MMAR_1190|M.marinum_M LVTAAPAQLLSAVAKLAEAISSGRSGTIAGIHLEGPWLSPA------RCG
Mb3365|M.bovis_AF2122/97 LVTAGPAELLSAVGALAEAT---RDGVVAGIHLEGPWLSPA------RCG
Rv3332|M.tuberculosis_H37Rv LVTAGPAELLSAVGALAEAT---RDGVVAGIHLEGPWLSPA------RCG
MAV_4307|M.avium_104 LVTGSPAELLGGVRALAEAT---RDRTVAGIHLEGPWLSRA------RCG
MAB_0362c|M.abscessus_ATCC_199 LVTLAPDDLLRAVRVLAEMT---GAEGIAGIHLEGPWLSPQ------YAG
MSMEG_2119|M.smegmatis_MC2_155 LVTAGPEDLLRQVSGLARQV---RAGLIDGIHLEGPWLSTL------RCG
Mflv_2437|M.gilvum_PYR-GCK FTTVRNLGLFVKTGGYLLDVA--LGKAIAAGWIDGPRVIPAGHAITPTGG
Mvan_4215|M.vanbaalenii_PYR-1 FTTVRNLGLFVKTGGYLLDVA--LGKAIDAGWIDGPRVIPAGHAITPTGG
:.* *: . : . ::** : *
MUL_1443|M.ulcerans_Agy99 AHDHTQVRAPDPAEIDALLAAANG-TIRMVTLAP--ELPGSADTIRRFLA
MMAR_1190|M.marinum_M AHDHTQVRAPDPAEIDALLAAANG-TIRMVTLAP--ELPGSADTIRRFLA
Mb3365|M.bovis_AF2122/97 AHDHTRMRAPDPAEIESVLAAADG-AVRMVTLAP--ELPGSDAAIRRFRD
Rv3332|M.tuberculosis_H37Rv AHDHTRMRAPDPAEIESVLAAADG-AVRMVTLAP--ELPGSDAAIRRFRD
MAV_4307|M.avium_104 AHDARRMRDPDPHEIDAVLSAGGG-AIRMVTLAP--ELPGADAAIRRFVD
MAB_0362c|M.abscessus_ATCC_199 AHDPRLLREPDLGELERLLDAGGG-HIKMVTIAP--ELPGAISAIEMLSG
MSMEG_2119|M.smegmatis_MC2_155 AHQPVLMRDPDPGEIGRVLDAGEG-TVRMVTIAP--ERDGALAAIAQLVN
Mflv_2437|M.gilvum_PYR-GCK HLDPTMFAAFMPGVLELTIEEGIANGVDEIRKAVRYQIKHGAELIKVCCS
Mvan_4215|M.vanbaalenii_PYR-1 HLDPTMFAAFMPGVLELTVEEGIANGVDEIRKAVRYQIKHGAQLIKVCCS
: . : : . . : : * : . *
MUL_1443|M.ulcerans_Agy99 AGVVVALGHSDATYEQTC-------QAIGHGATVATHLFNAMAPLGHREP
MMAR_1190|M.marinum_M ADVVVALGHTDATYEQTC-------QAIGHGATVATHLFNAMAPLGHREP
Mb3365|M.bovis_AF2122/97 AEVVVAVGHTDATYTQTR-------HAIDLGATVGTHLFNAMPPLDHRAP
Rv3332|M.tuberculosis_H37Rv AEVVVAVGHTDATYTQTR-------HAIDLGATVGTHLFNAMPPLDHRAP
MAV_4307|M.avium_104 AGVVVAVGHTNADYRQTR-------HAIALGATVGTHLFNAMPPLHHREP
MAB_0362c|M.abscessus_ATCC_199 RGVVAAVGHTNATYEQTQ-------QAISAGATVATHLFNAMRPIHHREP
MSMEG_2119|M.smegmatis_MC2_155 AGVVAAVGHTEATYDQTR-------AAIDAGATVGTHLFNAMRPIDRREP
Mflv_2437|M.gilvum_PYR-GCK GGVMSLTGEAGAQHYSDEELRVIVDEAHRRGLRVAAHTHGAEAVKHAIDC
Mvan_4215|M.vanbaalenii_PYR-1 GGVMSLTGEAGAQHYSDEELRVIVDEAHRRGLRVAAHTHGAEAVKHAVEC
*: *.: * : . * * *.:* ..*
MUL_1443|M.ulcerans_Agy99 GPALALLKDPAVTLELIADGVHVHPAVVAAVIEAVGPDRVALVTDAIAAA
MMAR_1190|M.marinum_M GPALALLKDPAVTLELIADGVHVHPAVVAAVIEAVGPDRVALVTDAIAAA
Mb3365|M.bovis_AF2122/97 GPVLALLCDPRVTVEIIADGVHVHPAVVHAVIEAVGPDRVAVVTDAIAAA
Rv3332|M.tuberculosis_H37Rv GPVLALLCDPRVTVEIIADGVHVHPAVVHAVIEAVGPDRVAVVTDAIAAA
MAV_4307|M.avium_104 GPALALLRDPRVTVELIADGVHVHPDVVHAVIDAAGPERVALVTDALAAA
MAB_0362c|M.abscessus_ATCC_199 GPIPALLESPDVTIELIADGVHIHPAIYRTVLAAVGPDRIALVTDAMCAA
MSMEG_2119|M.smegmatis_MC2_155 GPAVALTEDSRVTVEMIVDGVHVAPAIYRHITQTVGPERLSLITDAMAAT
Mflv_2437|M.gilvum_PYR-GCK G--IDCIEHGFLMDDEAIQMLVDNDRFLVSTRRLAEYMDVSKAPKELQAK
Mvan_4215|M.vanbaalenii_PYR-1 G--IDCIEHGFLMDDEAIQMLVDNDRFLVSTRRLAEYMDVSKAPPELQAK
* : : : : . . :: . : *
MUL_1443|M.ulcerans_Agy99 GCGDGTYRLGSVPIEVESNVARVCGTPTIAG-STATMDRLFRAAFRAG-A
MMAR_1190|M.marinum_M GCGDGTYRLGSVPIEVESNVARVCGTPTIAG-STATMDRLFRAAFRAG-P
Mb3365|M.bovis_AF2122/97 GCGDGAFRLGTMPIEVESSVARVAGASTLAG-STTTMDQLFRTVAGLGSK
Rv3332|M.tuberculosis_H37Rv GCGDGAFRLGTMPIEVESSVARVAGASTLAG-STTTMDQLFRTVAGLGSK
MAV_4307|M.avium_104 GRPDGAFRLGPVHIDVVAGVARVHGTTTIAG-STATMDRLFRTVAGSG--
MAB_0362c|M.abscessus_ATCC_199 GMPDGAYQLGDLPVTVAGGEARLP-NGTIAG-STASMADLHRFAAAQAG-
MSMEG_2119|M.smegmatis_MC2_155 GMSDGVYRLGPLDIDVVAGVARVAGTDTIAG-STATMEQVFRLAVAHCG-
Mflv_2437|M.gilvum_PYR-GCK AAEMFPKARTSIKAAYEAGVKIAVGTDAPAIPHGKNADELVTLVDWGMPE
Mvan_4215|M.vanbaalenii_PYR-1 AAEMFPKARTSIKAAYEAGVKIAVGTDAPAIPHGKNADELVTLVDWGMPP
. : .. : * . : .
MUL_1443|M.ulcerans_Agy99 GAALDAGALAAAVQMTSATPARAVGLARRGSLRAGFDANLVVLDRDLRVA
MMAR_1190|M.marinum_M GAALDAGALAAAVQMTSATPARAVGLARRGSLRAGFDANLVVLDRDLRVA
Mb3365|M.bovis_AF2122/97 SDSAGDVALAAAVQVTSATPARALGLTGVGRLAAGYAANLVVLDRDLRVT
Rv3332|M.tuberculosis_H37Rv SDSAGDVALAAAVQVTSATPARALGLTGVGRLAAGYAANLVVLDRDLRVT
MAV_4307|M.avium_104 --TDRDAALAAAVQMTSTTPARALGLDRVGSLRAGHEANLVVLDDDWRVR
MAB_0362c|M.abscessus_ATCC_199 --T------DIATRQTSVNPRRAVGC------------------------
MSMEG_2119|M.smegmatis_MC2_155 --LPRDDALSLAVRQACVNPARALGLPAAG-LAAGARADLVVLDHDLAVT
Mflv_2437|M.gilvum_PYR-GCK AAVLRAATVVAADLINRSDSLGRLAEGYIADIIAVPGDPLADIRVTQAVN
Mvan_4215|M.vanbaalenii_PYR-1 AAVLRAATVVAADLINRSDSLGRIAEGYLADIIAVPGDPLADIGVTKNVT
* . :.
MUL_1443|M.ulcerans_Agy99 AVMANGEWQAVED-----
MMAR_1190|M.marinum_M AVMANGEWQAVED-----
Mb3365|M.bovis_AF2122/97 AVMVNDDWRVG-------
Rv3332|M.tuberculosis_H37Rv AVMVNDDWRVG-------
MAV_4307|M.avium_104 AVMVRGDWLADP------
MAB_0362c|M.abscessus_ATCC_199 ------------------
MSMEG_2119|M.smegmatis_MC2_155 AVMRAGEWVVTPGAAHTV
Mflv_2437|M.gilvum_PYR-GCK FVMKDGKVFKNDVTH---
Mvan_4215|M.vanbaalenii_PYR-1 FVMKGGKVYKNEHATDTN