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IPMTGPVSLELAGRQVKITHPDRVVFPGQGDRPSRTKLDLVRYYLSVADGALRGVAGRPMMLKRFVKGID VEAVFQKRAPTNRPDWVDVAELRYASGTSAQEAVIHDAAGLAWAINLGCVDLNPHPVLARDLDHPDELRI DLDPMPGVEWRRILDVAQVVREVLEDYGLTPWPKTSGSRGFHVYARIAPQWSFSQVRLAAQTVAREVERR MPGVATSRWWKEEREGVFVDFNQNAKDRTVASAYSVRANPDARVSTPLHWHEVADCDPQDFTLDAVPDRF AELGDPWSGMDGAVGALDRLLMLAEELGPPQRAPAGAGKRRDGRRQPSMPLIEVARTKTKDEAMAALDTW RARHPAVADRLQPADVLVDGMRGPSSIWYRIRINLQHIPPEARPPQEELIAEYNPWHGYRPPDGRGRPGA DG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1190 | - | - | 100% (423) | hypothetical protein MUL_1190 |
| M. ulcerans Agy99 | MUL_4339 | - | 3e-75 | 46.15% (325) | hypothetical protein MUL_4339 |
| M. ulcerans Agy99 | MUL_4434 | - | 1e-38 | 32.67% (300) | ATP-dependent DNA ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0275c | - | 0.0 | 77.72% (404) | hypothetical protein Mb0275c |
| M. gilvum PYR-GCK | Mflv_0342 | - | 1e-174 | 72.48% (407) | DNA primase, small subunit |
| M. tuberculosis H37Rv | Rv0269c | - | 0.0 | 77.72% (404) | hypothetical protein Rv0269c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4341 | - | 1e-167 | 70.85% (398) | hypothetical protein MAB_4341 |
| M. marinum M | MMAR_0527 | - | 0.0 | 99.29% (420) | hypothetical protein MMAR_0527 |
| M. avium 104 | MAV_4893 | - | 0.0 | 80.38% (423) | hypothetical protein MAV_4893 |
| M. smegmatis MC2 155 | MSMEG_0597 | - | 1e-180 | 72.86% (409) | hypothetical protein MSMEG_0597 |
| M. thermoresistible (build 8) | TH_3847 | - | 1e-173 | 72.89% (402) | PUTATIVE conserved hypothetical protein |
| M. vanbaalenii PYR-1 | Mvan_0396 | - | 1e-177 | 73.71% (407) | hypothetical protein Mvan_0396 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0342|M.gilvum_PYR-GCK --------------MAARESYEIGGRTVPVTHLDKVVFG------ELG--
Mvan_0396|M.vanbaalenii_PYR-1 --------------MAARESFEIAGEQVPITNPDKVVFG------DLG--
TH_3847|M.thermoresistible__bu --------------MAESRTVEVDGRRVVVSNPNKVVFP------QLG--
MSMEG_0597|M.smegmatis_MC2_155 MTTIAVAGSHYDVMMAGALTLELDGLTVSVTNPDKVIFP------EYDGR
MAB_4341|M.abscessus_ATCC_1997 ----MADGLRASGSSKADLVLQVAGRDVTITHPDKVIFP------DSG--
MUL_1190|M.ulcerans_Agy99 -----------MIPMTGPVSLELAGRQVKITHPDRVVFP--GQGDRPS--
MMAR_0527|M.marinum_M --------------MTGPVSLELAGRQVKITHPDRVVFP--GQGDRPS--
Mb0275c|M.bovis_AF2122/97 -----------MSRMAAPVSLDVHGRQVIVTHPGRVVFP--AHNDRKG--
Rv0269c|M.tuberculosis_H37Rv -----------MSRMAAPVSLDVHGRQVIVTHPGRVVFP--AHNDRKG--
MAV_4893|M.avium_104 -----------MNHMTRPVSLEVAGRRVTITHPDKVVFPRAGGGETTGSA
:: * * ::: .:*:* .
Mflv_0342|M.gilvum_PYR-GCK ---LTKLDLIDYYASVADGALRGVRDRPMILKRFVKGIDEEAVFQKRAPK
Mvan_0396|M.vanbaalenii_PYR-1 ---LTKLDLMRYYAAVADGALRGVRDRPMILKRFVKGIEQEAVFQKRAPE
TH_3847|M.thermoresistible__bu ---LTKSDLVDYYLSVAEPALRGVRNRPMILKRFVKGITEEAVFQKRAPA
MSMEG_0597|M.smegmatis_MC2_155 AA-VTKLDLVNYYRAVADGALRGVFGRPMILKRFVKGIATEAIFQKRAPE
MAB_4341|M.abscessus_ATCC_1997 ---ITKGNLVHYYLDVAEGALRGVRDRPMILKRFVKGIAQEAVFQKRVPE
MUL_1190|M.ulcerans_Agy99 ---RTKLDLVRYYLSVADGALRGVAGRPMMLKRFVKGIDVEAVFQKRAPT
MMAR_0527|M.marinum_M ---RTKLDLVRYYLSVADGALRGVAGRPMMLKRFVKGIDVEAVFQKRAPT
Mb0275c|M.bovis_AF2122/97 ---YTKFDLVRYYLAVAEGAMRGVAGRPMILKRFVKGISAEAVFQKRAPA
Rv0269c|M.tuberculosis_H37Rv ---YTKFDLVRYYLAVAEGAMRGVAGRPMILKRFVKGISAEAVFQKRAPA
MAV_4893|M.avium_104 AGPYTKLDLVRYYLSVADGALRGVAGRPMILKRFVKGITQEAVFQKRAPA
** :*: ** **: *:*** .***:******** **:****.*
Mflv_0342|M.gilvum_PYR-GCK NRPDFVDVAELKYASGTSAAEAVLRDPAGLVWAVNLGCVDLNPHPVRAED
Mvan_0396|M.vanbaalenii_PYR-1 KRPDFVDVAELKYASGTSAKEAVLHDAAGLIWAVNLGCVDLNPHPVRADD
TH_3847|M.thermoresistible__bu KRPDFVDTAELRYASGTSAAEAVIHDAAGLVWAVNLGCVDLNPHPVRADD
MSMEG_0597|M.smegmatis_MC2_155 KRPDFIEVAELKYRSGTSAKEAVLRNTAGLAWAVNLGCVDLNPHPVRADD
MAB_4341|M.abscessus_ATCC_1997 KRPDWIASAELHYARGTSAREAVVTDAASLAWVVNLGCVDLNPHPVRADD
MUL_1190|M.ulcerans_Agy99 NRPDWVDVAELRYASGTSAQEAVIHDAAGLAWAINLGCVDLNPHPVLARD
MMAR_0527|M.marinum_M NRPDWVDVAELRYASGTSAQEAVIHDAAGLAWAINLGCVDLNPHPVLARD
Mb0275c|M.bovis_AF2122/97 NRPDWVDVAELHYASGRSAAEAVIHDAAGLAWVINLGCVDLNPHPVLAGD
Rv0269c|M.tuberculosis_H37Rv NRPDWVDVAELHYASGRSAAEAVIHDAAGLAWVINLGCVDLNPHPVLAGD
MAV_4893|M.avium_104 NRPDWVDVAELRYARGTSAAEAVIHDAAGLAWVINLGCVDLNPHPVLADD
:***:: ***:* * ** ***: :.*.* *.:************ * *
Mflv_0342|M.gilvum_PYR-GCK LDHPDELRVDLDPMPGVGWRQILDVAFVAREVLEDHGLVAWPKTSGSRGF
Mvan_0396|M.vanbaalenii_PYR-1 LEHPDELRVDLDPMPGVGWRQILDVAFVAREVLEDHGLVAWPKTSGSRGF
TH_3847|M.thermoresistible__bu LAHPDELRVDLDPMPGVGWRQIIDVAWVAREVLEDHGLTAWPKTSGSRGF
MSMEG_0597|M.smegmatis_MC2_155 LDHPDELRVDLDPMPGVEWQQILDVAMVAREVLSDHGLTAWPKTSGSRGF
MAB_4341|M.abscessus_ATCC_1997 LDHPDELRIDLDPVPGVPWSQILDVAFVVRGVLEDHGLTAWPKTSGSRGF
MUL_1190|M.ulcerans_Agy99 LDHPDELRIDLDPMPGVEWRRILDVAQVVREVLEDYGLTPWPKTSGSRGF
MMAR_0527|M.marinum_M LDHPDELRIDLDPMPGVEWRRILDVAQVVREVLEDYGLTPWPKTSGSRGF
Mb0275c|M.bovis_AF2122/97 LDHPDELRVDLDPMPGVAWQRVVEVALVVREVLEDYGLTAWPKTSGSRGF
Rv0269c|M.tuberculosis_H37Rv LDHPDELRVDLDPMPGVAWQRVVEVALVVREVLEDYGLTAWPKTSGSRGF
MAV_4893|M.avium_104 LDHPDELRVDLDPMPGVSWRRIVDVALVAREVLEDYGLTPWPKTSGSRGF
* ******:****:*** * ::::** *.* **.*:**..**********
Mflv_0342|M.gilvum_PYR-GCK HIYARIHPRWPFKQVRLAAEAVAREVERRAPESATARWWKEERHGVFVDF
Mvan_0396|M.vanbaalenii_PYR-1 HIYARIHRRWPFKLVRLAAETVAREVERRAPESATARWWKEERQGVFVDF
TH_3847|M.thermoresistible__bu HIYARIERRWPFKQVRLAAQAVAREVERRAPESATARWWKEERHGVFVDF
MSMEG_0597|M.smegmatis_MC2_155 HIYARISRDWPYAKVRLAAQTVAREVERRAPDLATAHWWKEEREGVFVDF
MAB_4341|M.abscessus_ATCC_1997 HIYAPVARRWTYRELRLAAETVAREVERRAPELATSRWWKEERHGVFVDF
MUL_1190|M.ulcerans_Agy99 HVYARIAPQWSFSQVRLAAQTVAREVERRMPGVATSRWWKEEREGVFVDF
MMAR_0527|M.marinum_M HVYARIAPQWSFSQVRLAAQTVAREVERRMPGVATSRWWKEEREGVFVDF
Mb0275c|M.bovis_AF2122/97 HVYARIAPCWSFPQVRLAAQTVAREVERRLPDAATSRWWKEEREGVFVDF
Rv0269c|M.tuberculosis_H37Rv HVYARIAPCWSFPQVRLAAQTVAREVERRLPDAATSRWWKEEREGVFVDF
MAV_4893|M.avium_104 HIYAHIARRWEFRQVRLAAQTVAREVERRAPEAATSRWWKEEREGVFVDF
*:** : * : :****::******** * **::******.******
Mflv_0342|M.gilvum_PYR-GCK NQNAKDRTVASAYSVRATPDARVSTPLFWDELAGCKPEEFTVHTVPARFA
Mvan_0396|M.vanbaalenii_PYR-1 NQNAKDRTVASAYSVRATPDARVSTPLFWDEVADCRPEEFTVRTVPRRFS
TH_3847|M.thermoresistible__bu NQNAYDRTVASAYSVRATPDARVSTPLRWDEVSRCDPAEFTIATVPGRVA
MSMEG_0597|M.smegmatis_MC2_155 NQNAKDRTVASAYSVRATPDARVSTPLRWDEVPTCRPEEFTIATVPDRFA
MAB_4341|M.abscessus_ATCC_1997 NQNAKDRTVASAYSVRATPDARVSTPLRWDEVAGCRPESFTLHTVRERFA
MUL_1190|M.ulcerans_Agy99 NQNAKDRTVASAYSVRANPDARVSTPLHWHEVADCDPQDFTLDAVPDRFA
MMAR_0527|M.marinum_M NQNAKDRTVASAYSVRANPDARVSTPLHWHEVADCDPQDFTLDTVPDRFA
Mb0275c|M.bovis_AF2122/97 NQNAKDRTVASAYSVRATPDARVSTPLHWEEVPGCDPAVFTMATVPSRLA
Rv0269c|M.tuberculosis_H37Rv NQNAKDRTVASAYSVRATPDARVSTPLHWEEVPGCDPAVFTMATVPSRLA
MAV_4893|M.avium_104 NQNAKDRTVASAYSVRATPDARVSTPLRWDEVAGCRPEAFTIDTVPARLA
**** ************.********* *.*:. * * **: :* *.:
Mflv_0342|M.gilvum_PYR-GCK ELGDPWEGMDDAAGGLEALLELSDRLGPAEKAPRGAKKSVDGRRASVMPL
Mvan_0396|M.vanbaalenii_PYR-1 ERGDPWEGMDDAAGGLEALLDLADRLGPAEKAPRGARKSADGRRVSVMPL
TH_3847|M.thermoresistible__bu DIGDPWEPMDDHAGSLDALLTLAEDLGPPERAPRGVSRGT-GRRQSSKPL
MSMEG_0597|M.smegmatis_MC2_155 EIGDPWEGMDTAVGGLDGLLALAEELGPAEKAPKGASRDG--RRASTMPL
MAB_4341|M.abscessus_ATCC_1997 DIDDPWRGMDDATGTLDQLLELAAELGPAEKAPKGASRDG--RRRPTMPL
MUL_1190|M.ulcerans_Agy99 ELGDPWSGMDGAVGALDRLLMLAEELGPPQRAPAGAGKRRDGRRQPSMPL
MMAR_0527|M.marinum_M EMGDPWSGMDGAVGALDRLLMLAEELGPPQRAPAGAGKRSDGRRQPSMPL
Mb0275c|M.bovis_AF2122/97 DIGDPWAGMDDAVGRLDRLLMLAEELGPPQKA------------QSAKPL
Rv0269c|M.tuberculosis_H37Rv DIGDPWAGMDDAVGRLDRLLMLAEELGPPQKA------------QSAKPL
MAV_4893|M.avium_104 EIGDPWAGMDDAVGDLDRLLVLAEELGPPERAPKGAGTRSGGRRRSSMPL
: .*** ** .* *: ** *: ***.::* . **
Mflv_0342|M.gilvum_PYR-GCK IEIARTKTKDEALSALAQWRDKYPAVSEKLEPADVLVDGMRGPSSIWYRI
Mvan_0396|M.vanbaalenii_PYR-1 IEIARTKTKDEAMAALQQWRDKYPAAAEKLEPADVLVDGMRGPSSIWYRI
TH_3847|M.thermoresistible__bu IEIARTRTRDEAMAALDTWRDRYPAVAEKLQPADILVDGMRGPSSIWYRI
MSMEG_0597|M.smegmatis_MC2_155 IEIARTKTKDEAMAALDIWRERYPEVSKKLEPVDILVDGMRGPSSIWYRI
MAB_4341|M.abscessus_ATCC_1997 IEIARTKTKPEAQAALDVWRDTYPRVAGLLEPQDILIDGMRGPSSVWYRV
MUL_1190|M.ulcerans_Agy99 IEVARTKTKDEAMAALDTWRARHPAVADRLQPADVLVDGMRGPSSIWYRI
MMAR_0527|M.marinum_M IEVARTKTKDEAMAALDTWRARHPAVADRLQPADVLVDGMRGPSSIWYRI
Mb0275c|M.bovis_AF2122/97 IEIARAKTRAEAMAALDIWRDRYPGAAALLRPADVLVDGMRGPSSIWYRI
Rv0269c|M.tuberculosis_H37Rv IEIARAKTRAEAMAALDIWRDRYPGAAALLRPADVLVDGMRGPSSIWYRI
MAV_4893|M.avium_104 IEVARTKTRDEAMAALDVWRDRHPGAAARLQPADVLVDGMRGPSSIWYRI
**:**::*: ** :** ** :* .: *.* *:*:********:***:
Mflv_0342|M.gilvum_PYR-GCK RINLQHVAEDQRPPQEELLADYSPWTHYTGAQQQRRD----
Mvan_0396|M.vanbaalenii_PYR-1 RINLQHVAEDARPAQEELLADYNPWHNYTGAQQQRRD----
TH_3847|M.thermoresistible__bu RINLEHVPEAERPPQEPLLADYDPWQNYSGHQQRRS-----
MSMEG_0597|M.smegmatis_MC2_155 RINLQHVPEGERPPQEELIADYSPWENYSGAQWRR------
MAB_4341|M.abscessus_ATCC_1997 RINLVHVPEGQRPAQEELIADYSPWS---------------
MUL_1190|M.ulcerans_Agy99 RINLQHIPPEARPPQEELIAEYNPWHGYRPPDGRGRPGADG
MMAR_0527|M.marinum_M RINLQHIPPEARPPQEELIAEYNPWHGYRPPDGRGRPGADG
Mb0275c|M.bovis_AF2122/97 RINLQHVPADQRPPQEELIADYSPWPR--------------
Rv0269c|M.tuberculosis_H37Rv RINLQHVPADQRPPQEELIADYSPWPR--------------
MAV_4893|M.avium_104 RINLQHVPEDQRPPQEELIADYSPWQGYG---GRQKPSWG-
**** *:. **.** *:*:*.**