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SRMAAPVSLDVHGRQVIVTHPGRVVFPAHNDRKGYTKFDLVRYYLAVAEGAMRGVAGRPMILKRFVKGIS AEAVFQKRAPANRPDWVDVAELHYASGRSAAEAVIHDAAGLAWVINLGCVDLNPHPVLAGDLDHPDELRV DLDPMPGVAWQRVVEVALVVREVLEDYGLTAWPKTSGSRGFHVYARIAPCWSFPQVRLAAQTVAREVERR LPDAATSRWWKEEREGVFVDFNQNAKDRTVASAYSVRATPDARVSTPLHWEEVPGCDPAVFTMATVPSRL ADIGDPWAGMDDAVGRLDRLLMLAEELGPPQKAQSAKPLIEIARAKTRAEAMAALDIWRDRYPGAAALLR PADVLVDGMRGPSSIWYRIRINLQHVPADQRPPQEELIADYSPWPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0269c | - | - | 100% (397) | hypothetical protein Rv0269c |
| M. tuberculosis H37Rv | Rv3730c | - | 1e-75 | 49.34% (304) | hypothetical protein Rv3730c |
| M. tuberculosis H37Rv | Rv0938 | - | 8e-36 | 32.01% (328) | ATP-dependent DNA ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0275c | - | 0.0 | 100.00% (397) | hypothetical protein Mb0275c |
| M. gilvum PYR-GCK | Mflv_0342 | - | 1e-165 | 70.30% (404) | DNA primase, small subunit |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4341 | - | 1e-164 | 69.75% (400) | hypothetical protein MAB_4341 |
| M. marinum M | MMAR_0527 | - | 0.0 | 77.97% (404) | hypothetical protein MMAR_0527 |
| M. avium 104 | MAV_4893 | - | 0.0 | 79.23% (414) | hypothetical protein MAV_4893 |
| M. smegmatis MC2 155 | MSMEG_0597 | - | 1e-171 | 71.89% (402) | hypothetical protein MSMEG_0597 |
| M. thermoresistible (build 8) | TH_3847 | - | 1e-171 | 72.95% (403) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_1190 | - | 0.0 | 77.72% (404) | hypothetical protein MUL_1190 |
| M. vanbaalenii PYR-1 | Mvan_0396 | - | 1e-163 | 70.30% (404) | hypothetical protein Mvan_0396 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0342|M.gilvum_PYR-GCK --------------MAARESYEIGGRTVPVTHLDKVVFG------ELG--
Mvan_0396|M.vanbaalenii_PYR-1 --------------MAARESFEIAGEQVPITNPDKVVFG------DLG--
TH_3847|M.thermoresistible__bu --------------MAESRTVEVDGRRVVVSNPNKVVFP------QLG--
MSMEG_0597|M.smegmatis_MC2_155 MTTIAVAGSHYDVMMAGALTLELDGLTVSVTNPDKVIFP------EYDGR
MAB_4341|M.abscessus_ATCC_1997 ----MADGLRASGSSKADLVLQVAGRDVTITHPDKVIFP------DSG--
Rv0269c|M.tuberculosis_H37Rv -----------MSRMAAPVSLDVHGRQVIVTHPGRVVFP--AHNDRKG--
Mb0275c|M.bovis_AF2122/97 -----------MSRMAAPVSLDVHGRQVIVTHPGRVVFP--AHNDRKG--
MMAR_0527|M.marinum_M --------------MTGPVSLELAGRQVKITHPDRVVFP--GQGDRPS--
MUL_1190|M.ulcerans_Agy99 -----------MIPMTGPVSLELAGRQVKITHPDRVVFP--GQGDRPS--
MAV_4893|M.avium_104 -----------MNHMTRPVSLEVAGRRVTITHPDKVVFPRAGGGETTGSA
:: * * ::: .:*:* .
Mflv_0342|M.gilvum_PYR-GCK ---LTKLDLIDYYASVADGALRGVRDRPMILKRFVKGIDEEAVFQKRAPK
Mvan_0396|M.vanbaalenii_PYR-1 ---LTKLDLMRYYAAVADGALRGVRDRPMILKRFVKGIEQEAVFQKRAPE
TH_3847|M.thermoresistible__bu ---LTKSDLVDYYLSVAEPALRGVRNRPMILKRFVKGITEEAVFQKRAPA
MSMEG_0597|M.smegmatis_MC2_155 AA-VTKLDLVNYYRAVADGALRGVFGRPMILKRFVKGIATEAIFQKRAPE
MAB_4341|M.abscessus_ATCC_1997 ---ITKGNLVHYYLDVAEGALRGVRDRPMILKRFVKGIAQEAVFQKRVPE
Rv0269c|M.tuberculosis_H37Rv ---YTKFDLVRYYLAVAEGAMRGVAGRPMILKRFVKGISAEAVFQKRAPA
Mb0275c|M.bovis_AF2122/97 ---YTKFDLVRYYLAVAEGAMRGVAGRPMILKRFVKGISAEAVFQKRAPA
MMAR_0527|M.marinum_M ---RTKLDLVRYYLSVADGALRGVAGRPMMLKRFVKGIDVEAVFQKRAPT
MUL_1190|M.ulcerans_Agy99 ---RTKLDLVRYYLSVADGALRGVAGRPMMLKRFVKGIDVEAVFQKRAPT
MAV_4893|M.avium_104 AGPYTKLDLVRYYLSVADGALRGVAGRPMILKRFVKGITQEAVFQKRAPA
** :*: ** **: *:*** .***:******** **:****.*
Mflv_0342|M.gilvum_PYR-GCK NRPDFVDVAELKYASGTSAAEAVLRDPAGLVWAVNLGCVDLNPHPVRAED
Mvan_0396|M.vanbaalenii_PYR-1 KRPDFVDVAELKYASGTSAKEAVLHDAAGLIWAVNLGCVDLNPHPVRADD
TH_3847|M.thermoresistible__bu KRPDFVDTAELRYASGTSAAEAVIHDAAGLVWAVNLGCVDLNPHPVRADD
MSMEG_0597|M.smegmatis_MC2_155 KRPDFIEVAELKYRSGTSAKEAVLRNTAGLAWAVNLGCVDLNPHPVRADD
MAB_4341|M.abscessus_ATCC_1997 KRPDWIASAELHYARGTSAREAVVTDAASLAWVVNLGCVDLNPHPVRADD
Rv0269c|M.tuberculosis_H37Rv NRPDWVDVAELHYASGRSAAEAVIHDAAGLAWVINLGCVDLNPHPVLAGD
Mb0275c|M.bovis_AF2122/97 NRPDWVDVAELHYASGRSAAEAVIHDAAGLAWVINLGCVDLNPHPVLAGD
MMAR_0527|M.marinum_M NRPDWVDVAELRYASGTSAQEAVIHDAAGLAWAINLGCVDLNPHPVLARD
MUL_1190|M.ulcerans_Agy99 NRPDWVDVAELRYASGTSAQEAVIHDAAGLAWAINLGCVDLNPHPVLARD
MAV_4893|M.avium_104 NRPDWVDVAELRYARGTSAAEAVIHDAAGLAWVINLGCVDLNPHPVLADD
:***:: ***:* * ** ***: :.*.* *.:************ * *
Mflv_0342|M.gilvum_PYR-GCK LDHPDELRVDLDPMPGVGWRQILDVAFVAREVLEDHGLVAWPKTSGSRGF
Mvan_0396|M.vanbaalenii_PYR-1 LEHPDELRVDLDPMPGVGWRQILDVAFVAREVLEDHGLVAWPKTSGSRGF
TH_3847|M.thermoresistible__bu LAHPDELRVDLDPMPGVGWRQIIDVAWVAREVLEDHGLTAWPKTSGSRGF
MSMEG_0597|M.smegmatis_MC2_155 LDHPDELRVDLDPMPGVEWQQILDVAMVAREVLSDHGLTAWPKTSGSRGF
MAB_4341|M.abscessus_ATCC_1997 LDHPDELRIDLDPVPGVPWSQILDVAFVVRGVLEDHGLTAWPKTSGSRGF
Rv0269c|M.tuberculosis_H37Rv LDHPDELRVDLDPMPGVAWQRVVEVALVVREVLEDYGLTAWPKTSGSRGF
Mb0275c|M.bovis_AF2122/97 LDHPDELRVDLDPMPGVAWQRVVEVALVVREVLEDYGLTAWPKTSGSRGF
MMAR_0527|M.marinum_M LDHPDELRIDLDPMPGVEWRRILDVAQVVREVLEDYGLTPWPKTSGSRGF
MUL_1190|M.ulcerans_Agy99 LDHPDELRIDLDPMPGVEWRRILDVAQVVREVLEDYGLTPWPKTSGSRGF
MAV_4893|M.avium_104 LDHPDELRVDLDPMPGVSWRRIVDVALVAREVLEDYGLTPWPKTSGSRGF
* ******:****:*** * ::::** *.* **.*:**..**********
Mflv_0342|M.gilvum_PYR-GCK HIYARIHPRWPFKQVRLAAEAVAREVERRAPESATARWWKEERHGVFVDF
Mvan_0396|M.vanbaalenii_PYR-1 HIYARIHRRWPFKLVRLAAETVAREVERRAPESATARWWKEERQGVFVDF
TH_3847|M.thermoresistible__bu HIYARIERRWPFKQVRLAAQAVAREVERRAPESATARWWKEERHGVFVDF
MSMEG_0597|M.smegmatis_MC2_155 HIYARISRDWPYAKVRLAAQTVAREVERRAPDLATAHWWKEEREGVFVDF
MAB_4341|M.abscessus_ATCC_1997 HIYAPVARRWTYRELRLAAETVAREVERRAPELATSRWWKEERHGVFVDF
Rv0269c|M.tuberculosis_H37Rv HVYARIAPCWSFPQVRLAAQTVAREVERRLPDAATSRWWKEEREGVFVDF
Mb0275c|M.bovis_AF2122/97 HVYARIAPCWSFPQVRLAAQTVAREVERRLPDAATSRWWKEEREGVFVDF
MMAR_0527|M.marinum_M HVYARIAPQWSFSQVRLAAQTVAREVERRMPGVATSRWWKEEREGVFVDF
MUL_1190|M.ulcerans_Agy99 HVYARIAPQWSFSQVRLAAQTVAREVERRMPGVATSRWWKEEREGVFVDF
MAV_4893|M.avium_104 HIYAHIARRWEFRQVRLAAQTVAREVERRAPEAATSRWWKEEREGVFVDF
*:** : * : :****::******** * **::******.******
Mflv_0342|M.gilvum_PYR-GCK NQNAKDRTVASAYSVRATPDARVSTPLFWDELAGCKPEEFTVHTVPARFA
Mvan_0396|M.vanbaalenii_PYR-1 NQNAKDRTVASAYSVRATPDARVSTPLFWDEVADCRPEEFTVRTVPRRFS
TH_3847|M.thermoresistible__bu NQNAYDRTVASAYSVRATPDARVSTPLRWDEVSRCDPAEFTIATVPGRVA
MSMEG_0597|M.smegmatis_MC2_155 NQNAKDRTVASAYSVRATPDARVSTPLRWDEVPTCRPEEFTIATVPDRFA
MAB_4341|M.abscessus_ATCC_1997 NQNAKDRTVASAYSVRATPDARVSTPLRWDEVAGCRPESFTLHTVRERFA
Rv0269c|M.tuberculosis_H37Rv NQNAKDRTVASAYSVRATPDARVSTPLHWEEVPGCDPAVFTMATVPSRLA
Mb0275c|M.bovis_AF2122/97 NQNAKDRTVASAYSVRATPDARVSTPLHWEEVPGCDPAVFTMATVPSRLA
MMAR_0527|M.marinum_M NQNAKDRTVASAYSVRANPDARVSTPLHWHEVADCDPQDFTLDTVPDRFA
MUL_1190|M.ulcerans_Agy99 NQNAKDRTVASAYSVRANPDARVSTPLHWHEVADCDPQDFTLDAVPDRFA
MAV_4893|M.avium_104 NQNAKDRTVASAYSVRATPDARVSTPLRWDEVAGCRPEAFTIDTVPARLA
**** ************.********* *.*:. * * **: :* *.:
Mflv_0342|M.gilvum_PYR-GCK ELGDPWEGMDDAAGGLEALLELSDRLGPAEKAPRGAKKSVDGRRASVMPL
Mvan_0396|M.vanbaalenii_PYR-1 ERGDPWEGMDDAAGGLEALLDLADRLGPAEKAPRGARKSADGRRVSVMPL
TH_3847|M.thermoresistible__bu DIGDPWEPMDDHAGSLDALLTLAEDLGPPERAPRGVSRGT-GRRQSSKPL
MSMEG_0597|M.smegmatis_MC2_155 EIGDPWEGMDTAVGGLDGLLALAEELGPAEKAPKGASRDG--RRASTMPL
MAB_4341|M.abscessus_ATCC_1997 DIDDPWRGMDDATGTLDQLLELAAELGPAEKAPKGASRDG--RRRPTMPL
Rv0269c|M.tuberculosis_H37Rv DIGDPWAGMDDAVGRLDRLLMLAEELGPPQKA------------QSAKPL
Mb0275c|M.bovis_AF2122/97 DIGDPWAGMDDAVGRLDRLLMLAEELGPPQKA------------QSAKPL
MMAR_0527|M.marinum_M EMGDPWSGMDGAVGALDRLLMLAEELGPPQRAPAGAGKRSDGRRQPSMPL
MUL_1190|M.ulcerans_Agy99 ELGDPWSGMDGAVGALDRLLMLAEELGPPQRAPAGAGKRRDGRRQPSMPL
MAV_4893|M.avium_104 EIGDPWAGMDDAVGDLDRLLVLAEELGPPERAPKGAGTRSGGRRRSSMPL
: .*** ** .* *: ** *: ***.::* . **
Mflv_0342|M.gilvum_PYR-GCK IEIARTKTKDEALSALAQWRDKYPAVSEKLEPADVLVDGMRGPSSIWYRI
Mvan_0396|M.vanbaalenii_PYR-1 IEIARTKTKDEAMAALQQWRDKYPAAAEKLEPADVLVDGMRGPSSIWYRI
TH_3847|M.thermoresistible__bu IEIARTRTRDEAMAALDTWRDRYPAVAEKLQPADILVDGMRGPSSIWYRI
MSMEG_0597|M.smegmatis_MC2_155 IEIARTKTKDEAMAALDIWRERYPEVSKKLEPVDILVDGMRGPSSIWYRI
MAB_4341|M.abscessus_ATCC_1997 IEIARTKTKPEAQAALDVWRDTYPRVAGLLEPQDILIDGMRGPSSVWYRV
Rv0269c|M.tuberculosis_H37Rv IEIARAKTRAEAMAALDIWRDRYPGAAALLRPADVLVDGMRGPSSIWYRI
Mb0275c|M.bovis_AF2122/97 IEIARAKTRAEAMAALDIWRDRYPGAAALLRPADVLVDGMRGPSSIWYRI
MMAR_0527|M.marinum_M IEVARTKTKDEAMAALDTWRARHPAVADRLQPADVLVDGMRGPSSIWYRI
MUL_1190|M.ulcerans_Agy99 IEVARTKTKDEAMAALDTWRARHPAVADRLQPADVLVDGMRGPSSIWYRI
MAV_4893|M.avium_104 IEVARTKTRDEAMAALDVWRDRHPGAAARLQPADVLVDGMRGPSSIWYRI
**:**::*: ** :** ** :* .: *.* *:*:********:***:
Mflv_0342|M.gilvum_PYR-GCK RINLQHVAEDQRPPQEELLADYSPWTHYTGAQQQRRD----
Mvan_0396|M.vanbaalenii_PYR-1 RINLQHVAEDARPAQEELLADYNPWHNYTGAQQQRRD----
TH_3847|M.thermoresistible__bu RINLEHVPEAERPPQEPLLADYDPWQNYSGHQQRRS-----
MSMEG_0597|M.smegmatis_MC2_155 RINLQHVPEGERPPQEELIADYSPWENYSGAQWRR------
MAB_4341|M.abscessus_ATCC_1997 RINLVHVPEGQRPAQEELIADYSPWS---------------
Rv0269c|M.tuberculosis_H37Rv RINLQHVPADQRPPQEELIADYSPWPR--------------
Mb0275c|M.bovis_AF2122/97 RINLQHVPADQRPPQEELIADYSPWPR--------------
MMAR_0527|M.marinum_M RINLQHIPPEARPPQEELIAEYNPWHGYRPPDGRGRPGADG
MUL_1190|M.ulcerans_Agy99 RINLQHIPPEARPPQEELIAEYNPWHGYRPPDGRGRPGADG
MAV_4893|M.avium_104 RINLQHVPEDQRPPQEELIADYSPWQGYG---GRQKPSWG-
**** *:. **.** *:*:*.**