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RNTLRNNASHVLRGTMAWLLCVVIAVSLVACGGGRQKTHYDAAPCPEPNFPGVPQAELGANYSCGYLTVP ENRLDPQSRTIRLLVARVEAVSNKPKADPIVYLAGGPGGAATLSAPRVVAGGLNADRDVIFVNQRDTLHS DPHLSCPEMDDFAVRALDLDFEAPATADLDAAAVTACRNRLVAEGFHLASYSSRENAADIAALRKQLGIE KWNIYGVSYGSDLAQQLLRTHREGIRSMVLDSVVPTSFNLIDRWWQAPASGLAAIIGACNDQPGCAQAYP DLATVFVNVVSTLSRKPLKVSTFDANGDPVQVTIDGFKVVPLVLSWSADPAKVTDIPRMIFALARGEGRL AAAGIAETVPPPEQRGLLGAGLALGTYCQEMANWTTPEQALSRARTAIPGLPDSVLRITPTGSWIFRKCA AWGLGRPDTADRLSVSRGCPPSSCRARSTPAPRHSGPRRSPPGWATRSWCGFPGCAMVSCRIRRAPSRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0698 | - | - | 100% (490) | hypothetical protein MUL_0698 |
| M. ulcerans Agy99 | MUL_1334 | - | 7e-10 | 26.80% (291) | exported protease |
| M. ulcerans Agy99 | MUL_1332 | - | 3e-08 | 24.31% (218) | exported protease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2248c | - | 4e-09 | 24.23% (260) | exported protease |
| M. gilvum PYR-GCK | Mflv_2906 | - | 2e-11 | 27.78% (198) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv2224c | - | 4e-09 | 24.23% (260) | exported protease |
| M. leprae Br4923 | MLBr_01632 | - | 4e-10 | 24.75% (198) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_1918 | - | 3e-07 | 26.42% (193) | hypothetical protein MAB_1918 |
| M. marinum M | MMAR_0947 | - | 0.0 | 91.72% (459) | hypothetical protein MMAR_0947 |
| M. avium 104 | MAV_2243 | - | 5e-10 | 25.45% (224) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_4295 | - | 2e-11 | 27.14% (269) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_0213 | - | 3e-14 | 31.37% (204) | Probable exported protease |
| M. vanbaalenii PYR-1 | Mvan_3599 | - | 3e-13 | 26.87% (268) | TAP domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4295|M.smegmatis_MC2_155 -------MLP------ALMTALVTFG--IPVASATPEGDAATPFA-----
TH_0213|M.thermoresistible__bu -MWRVGRLMA------AALAALLLVGVFVPPASATPGETPVSNTG-----
Mflv_2906|M.gilvum_PYR-GCK --MTAMLRAG------PMIAALALISAALSPTASAAPGTSAEPYT-----
Mvan_3599|M.vanbaalenii_PYR-1 --MAAMLRAA------RLIAALAVTAAAQCPTAAAAPVAVEEPYT-----
MLBr_01632|M.leprae_Br4923 --MVAMPSLR------SLSSALLSLGLLL--QPAMTPPVVGASPE----Q
MAV_2243|M.avium_104 -----MSRLR------SLSSALLSFGLVLGGTSGVGLPVAGATPEPGAGQ
Mb2248c|M.bovis_AF2122/97 MGMR-LSRRDKIARMLLIWAALAAVALVLVGCIRVVGGRARMAEP-----
Rv2224c|M.tuberculosis_H37Rv MGMR-LSRRDKIARMLLIWAALAAVALVLVGCIRVVGGRARMAEP-----
MAB_1918|M.abscessus_ATCC_1997 MMLRGLGRPG-----LLPLLALASVVAVVSGCVRSVEGEATAAHP-----
MUL_0698|M.ulcerans_Agy99 --MRNTLRNN-ASHVLRGTMAWLLCVVIAVSLVACGGGRQKTHYD-----
MMAR_0947|M.marinum_M -------------------MAWLLCVVIAVSLVACGGGRQKTHYD-----
*
MSMEG_4295|M.smegmatis_MC2_155 ----------APPVWGGCAQWVADPARIP-TAQCGTLAVPVDWNNPDPQG
TH_0213|M.thermoresistible__bu ----------IAPVWGDCSRFIPNAAALP-TARCGYLPVPLNWAEPD--G
Mflv_2906|M.gilvum_PYR-GCK ----------AAAVWDSCTTVLADASAVP-TARCGTVAVPVDYADPG--G
Mvan_3599|M.vanbaalenii_PYR-1 ----------AAAVWSSCTPWIADVSRIP-TAQCGTVAVPVDYAKPE--G
MLBr_01632|M.leprae_Br4923 TPSPVP-----EQNWGNCSVFLSDTSDIP-SARCATVSVPVDYNNPD--G
MAV_2243|M.avium_104 TPAPNPPAAAAPQGWGSCSQFVTDTSDIP-TAQCTTVSVPIDYNNPG--A
Mb2248c|M.bovis_AF2122/97 -------KLGQPVEWTPCRSSNPQ-VKIPGGALCGKLAVPVDYDRPD--G
Rv2224c|M.tuberculosis_H37Rv -------KLGQPVEWTPCRSSNPQ-VKIPGGALCGKLAVPVDYDRPD--G
MAB_1918|M.abscessus_ATCC_1997 -------SETS-LSWGDCDGFTPENVTVPASTVCSELEVPVDYTKPD--G
MUL_0698|M.ulcerans_Agy99 -----------AAPCPEPNFPGVPQAELGANYSCGYLTVPENRLDPQSRT
MMAR_0947|M.marinum_M -----------AAPCPEPNFPGVPQAELGANYSCGYLTVPENRLDPQSRT
: * : ** : *
MSMEG_4295|M.smegmatis_MC2_155 AQAQLAVIRVPASGDRIGALFVNPGGPGASAVDTVAGMGAALAGTEIGQR
TH_0213|M.thermoresistible__bu PQVQLAVIRVPADGPKVGALFVNPGGPGGSAVNTVAGMAAALAGTDVTSR
Mflv_2906|M.gilvum_PYR-GCK AQAHLAVISVPATGPRIGVLVVNPGGPGASAVDTVAGMGAALAGTEIARR
Mvan_3599|M.vanbaalenii_PYR-1 AQAQLAIIKVPASGPRVGVLIVNPGGPGASAVNTVASMGGALAGSEIGRH
MLBr_01632|M.leprae_Br4923 VHAELAVIRAPATGQRIGSLLFNPGGPGASAVDMVAEMIPGLQRTDIGRH
MAV_2243|M.avium_104 GQAKLAVIRVPATGQRLGSLLVNPGGPGGSAVDMVAAMASDMDNSAIRRS
Mb2248c|M.bovis_AF2122/97 DVAALALIRFPATGDKIGSLVINPGGPGESGIEAALGVFQTLP-KRVHER
Rv2224c|M.tuberculosis_H37Rv DVAALALIRFPATGDKIGSLVINPGGPGESGIEAALGVFQTLP-KRVHER
MAB_1918|M.abscessus_ATCC_1997 AKARLAIIKYPAKGNKIGSLLMNPGGPGQSGIEAATAIVKQVP-KEIRDR
MUL_0698|M.ulcerans_Agy99 IRLLVARVEAVSNKPKADPIVYLAGGPGGAATLSAP----RVVAGGLNAD
MMAR_0947|M.marinum_M IRLLVARVKAVSDKPKADPIVYLAGGPGGAATLSAP----RVVAGGLNAD
:* : : : . :. .**** :. . : :
MSMEG_4295|M.smegmatis_MC2_155 FDLVGFDPRGVGHSTPELRCRTDAEFDAYRREPMADYSPAGVAHIESLYQ
TH_0213|M.thermoresistible__bu FDLIGFDPRGVGHSLPELRCRTDAEFDAYRREPMADYSPAGVAHIEELHR
Mflv_2906|M.gilvum_PYR-GCK FDLVGIDPRGVGHSTPQLRCRTDAEFDAFRTEPMVDYSPAGVAHIEDVLR
Mvan_3599|M.vanbaalenii_PYR-1 FDLVGIDPRGVGHSTPELRCRTDAEFDAFRAEPLADYSPGGVAHIEGVLR
MLBr_01632|M.leprae_Br4923 FDLVGFDPRGVGHSTPALRCRTDVEFDAYRTEPMVDYSPAGVAHIEQVYK
MAV_2243|M.avium_104 FDLVGFDPRGVGHSTPPLRCRTDAEFDAYRREPMVDYSPAGVAHIEQLYR
Mb2248c|M.bovis_AF2122/97 FDLVGFDPRGVASSRPAIWCNSDADNDRLRAEPQVDYSREGVAHIENETK
Rv2224c|M.tuberculosis_H37Rv FDLVGFDPRGVASSRPAIWCNSDADNDRLRAEPQVDYSREGVAHIENETK
MAB_1918|M.abscessus_ATCC_1997 FDFIGFDPRGVGSSTPAIECNSDKDVDRLRAQNDTDYSPEGVARMEQDSK
MUL_0698|M.ulcerans_Agy99 RDVIFVNQRDTLHSDPHLSCPEMDDFAVRALD--LDFEAPATADLDAAAV
MMAR_0947|M.marinum_M RDVIFVNQRGTLHSDPHLSCPEMDDFAVRALD--LDFEAPATADLDAAAV
*.: .: *.. * * : * : : *:. ..* ::
MSMEG_4295|M.smegmatis_MC2_155 QLAQQCLDRMGAPFLANIGTASAVRDMDAVRAALGEHQISYLGFSYGTEL
TH_0213|M.thermoresistible__bu RFAQSCLDRNGADFLAGLGTANAARDMDAVRAALGEEQINYLGFSYGTRL
Mflv_2906|M.gilvum_PYR-GCK QFAARCLDRMGPEFLAGVGTATAARDMDVVREALGEDQINYLGFSYGTQL
Mvan_3599|M.vanbaalenii_PYR-1 DFAAQCLDRMGAEFLASVGTATAARDMDVVRDALGEDRVNYLGFSYGTQL
MLBr_01632|M.leprae_Br4923 QLAQQCVARVGTAFLANVGTASAARDMDIVRLALGDEQINYLGYSYGTEL
MAV_2243|M.avium_104 QLAQQCVNRMGTVFLANAGTASVARDMDAVRQALGDEQINYLGYSYGTEL
Mb2248c|M.bovis_AF2122/97 QFVGRCVDKMGKNFLAHVGTVNVAKDLDAIRAALGDDKLTYLGYSYGTRI
Rv2224c|M.tuberculosis_H37Rv QFVGRCVDKMGKNFLAHVGTVNVAKDLDAIRAALGDDKLTYLGYSYGTRI
MAB_1918|M.abscessus_ATCC_1997 DFVKRCVDKVGLEFLANVGTVNVAKDMDRLRAALGDEKLTYLGYSYGTRI
MUL_0698|M.ulcerans_Agy99 TACRNRLVAEG-FHLASYSSRENAADIAALRKQLGIEKWNIYGVSYGSDL
MMAR_0947|M.marinum_M TACRNRLVAEG-FHLASYSSRENAADIAALRKQLGIEKWNVYGVSYGSDL
: * .** .: . *: :* ** .: . * ***: :
MSMEG_4295|M.smegmatis_MC2_155 GSAYAEAYPDRVRAMVLDGAIDPALNPIDKTIRQMASFQKAFDAYAADCG
TH_0213|M.thermoresistible__bu GAAYAEQFPDRVRTMVLDGAVDPSQDPLAGTTRQMAGFQAAFDEYAADCA
Mflv_2906|M.gilvum_PYR-GCK GAVYASRYPQRVRTMVLDGAVDPTLDPITESLTQNTGFQRAFERYAADCA
Mvan_3599|M.vanbaalenii_PYR-1 GAVYAARYPDRVRAMVLDGAVDPSLDPITESLNQQAGFQKAFEAYAADCA
MLBr_01632|M.leprae_Br4923 GTAYLERFSDHVRAMVLDGAIDPSVSSIQKDIQQMAGFQIAFTDYAADCA
MAV_2243|M.avium_104 GTAYLEKFSNHVRAMVLDGAIDPTVGPVDENINQMAGFQTAFNDYATDCA
Mb2248c|M.bovis_AF2122/97 GSAYAEEFPQRVRAMILDGAVDPNADPIEAELRQAKGFQDAFNNYAADCA
Rv2224c|M.tuberculosis_H37Rv GSAYAEEFPQRVRAMILDGAVDPNADPIEAELRQAKGFQDAFNNYAADCA
MAB_1918|M.abscessus_ATCC_1997 GTTYAEEFPQNVRALILDGVIDPNADPTQADIDQIAGFQKAFDNYAADCA
MUL_0698|M.ulcerans_Agy99 AQQLLRTHREGIRSMVLDSVVPTSFNLIDRWWQAPA---SGLAAIIGACN
MMAR_0947|M.marinum_M AQQLLRTHREGIRSMVLDSVVPTSFNLIDRWWQAPA---SGLAAIIGACN
. . : :*:::**..: . . .: *
MSMEG_4295|M.smegmatis_MC2_155 KLVGCPLGNDPAQYVNRFHQLVDPLVA-------RPGATSDPRGLSYQDA
TH_0213|M.thermoresistible__bu RSPDCPLGTDPAKWVARYHELVDPLVH-------RPAPTSDPRGLSYQDA
Mflv_2906|M.gilvum_PYR-GCK KSAGCPLGTDPTQFVARFHQLVNPLAV-------RPAATSDPRGLGYQDA
Mvan_3599|M.vanbaalenii_PYR-1 ESVGCPLGTDPAQFVARFHQLVDPLVT-------RPAATSDPRGLGYQDA
MLBr_01632|M.leprae_Br4923 RSASCPLGTDPSQWVNRYHALIDPLVT-------KPGRTSDPRGLGYADA
MAV_2243|M.avium_104 RSPGCPLGTDPAQFVNRYHALVDPLVT-------RPGRTADPRGLSYADA
Mb2248c|M.bovis_AF2122/97 KNAGCPLGADPAKAVEVYHSLVDPLVDPDNPRISRPARTKDPRGLSYSDA
Rv2224c|M.tuberculosis_H37Rv KNAGCPLGADPAKAVEVYHSLVDPLVDPDNPRISRPARTKDPRGLSYSDA
MAB_1918|M.abscessus_ATCC_1997 KSPSCPLGTDPAQATARYRAMVDPLVD-------HPAKTKDGRGLSHSDA
MUL_0698|M.ulcerans_Agy99 DQPGCAQAYP--DLATVFVNVVSTLSRK-----PLKVSTFDANGDPVQVT
MMAR_0947|M.marinum_M DQPGCAQAYP--DLATVFVNVVSTLSRK-----PLKVSTSDANGDPVQVT
.*. . . . : ::..* * * .* :
MSMEG_4295|M.smegmatis_MC2_155 ITG------TGNALYSPRYWPFLTSGLLGLERGTDAEDLLLLADDYQHRD
TH_0213|M.thermoresistible__bu ITG------TVQALYSRQYWKYLTSGLLGLRRGTDPVDLLLLADEYLRRD
Mflv_2906|M.gilvum_PYR-GCK ITG------TVSALYSQRFWPYLTSGLLGLQRGTDPGDLLLLADEYQRRD
Mvan_3599|M.vanbaalenii_PYR-1 ITG------TASGLYSQRYWPYLTSGLLGLQRGTDPGDLLLLADDYQQRD
MLBr_01632|M.leprae_Br4923 TTG------TINALYTPVHWKYLTSGLLGLQRGTDAGDLLLLADDYNGRD
MAV_2243|M.avium_104 TTG------TINALYTPAHWKYLTSGLLGLARGTDAGDLLALADDYQGRD
Mb2248c|M.bovis_AF2122/97 IVG------TIMALYSPNLWQHLTDGLSELVDNRG-DTLLALADMYMRRD
Rv2224c|M.tuberculosis_H37Rv IVG------TIMALYSPNLWQHLTDGLSELVDNRG-DTLLALADMYMRRD
MAB_1918|M.abscessus_ATCC_1997 IIG------TIMVMYSPTLWEAFTKALRQLSEGSG-DILQLLADAYMKRD
MUL_0698|M.ulcerans_Agy99 IDGFKVVPLVLSWSADPAKVTDIPRMIFALARGEGRLAAAGIAETVPPPE
MMAR_0947|M.marinum_M IDGFKVVPLVLSWSADPAKVTDIPRMIFALARGEGRLAAAGIAETVPPPE
* . :. : * . . :*: :
MSMEG_4295|M.smegmatis_MC2_155 RNGHYQNMQDAFTAIRCVDDVYPTDPAVWAEADRQIREVAPFFAYGGFTG
TH_0213|M.thermoresistible__bu VNGHYQNQQDAFTAIRCVDAPYPTDPAVWAETDRQVRAVAPFLSYGEFTG
Mflv_2906|M.gilvum_PYR-GCK RDGHYSNQQDAFTAIRCVDAVFPTDPAVWADADRRSRAAVPFLAYGQFTG
Mvan_3599|M.vanbaalenii_PYR-1 RNGHYKNRQDAFNAIRCVDAVYPTDSAPWVEADRRSREVAPFLSYGPFTG
MLBr_01632|M.leprae_Br4923 RNGHYTNDQDAFNAIRCVDAPVPTDSASWVSADQQIRQAAPFLNYGQFTG
MAV_2243|M.avium_104 RNGHYSNDQDAFNAVRCVDAPNPTDQASWVSADQKIRQAAPFLSYGPFTG
Mb2248c|M.bovis_AF2122/97 SHGRYNNSGDARVAINCVDQPPVTDRDKVIDEDRRAREIAPFMSYGKFTG
Rv2224c|M.tuberculosis_H37Rv SHGRYNNSGDARVAINCVDQPPVTDRDKVIDEDRRAREIAPFMSYGKFTG
MAB_1918|M.abscessus_ATCC_1997 EDGHYSHAQDAQTAINCVDEPPEKDRAKAVEKDRRIREVAPFQDYGEFTG
MUL_0698|M.ulcerans_Agy99 QRGLLG-AGLALGTYCQEMANWTTPEQALSRARTAIPGLPDSVLRITPTG
MMAR_0947|M.marinum_M QRGLLG-AGLALGTYCQEMANWTTPEQALSRARTAIPGLPDSVLRITPTG
* * : . **
MSMEG_4295|M.smegmatis_MC2_155 FAPRDVCAFWPVPATSTARPVTGPGPGKVVVVSTTGDPATPYQAGVDLAR
TH_0213|M.thermoresistible__bu FAPRNVCAMWPVPPTSTPAPATSPGPGKVVVVSTTRDPATPHEAGLALAR
Mflv_2906|M.gilvum_PYR-GCK FAPRDVCAMWPVPPTSVVGAATSPGPGKVVVVSTTGDPATPYEAGIALAD
Mvan_3599|M.vanbaalenii_PYR-1 FAPRDLCAMWPVPPTPVVGVASSPGPGKVVVVSTTGDPATPYQAGVNLAQ
MLBr_01632|M.leprae_Br4923 NAPRDICALWPVPATSMPHPAPPVAPGKVVVVSTTHDPATPYQAGVDLAR
MAV_2243|M.avium_104 NAPRDLCALWPVPATSAPHAAPPMPAGKVVVVSTTHDPATPYQAGVNLAR
Mb2248c|M.bovis_AF2122/97 DAPLGTCAFWPVPPTSQPHAVSAPGLVPTVVVSTTHDPATPYKAGVDLAN
Rv2224c|M.tuberculosis_H37Rv DAPLGTCAFWPVPPTSQPHAVSAPGLVPTVVVSTTHDPATPYKAGVDLAN
MAB_1918|M.abscessus_ATCC_1997 NAPLGVCAFWPVPPTSKPHPIHAAGLPKLLVVSTTYDPATPYQAGVELAK
MUL_0698|M.ulcerans_Agy99 SWIFRKCAAWGLGRPDTADRLSVSRGCPPSSCRARSTPAPRHSGPRRSPP
MMAR_0947|M.marinum_M SWIFRECAAWGLGRSDTADRLSVSSGVPTLILSGTFDSSTAPQWAEEITP
** * : . .:. . .
MSMEG_4295|M.smegmatis_MC2_155 QMG-AALISFDGAQHTVVFNGDACVDTAVLRFLTDLQSPPGNLAC-----
TH_0213|M.thermoresistible__bu QLD-AALITFDGAQHTVVFNGNPCVDTAVLNFLIDGVPPPNGLAC-----
Mflv_2906|M.gilvum_PYR-GCK QLD-AQLISFTGTQHTVVFNGDACVDTAVVAFLTNSTPPPSGLRC-----
Mvan_3599|M.vanbaalenii_PYR-1 QMD-ARLITFEGTQHTVVFNGDACVDTATVEFLVNSTPPPAGLRC-----
MLBr_01632|M.leprae_Br4923 ELS-SPLITYDGTQHTAVFNGDQCVDSAVVHYFVDETLLPASLQCQP---
MAV_2243|M.avium_104 QLG-GPLITYDGTQHTAVFNGDQCVDNAVVRYFVAGTPPPASYRCQS---
Mb2248c|M.bovis_AF2122/97 QLR-GSLLTFDGTQHTVVFQGDSCIDEYVTAYLIGGTTPPSGAKC-----
Rv2224c|M.tuberculosis_H37Rv QLR-GSLLTFDGTQHTVVFQGDSCIDEYVTAYLIGGTTPPSGAKC-----
MAB_1918|M.abscessus_ATCC_1997 QLG-GGLLTYDGTKHTIVFDGNQCVDKAAEDYLIKVTTPPEGARC-----
MUL_0698|M.ulcerans_Agy99 GWATRSWCGFPGC-------------AMVSCRIRRAPSRS----------
MMAR_0947|M.marinum_M GLGNSQLVRFPGVGHGVLPS--SACAQSIVTAFVDDPSRDIDKSCVWKMT
: * :
MSMEG_4295|M.smegmatis_MC2_155 -----------
TH_0213|M.thermoresistible__bu -----------
Mflv_2906|M.gilvum_PYR-GCK -----------
Mvan_3599|M.vanbaalenii_PYR-1 -----------
MLBr_01632|M.leprae_Br4923 -----------
MAV_2243|M.avium_104 -----------
Mb2248c|M.bovis_AF2122/97 -----------
Rv2224c|M.tuberculosis_H37Rv -----------
MAB_1918|M.abscessus_ATCC_1997 -----------
MUL_0698|M.ulcerans_Agy99 -----------
MMAR_0947|M.marinum_M MPTFSLPEPAR