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AWLLCVVIAVSLVACGGGRQKTHYDAAPCPEPNFPGVPQAELGANYSCGYLTVPENRLDPQSRTIRLLVA RVKAVSDKPKADPIVYLAGGPGGAATLSAPRVVAGGLNADRDVIFVNQRGTLHSDPHLSCPEMDDFAVRA LDLDFEAPATADLDAAAVTACRNRLVAEGFHLASYSSRENAADIAALRKQLGIEKWNVYGVSYGSDLAQQ LLRTHREGIRSMVLDSVVPTSFNLIDRWWQAPASGLAAIIGACNDQPGCAQAYPDLATVFVNVVSTLSRK PLKVSTSDANGDPVQVTIDGFKVVPLVLSWSADPAKVTDIPRMIFALARGEGRLAAAGIAETVPPPEQRG LLGAGLALGTYCQEMANWTTPEQALSRARTAIPGLPDSVLRITPTGSWIFRECAAWGLGRSDTADRLSVS SGVPTLILSGTFDSSTAPQWAEEITPGLGNSQLVRFPGVGHGVLPSSACAQSIVTAFVDDPSRDIDKSCV WKMTMPTFSLPEPAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0947 | - | - | 100% (506) | hypothetical protein MMAR_0947 |
| M. marinum M | MMAR_3295 | - | 4e-11 | 23.48% (528) | exported protease |
| M. marinum M | MMAR_3297 | - | 2e-09 | 25.23% (218) | exported protease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2248c | - | 6e-12 | 22.61% (522) | exported protease |
| M. gilvum PYR-GCK | Mflv_2904 | - | 1e-14 | 24.64% (487) | TAP domain-containing protein |
| M. tuberculosis H37Rv | Rv2224c | - | 6e-12 | 22.61% (522) | exported protease |
| M. leprae Br4923 | MLBr_01632 | - | 6e-11 | 25.25% (198) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_1919 | - | 5e-11 | 23.84% (474) | hypothetical protein MAB_1919 |
| M. avium 104 | MAV_2243 | - | 8e-11 | 25.89% (224) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_4296 | - | 3e-16 | 22.92% (506) | protease |
| M. thermoresistible (build 8) | TH_0213 | - | 5e-16 | 29.86% (278) | Probable exported protease |
| M. ulcerans Agy99 | MUL_0698 | - | 0.0 | 91.72% (459) | hypothetical protein MUL_0698 |
| M. vanbaalenii PYR-1 | Mvan_3599 | - | 1e-14 | 27.61% (268) | TAP domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
TH_0213|M.thermoresistible__bu ----MWRVGRLMAAALAAL-----LLVGVFVPPASATPG----ETPVSNT
Mvan_3599|M.vanbaalenii_PYR-1 -MAAMLRAARLIAALAVT--------AAAQCPTAAAAPV----AVEEPYT
MLBr_01632|M.leprae_Br4923 --MVAMPSLRSLSSALLSLGLLL--QPAMTPPVVGASPE----QTPSPVP
MAV_2243|M.avium_104 -----MSRLRSLSSALLSFGLVLGGTSGVGLPVAGATPEPGAGQTPAPNP
MAB_1919|M.abscessus_ATCC_1997 ----MMRMRRALPVIFLMLTAAVPAIPAAAAPLPAPSPS---LQAFYDQK
Mb2248c|M.bovis_AF2122/97 MGMRLSRRDKIARMLLIWAALAAVALVLVGCIRVVGGRA----RMAEPKL
Rv2224c|M.tuberculosis_H37Rv MGMRLSRRDKIARMLLIWAALAAVALVLVGCIRVVGGRA----RMAEPKL
Mflv_2904|M.gilvum_PYR-GCK ----------------------MSALLVAGCSKVVDGNA----LVSVPRP
MSMEG_4296|M.smegmatis_MC2_155 ----MAACGAMKVRFGLGALLAVTVLAAGGCSQVIDGRA----IVAVPRP
MMAR_0947|M.marinum_M ------------------MAWLLCVVIAVSLVACGGGRQ----KTHYDAA
MUL_0698|M.ulcerans_Agy99 --MRNTLRNNASHVLRGTMAWLLCVVIAVSLVACGGGRQ----KTHYDAA
TH_0213|M.thermoresistible__bu G---IAPVWGDCSRFIPNAAALP-TARCGYLPVPLNWAEP---DGPQVQL
Mvan_3599|M.vanbaalenii_PYR-1 ----AAAVWSSCTPWIADVSRIP-TAQCGTVAVPVDYAKP---EGAQAQL
MLBr_01632|M.leprae_Br4923 -----EQNWGNCSVFLSDTSDIP-SARCATVSVPVDYNNP---DGVHAEL
MAV_2243|M.avium_104 PAAAAPQGWGSCSQFVTDTSDIP-TAQCTTVSVPIDYNNP---GAGQAKL
MAB_1919|M.abscessus_ATCC_1997 ------VVWGGCDSFVTDTSRIP-TARCAKVKVPVNYDKL---MGAVAEL
Mb2248c|M.bovis_AF2122/97 G---QPVEWTPCRS-SNPQVKIPGGALCGKLAVPVDYDRP---DGDVAAL
Rv2224c|M.tuberculosis_H37Rv G---QPVEWTPCRS-SNPQVKIPGGALCGKLAVPVDYDRP---DGDVAAL
Mflv_2904|M.gilvum_PYR-GCK G---TPIDWSPCETGPSDQKRIPPGSECGMLSVPVDWDNPEDPDGDVAQL
MSMEG_4296|M.smegmatis_MC2_155 G---TPVQWLPCNGGAGNQTPIPDSAECGMLSVPVDYSKP---DGDVARL
MMAR_0947|M.marinum_M P-------CPEPNFPGVPQAELGANYSCGYLTVPENRLDP---QSRTIRL
MUL_0698|M.ulcerans_Agy99 P-------CPEPNFPGVPQAELGANYSCGYLTVPENRLDP---QSRTIRL
: * : ** : . *
TH_0213|M.thermoresistible__bu AVIRVPADG--PKVGALFVNPGGPGGSAVNTVAGMAAALAGTDVTSRFDL
Mvan_3599|M.vanbaalenii_PYR-1 AIIKVPASG--PRVGVLIVNPGGPGASAVNTVASMGGALAGSEIGRHFDL
MLBr_01632|M.leprae_Br4923 AVIRAPATG--QRIGSLLFNPGGPGASAVDMVAEMIPGLQRTDIGRHFDL
MAV_2243|M.avium_104 AVIRVPATG--QRLGSLLVNPGGPGGSAVDMVAAMASDMDNSAIRRSFDL
MAB_1919|M.abscessus_ATCC_1997 AVLRVPATG--KRVGALLVNPGGPGGSGVDLAAGMGAKLGDSAIGQSFDI
Mb2248c|M.bovis_AF2122/97 ALIRFPATG--DKIGSLVINPGGPGESGIEAALGVFQTLP-KRVHERFDL
Rv2224c|M.tuberculosis_H37Rv ALIRFPATG--DKIGSLVINPGGPGESGIEAALGVFQTLP-KRVHERFDL
Mflv_2904|M.gilvum_PYR-GCK AVLRVPATG--DRIGSLVVNPGGPGKSGVEAAAAMVSTLP-EEVLERFDI
MSMEG_4296|M.smegmatis_MC2_155 AMIRFPATG--DRIGSLVINPGGPGESGVESALSLLPSLP-QEVKERFDI
MMAR_0947|M.marinum_M LVARVKAVSDKPKADPIVYLAGGPGG----AATLSAPRVVAGGLNADRDV
MUL_0698|M.ulcerans_Agy99 LVARVEAVSNKPKADPIVYLAGGPGG----AATLSAPRVVAGGLNADRDV
: : * . : . :. .**** . : : *:
TH_0213|M.thermoresistible__bu IGFDPRGVGHSLPELRCRTDAEFDAYRREPMADYSPAGVAHIEELHRRFA
Mvan_3599|M.vanbaalenii_PYR-1 VGIDPRGVGHSTPELRCRTDAEFDAFRAEPLADYSPGGVAHIEGVLRDFA
MLBr_01632|M.leprae_Br4923 VGFDPRGVGHSTPALRCRTDVEFDAYRTEPMVDYSPAGVAHIEQVYKQLA
MAV_2243|M.avium_104 VGFDPRGVGHSTPPLRCRTDAEFDAYRREPMVDYSPAGVAHIEQLYRQLA
MAB_1919|M.abscessus_ATCC_1997 VGFDPRGVGGSTPTLRCRTDAEFDAFRKEPLADYSQAGVAHIEDVYRQYV
Mb2248c|M.bovis_AF2122/97 VGFDPRGVASSRPAIWCNSDADNDRLRAEPQVDYSREGVAHIENETKQFV
Rv2224c|M.tuberculosis_H37Rv VGFDPRGVASSRPAIWCNSDADNDRLRAEPQVDYSREGVAHIENETKQFV
Mflv_2904|M.gilvum_PYR-GCK VGFDPRGVANSNPAVWCNSDADNDRLRADNVVEYTAEGVAHLESLTKEFI
MSMEG_4296|M.smegmatis_MC2_155 VGFDPRGVASSSPAVWCNSDADNDRLRADPTVEYTPEGVAHLEAETKAFV
MMAR_0947|M.marinum_M IFVNQRGTLHSDPHLSCPEMDDFAVRALD--LDFEAPATADLDAAAVTAC
MUL_0698|M.ulcerans_Agy99 IFVNQRDTLHSDPHLSCPEMDDFAVRALD--LDFEAPATADLDAAAVTAC
: .: *.. * * : * : : :: ..*.::
TH_0213|M.thermoresistible__bu QSCLDRNGADFLAGLGTANAARDMDAVRAALG----EEQINYLGFSYGTR
Mvan_3599|M.vanbaalenii_PYR-1 AQCLDRMGAEFLASVGTATAARDMDVVRDALG----EDRVNYLGFSYGTQ
MLBr_01632|M.leprae_Br4923 QQCVARVGTAFLANVGTASAARDMDIVRLALG----DEQINYLGYSYGTE
MAV_2243|M.avium_104 QQCVNRMGTVFLANAGTASVARDMDAVRQALG----DEQINYLGYSYGTE
MAB_1919|M.abscessus_ATCC_1997 NECANRMGLDFLANAGTASAARDMDIVRSIVGAGAADTRLNYLGYSYGTE
Mb2248c|M.bovis_AF2122/97 GRCVDKMGKNFLAHVGTVNVAKDLDAIRAALG----DDKLTYLGYSYGTR
Rv2224c|M.tuberculosis_H37Rv GRCVDKMGKNFLAHVGTVNVAKDLDAIRAALG----DDKLTYLGYSYGTR
Mflv_2904|M.gilvum_PYR-GCK QRCVDKMGTDFLANVGTASVVKDLDALRVALG----DEKLTYLGYSYGTR
MSMEG_4296|M.smegmatis_MC2_155 QRCVDKMGTEFLANVGTENVAKDLDAIRAALG----DDKLTYLGYSYGTR
MMAR_0947|M.marinum_M RNRLVAEG-FHLASYSSRENAADIAALRKQLG----IEKWNVYGVSYGSD
MUL_0698|M.ulcerans_Agy99 RNRLVAEG-FHLASYSSRENAADIAALRKQLG----IEKWNIYGVSYGSD
* .** .: . *: :* :* : . * ***:
TH_0213|M.thermoresistible__bu LGAAYAEQFPDRVRTMVLDGAVDPSQDPLAGTTRQMAGFQAAFDEYAADC
Mvan_3599|M.vanbaalenii_PYR-1 LGAVYAARYPDRVRAMVLDGAVDPSLDPITESLNQQAGFQKAFEAYAADC
MLBr_01632|M.leprae_Br4923 LGTAYLERFSDHVRAMVLDGAIDPSVSSIQKDIQQMAGFQIAFTDYAADC
MAV_2243|M.avium_104 LGTAYLEKFSNHVRAMVLDGAIDPTVGPVDENINQMAGFQTAFNDYATDC
MAB_1919|M.abscessus_ATCC_1997 LGTQYAEYFPQNVRTMVLDGAIDPTIDPVESNVRQMTGFQVAFNDYAADC
Mb2248c|M.bovis_AF2122/97 IGSAYAEEFPQRVRAMILDGAVDPNADPIEAELRQAKGFQDAFNNYAADC
Rv2224c|M.tuberculosis_H37Rv IGSAYAEEFPQRVRAMILDGAVDPNADPIEAELRQAKGFQDAFNNYAADC
Mflv_2904|M.gilvum_PYR-GCK IGASYAEQFPQNVRAMVLDGAIDPNADPLEADVRQAAAFQQAFDDYAADC
MSMEG_4296|M.smegmatis_MC2_155 IGATYAEQFPDKVRAMILDGAIDPNADPVEESIRQAAAFQKAFDDYAADC
MMAR_0947|M.marinum_M LAQQLLRTHREGIRSMVLDSVVPTSFNLIDRWWQAPA---SGLAAIIGAC
MUL_0698|M.ulcerans_Agy99 LAQQLLRTHREGIRSMVLDSVVPTSFNLIDRWWQAPA---SGLAAIIGAC
:. . : :*:*:**..: .. . : . .: *
TH_0213|M.thermoresistible__bu ARSPDCPLGTDPAKWVARYHELVDPLVHR-------PAPTSDPRGLSYQD
Mvan_3599|M.vanbaalenii_PYR-1 AESVGCPLGTDPAQFVARFHQLVDPLVTR-------PAATSDPRGLGYQD
MLBr_01632|M.leprae_Br4923 ARSASCPLGTDPSQWVNRYHALIDPLVTK-------PGRTSDPRGLGYAD
MAV_2243|M.avium_104 ARSPGCPLGTDPAQFVNRYHALVDPLVTR-------PGRTADPRGLSYAD
MAB_1919|M.abscessus_ATCC_1997 AKDPKCPLGPDPSQAVKRFHQLIDPLVTK-------PAKTNDPRGLSYQD
Mb2248c|M.bovis_AF2122/97 AKNAGCPLGADPAKAVEVYHSLVDPLVDPDNPRISRPARTKDPRGLSYSD
Rv2224c|M.tuberculosis_H37Rv AKNAGCPLGADPAKAVEVYHSLVDPLVDPDNPRISRPARTKDPRGLSYSD
Mflv_2904|M.gilvum_PYR-GCK AIDDDCPLGTDPAKAVEVYHSLVWPLVDE-------PAETSDPRGLSYND
MSMEG_4296|M.smegmatis_MC2_155 AKSPDCPLGTDPAKAVDVYKSIIDPLVEN-------PAKTRDGRGLSYSD
MMAR_0947|M.marinum_M NDQPGCAQAYP--DLATVFVNVVSTLSRK-----PLKVSTSDANGDPVQV
MUL_0698|M.ulcerans_Agy99 NDQPGCAQAYP--DLATVFVNVVSTLSRK-----PLKVSTFDANGDPVQV
. *. . . . : :: .* * * .*
TH_0213|M.thermoresistible__bu AITG------TVQALYSRQYWKYLTSGLLGLRRGTDPVDLLLLADEYLRR
Mvan_3599|M.vanbaalenii_PYR-1 AITG------TASGLYSQRYWPYLTSGLLGLQRGTDPGDLLLLADDYQQR
MLBr_01632|M.leprae_Br4923 ATTG------TINALYTPVHWKYLTSGLLGLQRGTDAGDLLLLADDYNGR
MAV_2243|M.avium_104 ATTG------TINALYTPAHWKYLTSGLLGLARGTDAGDLLALADDYQGR
MAB_1919|M.abscessus_ATCC_1997 AITG------TIQAMYTPRYWKYLTSGLSGLADGSGPDDLLWLADQYQER
Mb2248c|M.bovis_AF2122/97 AIVG------TIMALYSPNLWQHLTDGLSELVDNRG-DTLLALADMYMRR
Rv2224c|M.tuberculosis_H37Rv AIVG------TIMALYSPNLWQHLTDGLSELVDNRG-DTLLALADMYMRR
Mflv_2904|M.gilvum_PYR-GCK AVVG------TILPLYSPALWRHLTQALGEVKEGKG-DTMLALADLYMER
MSMEG_4296|M.smegmatis_MC2_155 ATVG------TILPLYSPNLWRHLTDALTALKKGDG-NLMLALADLYMGR
MMAR_0947|M.marinum_M TIDGFKVVPLVLSWSADPAKVTDIPRMIFALARGEGRLAAAGIAETVPPP
MUL_0698|M.ulcerans_Agy99 TIDGFKVVPLVLSWSADPAKVTDIPRMIFALARGEGRLAAAGIAETVPPP
: * . :. : : . . :*:
TH_0213|M.thermoresistible__bu DVNGHYQNQQDAFTAIRCVDAPYPTDPAVWAETDRQVRA-VAPFLSYGEF
Mvan_3599|M.vanbaalenii_PYR-1 DRNGHYKNRQDAFNAIRCVDAVYPTDSAPWVEADRRSRE-VAPFLSYGPF
MLBr_01632|M.leprae_Br4923 DRNGHYTNDQDAFNAIRCVDAPVPTDSASWVSADQQIRQ-AAPFLNYGQF
MAV_2243|M.avium_104 DRNGHYSNDQDAFNAVRCVDAPNPTDQASWVSADQKIRQ-AAPFLSYGPF
MAB_1919|M.abscessus_ATCC_1997 DDHGRYDNLQDAFNSIRCVDGPTPKDSAPWVAADKTLRE-QAPFSSYGSF
Mb2248c|M.bovis_AF2122/97 DSHGRYNNSGDARVAINCVDQPPVTDRDKVIDEDRRARE-IAPFMSYGKF
Rv2224c|M.tuberculosis_H37Rv DSHGRYNNSGDARVAINCVDQPPVTDRDKVIDEDRRARE-IAPFMSYGKF
Mflv_2904|M.gilvum_PYR-GCK NAQGRYTNSTDVRIAVNCVDKPAITDRATLVEQDRRVRD-AAPFMAYGEF
MSMEG_4296|M.smegmatis_MC2_155 DAKGHYNNSTDVRVAVNCMDKPAIKDKATVVEQDKRLRE-VAPFMSYGEF
MMAR_0947|M.marinum_M EQRGLLG--AGLALGTYCQEMANWTTPEQALSRARTAIPGLPDSVLRITP
MUL_0698|M.ulcerans_Agy99 EQRGLLG--AGLALGTYCQEMANWTTPEQALSRARTAIPGLPDSVLRITP
: .* . . * : . : .
TH_0213|M.thermoresistible__bu TGFAPRNVCAMWPVPPTSTPAPATSPGPGKVVVVSTTRDPATPHEAGLAL
Mvan_3599|M.vanbaalenii_PYR-1 TGFAPRDLCAMWPVPPTPVVGVASSPGPGKVVVVSTTGDPATPYQAGVNL
MLBr_01632|M.leprae_Br4923 TGNAPRDICALWPVPATSMPHPAPPVAPGKVVVVSTTHDPATPYQAGVDL
MAV_2243|M.avium_104 TGNAPRDLCALWPVPATSAPHAAPPMPAGKVVVVSTTHDPATPYQAGVNL
MAB_1919|M.abscessus_ATCC_1997 TGYAPRDMCAFWPVPPTSTPHTPSTPGLAPVVVISTTHDPATPYEAGVAL
Mb2248c|M.bovis_AF2122/97 TGDAPLGTCAFWPVPPTSQPHAVSAPGLVPTVVVSTTHDPATPYKAGVDL
Rv2224c|M.tuberculosis_H37Rv TGDAPLGTCAFWPVPPTSQPHAVSAPGLVPTVVVSTTHDPATPYKAGVDL
Mflv_2904|M.gilvum_PYR-GCK TGLAPMPTCGFWPVPPTSKPHEISVTGLPPILVVSTTNDPATPYQAGVNL
MSMEG_4296|M.smegmatis_MC2_155 TGDAPLGTCAFWPVPPTSEPHELKVEGLPPILVVSTTNDPATPYQAGVDL
MMAR_0947|M.marinum_M TGSWIFRECAAWGLGRSDTADRLSVSSGVPTLILSGTFDSSTAPQWAEEI
MUL_0698|M.ulcerans_Agy99 TGSWIFRKCAAWGLGRPDTADRLSVSRGCPPSSCRARSTPAPRHSGPRRS
** *. * : . .:. .
TH_0213|M.thermoresistible__bu ARQLD-AALITFDGAQHTVVFNGNPCVDTAVLNFLIDGVPPPNGLAC---
Mvan_3599|M.vanbaalenii_PYR-1 AQQMD-ARLITFEGTQHTVVFNGDACVDTATVEFLVNSTPPPAGLRC---
MLBr_01632|M.leprae_Br4923 ARELS-SPLITYDGTQHTAVFNGDQCVDSAVVHYFVDETLLPASLQCQP-
MAV_2243|M.avium_104 ARQLG-GPLITYDGTQHTAVFNGDQCVDNAVVRYFVAGTPPPASYRCQS-
MAB_1919|M.abscessus_ATCC_1997 ARQLG-GSLISYEGTQHTVAFNGEACVDDVVTRYFVDGTVPPKDVRC---
Mb2248c|M.bovis_AF2122/97 ANQLR-GSLLTFDGTQHTVVFQGDSCIDEYVTAYLIGGTTPPSGAKC---
Rv2224c|M.tuberculosis_H37Rv ANQLR-GSLLTFDGTQHTVVFQGDSCIDEYVTAYLIGGTTPPSGAKC---
Mflv_2904|M.gilvum_PYR-GCK ARQLG-GALVTFEGTQHTVALQGDSCVDDIVVPYLIDGSVPPPDTRC---
MSMEG_4296|M.smegmatis_MC2_155 ARQLG-GTLVTFEGTQHTVVFQGNKCVDDVAATYLIDVEVPPADTRC---
MMAR_0947|M.marinum_M TPGLGNSQLVRFPGVGHGVLPS--SACAQSIVTAFVDDPSRDIDKSCVWK
MUL_0698|M.ulcerans_Agy99 PPGWATRSWCGFPGC-------------AMVSCRIRRAPSRS--------
. : * :
TH_0213|M.thermoresistible__bu -------------
Mvan_3599|M.vanbaalenii_PYR-1 -------------
MLBr_01632|M.leprae_Br4923 -------------
MAV_2243|M.avium_104 -------------
MAB_1919|M.abscessus_ATCC_1997 -------------
Mb2248c|M.bovis_AF2122/97 -------------
Rv2224c|M.tuberculosis_H37Rv -------------
Mflv_2904|M.gilvum_PYR-GCK -------------
MSMEG_4296|M.smegmatis_MC2_155 -------------
MMAR_0947|M.marinum_M MTMPTFSLPEPAR
MUL_0698|M.ulcerans_Agy99 -------------