For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VGMRLSRRDKIARMLLIWAALAAVALVLVGCIRVVGGRARMAEPKLGQPVEWTPCRSSNPQVKIPGGALC GKLAVPVDYDRPDGDVAALALIRFPATGDKIGSLVINPGGPGESGIEAALGVFQTLPKRVHERFDLVGFD PRGVASSRPAIWCNSDADNDRLRAEPQVDYSREGVAHIENETKQFVGRCVDKMGKNFLAHVGTVNVAKDL DAIRAALGDDKLTYLGYSYGTRIGSAYAEEFPQRVRAMILDGAVDPNADPIEAELRQAKGFQDAFNNYAA DCAKNAGCPLGADPAKAVEVYHSLVDPLVDPDNPRISRPARTKDPRGLSYSDAIVGTIMALYSPNLWQHL TDGLSELVDNRGDTLLALADMYMRRDSHGRYNNSGDARVAINCVDQPPVTDRDKVIDEDRRAREIAPFMS YGKFTGDAPLGTCAFWPVPPTSQPHAVSAPGLVPTVVVSTTHDPATPYKAGVDLANQLRGSLLTFDGTQH TVVFQGDSCIDEYVTAYLIGGTTPPSGAKC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2248c | - | - | 100% (520) | exported protease |
| M. bovis AF2122 / 97 | Mb2247c | - | e-142 | 49.61% (508) | exported protease |
| M. bovis AF2122 / 97 | Mb2691 | - | 3e-16 | 23.19% (552) | secreted protease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2904 | - | 0.0 | 64.20% (500) | TAP domain-containing protein |
| M. tuberculosis H37Rv | Rv2224c | - | 0.0 | 100.00% (520) | exported protease |
| M. leprae Br4923 | MLBr_01633 | - | 0.0 | 85.00% (520) | putative secreted hydrolase |
| M. abscessus ATCC 19977 | MAB_1918 | - | 0.0 | 60.16% (507) | hypothetical protein MAB_1918 |
| M. marinum M | MMAR_3297 | - | 0.0 | 88.22% (518) | exported protease |
| M. avium 104 | MAV_2241 | - | 0.0 | 84.23% (520) | hydrolase, alpha/beta fold family protein, putative |
| M. smegmatis MC2 155 | MSMEG_4296 | - | 0.0 | 66.80% (503) | protease |
| M. thermoresistible (build 8) | TH_0212 | - | 0.0 | 71.63% (416) | Probable exported protease |
| M. ulcerans Agy99 | MUL_1332 | - | 0.0 | 88.22% (518) | exported protease |
| M. vanbaalenii PYR-1 | Mvan_3600 | - | 0.0 | 62.70% (504) | TAP domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2904|M.gilvum_PYR-GCK -------------------------------------MSALLVAGCSKVV
Mvan_3600|M.vanbaalenii_PYR-1 ----------------MAACGAMKLKTGVARSGLLLSLAVLLVAGCSQVV
MSMEG_4296|M.smegmatis_MC2_155 ----------------MAACGAMKVRFGLG---ALLAVTVLAAGGCSQVI
TH_0212|M.thermoresistible__bu --------------------------------------------------
Mb2248c|M.bovis_AF2122/97 ---------------MGMRLSRRDKIARMLLIWAALAAVALVLVGCIRVV
Rv2224c|M.tuberculosis_H37Rv ---------------MGMRLSRRDKIARMLLIWAALAAVALVLVGCIRVV
MMAR_3297|M.marinum_M -----------------MFLSRRDKLARMLLIWTAIASVALVLTGCIRVV
MUL_1332|M.ulcerans_Agy99 -----------------MFLSRRDKLARMLLIWTAIASVALVLTGCIRVV
MLBr_01633|M.leprae_Br4923 MTAAHQEPKPSLAAYVSMALSYRDKIARMLLLGTAIAAVALVLAGCVRVV
MAV_2241|M.avium_104 ---------------MGMGLSRRGKSARTLLIWMSIAAVALLLAGCVRVV
MAB_1918|M.abscessus_ATCC_1997 -------------------MMLRGLGRPGLLPLLALASVVAVVSGCVRSV
Mflv_2904|M.gilvum_PYR-GCK DGNALVSVPRPGTPIDWSPCETGPSDQKRIPPGSECGMLSVPVDWDNPED
Mvan_3600|M.vanbaalenii_PYR-1 AGRALISVPRPGTPIEWGPCEAGPSDQVRIPPGAECGMLSVPVDWVRADA
MSMEG_4296|M.smegmatis_MC2_155 DGRAIVAVPRPGTPVQWLPCNGGAGNQTPIPDSAECGMLSVPVDYSK---
TH_0212|M.thermoresistible__bu --------------------------------------------------
Mb2248c|M.bovis_AF2122/97 GGRARMAEPKLGQPVEWTPCR-SSNPQVKIPGGALCGKLAVPVDYDR---
Rv2224c|M.tuberculosis_H37Rv GGRARMAEPKLGQPVEWTPCR-SSNPQVKIPGGALCGKLAVPVDYDR---
MMAR_3297|M.marinum_M GGHARMAEPKLGQPIQWSPCR-SSNPNVKIPGGALCGKLAVPVDYRQ---
MUL_1332|M.ulcerans_Agy99 GGHARMAEPKLGQPIQWSPCR-SSNPNVKIPGGALCGKLAVPVDYRQ---
MLBr_01633|M.leprae_Br4923 SGRALMAGPKLGEPVAWAPCR-PSNPAVKLPGGALCGKLAVPVDYDH---
MAV_2241|M.avium_104 VGRAVMSGPKLGQAVEWTPCR-AANPKVKLPAGALCGKLAVPVDYDH---
MAB_1918|M.abscessus_ATCC_1997 EGEATAAHPS-ETSLSWGDCDGFTPENVTVPASTVCSELEVPVDYTK---
Mflv_2904|M.gilvum_PYR-GCK PDGDVAQLAVLRVPATGDRIGSLVVNPGGPGKSGVEAAAAMVSTLPEEVL
Mvan_3600|M.vanbaalenii_PYR-1 PDGEVAQIAVLRIKAAGEKIGSLIINPGGPGKSGKESAAVMAPTLPEEVR
MSMEG_4296|M.smegmatis_MC2_155 PDGDVARLAMIRFPATGDRIGSLVINPGGPGESGVESALSLLPSLPQEVK
TH_0212|M.thermoresistible__bu -----------------------VINPGGPGESGVEAAAQMLATIPAPVR
Mb2248c|M.bovis_AF2122/97 PDGDVAALALIRFPATGDKIGSLVINPGGPGESGIEAALGVFQTLPKRVH
Rv2224c|M.tuberculosis_H37Rv PDGDVAALALIRFPATGDKIGSLVINPGGPGESGIEAALGVFQTLPKRVH
MMAR_3297|M.marinum_M PRGDVAALALIRFPATGDKIGSLVINPGGPGESGIEAALGVFQTLPKRVH
MUL_1332|M.ulcerans_Agy99 PRGDVAALALIRFPATGDKIGSLVINPGGPGESGIEAALGVFQTLPKRVH
MLBr_01633|M.leprae_Br4923 HDDDVAALAMIRFPATGDRMGSLVINPGGPGESGIEAALGVVQTLPKRVR
MAV_2241|M.avium_104 LDGDVATLAMIRFPATGDKIGSLVINPGGPGESGIEAALGVVQSLPKRVR
MAB_1918|M.abscessus_ATCC_1997 PDGAKARLAIIKYPAKGNKIGSLLMNPGGPGQSGIEAATAIVKQVPKEIR
::******:** *:* : :* :
Mflv_2904|M.gilvum_PYR-GCK ERFDIVGFDPRGVANSNPAVWCNSDADNDRLRADNVVEYTAEGVAHLESL
Mvan_3600|M.vanbaalenii_PYR-1 QRFDLVGFDPRGVAESTPAVRCNSDADHDRLRADNVVEYTPEGVAHLENL
MSMEG_4296|M.smegmatis_MC2_155 ERFDIVGFDPRGVASSSPAVWCNSDADNDRLRADPTVEYTPEGVAHLEAE
TH_0212|M.thermoresistible__bu ERFDVVGFDPRGVANSSPAVWCNSDEDNDRLRADPQVDYSPEGVEYIENQ
Mb2248c|M.bovis_AF2122/97 ERFDLVGFDPRGVASSRPAIWCNSDADNDRLRAEPQVDYSREGVAHIENE
Rv2224c|M.tuberculosis_H37Rv ERFDLVGFDPRGVASSRPAIWCNSDADNDRLRAEPQVDYSREGVAHIENE
MMAR_3297|M.marinum_M ERFDLVGFDPRGVASSRPALWCNSDADNDRLRAEPQVDYSEAGVARMEEE
MUL_1332|M.ulcerans_Agy99 ERFDLVGFDPRGVASSRPALWCNSDADNDRLRAEPQVDYSEAGVARMEEE
MLBr_01633|M.leprae_Br4923 ERFDLVGFDPRGVGASRPAVWCNSDADNDRLRSESQVDYSPAGVAHIEDE
MAV_2241|M.avium_104 ERFDLVGFDPRGVGASRPAVWCNSDADNDRLRTEPNVDYSPAGVAHIEDE
MAB_1918|M.abscessus_ATCC_1997 DRFDFIGFDPRGVGSSTPAIECNSDKDVDRLRAQNDTDYSPEGVARMEQD
:***.:*******. * **: **** * ****:: .:*: ** :*
Mflv_2904|M.gilvum_PYR-GCK TKEFIQRCVDKMGTDFLANVGTASVVKDLDALRVALGDEKLTYLGYSYGT
Mvan_3600|M.vanbaalenii_PYR-1 TKEFVQRCVDKMGTDFLSNVGTESVVKDLDALRAALGDEKLTFLGYSYGT
MSMEG_4296|M.smegmatis_MC2_155 TKAFVQRCVDKMGTEFLANVGTENVAKDLDAIRAALGDDKLTYLGYSYGT
TH_0212|M.thermoresistible__bu AKEFVQRCLDKTGEKFLANVGTVNVAKDLDLIREAVGDDELTYLGYSYGT
Mb2248c|M.bovis_AF2122/97 TKQFVGRCVDKMGKNFLAHVGTVNVAKDLDAIRAALGDDKLTYLGYSYGT
Rv2224c|M.tuberculosis_H37Rv TKQFVGRCVDKMGKNFLAHVGTVNVAKDLDAIRAALGDDKLTYLGYSYGT
MMAR_3297|M.marinum_M TKQFVARCVGKMGKNFLENVGTVNVARDLDAIRAALGDDKLTYLGYSYGT
MUL_1332|M.ulcerans_Agy99 TKQFVARCVGKMGKNFLENVGTVNVARDLDAIRAALGDDKLTYLGYSYGT
MLBr_01633|M.leprae_Br4923 TKQFIGRCIAKMGKIFLENIGTVNVAKDLDAIRAALGDDKLTYLGYSYGT
MAV_2241|M.avium_104 TKQFVGRCVDKMGKKFLANVGTVNVARDLDAIRAALGDDKLTYLGYSYGT
MAB_1918|M.abscessus_ATCC_1997 SKDFVKRCVDKVGLEFLANVGTVNVAKDMDRLRAALGDEKLTYLGYSYGT
:* *: **: * * ** ::** .*.:*:* :* *:**::**:*******
Mflv_2904|M.gilvum_PYR-GCK RIGASYAEQFPQNVRAMVLDGAIDPNADPLEADVRQAAAFQQAFDDYAAD
Mvan_3600|M.vanbaalenii_PYR-1 RIGAGYAEEYPQNVRAMILDGAIDPNADPVEADVRQAAAFQQAFDDYATD
MSMEG_4296|M.smegmatis_MC2_155 RIGATYAEQFPDKVRAMILDGAIDPNADPVEESIRQAAAFQKAFDDYAAD
TH_0212|M.thermoresistible__bu RIGAAYAEEFPDKVRAMILDGAVDPNADPIEADIRQAKAFQTAFDDYAAD
Mb2248c|M.bovis_AF2122/97 RIGSAYAEEFPQRVRAMILDGAVDPNADPIEAELRQAKGFQDAFNNYAAD
Rv2224c|M.tuberculosis_H37Rv RIGSAYAEEFPQRVRAMILDGAVDPNADPIEAELRQAKGFQDAFNNYAAD
MMAR_3297|M.marinum_M RIGSAYAEAYPQRVRAMILDGAVDPNADPIEADLRQAKGFQEAFNDYAAD
MUL_1332|M.ulcerans_Agy99 RIGSAYAEAYPQRVRAMILDGAVDPNADPIEADLRQAKGFQEAFNDYAAD
MLBr_01633|M.leprae_Br4923 RIGAAYAEAYPQNVRSMILDGAVDPNADPIEADLRQAKGFQDAFNNYAAD
MAV_2241|M.avium_104 RIGSAYAEAYPHNVRAMILDGAVDPNADQIEADLRQAKGFQDAFNNFAAE
MAB_1918|M.abscessus_ATCC_1997 RIGTTYAEEFPQNVRALILDGVIDPNADPTQADIDQIAGFQKAFDNYAAD
***: *** :*..**:::***.:***** : .: * .** **:::*::
Mflv_2904|M.gilvum_PYR-GCK CAIDDDCPLGTDPAKAVEVYHSLVWPLVDE-------PAETSDPRGLSYN
Mvan_3600|M.vanbaalenii_PYR-1 CAIDEDCPLGTDPAKAVDVYRSLVWPLVDA-------PADTTDPRGLSYN
MSMEG_4296|M.smegmatis_MC2_155 CAKSPDCPLGTDPAKAVDVYKSIIDPLVEN-------PAKTRDGRGLSYS
TH_0212|M.thermoresistible__bu CATNPDCPLGTDPEKAVEVYRSMVDPLVEQ-------PAETSDPRGLSYS
Mb2248c|M.bovis_AF2122/97 CAKNAGCPLGADPAKAVEVYHSLVDPLVDPDNPRISRPARTKDPRGLSYS
Rv2224c|M.tuberculosis_H37Rv CAKNAGCPLGADPAKAVEVYHSLVDPLVDPDNPRISRPARTKDPRGLSYS
MMAR_3297|M.marinum_M CAENDSCPLGTDPAKAVAVYHSLVDKLVDPNNLQVSRPARTKDPRGLSYS
MUL_1332|M.ulcerans_Agy99 CAENDSCPLGTDPAKAVAVYHSLVDKLVDPNNLQVSRPARTKDPRGLSYS
MLBr_01633|M.leprae_Br4923 CARKLSCPLGADPAKAVDVYHNLVNPLVDPNNPMVSRPAPTKDPRGLSYS
MAV_2241|M.avium_104 CAKQPNCPLGTDPAKAVDVYHSLVDPMVDPDNPMVGRPIPTNDPRGLSYS
MAB_1918|M.abscessus_ATCC_1997 CAKSPSCPLGTDPAQATARYRAMVDPLVDH-------PAKTKDGRGLSHS
** . .****:** :*. *: :: :*: * * * ****:.
Mflv_2904|M.gilvum_PYR-GCK DAVVGTILPLYSPALWRHLTQALGEVKEGKGDTMLALADLYMERNAQGRY
Mvan_3600|M.vanbaalenii_PYR-1 DAVVGTILPLYSPGLWRHLTQALTEIKKGRGDTMLALSDLYMGRDAQGHY
MSMEG_4296|M.smegmatis_MC2_155 DATVGTILPLYSPNLWRHLTDALTALKKGDGNLMLALADLYMGRDAKGHY
TH_0212|M.thermoresistible__bu DAIVGTILTLYSPELWRLLTQGLTELKEGRGDTLLRLADVYMKRDKDGHY
Mb2248c|M.bovis_AF2122/97 DAIVGTIMALYSPNLWQHLTDGLSELVDNRGDTLLALADMYMRRDSHGRY
Rv2224c|M.tuberculosis_H37Rv DAIVGTIMALYSPNLWQHLTDGLSELVDNRGDTLLALADMYMRRDSHGRY
MMAR_3297|M.marinum_M DAIVGTIMALYSPNLWQHLTDGLTELTEDRGDTLLALADMYMRRDSHGHY
MUL_1332|M.ulcerans_Agy99 DAIVGTIMALYSPNLWQHLTDGLTELTEDRGDTLLALADMYMRRDSHGHY
MLBr_01633|M.leprae_Br4923 DAIVGTIMTLYSPTLWHHLTDGLSELVDHRGDTLLALADMYMRRDSQGHY
MAV_2241|M.avium_104 DAIVGTIMALYSPNLWHHLTDGLSELVDHHGDTLLALADMYMRRDAHGHY
MAB_1918|M.abscessus_ATCC_1997 DAIIGTIMVMYSPTLWEAFTKALRQLSEGSGDILQLLADAYMKRDEDGHY
** :***: :*** **. :*..* : . *: : *:* ** *: .*:*
Mflv_2904|M.gilvum_PYR-GCK TNSTDVRIAVNCVDKPAITDRATLVEQDRRVRDAAPFMAYGEFTGLAPMP
Mvan_3600|M.vanbaalenii_PYR-1 SNDTDSRVAVNCVDKPAITDRATLVEQDRRVREAAPFMAYGEFTGLAPMT
MSMEG_4296|M.smegmatis_MC2_155 NNSTDVRVAVNCMDKPAIKDKATVVEQDKRLREVAPFMSYGEFTGDAPLG
TH_0212|M.thermoresistible__bu SNSTDARIAVNCVDKPAVTDREKIVELDRQLREVAPFMSYGEFTGHAPLG
Mb2248c|M.bovis_AF2122/97 NNSGDARVAINCVDQPPVTDRDKVIDEDRRAREIAPFMSYGKFTGDAPLG
Rv2224c|M.tuberculosis_H37Rv NNSGDARVAINCVDQPPVTDRDKVIDEDRRAREIAPFMSYGKFTGDAPLG
MMAR_3297|M.marinum_M TNATDARVAINCVDQPPITDRAKIVDEDRRSREIAPFMSYGKFTGHAPLG
MUL_1332|M.ulcerans_Agy99 TNATDARVAINCVDQPPITDRAKIVDEDRRSREIAPFMSYGKFTGHAPLG
MLBr_01633|M.leprae_Br4923 TNATDARVAVNCVDQPPITDRAKVIDEDRRSREVAPFMSYGKFTGDAPLG
MAV_2241|M.avium_104 TNATDARVAINCVDQPPITDRAKVIDEDRRSREIAPFMSYGQFTGNAPLG
MAB_1918|M.abscessus_ATCC_1997 SHAQDAQTAINCVDEPPEKDRAKAVEKDRRIREVAPFQDYGEFTGNAPLG
.: * : *:**:*:*. .*: . :: *:: *: *** **:*** **:
Mflv_2904|M.gilvum_PYR-GCK TCGFWPVPPTSKPHEISVTGLPPILVVSTTNDPATPYQAGVNLARQLGGA
Mvan_3600|M.vanbaalenii_PYR-1 TCGFWPVPPTSVPHELDVSGLPPILVISTTNDPATPYQAGVDLARQLDGT
MSMEG_4296|M.smegmatis_MC2_155 TCAFWPVPPTSEPHELKVEGLPPILVVSTTNDPATPYQAGVDLARQLGGT
TH_0212|M.thermoresistible__bu TCAFWPVPPTSTPHEIEVEGLPPVLVVSTTNDPATPYQAGIDLARQLGGT
Mb2248c|M.bovis_AF2122/97 TCAFWPVPPTSQPHAVSAPGLVPTVVVSTTHDPATPYKAGVDLANQLRGS
Rv2224c|M.tuberculosis_H37Rv TCAFWPVPPTSQPHAVSAPGLVPTVVVSTTHDPATPYKAGVDLANQLRGS
MMAR_3297|M.marinum_M TCAFWPVPPTSKPHAVSVPGLVPTVIVSTTHDPATPYKAGVDLANQLHGS
MUL_1332|M.ulcerans_Agy99 TCAFWPVPPTSKPHAVSVPGLVPTVIVSTTHDPATPYKAGVDLANQLHGS
MLBr_01633|M.leprae_Br4923 TCAFWPVPPTSKPHIVSAPGLAPTVVVSTTHDPATPYKAGVDLANQLRGS
MAV_2241|M.avium_104 TCAFWPVPPTSKPHTISAPGLAPTVVVSTTHDPATPYKAGVDLANELRSS
MAB_1918|M.abscessus_ATCC_1997 VCAFWPVPPTSKPHPIHAAGLPKLLVVSTTYDPATPYQAGVELAKQLGGG
.*.******** ** : . ** :::*** ******:**::**.:* .
Mflv_2904|M.gilvum_PYR-GCK LVTFEGTQHTVALQGDSCVDDIVVPYLIDGSVPPPDTRC
Mvan_3600|M.vanbaalenii_PYR-1 LVTFEGTQHTVSLQGDSCIDDIAVRYLVDVTVPPPDTRC
MSMEG_4296|M.smegmatis_MC2_155 LVTFEGTQHTVVFQGNKCVDDVAATYLIDVEVPPADTRC
TH_0212|M.thermoresistible__bu LVTYEGTQHTVVFQGDACIDEIATAYLIDGELPADGARC
Mb2248c|M.bovis_AF2122/97 LLTFDGTQHTVVFQGDSCIDEYVTAYLIGGTTPPSGAKC
Rv2224c|M.tuberculosis_H37Rv LLTFDGTQHTVVFQGDSCIDEYVTAYLIGGTTPPSGAKC
MMAR_3297|M.marinum_M LLTFAGTQHTVVFQGDSCIDDYVTAYLIGGTTPPRGAKC
MUL_1332|M.ulcerans_Agy99 LLTFAGTQHTVVFQGDSCIDDYVTAYLIGGTTPPRGAKC
MLBr_01633|M.leprae_Br4923 LLTFDGTQHTVVFQGDSCVDDYVTEYLIGGTTPPSGAKC
MAV_2241|M.avium_104 LLTYDGTQHTVVFQGDGCIDNYVTAYLVGGTIPPSGAKC
MAB_1918|M.abscessus_ATCC_1997 LLTYDGTKHTIVFDGNQCVDKAAEDYLIKVTTPPEGARC
*:*: **:**: ::*: *:*. . **: *. .::*