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VVGHALRIGIIGAGVMGTKHAEYVAREQDATVVAVADPFSRTLAGKLGVPHFDSYHDLLAASGAEAVIIA NPNSAHVETTLAAIEARIPALLEKPVAVTAAEAAHLVAAVRDSDTVVLVGHHRRHHPAVSKARNLIASGV IGRLVAVNGMWLTKKSDDYFEQRWRRETGAGVMLINLVHDLDLARYLCGEITTVQAVSSNALRGFEVEDT AAVIVGFDNGAIGTFILSDSAVAPWGWDQATQDDPQFPCNPDIPAWSIAGTTGSLTFPQLARFYHQGESD WYQPLSRRYESTDAGDSYTRQLQHFIAVARGDAAPLVTVEDAAASLTVIEVAQRAAKCGHRLDVPMVSAP TGKTTE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6717 | - | - | 100% (356) | oxidoreductase, Gfo/Idh/MocA family protein |
| M. smegmatis MC2 155 | MSMEG_4650 | - | 3e-25 | 28.61% (360) | oxidoreductase YisS |
| M. smegmatis MC2 155 | MSMEG_4652 | - | 2e-18 | 30.14% (345) | D-oliose 4-ketoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2613 | - | 7e-22 | 29.82% (275) | inositol 2-dehydrogenase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2612 | - | 3e-19 | 31.47% (251) | putative oxidoreductase |
| M. marinum M | MMAR_2628 | - | 4e-16 | 28.86% (350) | hypothetical protein MMAR_2628 |
| M. avium 104 | MAV_2987 | - | 1e-14 | 28.16% (348) | NAD binding oxidoreductase |
| M. thermoresistible (build 8) | TH_3104 | - | 1e-06 | 28.68% (136) | PUTATIVE oxidoreductase domain protein |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_3968 | - | 5e-24 | 30.82% (279) | inositol 2-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2613|M.gilvum_PYR-GCK ----------MTSLGLIGLGRIG-AFHTETLINLPEVSRLVITDERPGVV
Mvan_3968|M.vanbaalenii_PYR-1 ----------MTTLGLIGLGRIG-AFHAETLTNLPEVSGLVVTDERPEVV
MMAR_2628|M.marinum_M MTG----HGSPLRIGILGAARIAPQALVKPAQGNVEAVVAAVAARDGARA
MAV_2987|M.avium_104 MSAMAEVHAPKLRIGILGAARIAPLALIKPSAENPDVVVAAVAARDASRA
MSMEG_6717|M.smegmatis_MC2_155 ------MVGHALRIGIIGAGVMG-TKHAEYVAREQDATVVAVADP---FS
MAB_2612|M.abscessus_ATCC_1997 ----------MLKVGIIGAGGVA-RAHARALNTLKSAELVGVLDIDARAA
TH_3104|M.thermoresistible__bu -----------MRVLVIGTGFGRQAMAPVYRGLGFDVEVVSPRDE-----
: ::* . ..
Mflv_2613|M.gilvum_PYR-GCK GEVAAKYGATPVESVEKLLSSG--IDGVVVAAATPAHAELTLAAVERGLP
Mvan_3968|M.vanbaalenii_PYR-1 SQLATKYGATPANSVQELLASG--VDGVIVAAATPAHAELTLAAVERGLP
MMAR_2628|M.marinum_M QAFAAKHGISRVHSSYEALIADPTLDAVYIPLPNGLHGRWTQAALTAGKH
MAV_2987|M.avium_104 RAFATRHGIATVHDHYEALIADPDIDAIYNPLPNGLHGRWTRAALAAGKH
MSMEG_6717|M.smegmatis_MC2_155 RTLAGKLGVPHFDSYHDLLAASG-AEAVIIANPNSAHVETTLAAIEARIP
MAB_2612|M.abscessus_ATCC_1997 ESFTDAYGGTPVTDVDALLELA---DAVVVASPNFTHRDHSLSALRAGRS
TH_3104|M.thermoresistible__bu ------------SALHRALNAG--VDLVSVHSPPFLHRQHVTAAVDRGYP
* : : . * :*:
Mflv_2613|M.gilvum_PYR-GCK TFCEKPIASTAAESARVAEIIARSGVPVQVGYQRRFDTAFAAVKQAADSG
Mvan_3968|M.vanbaalenii_PYR-1 TFCEKPIAATAAESARVGEVITRSGVPVQVGYQRRFDAAFAAVKHAVDDG
MMAR_2628|M.marinum_M VLCEKPFTANAAEADEIAQLAATTDRVVMEAFHYRYHPLTLRIEQILASG
MAV_2987|M.avium_104 VLCEKPFTANAAEAREIADLAEHSDRVVMEAFHYRYHPLTLRAEEIIASG
MSMEG_6717|M.smegmatis_MC2_155 ALLEKPVAVTAAEAAHLVAAVRDSDTVVLVGHHRRHHPAVSKARNLIASG
MAB_2612|M.abscessus_ATCC_1997 VLCEKPLALSRVEAKEMVAAAGEIASPALVGFNYRHLPVVTELRRRLQHG
TH_3104|M.thermoresistible__bu VLCDKPFGRNADEARAMRDHAARRAVPTFLNFELRHQPARAEFKKLADSG
.: :**. . *: : . .. *. . .. *
Mflv_2613|M.gilvum_PYR-GCK SLGALHTVRSTTMDPAP-PPMDYIRG-------SGGIFRDCAVHDFDVIR
Mvan_3968|M.vanbaalenii_PYR-1 SLGALHTVRSTTMDPAP-PPMDYIKG-------SGGIFRDCAVHDFDVIR
MMAR_2628|M.marinum_M ELGTLQRVETSMCFPLP-KFSDIRYNYAL----AGGATMDAGCYAVHMAR
MAV_2987|M.avium_104 ELGTLQHVEAALCFPLP-KFSDIRYDYAL----AGGATMDAGCYAVHMAR
MSMEG_6717|M.smegmatis_MC2_155 VIGRLVAVNGMWLTKKSDDYFEQRWRRET----GAGVMLINLVHDLDLAR
MAB_2612|M.abscessus_ATCC_1997 DFGTICAVELGFRKDSAYRRKNHTWRDSGRSNGTSGALGDLGVHLLDLLT
TH_3104|M.thermoresistible__bu VIGTPRHLSWTFFGAGLRGRPHGWINERD---TGGGWIGANGAHLIDYTR
:* : . .* : ..
Mflv_2613|M.gilvum_PYR-GCK WVTGQNVVEVYATGSVQGDPLFTE---YGDVDTAAIVVRFDGGALGVVSA
Mvan_3968|M.vanbaalenii_PYR-1 WVTGQNVVDVYATGSVQGDPRFAE---YGDVDTAAVVVRFDGGALGVVSA
MMAR_2628|M.marinum_M TFGGGTPEVVSAQAKRRDSE---------VDRAMTAELRFPAGHSGRIQC
MAV_2987|M.avium_104 TFGGRSPEVVSAQAKLRGPK---------VDRAMTAELRFPAGHTGRVRC
MSMEG_6717|M.smegmatis_MC2_155 YLCGEITTVQAVSSNALRGF--------EVEDTAAVIVGFDNGAIGTFIL
MAB_2612|M.abscessus_ATCC_1997 YISGGRILVDECQARITTHVTNKSDEAVEVDDHAEIYGRLSTGSIFTLVA
TH_3104|M.thermoresistible__bu YLFGSEITGCGGVARIEDPHR-------PDPQGRPRRATAEDAYSAWFVT
. * . . .
Mflv_2613|M.gilvum_PYR-GCK ARYNGRGYD-CRLEVHGFDDT----------VVAGWDQGAPVRNADP---
Mvan_3968|M.vanbaalenii_PYR-1 ARYNGRGYD-CRLEVHGFDDT----------VVAGWDQGAPVRNADPDFS
MMAR_2628|M.marinum_M SMWSSH--------LLNMSAR----------VVGDRGELRVLNPVVPQLF
MAV_2987|M.avium_104 SMWSTR--------LLQISAR----------VVGEHGELRIVNPVLPQAF
MSMEG_6717|M.smegmatis_MC2_155 SDSAVAPWG-WDQATQDDPQFPCNPDIPAWSIAGTTGSLTFPQLARFYHQ
MAB_2612|M.abscessus_ATCC_1997 SKAAPAADCGFSIRIVGTNAVFR-------YHTADPGRYLVSRGADTETV
TH_3104|M.thermoresistible__bu ENGCTATHDTAFAAAVALPPR----------MVLTGSAGALELIGDSRLI
. .
Mflv_2613|M.gilvum_PYR-GCK -ANDFPTGQPHHFFMDRFTEAFRTELSSFVDVVEGGPNLGATVADAVEVA
Mvan_3968|M.vanbaalenii_PYR-1 SPGAFPAGPPHHFFMDRFTEAFRAELRAFVDVVEGGPIRGATVADAVEVA
MMAR_2628|M.marinum_M HRLTVQSAIGRRVERFPRRASYAYQLDAFTGAILRGEAVKTTPQDAVQNM
MAV_2987|M.avium_104 HRLTVRSRDGRRTERFERRASYAYQLDAFAAGVLRGEPVKTSARDAVDNM
MSMEG_6717|M.smegmatis_MC2_155 GESDWYQPLSRRYESTDAGDSYTRQLQHFIAVARGDAAPLVTVEDAAASL
MAB_2612|M.abscessus_ATCC_1997 DLARTLLSDPD-NEVHGWSDSFRSEIDHWSRLVAVGGGANRQALATFDDG
TH_3104|M.thermoresistible__bu VHRADADPMTHEFPPAPPRSFYEPALTPWLEQVADALRTGRPATPSFDDG
: : : :
Mflv_2613|M.gilvum_PYR-GCK WIAEAATESLRRGVPVTIDSVRKEAQQ------
Mvan_3968|M.vanbaalenii_PYR-1 WIAEAATESLRRGVPVTIESVRKETQQ------
MMAR_2628|M.marinum_M TVIDAIYR--AAGLPLRNPS-------------
MAV_2987|M.avium_104 TVIDAIYR--AAGLPLRYPT-------------
MSMEG_6717|M.smegmatis_MC2_155 TVIEVAQRAAKCGHRLDVPMVSAPTGKTTE---
MAB_2612|M.abscessus_ATCC_1997 LAAQEVLESLLRGSKPQPERLPVEHTLPTPAEL
TH_3104|M.thermoresistible__bu VAVAEVMDRLRANVIEQVMQ-------------
.