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M. smegmatis MC2 155 MSMEG_6071 (-)

annotation: metallo-beta-lactamase superfamily protein
coordinates: 6135261 - 6136205
length: 314

MRLKPGRPDLADHARFFDAPTATPDSPVTVTWAGVTTLLVDDGTSALLTDGFFSRPGLLTVGLRPLAPNV
PRIDGCLARLGVDRLAAVLPVHTHFDHAMDSAVVAERTGAALVGGSSAAQIGIGGGLPDDRIVTVTPGEP
VAMEAYDVTLFVSEHCPPDRFPGVITEPVVPPAKASAYKCGEAWSTLVHHRPSDRRVLIVGSAGAVPGAL
AGQRADVVYLGVGQLGRQPERYLTDYWTQTVRTVGARRVVLIHWDDFFRPLHRPLRALPYVADDLDATMR
VLTTLAAHDGVALHLPTLWQRSDPWIETGSGPWR
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_6071--100% (314)metallo-beta-lactamase superfamily protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3608-1e-11968.29% (287) hypothetical protein Mb3608
M. gilvum PYR-GCKMflv_1449-1e-12571.90% (306) hypothetical protein Mflv_1449
M. tuberculosis H37RvRv3577-1e-11968.29% (287) hypothetical protein Rv3577
M. leprae Br4923-----
M. abscessus ATCC 19977-----
M. marinum MMMAR_5077-1e-11964.38% (306) hypothetical protein MMAR_5077
M. avium 104MAV_0579-1e-12367.54% (305) hypothetical protein MAV_0579
M. thermoresistible (build 8)TH_1750-1e-12669.84% (305) CONSERVED HYPOTHETICAL PROTEIN
M. ulcerans Agy99MUL_4153-1e-11964.71% (306) hypothetical protein MUL_4153
M. vanbaalenii PYR-1Mvan_5335-1e-12369.84% (305) hypothetical protein Mvan_5335

CLUSTAL 2.0.9 multiple sequence alignment


Mb3608|M.bovis_AF2122/97            ------------------MPTARSDAPLSVTWMGVATLLVDDGSSALMTD
Rv3577|M.tuberculosis_H37Rv         ------------------MPTARSDAPLSVTWMGVATLLVDDGSSALMTD
MMAR_5077|M.marinum_M               MRLRFGRPDLKRYSHRFGVPAAKPDAPLSAMWIGVSTVLLDDGSSALMTD
MUL_4153|M.ulcerans_Agy99           MRLRFGRPDLKRYSHRFGVPAAKPDAPLSAMWIGVSTVLLDDGSSALMTD
MAV_0579|M.avium_104                MRLRLGRPDITRYADRFDVPAAGPGG-LSVTWLGVASLLIDDGSSALLTD
Mflv_1449|M.gilvum_PYR-GCK          MRCKPGRPDLDAYATYFDLPAATPASPVTVSWAGVTTLLINDGTSALMTD
Mvan_5335|M.vanbaalenii_PYR-1       MRLKLGRPDLQAYSAYFDLPPAPPGAPVTVTWAGVTTLLVDDGESAVMTD
MSMEG_6071|M.smegmatis_MC2_155      MRLKPGRPDLADHARFFDAPTATPDSPVTVTWAGVTTLLVDDGTSALLTD
TH_1750|M.thermoresistible__bu      MRIRPGRPSLTPYAHRFDVPAAAATSRLTVTWAGVTTLLIDDGKSALLTD
                                                       *.* . . ::. * **:::*::** **::**

Mb3608|M.bovis_AF2122/97            GYFSRPGLARVAAG-KVSPSAERVDGCLARANVSRLTAVIPVHTHIDHAM
Rv3577|M.tuberculosis_H37Rv         GYFSRPGLARVAAG-KVSPSAERVDGCLARANVSRLTAVIPVHTHIDHAM
MMAR_5077|M.marinum_M               GYFSRPSLAQVAAG-KLAPSAARVDGCLAQAKASELAAVIPVHTHIDHAM
MUL_4153|M.ulcerans_Agy99           GYFSRPSLAQVAAG-KLAPSAARVDGCLAQAKASELAAVIPVHTHIDHAM
MAV_0579|M.avium_104                GYFSRPGLARVVAG-KVSPSPPRVDGCLARAKVSRLEAVIPVHTHFDHAL
Mflv_1449|M.gilvum_PYR-GCK          GFFSRPGLLRVATRRPLASSDSRIDAALQRLGVTRLDGVTPVHTHFDHAM
Mvan_5335|M.vanbaalenii_PYR-1       GFFSRPSHLSVAAR-PLRSSRSRIDDALSRLGVRRLDAVTPVHTHYDHAM
MSMEG_6071|M.smegmatis_MC2_155      GFFSRPGLLTVGLR-PLAPNVPRIDGCLARLGVDRLAAVLPVHTHFDHAM
TH_1750|M.thermoresistible__bu      GFFSRPALATVALR-RLEPDTARIEGSLARLRLHRLAAVIPVHTHYDHVL
                                    *:****.   *     : ..  *:: .* :    .* .* ***** **.:

Mb3608|M.bovis_AF2122/97            DSALVADRTGAQLVGGESAANVGRGYGLPEESLVVAVPGEPIQLGAFDVT
Rv3577|M.tuberculosis_H37Rv         DSALVADRTGAQLVGGESAANVGRGYGLPEESLVVAVPGEPIQLGAFDVT
MMAR_5077|M.marinum_M               DSALVADRTGALLVGGESAANIGRGYGLAEDRLVVAVPGQSMELGGYDVT
MUL_4153|M.ulcerans_Agy99           DSALVADRTGALLVGGESAANIGRGYGLADDRLVVAVPGQSMELGAYDVT
MAV_0579|M.avium_104                DSALVADRTGALLVGGESAANVGRGYGLPEDRIVVAADGEPIRLGAFDVT
Mflv_1449|M.gilvum_PYR-GCK          DSAAVAGRTGARLIGGSSAAHIGRGHGL--DRVEVVTSGDATAVGAFDVT
Mvan_5335|M.vanbaalenii_PYR-1       DSAVVADLTGARLIGGRSAAAIGRGHGL--DRVDVVAPAETVSVGSYDIT
MSMEG_6071|M.smegmatis_MC2_155      DSAVVAERTGAALVGGSSAAQIGIGGGLPDDRIVTVTPGEPVAMEAYDVT
TH_1750|M.thermoresistible__bu      DSPAVADRTGAVLIGGASAAQVGRGAGLPDDRIVVAADGASVSAGSFDIT
                                    **. **  *** *:** *** :* * **  : : ... . .    .:*:*

Mb3608|M.bovis_AF2122/97            LVESHHCPPDRFPGVISAPLTPPVKASAYRCGEAWSTLVHHRPSGRRLLI
Rv3577|M.tuberculosis_H37Rv         LVESHHCPPDRFPGVISAPLTPPVKASAYRCGEAWSTLVHHRPSGRRLLI
MMAR_5077|M.marinum_M               LIESHHCPPDRFPGVISEPVVPPVKASAYRCGEAWSTHIHHRPSGRRLLI
MUL_4153|M.ulcerans_Agy99           LIESHHCPPDRFPGVISEPVVPPVKASAYRCGEAWSTHIHHRPSGRRLLI
MAV_0579|M.avium_104                LVKSHHCPPDRFPGVIAEPLIPPARASAYRCGESWSTLVRHRPTGRRLLI
Mflv_1449|M.gilvum_PYR-GCK          LIESHHCPPDRFPGAITAPVAPRASVSAYRCGEAWSTLVRHRGTGRGLLI
Mvan_5335|M.vanbaalenii_PYR-1       LVEGSHCPPDRFPGTITAPVISPARVSAYRCGEAWSTLVHHRPTGVGLLV
MSMEG_6071|M.smegmatis_MC2_155      LFVSEHCPPDRFPGVITEPVVPPAKASAYKCGEAWSTLVHHRPSDRRVLI
TH_1750|M.thermoresistible__bu      LIDTGHCPPDRFPGTIDAPVAPPARVSAYRCGEAWSLLVGHRPSGRRLLI
                                    *.   *********.*  *: . . .***:***:**  : ** :.  :*:

Mb3608|M.bovis_AF2122/97            QDSAGFVSGALAGYRADAAYLSVGQLGLQPPSYLLEYWTETVRTVGVRRV
Rv3577|M.tuberculosis_H37Rv         QDSAGFVSGALAGYRADAAYLSVGQLGLQPPSYLLEYWTETVRTVGVRRV
MMAR_5077|M.marinum_M               QGSAGFVAGALDGYRAEVVYLGVGQLGLQRRSYLIDYWNEVVRAVAARRV
MUL_4153|M.ulcerans_Agy99           QGSAGFVAGALDGYRAEVVYLGVGQLGLQRRSYLIDYWNEVVRAVAARRV
MAV_0579|M.avium_104                CGSAGFVPGALAGQRAGAAYLSVGQLGLRPRSYLDEYWDQTVRTVGARRV
Mflv_1449|M.gilvum_PYR-GCK          VGSAGFVPGALAGRHADVVYLGVGQLGLQPHDYLAAYWTETVRTVGARRV
Mvan_5335|M.vanbaalenii_PYR-1       VGSAGFVPDALAGRRADVVYLGVGQLGLQPEGYLVDYWTQTVRTVGARQV
MSMEG_6071|M.smegmatis_MC2_155      VGSAGAVPGALAGQRADVVYLGVGQLGRQPERYLTDYWTQTVRTVGARRV
TH_1750|M.thermoresistible__bu      VGSAGFRRGALAGQHAEVAYLGVGQLGLQPERYLVDYWTETVRTVGARRV
                                     .***   .** * :* ..**.***** :   **  ** :.**:*..*:*

Mb3608|M.bovis_AF2122/97            ILIHWDDFFRPLSKPLRALPYAADDLDLSIRILDELAAQDGVALQMPTVW
Rv3577|M.tuberculosis_H37Rv         ILIHWDDFFRPLSKPLRALPYAADDLDLSIRILDELAAQDGVALQMPTVW
MMAR_5077|M.marinum_M               VLVHWDDFFRPLSKPMRAFPYAADDLDMSIRILDELAAQDGIPLQMPTVW
MUL_4153|M.ulcerans_Agy99           VLVHWDDFFRPLSKPMRAFPYAADDLDMSIRILDELAAQDGIPLQMPTVW
MAV_0579|M.avium_104                ILIHWDDFFRPLSKPLRALPYAGDDLDSSIRVLDELAERDGVALHLPSVW
Mflv_1449|M.gilvum_PYR-GCK          VLIHWDDFFRPLDKPLRALPFVADNLDVSMRILARLAREDGVDLHLPTLW
Mvan_5335|M.vanbaalenii_PYR-1       VLIHWDDFFRPLDKPLRSLPFAVDDLDVSMRVLSRLAAEDGVGLHLPTLW
MSMEG_6071|M.smegmatis_MC2_155      VLIHWDDFFRPLHRPLRALPYVADDLDATMRVLTTLAAHDGVALHLPTLW
TH_1750|M.thermoresistible__bu      VLTHWDDFFRPLHRPVRALPYAADDLDFSMRVLGGLAETDGIPLHLPTVW
                                    :* ********* :*:*::*:. *:** ::*:*  **  **: *::*::*

Mb3608|M.bovis_AF2122/97            RREDPWM--------
Rv3577|M.tuberculosis_H37Rv         RREDPWM--------
MMAR_5077|M.marinum_M               QREDPWV--------
MUL_4153|M.ulcerans_Agy99           QREDHWV--------
MAV_0579|M.avium_104                RREDPWA--------
Mflv_1449|M.gilvum_PYR-GCK          ERADPWR--------
Mvan_5335|M.vanbaalenii_PYR-1       QPAAPWS--------
MSMEG_6071|M.smegmatis_MC2_155      QRSDPWIETGSGPWR
TH_1750|M.thermoresistible__bu      QRTDPWR--------
                                    .    *