For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
GSAPGVEVAVRALRTESADRVPVILLHGARVPGIASFDLPVPGYSLAEDLVRAGHPTFIMDARGYGGSSR PAEMDGDPGTGRPLVRSNEVVEDIHAVVEHVAATTGAERVALVGWATGGHWAGMYAATHPDRVSHLVIYN SLYGAADGHPTLAVFDPESGPYRLSDGPSLLTSWDRSIPASDVTLWRDPRVAEAYQREALASDPTSESRT PASFRAPNGAMEDSHYLATGRQLWDASLITAETLIIRSELDFWSRPEDVEDMRRHLVHAAGVRTVVLPQA THYVHLDRPERGRDQFLGALLDFLP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5652 | - | - | 100% (306) | alpha/beta hydrolase fold |
| M. smegmatis MC2 155 | MSMEG_2900 | - | 1e-05 | 26.40% (303) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase |
| M. smegmatis MC2 155 | MSMEG_6106 | - | 3e-05 | 32.52% (123) | epoxide hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2400 | - | 2e-05 | 25.30% (249) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4366c | - | 9e-06 | 24.32% (292) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_4778 | bphD_1 | 4e-07 | 25.78% (287) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD_1 |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_4528 | - | 6e-06 | 24.42% (303) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_4193 | ephA | 7e-05 | 31.54% (130) | epoxide hydrolase EphA |
| M. vanbaalenii PYR-1 | Mvan_0150 | - | 9e-06 | 26.37% (201) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2400|M.gilvum_PYR-GCK MAEFESVWSDLQGVAFSQGYLD-AGGVRTRYLHAGDPADP--ALVFLHGS
TH_4528|M.thermoresistible__bu ------VWSDLQGVAFTQGYLD-AGGVRTRYLHAGEADKP--VLIFLHGS
MMAR_4778|M.marinum_M MTDFESVWSDLQGVMFEQGYLTTAQGVRTRYLRAGEPDRP--LLMLLHGS
MAB_4366c|M.abscessus_ATCC_199 ----MTIHTHLQSISTTLGEIA-----VHDVPAAGGADAP--TLVMLHGG
MUL_4193|M.ulcerans_Agy99 ------------MVATSTERLVDTNGVRLRVTEAGERGAP--VVILAHGF
Mvan_0150|M.vanbaalenii_PYR-1 -----------MAVTRTERSFDGVGGVRIVYDVWTPETPPRGIVVLAHGY
MSMEG_5652|M.smegmatis_MC2_155 -------MGSAPGVEVAVRALRTESADRVPVILLHGARVPG---IASFDL
: : * : ..
Mflv_2400|M.gilvum_PYR-GCK G---GHAEAYVRNLEAHAEH-FSTWSIDMLGHGYTDKP-GHPLEIP----
TH_4528|M.thermoresistible__bu G---GHAEAYVRNLEAHAEH-FSTWSIDMLGHGYTDKP-GHPLEVR----
MMAR_4778|M.marinum_M G---GHAEAYVRNLAAHAEH-FWTWAIDMLGHGYTDKP-GHPLEIR----
MAB_4366c|M.abscessus_ATCC_199 GPGASGLSNYEQNIPALSRT-FRILLPDQPGFGGSYRPTGADLDERS---
MUL_4193|M.ulcerans_Agy99 P---ELAYSWRHQIPVLAEAGYHVLAPDQRGYGGSSRP--EAIEDYD---
Mvan_0150|M.vanbaalenii_PYR-1 A---EHARRYDHVAARFAEAGLGIYALDHRGHGRSGGKRVYVRDISE---
MSMEG_5652|M.smegmatis_MC2_155 P-----VPGYS-LAEDLVRAGHPTFIMDARGYGGSSRPAEMDGDPGTGRP
: . * *.* : :
Mflv_2400|M.gilvum_PYR-GCK ---------HYVDHLAAFLDAIGARRAHISGESLGGWVAARIAADRPERV
TH_4528|M.thermoresistible__bu ---------HYVEHLAAVLDAIGADRAHISGESLGGWVASRFAIDRPDRL
MMAR_4778|M.marinum_M ---------HYVEHLMAVLRAIGAQRASISGESLGGWVAARAAVDHPEAV
MAB_4366c|M.abscessus_ATCC_199 ------ITEITVDALFQVLDDLAVGSFHLLGNSLGGAAAIRMAQLRPERV
MUL_4193|M.ulcerans_Agy99 ------IH-QLTADLVGLLDDVGAERAAWVGHDWGAVVVWNAPLLHPDRV
Mvan_0150|M.vanbaalenii_PYR-1 ------YTGDFHSLVRIAAGEHPGRKLVVLGHSMGGGVVFTYGVEHPDDY
MSMEG_5652|M.smegmatis_MC2_155 LVRSNEVVEDIHAVVEHVAATTGAERVALVGWATGGHWAGMYAATHPDRV
: * *. . :*:
Mflv_2400|M.gilvum_PYR-GCK DRLVLNTAGG---SQADPEVMKRI-------ITLSMAA---AENPTWDTV
TH_4528|M.thermoresistible__bu DRLVLNTAGG---SQADPEVMKRI-------ITLSMAA---AENPSWDTV
MMAR_4778|M.marinum_M ERLVLNTAGG---SQADPEVMARI-------VTLSMAA---AENPTWETV
MAB_4366c|M.abscessus_ATCC_199 TRLVLMAPGGGWLPFGPTPTEGQK-------EMFRYFN---GEGPTEKKM
MUL_4193|M.ulcerans_Agy99 AAVAGLSVPVLPRAQVPPIQAFRQRFGEHFFYILYFQQPGVADAELNGDP
Mvan_0150|M.vanbaalenii_PYR-1 DAMVLSGPAVDAHSSVSPVMVLLA-------KVLGRLS---PGLPVENLP
MSMEG_5652|M.smegmatis_MC2_155 SHLVIYNSLYGAADGHPTLAVFDPESGP--YRLSDGPSLLTSWDRSIPAS
:. .
Mflv_2400|M.gilvum_PYR-GCK QARIKWLMADKSKDYDDIVASRQRVYRQPGFANAMR--------------
TH_4528|M.thermoresistible__bu QARITWLMADKSKGYDDIVASRQKIYRQPGFVDAMR--------------
MMAR_4778|M.marinum_M QARIKWLMADKSKDYDDLVASRQRIYRQPGFVAAMR--------------
MAB_4366c|M.abscessus_ATCC_199 AAFIRAMVFDHKQFGRDVVSRRYQASLDEGHIEFYH--------------
MUL_4193|M.ulcerans_Agy99 ARTMRRMIGGQRSPTDQGAALRMVAPGPEGFIDRLPEPDAPPSWISRDEL
Mvan_0150|M.vanbaalenii_PYR-1 ADAVSRDPQVVAAYENDPLVHHGKLPAGVG--------------------
MSMEG_5652|M.smegmatis_MC2_155 DVTLWRDPRVAEAYQREALASDPTSESRTPASFRAP--------------
: :
Mflv_2400|M.gilvum_PYR-GCK -DIMALQDPE------------IRQRNLLGPNEYGAITAPTLVVWTSDDP
TH_4528|M.thermoresistible__bu -NIMALQDPE------------IRARNLLGPEEYGAITAPTLVVWTSDDP
MMAR_4778|M.marinum_M -DIMALQDPQ------------IRARNLLGPAEYGAIKAPTLVLWTSHDP
MAB_4366c|M.abscessus_ATCC_199 -HYNAAFAKR------------NGMDPLWR--DLHTITAPTLLLWGRDDR
MUL_4193|M.ulcerans_Agy99 DHYISEFTRTGFTGGLNWYRNFDRNWETTADLEGATITVPSLFMAGTKDP
Mvan_0150|M.vanbaalenii_PYR-1 ---RALIGVG-----------------ETMPARAAAITAPLLIVHGDNDK
MSMEG_5652|M.smegmatis_MC2_155 ---NGAMEDS------------HYLATGRQLWDASLITAETLIIRSELDF
. *.. *.: *
Mflv_2400|M.gilvum_PYR-GCK TADVEEGRRIASMIP--GARFEVMPG-CGHWPQYEDPKTFDRLHLDFLLG
TH_4528|M.thermoresistible__bu TADVDEGKRIASMIP--GARFEVMPG-CGHWPQYEDPATFNRLHIDFLLG
MMAR_4778|M.marinum_M TADVTEGRRIASMIP--GARFEVMSG-CGHWPQYEDAKSFNRRHLDFLMG
MAB_4366c|M.abscessus_ATCC_199 TITLEGAQMMLKHIS--DVQLHVFGR-CGHWVQLERQAEFDRLVADFLGE
MUL_4193|M.ulcerans_Agy99 VLSFARSDRASEVIT--GPYREVMVEGAGHWLQQERPDEVNATLLDFLKG
Mvan_0150|M.vanbaalenii_PYR-1 LIPVEGSRKLVDRVGSADVHLKEYPGLYHEVFNEPEKALVLDDVTSWIES
MSMEG_5652|M.smegmatis_MC2_155 WSRPEDVEDMRRHLVHAAGVRTVVLPQATHYVHLDRPERGRDQFLGALLD
: . : . :
Mflv_2400|M.gilvum_PYR-GCK RA-
TH_4528|M.thermoresistible__bu RS-
MMAR_4778|M.marinum_M H--
MAB_4366c|M.abscessus_ATCC_199 PA-
MUL_4193|M.ulcerans_Agy99 VQW
Mvan_0150|M.vanbaalenii_PYR-1 QL-
MSMEG_5652|M.smegmatis_MC2_155 FLP