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MTRPTPPRLQKAKAAAVTTAVVATTAALTAGVGSAAPEALLAQKRTVEAEVALAALPNIPAVPDIVGIYG VGPIFWAADLLGLTPTGVIQAAAGLLGGSEVAGAVTDLLDLLELLSPIEAGIKGPLPGDVYDAVNGLDYS TNGVIDMLGDPIRSIPLVGNTVWNAIDGLVEKIIKAAPILNQRRAVVFSESLGGVTTSLAYRDMINAVRS NAADWEEGVTGQWLIFFNNPSRPGGGLFALATPFTNQFGLNLSTPPAGSYTNEDENNGKITKVLNTSILD VTWAYNILSDAPTTANPLAWANAATGAVFLTYLLPNEGNNILNHVAPLLLVGVLDGAKVMIDPTGGQGLD MVPGWTELVTAISKLPLLGRKLADVLDDVSGATKFPGTGTYITYDSGNLPLLEPFRVMPHLLNLIPGTNI PTPLTDSIEDALRMMVNMGYQDVDPDTLERGFDMADQQAYFYDNPLTPTQHLAAQQKIFNALVDGIQEHA LNPAAWTPSISVPGIDFQPIVQNAASVALMAALRDALEGFQDAANPAFTAVRTGLAPVTKVLDDIDEQVT KALDSRFKVTEPKPTEGSPLNLNQRSAPSITNFSSDDAELRTITVTKEDIEPVAEKAEEPVGEQDSQKDS EKKDAKKQPRGLKKVTESFKATPGKHALDANNPVKKSVQETVEKVNAGVTDAVKNLEKAAKDAKAKAKAK ASASKDSDKKSGGADSEASDDKAAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5502 | - | - | 100% (725) | hypothetical protein MSMEG_5502 |
| M. smegmatis MC2 155 | MSMEG_5501 | - | 0.0 | 57.87% (762) | hypothetical protein MSMEG_5501 |
| M. smegmatis MC2 155 | MSMEG_0200 | - | 2e-22 | 23.55% (654) | hypothetical protein MSMEG_0200 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0157c | PE2 | 3e-05 | 28.57% (175) | PE family protein |
| M. gilvum PYR-GCK | Mflv_3378 | - | 7e-07 | 22.02% (327) | hypothetical protein Mflv_3378 |
| M. tuberculosis H37Rv | Rv0152c | PE2 | 3e-05 | 28.57% (175) | PE family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0384 | - | 2e-06 | 23.45% (550) | PE family protein, PE4 |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_2574 | - | 1e-143 | 44.53% (649) | PUTATIVE putative hypothetical protein MSMEG_5502 |
| M. ulcerans Agy99 | MUL_1034 | - | 2e-06 | 23.45% (550) | PE family protein |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5502|M.smegmatis_MC2_155 -MTRPTPPRLQKAKAAAVTTAVVATTAALTAGVGSAAPEALLAQKRTVEA
TH_2574|M.thermoresistible__bu --------------------MALATTAALTVGVTAPSLQNQAAP-QVVDI
MMAR_0384|M.marinum_M MSYVLTAPDLLASAATDVDGIAATLQVANSAAAAPTSGLLAAAQDEVSAA
MUL_1034|M.ulcerans_Agy99 MSYVLTAPDLLASAATDVDGIAATLQVANSAAAALTSGLLAAAQDEVSAA
Mb0157c|M.bovis_AF2122/97 --------------------MRCRPPSRNRSAHTARN-------------
Rv0152c|M.tuberculosis_H37Rv --------------------MRCRPPSRNRSAHTARN-------------
Mflv_3378|M.gilvum_PYR-GCK --------MHSALRPYVTTGLALVGTSVIALAPIAPPAPAFGGATVAKQV
.
MSMEG_5502|M.smegmatis_MC2_155 EVALAALPNIPAVPDIVGIYGVGPIFWAADLLG-LTPTGVIQAAAGLLGG
TH_2574|M.thermoresistible__bu DEHRIVDDAEVALSAIAGLYGVGPIFWAAEALG-ITPENVVRSAVGTLGS
MMAR_0384|M.marinum_M IAKVFSAYGQEYQAAIAQASAFHTEFTRALAAA-GAAYAQAEAANASLIT
MUL_1034|M.ulcerans_Agy99 IAKVFSAYGQEYQAAIAQASAFHTEFTRALAAA-GAAYAQAEAANASLIT
Mb0157c|M.bovis_AF2122/97 -----------TRPCSLKSRRFTVRFHQTLAAA-ANSYADAEAAIASTRQ
Rv0152c|M.tuberculosis_H37Rv -----------TRPCSLKSRRFTVRFHQTLAAA-ANSYADAEAAIASTRQ
Mflv_3378|M.gilvum_PYR-GCK TQDVTLSARVVTLNPTPDALEMGEQLQGSICGGNGTPCYEVEYAPIWTGP
. : : . . . *
MSMEG_5502|M.smegmatis_MC2_155 SEVAGAVTDLLDLLELLSPIEAGIKGPLPGDVYDAVNGLDYSTNGVIDML
TH_2574|M.thermoresistible__bu PLLDDTVELLFDALGLV--FDTGAPGPLPGDVYGRVNGLNYTTDLILELV
MMAR_0384|M.marinum_M AGVSDALTAITTPIQSLLGPAAIGTGGAGSAGALTAVSSTLMADPVVALI
MUL_1034|M.ulcerans_Agy99 AGVSDALTAITTPIQSLLGPAAIGTGGAGSAGALTAVSSTLMADPVVALI
Mb0157c|M.bovis_AF2122/97 NQLAVPAAAPTPAAAAMIPPFPAN---------------------LTTLF
Rv0152c|M.tuberculosis_H37Rv NQLAVPAAAPTPAAAAMIPPFPAN---------------------LTTLF
Mflv_3378|M.gilvum_PYR-GCK GYFGLGVEALREALTGNPGEETTIFAFSEGAVVASQWLEKHLEDPEAYPA
. .
MSMEG_5502|M.smegmatis_MC2_155 GDPIR--SIPLVG---NTVWN-------------AIDGLVEKIIKAAPIL
TH_2574|M.thermoresistible__bu PEGLRNLRVGLVG---AGALNLLFGADVIAPGQ-TIGQAAQAVFDRLPIL
MMAR_0384|M.marinum_M MGGTS---VPLPG---PGYVSDINNNYIQPLFSGAIPQALFTPEQFWPVT
MUL_1034|M.ulcerans_Agy99 MGGTS---VPLPG---PGYVSDINNNYIQPLFSGAIPQALFTPEQFWPVT
Mb0157c|M.bovis_AF2122/97 FGPTG---IPLPP---PSMLTPP----IRCRSVRRALQAVFTPEELYPLT
Rv0152c|M.tuberculosis_H37Rv FGPTG---IPLPP---PSMLTPP----IRCRSVRRALQAVFTPEELYPLT
Mflv_3378|M.gilvum_PYR-GCK PENLTFVVIGNPARKYGGSGTIWGRQWPTSPYQVIDVAQQYDPTVDMPVN
: . *:
MSMEG_5502|M.smegmatis_MC2_155 NQRRAVVFSESLGGVTTSLA--YRDMINAVRSNAADWEEGVTGQWLIFFN
TH_2574|M.thermoresistible__bu KQRRAVILSEGLGGLTTSLA--YRDMIKAVTSDDPDWEPGVTGQWLIFVN
MMAR_0384|M.marinum_M PGLGNLTFNQSVAQGVTLLN--DAINTQLALG-NKVVAFGYSQSATIVNN
MUL_1034|M.ulcerans_Agy99 PGLGNLTFNQSVAQGVTLLN--DAINTQLALG-NKVVAFGYSQSATIVNN
Mb0157c|M.bovis_AF2122/97 -GVRSLVLNTSVEEGLTILH--DAIMVELATTGNAVTVFGWSQSAIIASL
Rv0152c|M.tuberculosis_H37Rv -GVRSLVLNTSVEEGLTILH--DAIMVELATTGNAVTVFGWSQSAIIASL
Mflv_3378|M.gilvum_PYR-GCK NLNVLATLNATMGFFTNHLGRGYSDVDIDDPANSRWEEDGIEYVFVPAKT
:. : . * *
MSMEG_5502|M.smegmatis_MC2_155 NPSRPGGGLFALATPFTNQFGLNLSTPPAGSYTNEDENNGKITKVLNTSI
TH_2574|M.thermoresistible__bu NPGRPGGGLFALATPLTSLVGLNLTTPAGGSYVNDPDDP---TKVLNTSV
MMAR_0384|M.marinum_M EILA----LMAMGTGAPDPGDLSFIMVGAPNNPDGGLLARFPGFYIPFLD
MUL_1034|M.ulcerans_Agy99 EILA----LMAMGTGAPDPGDLSFIMVGAPNNPDGGLLARFPGFYIPFLD
Mb0157c|M.bovis_AF2122/97 EMQR----FTAMGGAAPSASDLNFVLVGNEMNPNGGMLARFPDLTLPTLD
Rv0152c|M.tuberculosis_H37Rv EMQR----FTAMGGAAPSASDLNFVLVGNEMNPNGGMLARFPDLTLPTLD
Mflv_3378|M.gilvum_PYR-GCK LPLVEPLRWVGLGQLADELTPGLQYLIEQGYNRDDRITGTTIDAPEKSWS
.:. . :
MSMEG_5502|M.smegmatis_MC2_155 LDVTWAYNILSDAPTTANPLAWANAATGAVFLTYLLPNEG----NNILNH
TH_2574|M.thermoresistible__bu LDIGWAYNVMSDAPTTLSPLAWANALAGAIFLSHLIPDDLNIADTNLLEQ
MMAR_0384|M.marinum_M VSFNGATPAANPYPTSIFTAQYDGIAHAPQYPLNILSDINAIMGYFYVHG
MUL_1034|M.ulcerans_Agy99 VSFNGATPAANPYPTSIFTAQYDGIAHAPQYRLNILSDINAIMGYFYVHG
Mb0157c|M.bovis_AF2122/97 LTFYGATPSDTIYPTAIYTLEYDGFADFSRYPLNFISDLNAVAGITFVHT
Rv0152c|M.tuberculosis_H37Rv LTFYGATPSDTIYPTAIYTLEYDGFADFSRYPLNFISDLNAVAGITFVHT
Mflv_3378|M.gilvum_PYR-GCK YAPINFLEAIANIPYYSVAGTNRFANAMRASGSWWVYTPTNVLGWDPANP
* . : .
MSMEG_5502|M.smegmatis_MC2_155 VAPLLLVGVLDGAKVMIDPTGGQGLDMVPGWTELVTAISKLPLLGRKLAD
TH_2574|M.thermoresistible__bu ALP-LTVGLANGVAVLLDPTGGQGSKVVPILGDLIDALNKIPLVD-----
MMAR_0384|M.marinum_M NYPDLMSG---QAIQLPTSPG-----------------------------
MUL_1034|M.ulcerans_Agy99 NYPDLMSG---QAIQLPTSPG-----------------------------
Mb0157c|M.bovis_AF2122/97 KYLDLTPAQVEGATKLPTSPG-----------------------------
Rv0152c|M.tuberculosis_H37Rv KYLDLTPAQVEGATKLPTSPG-----------------------------
Mflv_3378|M.gilvum_PYR-GCK EMTRAFVDFLVAIPSISTPMGMTADWWARANLPMNEGCTGFPPCDNPAGI
: . *
MSMEG_5502|M.smegmatis_MC2_155 VLDDVSGATKFPGTGTYITYDSGNLPLLEPFRVMPHLLNLIP--------
TH_2574|M.thermoresistible__bu -LPHVPGLN---GTSTYITYDSGNLPLLEPFDVLPRMLGMV---------
MMAR_0384|M.marinum_M ----------YTGNTDYYMYLTQDLPLVQPIRDIP---------------
MUL_1034|M.ulcerans_Agy99 ----------YTGNTDYYMYLTQDLPLVQPIRDIP---------------
Mb0157c|M.bovis_AF2122/97 ----------YTGVTDYYIIRTENRPLLQPLRAVP---------------
Rv0152c|M.tuberculosis_H37Rv ----------YTGVTDYYIIRTENRPLLQPLRAVP---------------
Mflv_3378|M.gilvum_PYR-GCK TDQMFKVQLWDFFAPGGFTFTDPITPEYNPISDTEAFWGQELGLTGDKVE
* :*:
MSMEG_5502|M.smegmatis_MC2_155 --GTNIPTPLTDSIEDALRMMVNMGYQDVDPDTLERGFDMADQQAYFYD-
TH_2574|M.thermoresistible__bu --GLNVPQPVLNSVENALRLAINTSYQDVDPVTLERRFDMAGRQAVFGQ-
MMAR_0384|M.marinum_M ----YAGPPLADLIQPQLRVLVDLGYSD-----YGPGLSYADVPTPAGL-
MUL_1034|M.ulcerans_Agy99 ----YAGPPLADLIQPQLRVLVDLGYSD-----YGPGLSYADVPTPAGL-
Mb0157c|M.bovis_AF2122/97 ----VIGDPLADLIQPNLKVIVNLGYGDPN---YGYSTSYADVRTPFGL-
Rv0152c|M.tuberculosis_H37Rv ----VIGDPLADLIQPNLKVIVNLGYGDPN---YGYSTSYADVRTPFGL-
Mflv_3378|M.gilvum_PYR-GCK WYGETVHPEPFGETKGFLDFLISTPEGIKTPTLQDQLNAFRNLADGLTTT
. : * . :. .
MSMEG_5502|M.smegmatis_MC2_155 -NPLTPTQHLAAQQKIFNALVDGIQEHALNPAAWTPSIS-----------
TH_2574|M.thermoresistible__bu -SPLTPSQQFDAGWLIANTLINDIQDNLLNPVAWTPSVAG--------QP
MMAR_0384|M.marinum_M -LSVPNP------FAVSYYLLKG---------------------------
MUL_1034|M.ulcerans_Agy99 -LSVPNP------FAVSYYLLKG---------------------------
Mb0157c|M.bovis_AF2122/97 -WPNVPP------QVIADALAAGTQEGILDFTADLQALS-----------
Rv0152c|M.tuberculosis_H37Rv -WPNVPP------QVIADALAAGTQEGILDFTADLQALS-----------
Mflv_3378|M.gilvum_PYR-GCK WNPFVPKSYVWNPDMTPFAYLARPLAKILCPTCNAVDPFMPEDWKVGLDV
.
MSMEG_5502|M.smegmatis_MC2_155 VPGIDFQPIVQNAASVALMAALRDALEGFQDAANPAFTAVRTGLAPVTKV
TH_2574|M.thermoresistible__bu VLNEALRALIQNAAAIAVSQLINAGIDVVQDIGEAGFGQVRTALTPVLDV
MMAR_0384|M.marinum_M --------SLQAPYGAAVEIGVEAG-------------------------
MUL_1034|M.ulcerans_Agy99 --------SLQAPYGAAVEIGVEAG-------------------------
Mb0157c|M.bovis_AF2122/97 -AQPLTLPQIQLPQPADLVAAVAAAPTPAEVVNTLARIISTNYAVLLPTV
Rv0152c|M.tuberculosis_H37Rv -AQPLTLPQIQLPQPADLVAAVAAAPTPAEVVNTLARIISTNYAVLLPTV
Mflv_3378|M.gilvum_PYR-GCK YPGAYIPPSVKDQYDPETGKYIGDPVDGLTDAEIAEWNEKAGLNDIVDET
:: :
MSMEG_5502|M.smegmatis_MC2_155 LDDIDEQVTK---------------ALDSRFKVTEPKPTEGSPLNLNQRS
TH_2574|M.thermoresistible__bu ADELNRQTRA---------------TTTVTLQVDQPATAAKTSEKPAAAA
MMAR_0384|M.marinum_M -----LLGPE---------------SFPDTYPWVPSLNPG-LNFYLGQPS
MUL_1034|M.ulcerans_Agy99 -----LLGPE---------------SFPDTYPWVPSLNPG-LNFYLGQPS
Mb0157c|M.bovis_AF2122/97 DIALALVTTL---------------PLYTTQLFVRQLAAGNLINAIGYPL
Rv0152c|M.tuberculosis_H37Rv DIALALVTTL---------------PLYTTQLFVRQLAAGNLINAIGYPL
Mflv_3378|M.gilvum_PYR-GCK TDGTEETEESGDVSEDPADADTSLLSARSMATVDESSEDTGASDKKTDVI
.
MSMEG_5502|M.smegmatis_MC2_155 APSITNFSSDDAELRTITVTKEDIEPVAEKAEEPVGEQDSQKDSEKKDAK
TH_2574|M.thermoresistible__bu TSALQTSAADTARTAPAIDTDGDDEPTAEAGKP------VEKTSTQRRAR
MMAR_0384|M.marinum_M VTLLSL-------------LSGGLGDIFHLIPP-------PVFP------
MUL_1034|M.ulcerans_Agy99 VTLLSL-------------LSGGLGDIFHLIPP-------PVFP------
Mb0157c|M.bovis_AF2122/97 AATVGLGTIDSGRRGIAHPPRGGLGHRSKHRGP-------RHLTDSRRHR
Rv0152c|M.tuberculosis_H37Rv AATVGLGTIDSGRRGIAHPPRGGLGHRSKHRGP-------RHLTDSRRHR
Mflv_3378|M.gilvum_PYR-GCK SAAVQDLVDTFDKTPAAEDTEQGAETPAGSEEPTQPQDETPAADADDDAG
. : .
MSMEG_5502|M.smegmatis_MC2_155 KQPRGLKKVTESFKATPGKHALDANNPVKKSVQETVEKVNAGVTDAVKNL
TH_2574|M.thermoresistible__bu TQPGGQP-----------------------------DKAGHSGTSAVD--
MMAR_0384|M.marinum_M --------------------------------------------------
MUL_1034|M.ulcerans_Agy99 --------------------------------------------------
Mb0157c|M.bovis_AF2122/97 RPPTTVYRPRQ---------------------------------------
Rv0152c|M.tuberculosis_H37Rv RPPTTVYRPRQ---------------------------------------
Mflv_3378|M.gilvum_PYR-GCK VDAEPVTTPRKPSSTTKSDVDASESADADATTSGTAGTSESSESEKSDTS
MSMEG_5502|M.smegmatis_MC2_155 EKAAKDAKAKAKAKASASKDSDKKSGGADSEASDDKAAA--
TH_2574|M.thermoresistible__bu -RPASKPKPPSIGKSPAEKAG--KSGQRDGRDKRDRNAA--
MMAR_0384|M.marinum_M -----------------------------------------
MUL_1034|M.ulcerans_Agy99 -----------------------------------------
Mb0157c|M.bovis_AF2122/97 -----------------------------------------
Rv0152c|M.tuberculosis_H37Rv -----------------------------------------
Mflv_3378|M.gilvum_PYR-GCK SDSSASDSSASDSASSSDSSGSGAGSSGSGGSAGSGGGSDD