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GSSFIAANGLWTQHQEEAAAKLVAQLDDLNLRQVRISWGDQHGILRGETLEVDAFRSALKEGKDFQTATL IFDSTNNPVVPPFEADGFGDKRLTGLPDAVLVPDPTTFRVLPWADRTGWVLSEMYYRSGERVPFDTRGVL KTQLAKLEAEGFSFTTGAELEFYITRLVDPKLSFVDSGWPPAAPEVTALSHGYQYLTENRGDEIDHILSI LRDHIVALGMPLATVEDEWGPGQVEMSFDPLVGVETADNVLLIRSAIKQICRRHGYHATFMSRPAFPNIV SSGWHLHQSLGAAGQANIFPGEDGKLLSDTAMHYMAGLLEHAKASSVLTTPTINGYKRYIANSFAPDRIA WAEENRGAMIRISGARGDNSTHLENRIGEPAANPYLYMASQLIGGRDGIARKLEPGPSADEAYTADVPLL PATLEEAVGHFESSAVMRRELGDMFVDYLTTVKKNEISRFNAYVTDWEQREYFEVF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5374 | - | - | 100% (477) | glutamate--ammonia ligase |
| M. smegmatis MC2 155 | MSMEG_3828 | - | 2e-43 | 29.89% (445) | glutamine synthetase |
| M. smegmatis MC2 155 | MSMEG_2595 | - | 3e-43 | 30.00% (460) | gamma-glutamylisopropylamide synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2885c | glnA4 | 2e-44 | 31.77% (384) | glutamine synthetase |
| M. gilvum PYR-GCK | Mflv_4065 | - | 6e-44 | 29.94% (471) | glutamate--ammonia ligase |
| M. tuberculosis H37Rv | Rv2860c | glnA4 | 2e-44 | 31.77% (384) | glutamine synthetase |
| M. leprae Br4923 | MLBr_01631 | glnA2 | 8e-40 | 28.51% (470) | glutamine synthase class II |
| M. abscessus ATCC 19977 | MAB_1920 | - | 2e-42 | 29.40% (466) | glutamine synthetase |
| M. marinum M | MMAR_3294 | glnA2 | 2e-39 | 28.18% (472) | glutamine synthetase GlnA2 |
| M. avium 104 | MAV_3718 | glnA | 1e-41 | 32.03% (384) | glutamine synthetase catalytic domain |
| M. thermoresistible (build 8) | TH_3396 | - | 8e-41 | 27.91% (473) | PUTATIVE glutamine synthetase, type I |
| M. ulcerans Agy99 | MUL_1335 | glnA2 | 5e-40 | 28.18% (472) | glutamine synthetase GlnA2 |
| M. vanbaalenii PYR-1 | Mvan_1603 | - | 3e-52 | 31.51% (476) | glutamate--ammonia ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3294|M.marinum_M -----------------MDRQKEFVLRTLEERD---IRFVRLWFTDVLGF
MUL_1335|M.ulcerans_Agy99 -----------------MDRQKEFVLRTLEERD---IRFVRLWFTDVLGF
MLBr_01631|M.leprae_Br4923 -----------------MDRQKEFVLRTLEERD---IRFVRLWFTDVLGY
TH_3396|M.thermoresistible__bu -----------------MDRQKEFVLRSLEERD---IRFVRLWFTDVLGF
MAB_1920|M.abscessus_ATCC_1997 -----------------MDRQKEFVLRTLEERD---IRFVRLWFTDVLGY
Mb2885c|M.bovis_AF2122/97 ----------MTGPGSPPLAWTELERLVAAGD----VDTVIVAFTDMQGR
Rv2860c|M.tuberculosis_H37Rv ----------MTGPGSPPLAWTELERLVAAGD----VDTVIVAFTDMQGR
MAV_3718|M.avium_104 ---MASEDSALTGSDTAMLSLAALDRLVAAGAPETRVDTVIVAFPDMQGR
Mflv_4065|M.gilvum_PYR-GCK -MTDRTKGRLELMTTRGMLTLEDLEKQVADGD----IDTVIVAFCDMQGR
Mvan_1603|M.vanbaalenii_PYR-1 MTNASIRPGRIDATNGQVESAPDAVRAMFERHG---IRTVQFGMADIDGQ
MSMEG_5374|M.smegmatis_MC2_155 -----MGSSFIAANGLWTQHQEEAAAKLVAQLDDLNLRQVRISWGDQHGI
: * . * *
MMAR_3294|M.marinum_M LKSVAIAPAELEGAFEEG----------IGFDGSSIEGFAR--------V
MUL_1335|M.ulcerans_Agy99 LKSVAIAPAELEGAFEEG----------IGFDGSSIEGFAR--------V
MLBr_01631|M.leprae_Br4923 LKSVAIAPAELEGAFEEG----------IGFDGSSIEGFAR--------V
TH_3396|M.thermoresistible__bu LKSVAIAPAELEGAFEEG----------IGFDGSAIEGFAR--------V
MAB_1920|M.abscessus_ATCC_1997 LKSVSIAPAELEGAFEEG----------IGFDGSSIEGFAR--------V
Mb2885c|M.bovis_AF2122/97 LAGKRISGRHFVDDIATRGVECCSYLLAVDVDLNTVPGYAMASWD----T
Rv2860c|M.tuberculosis_H37Rv LAGKRISGRHFVDDIATRGVECCSYLLAVDVDLNTVPGYAMASWD----T
MAV_3718|M.avium_104 LVGKRMDARLFVDEAAATGVECCGYLLAVDVDMNTVGGYAISGWD----T
Mflv_4065|M.gilvum_PYR-GCK LTGKRISSRLFVDDVAEHGAECCNYLLAVDVDMNTVDGYAISSWE----K
Mvan_1603|M.vanbaalenii_PYR-1 VRGKFVPAEFFLDSVARRGSSIPNIVFGWDIEDTLMDCFTVSGWH----T
MSMEG_5374|M.smegmatis_MC2_155 LRGETLEVDAFRSALKEGKDFQTATLIFDSTNNPVVPPFEADGFGDKRLT
: . : : . . : : :
MMAR_3294|M.marinum_M SESDTVAHPDPSTFQVLPWVTDAGHHHSARIFCDITMPDGSPSWADPRHV
MUL_1335|M.ulcerans_Agy99 SESDTVAHPDPSTFQVLPWVTDAGHHHSARIFCDITMPDGSPSWADPRHV
MLBr_01631|M.leprae_Br4923 SESDTVAHPDPSTFQILPWATTAGHHHSARMFCDITMPDGSSSWADPRHV
TH_3396|M.thermoresistible__bu SEADMVARPDPSTFQVLPWTGDSGKHYSARMFCDITMPDGSPSWADPRHV
MAB_1920|M.abscessus_ATCC_1997 SESDTVAHPDPSTFQVLPWTTSAGKHHSARMFCDIKLPDGSPSWSDPRHV
Mb2885c|M.bovis_AF2122/97 GYGDMVMTPDLSTLRLIPWLPG-----TALVIADLVWADGSEVAVSPRSI
Rv2860c|M.tuberculosis_H37Rv GYGDMVMTPDLSTLRLIPWLPG-----TALVIADLVWADGSEVAVSPRSI
MAV_3718|M.avium_104 GFGDLVMRPDLSTLRRIPWLPG-----TALVIADVVGADGSPVAVSPRAV
Mflv_4065|M.gilvum_PYR-GCK GYGDMVMTPDMSTLRRVPWLPA-----TALVMADLSWTDGRPVTQAPRGI
Mvan_1603|M.vanbaalenii_PYR-1 GYSDVVLAPDLSTLRPVPWEPG-----HAFVLCDVVNTDGSPVPVAPRTV
MSMEG_5374|M.smegmatis_MC2_155 GLPDAVLVPDPTTFRVLPWADR-----TGWVLSEMYYRSGERVPFDTRGV
. * * ** :*:: :** . ::.:: .* .* :
MMAR_3294|M.marinum_M LRRQLTKANELGFSCYVHPEIEFFLLNPGP------EDG------TEPVP
MUL_1335|M.ulcerans_Agy99 LRRQLIKANELGFSCYVHPEIEFFLLNPGP------EDG------TEPVP
MLBr_01631|M.leprae_Br4923 LRRQLTKANDLGFSCYVHPEIEFFLLKAGP------EDGSM----PIPVP
TH_3396|M.thermoresistible__bu LRRQLAKAGDQGFTCYVHPEIEFFLLKPGP------HDG------SPPVP
MAB_1920|M.abscessus_ATCC_1997 LRRQLAKASDLGFSCYVHPEIEFFLLKNLP------DDG------TAPIP
Mb2885c|M.bovis_AF2122/97 LRRQLDRLKARGLVADVATELEFIVFDQPY------RQAWASGYRGLTPA
Rv2860c|M.tuberculosis_H37Rv LRRQLDRLKARGLVADVATELEFIVFDQPY------RQAWASGYRGLTPA
MAV_3718|M.avium_104 LRRQLDRLAGRGLFADAATELEFMVFDEPY------RQAWASGYRGLTPA
Mflv_4065|M.gilvum_PYR-GCK LRAQLDRLDALGLDAVAATELEFMVFDTGF------RDAWAAGYRNLKPA
Mvan_1603|M.vanbaalenii_PYR-1 LAGQVERAAALGYRLTAGYELEFYLYRETP------ETAAAKGYRNLTPA
MSMEG_5374|M.smegmatis_MC2_155 LKTQLAKLEAEGFSFTTGAELEFYITRLVDPKLSFVDSGWPPAAPEVTAL
* *: : * . *:** : .
MMAR_3294|M.marinum_M IDNAGYFDQAVHVSASKFRRHAIDALEFMGISVEFSHHEGAPGQQEIDLR
MUL_1335|M.ulcerans_Agy99 IDNAGYFDQAVHVSASKFRRHVIDALEFMGISVEFSHHEGAPGQQEIDLR
MLBr_01631|M.leprae_Br4923 VDNAGYFDQAVHDSALNFRRHAIEALEFMGISVEFSHHEGAPGQQEIDLR
TH_3396|M.thermoresistible__bu ADTSGYFDQSVHDTAPNFRRHAIEALEQMGISVEFSHHEGAPGQQEIDLR
MAB_1920|M.abscessus_ATCC_1997 ADDAGYFDQAVHEAAPNFRRHAIDALESMGISVEFSHHEGAPGQQEIDLR
Mb2885c|M.bovis_AF2122/97 SDYNIDYAILASSRMEPLLRDIRLGMAGAGLRFEAVKGECNMGQQEIGFR
Rv2860c|M.tuberculosis_H37Rv SDYNIDYAILASSRMEPLLRDIRLGMAGAGLRFEAVKGECNMGQQEIGFR
MAV_3718|M.avium_104 SDYNIDYAISASSRMEPLLRDIRRGMAGAGLRFESVKGECNRGQQEIGFR
Mflv_4065|M.gilvum_PYR-GCK TDYNIDYAMHASTRMEPLLRDIRLGMDGAGMYCEGVKGECNLGQQEIGFR
Mvan_1603|M.vanbaalenii_PYR-1 SPGTATFSLNRHSALEDVIGAIREGMRACDIPVLASNTEYGAGQIEINIE
MSMEG_5374|M.smegmatis_MC2_155 SHGYQYLTENRGDEIDHILSILRDHIVALGMPLATVEDEWGPGQVEMSFD
. : .: . * ** *:.:
MMAR_3294|M.marinum_M FADALSMADNVMTFRYVIKEVALEEGVRATFMPKPFGQHAGSA-MHTHMS
MUL_1335|M.ulcerans_Agy99 FADALSMADNVMTFRYVIKEVALEEGVRATFMPKPFGQHAGSA-MHTHMS
MLBr_01631|M.leprae_Br4923 FADALSMADNVMTFRYVIKEVAIENGARASFMPKPFAQHPGSA-MHTHMS
TH_3396|M.thermoresistible__bu YADALSMADNVMTFRYVVKQVAISDGVRASFMPKPFAEHPGSA-MHTHMS
MAB_1920|M.abscessus_ATCC_1997 YADALSMADNVMTFRNVVKEVAIIDGVHATFMPKPFSDHPGSA-MHTHMS
Mb2885c|M.bovis_AF2122/97 YDEALVTCDNHAIYKNGAKEIADQHGKSLTFMAKYD-EREGNS-CHIHVS
Rv2860c|M.tuberculosis_H37Rv YDEALVTCDNHAIYKNGAKEIADQHGKSLTFMAKYD-EREGNS-CHIHVS
MAV_3718|M.avium_104 YDEALRTCDNHVIYKNGAKEIADQHGKSLTFMAKYD-EREGNS-CHVHLS
Mflv_4065|M.gilvum_PYR-GCK YEQALVTCDNHTIYKNGAKEIADQHGKSLTFMAKFD-ESEGNS-CHIHIS
Mvan_1603|M.vanbaalenii_PYR-1 HADALTTADRVAIYKNGVRRIAEQHGYLATFMAKVATDSAGSS-AHIHQS
MSMEG_5374|M.smegmatis_MC2_155 PLVGVETADNVLLIRSAIKQICRRHGYHATFMSRPAFPNIVSSGWHLHQS
.: .*. : :.:. .* :**.: .: * * *
MMAR_3294|M.marinum_M LFEGDVN-----AFHSPDDPLQLSEVGKSFIAGILEHASEISAVTNQWVN
MUL_1335|M.ulcerans_Agy99 LFEGDVN-----AFHSPDDPLQLSEVGKSFIAGILEHASEISAVTNQWVN
MLBr_01631|M.leprae_Br4923 LFEGDVN-----AFHSDDDPLQLSDVGKSFIAGILEHASEISAVTNQWVN
TH_3396|M.thermoresistible__bu LFEGDTN-----AFHSPDDPLQLSDVAKSFIAGILEHANEISAVTNQWVN
MAB_1920|M.abscessus_ATCC_1997 LFEGDTN-----AFHNPDDPLQLSDVGKSFIAGILEHANEISAVTNQWVN
Mb2885c|M.bovis_AF2122/97 LRGTDGS----AVFADSNGPHGMSSMFRSFVAGQLATLREFTLCYAPTIN
Rv2860c|M.tuberculosis_H37Rv LRGTDGS----AVFADSNGPHGMSSMFRSFVAGQLATLREFTLCYAPTIN
MAV_3718|M.avium_104 LRDAQGG----AAFADPSRPHGMSTMFCSFLAGLLATMADFTLFYAPNIN
Mflv_4065|M.gilvum_PYR-GCK FRGRDGSPEDIAVFADDSDELGMSSMFRSFIAGQLATLREFTLFYAPNIN
Mvan_1603|M.vanbaalenii_PYR-1 MQQLDAPAR--NAMWDGDRP---SALMRQAVAGQLASMRDFTVLYCPTVN
MSMEG_5374|M.smegmatis_MC2_155 LGAAGQAN-----IFPGEDGKLLSDTAMHYMAGLLEHAKASSVLTTPTIN
: : . * :** * : :*
MMAR_3294|M.marinum_M SYKRLILGGEAPTAASWGAANRSALVRVPMYTPHKTSSRRIEVRSPDSAC
MUL_1335|M.ulcerans_Agy99 SYKRLILGGEAPTAASWGAANRSALVRVPMYTPHKTSSRRIEVRSPDSAC
MLBr_01631|M.leprae_Br4923 SYKRLVVGGEAPTTASWGAANRSALVRVPMYTPHKTSSRRVEVRSPDSAC
TH_3396|M.thermoresistible__bu SYKRLVHGGEAPTAASWGAANRSALVRVPMYTPHKASSRRVEVRSPDSAC
MAB_1920|M.abscessus_ATCC_1997 SYKRLVQGGEAPTAASWGAANRSALVRVPMYTPNKSSSRRIEVRSPDSAC
Mb2885c|M.bovis_AF2122/97 SYKRFADSSFAPTALAWGLDNRTCALRVVGHGQN----IRVECRVPGGDV
Rv2860c|M.tuberculosis_H37Rv SYKRFADSSFAPTALAWGLDNRTCALRVVGHGQN----IRVECRVPGGDV
MAV_3718|M.avium_104 SYKRFADESFAPTALAWGLDNRTCALRVVGHGAH----TRVECRVPGGDV
Mflv_4065|M.gilvum_PYR-GCK SYKRFAEGSFAPTAVAWGLDNRTCSLRVVGHGQG----MRMENRAPGGDV
Mvan_1603|M.vanbaalenii_PYR-1 SYKRRVPGSWSPVSAAWGVDNRTAALRVIAHDEAT---CRMENRVPGADA
MSMEG_5374|M.smegmatis_MC2_155 GYKRYIANSFAPDRIAWAEENRGAMIRISGARGDN--STHLENRIGEPAA
.*** . :* :*. ** . :*: ::* *
MMAR_3294|M.marinum_M NPYLAFAVLLAAGLRGVEKGYVLGPQAEDNVWDLTPEERRTMGYRELPTS
MUL_1335|M.ulcerans_Agy99 NPYLAFAVLLAAGLRGVEKGYVLGPQAEDNVWDLTPEERRTMGYRELPTS
MLBr_01631|M.leprae_Br4923 NPYLAFAVLLAAGLRGVEKGYVLGPQAEDNVWDLTPEERLAMGYRELPTS
TH_3396|M.thermoresistible__bu NPYLTFAVLLAAGLRGVEKGYVLGPEAEDNVWTLTPEERRAMGFKELPSS
MAB_1920|M.abscessus_ATCC_1997 NPYLTYAVLLAAGLRGVEQGYTLGPEAEDDVWGLTRAERQAMGYKELPST
Mb2885c|M.bovis_AF2122/97 NQYLAVAALIAGGLYGIERGLQLPEPCVGNAYQGADVER-------LPVT
Rv2860c|M.tuberculosis_H37Rv NQYLAVAALIAGGLYGIERGLQLPEPCVGNAYQGADVER-------LPVT
MAV_3718|M.avium_104 NPYLAVAAIVAGGLYGIEQGLALPEPCAGNAYRARGVGR-------LPAT
Mflv_4065|M.gilvum_PYR-GCK NQYLAVAALIAGGLYGIENKLELEDAVEGNAYT-SGADR-------LPTT
Mvan_1603|M.vanbaalenii_PYR-1 NPYLALAACLAGVLHGIENQLEPPAAVTGNAYQGADSP--------LPRS
MSMEG_5374|M.smegmatis_MC2_155 NPYLYMASQLIGGRDGIARKLEPGPSADEAYTADVPLLP---------AT
* ** * : . *: . :
MMAR_3294|M.marinum_M LDSALRAMESSELVAEALGEHVFDFFLRNKRREWATYRSHVTPYELSTYL
MUL_1335|M.ulcerans_Agy99 LDSALRAMESSELVAEALGEHVFDFFLRNKRREWATYRSHVTPYELSTYL
MLBr_01631|M.leprae_Br4923 LDSALGAMEVSEFVAEALGEHVFDFFLRNKRAEWANYRSHVSLYELKTYL
TH_3396|M.thermoresistible__bu LGQALAEMERSELVAEALGEHVFDFFLRNKRAEWENYRSHVTPYELKNYL
MAB_1920|M.abscessus_ATCC_1997 LENALIAMEGSELVAEALGEHVFDFFLRNKRAEWARYRSNVTPFELRAYL
Mb2885c|M.bovis_AF2122/97 LADAAVLFEDSALVREAFGEDVVAHYLNNARVELAAFNAAVTDWERIRGF
Rv2860c|M.tuberculosis_H37Rv LADAAVLFEDSALVREAFGEDVVAHYLNNARVELAAFNAAVTDWERIRGF
MAV_3718|M.avium_104 LAEAAALFEHSALARQVFGDDVVAHYLNNARVELAAFHAAVTDWERMRGF
Mflv_4065|M.gilvum_PYR-GCK LSEAVELFENSKIARDAFGDDVVDHYVNNARVELKAFNAAVTDWERVRGF
Mvan_1603|M.vanbaalenii_PYR-1 LAEAVDAFGASSLARTAFGDAFVDHYLASRGWERDRHREAVSDWETGRYF
MSMEG_5374|M.smegmatis_MC2_155 LEEAVGHFESSAVMRRELGDMFVDYLTTVKKNEISRFNAYVTDWEQREYF
* .* : * . :*: .. . * .. *: :* :
MMAR_3294|M.marinum_M SL-
MUL_1335|M.ulcerans_Agy99 SL-
MLBr_01631|M.leprae_Br4923 SL-
TH_3396|M.thermoresistible__bu SL-
MAB_1920|M.abscessus_ATCC_1997 GL-
Mb2885c|M.bovis_AF2122/97 ERL
Rv2860c|M.tuberculosis_H37Rv ERL
MAV_3718|M.avium_104 ERL
Mflv_4065|M.gilvum_PYR-GCK ERL
Mvan_1603|M.vanbaalenii_PYR-1 SRV
MSMEG_5374|M.smegmatis_MC2_155 EVF