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VSGEVAIALALALVLTAVVAIVVVRTRRVVATPTERAVHAALHTASSAARALRRGLDTDSAQTAAPYLRG LTVTQGLALFDGDGQLLALDPDDDALWQTDIVDTCTSTARDSIADQRRKLTSARPMTVVAQPLLTEAGDV LGALVVVTASTPGPGMLGAVGEVARYAASQIELAELDASRARLDRAEVLALRAQISPHFIYNALNTIASF VRTDPDRARELILEFADFTRYSFRAAGQYTTLADELRNIDRYLTLERARFGQSLKVRLQVAPEVLNVVVP FLALQPLVENAVRHGLAGQGGGTVEIIARDEGTDCVITVEDDGAGMDPETLRAGQGDALADRTDQGAHVG LTNVDHRLRAAFGNDYGLVVETALGAGTKVMMRVPKFRSGVHAGGGAFG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5158 | - | - | 100% (399) | sensor histidine kinase |
| M. smegmatis MC2 155 | MSMEG_2793 | - | 6e-06 | 25.44% (287) | sensor-type histidine kinase PrrB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0781 | phoR | 5e-05 | 31.48% (108) | two component system response sensor kinase membrane |
| M. gilvum PYR-GCK | Mflv_2144 | - | 1e-179 | 80.35% (402) | signal transduction histidine kinase, LytS |
| M. tuberculosis H37Rv | Rv0758 | phoR | 6e-05 | 31.48% (108) | two component system response sensor kinase membrane |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0674 | - | 4e-05 | 33.59% (128) | putative sensor histidine kinase PhoR |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_0147 | - | 4e-05 | 25.29% (257) | sensor-type histidine kinase PrrB |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_4559 | - | 1e-177 | 79.65% (403) | signal transduction histidine kinase, LytS |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2144|M.gilvum_PYR-GCK ---------------------------MPGELAIALTAALILLAVAAVVV
Mvan_4559|M.vanbaalenii_PYR-1 ---------------------------MSGELAIALTAALILLAVAAVVL
MSMEG_5158|M.smegmatis_MC2_155 ---------------------------MSGEVAIALALALVLTAVVAIVV
Mb0781|M.bovis_AF2122/97 -----------------------MARHLRGRLPLRVRLVAATLILVATGL
Rv0758|M.tuberculosis_H37Rv -----------------------MARHLRGRLPLRVRLVAATLILVATGL
MAB_0674|M.abscessus_ATCC_1997 MAWDTYCASRDERLREEQLALLVAVPGVRRGVPLRVSLVVGTLVLVALGL
MAV_0147|M.avium_104 ----------------------------MRVLSLRTIVIVAAISVMTLVV
:.: : : :
Mflv_2144|M.gilvum_PYR-GCK AVRTRRVVATPTERAVHAALHTASLAARALRQG---------LDTDSAKT
Mvan_4559|M.vanbaalenii_PYR-1 AVRTRRVVATPTERAVHAALHTASLAARALRQG---------LNTDSAQT
MSMEG_5158|M.smegmatis_MC2_155 -VRTRRVVATPTERAVHAALHTASSAARALRRG---------LDTDSAQT
Mb0781|M.bovis_AF2122/97 VASGIAVTSMLQHRLTSRIDRVLLEEAQIWAQITLPLAPDPYPIHNPDRP
Rv0758|M.tuberculosis_H37Rv VASGIAVTSMLQHRLTSRIDRVLLEEAQIWAQITLPLAPDPYPGHNPDRP
MAB_0674|M.abscessus_ATCC_1997 VASGIAVTTTMQRTMMNRADRELIDAANGWANR--PPPPPPAFETTRHRP
MAV_0147|M.avium_104 LLGTWVWVGVTNDQYNQLDRRLDSVSSLGDISS---LLTNPQHNSPDRAT
. : : .
Mflv_2144|M.gilvum_PYR-GCK SAPFLRELTGTDG---LALFGGDGALLARDPDDDA---------------
Mvan_4559|M.vanbaalenii_PYR-1 AAPFLRDLTGADG---LALFDGDGAVLAEDALDDA---------------
MSMEG_5158|M.smegmatis_MC2_155 AAPYLRGLTVTQG---LALFDGDGQLLALDPDDDA---------------
Mb0781|M.bovis_AF2122/97 PSRFYVRVISPDGQSYTALNDNT-AIPAVPANNDVGRHPTTLPSIGGSKT
Rv0758|M.tuberculosis_H37Rv PSRFYVRVISPDGQSYTALNDNT-AIPAVPANNDVGRHPTTLPSIGGSKT
MAB_0674|M.abscessus_ATCC_1997 PSLFFIRTTDDRGRVVIMLNDRARADPDLPFDNDVGGRPVTVRSSDGG-T
MAV_0147|M.avium_104 QDGNLVRTARIGGVTVSVPSNIVLPQLPDGYANTTING------------
* . : .
Mflv_2144|M.gilvum_PYR-GCK VWPPDVRDACDGAARQSISGGRRVMTHARTSAVVAQPMLTETGDLLGVLV
Mvan_4559|M.vanbaalenii_PYR-1 LWDDDVRDACDDAAHESISGQRRVMAHAGTSAVVAQPLLAESGDLLGVLV
MSMEG_5158|M.smegmatis_MC2_155 LWQTDIVDTCTSTARDSIADQRRKLTSARPMTVVAQPLLTEAGDVLGALV
Mb0781|M.bovis_AF2122/97 LWRAVSVRASDGYLTTVAIDLADVRSTVRSLVLLQVGIGSAVLVVLGVAG
Rv0758|M.tuberculosis_H37Rv LWRAVSVRASDGYLTTVAIDLADVRSTVRSLVLLQVGIGSAVLVVPGVAG
MAB_0674|M.abscessus_ATCC_1997 EWRAVSRHDALGGYTTVARDITDVRTTVRDLLWLQVAIGIAVLTVLGVAG
MAV_0147|M.avium_104 VQYRVRTFTAGPASIALAAPLAEAQHRINELHLRVLLICASVIGGTVVVG
. : .
Mflv_2144|M.gilvum_PYR-GCK VVTTRSPGPGMLGAVGEVARYAASQIELAELDAS-RARLDRAEVLALRAQ
Mvan_4559|M.vanbaalenii_PYR-1 VVTTRSPGPGMLGAVGEVARYAASQIELAELDAS-RARLDRAEVLALRAQ
MSMEG_5158|M.smegmatis_MC2_155 VVTASTPGPGMLGAVGEVARYAASQIELAELDAS-RARLDRAEVLALRAQ
Mb0781|M.bovis_AF2122/97 YAVVRRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVGRLSLALNGML
Rv0758|M.tuberculosis_H37Rv YAVVRRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVGRLSLALNGML
MAB_0674|M.abscessus_ATCC_1997 YWLVHRSLRPLAEVEATAADIAAGHLDRRVPERDPRTEVGRLSLALNGML
MAV_0147|M.avium_104 WVISLIMVNPFLLLAQQARAINAQSSPDEVQVRG-VREAVEIAEAVEGML
: . * . .
Mflv_2144|M.gilvum_PYR-GCK ISPHFIYNALNTIASFVRTDPDRARELILEFADFTRYSFRAAGQFTTLSD
Mvan_4559|M.vanbaalenii_PYR-1 ISPHFIYNALNTIASFVRTDPDRARELILEFADFTRYSFRAAGQFTTLAE
MSMEG_5158|M.smegmatis_MC2_155 ISPHFIYNALNTIASFVRTDPDRARELILEFADFTRYSFRAAGQYTTLAD
Mb0781|M.bovis_AF2122/97 AQIQRAVASAESSAEKARDSEDRMRQFITDASHELRTPLTTIRGFAELYR
Rv0758|M.tuberculosis_H37Rv AQIQRAVASAESSAEKARDSEDRMRQFITDASHELRTPLTTIRGFAELYR
MAB_0674|M.abscessus_ATCC_1997 AQIQRAVADSEKSAKAARTSEERMRRFITDASHELRTPLTTIRGYAELYR
MAV_0147|M.avium_104 ARIGKEQQRTKAALESARDFAAVASHELRTPLTAMRTNLEVLSTLDLPHE
: . .* . : * : .
Mflv_2144|M.gilvum_PYR-GCK ELRNIDRYLTLERARFG----------TALKVTLRVAPEVLNVVVPFLAL
Mvan_4559|M.vanbaalenii_PYR-1 ELRNIDRYLTLERARFG----------TALKVTLQVAPEVLNVVVPFLAL
MSMEG_5158|M.smegmatis_MC2_155 ELRNIDRYLTLERARFG----------QSLKVRLQVAPEVLNVVVPFLAL
Mb0781|M.bovis_AF2122/97 QGAARDVGMLLSRIESEASRMGLLVDDLLLLARLDAHRPLELCRVDLLAL
Rv0758|M.tuberculosis_H37Rv QGAARDVGMLLSRIESEASRMGLLVDDLLLLARLDAHRPLELCRVDLLAL
MAB_0674|M.abscessus_ATCC_1997 QGAATDTELVLGRIEGESTRMGQLVEDLLLLARLDAHRPMEQRLVDLLVL
MAV_0147|M.avium_104 QRQEVIGDVIRTQSRIEAT-----LTALERLAQGELTTVDDFVPFDITEL
: : : . . . : *
Mflv_2144|M.gilvum_PYR-GCK QPLVENAVRHGFAGR--------GSGSIELVARD----------------
Mvan_4559|M.vanbaalenii_PYR-1 QPLVENAVRHGFAGR--------GSGSIELVARD----------------
MSMEG_5158|M.smegmatis_MC2_155 QPLVENAVRHGLAGQ--------GGGTVEIIARD----------------
Mb0781|M.bovis_AF2122/97 ASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQ
Rv0758|M.tuberculosis_H37Rv ASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQ
MAB_0674|M.abscessus_ATCC_1997 ATDAVHDAKATAPERDVELEVFDGPGTPEVIGDELRLRQVLGNLVSNALG
MAV_0147|M.avium_104 LDRAAHDALRVYPDVEVS---LVPSPTVLMIGLPTGLRLVIDNAIANAVK
. : . . : ::.
Mflv_2144|M.gilvum_PYR-GCK --------------EGSDCVITVEDDGVGMDP-DALRSGPSDALSAGDAE
Mvan_4559|M.vanbaalenii_PYR-1 --------------EGSDCVITVEDDGVGMDP-DALRSGPGDALSDGAPA
MSMEG_5158|M.smegmatis_MC2_155 --------------EGTDCVITVEDDGAGMDP-ETLRAGQGDALAD----
Mb0781|M.bovis_AF2122/97 HTPESADVTVRVGTEGDDAILEVADDGPGMSQEDALRVFERFYRADSSRA
Rv0758|M.tuberculosis_H37Rv HTPESADVTVRVGTEGDDAILEVADDGPGMSQEDALRVFERFYRADSSRA
MAB_0674|M.abscessus_ATCC_1997 HT--TAAVRVRVGTEGDDAVLEVIDRGPGMTKTDAERVFERFYRADSSRT
MAV_0147|M.avium_104 HG-NAGKIQLTVSSSGEGVEIAIDDDGSGIPESERATVFERFARGS---T
.* . : : * * *: : .
Mflv_2144|M.gilvum_PYR-GCK PEGTGAHVGLTNVDHRLRAAFGNDYGLVVETAIGAGTKVIMRVPKFR---
Mvan_4559|M.vanbaalenii_PYR-1 SEGAGAHVGLTNVDHRLRAAFGNDYGLVVETAIGAGTKVIMRVPKFR---
MSMEG_5158|M.smegmatis_MC2_155 RTDQGAHVGLTNVDHRLRAAFGNDYGLVVETALGAGTKVMMRVPKFR---
Mb0781|M.bovis_AF2122/97 RASGGTGLGLSIVDS-LVAAHGG--AVTVTTALGEGCCFRVSLPRVS---
Rv0758|M.tuberculosis_H37Rv RASGGTGLGLSIVDS-LVAAHGG--AVTVTTALGEGCCFRVSLPRVS---
MAB_0674|M.abscessus_ATCC_1997 RSSGGTGLGLSIVDA-LTAAHGG--TVTVHTAPGAGCRFEVRLPRADMTD
MAV_0147|M.avium_104 ASRSGSGLGLALVAQ-QAELHGG--TAELQNSPLGGTRLLLRLAGDG---
*: :**: * .*. : .: * . : :.
Mflv_2144|M.gilvum_PYR-GCK --SGVRASGGGFGVGTK----------------
Mvan_4559|M.vanbaalenii_PYR-1 --SGVRASGGGFVVGRNE---------------
MSMEG_5158|M.smegmatis_MC2_155 --SGVHAGGGAFG--------------------
Mb0781|M.bovis_AF2122/97 ---DVDQ-LSLTPVVPGPP--------------
Rv0758|M.tuberculosis_H37Rv ---DVDQ-LSLTPVVPGPP--------------
MAB_0674|M.abscessus_ATCC_1997 DDADVDEPESATPDAAASEPKIVRASRSESAQP
MAV_0147|M.avium_104 ---------------RGPA--------------