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M. smegmatis MC2 155 MSMEG_4980 (-)

annotation: major facilitator superfamily protein MFS_1
coordinates: 5075384 - 5076751
length: 455

PTRQQPSFPRGTALLVAGALFMEILDATILAPAIPLIAESFGVAAVDVNVAISAYLVTVAVLIPATGWMA
DRFGVRRVFISAIAVFTLASVGCALSVSLPMLVAMRVAQGVGGAMMVPVGRLAVLRSSDKADLVRAIALL
TWPALAAPVVAPVLGGAIATLGDWRWIFAVNVPIGLIGILFALRLIHGDAPARPRSLDWFGLLTLGSGIA
ATLLALENIRVSGTHWSLVGSFGVAAVLLLAVALRRLLTVPNPLVQLRVLRVQTLRITVSAGSLYRMVIT
AVPFLLPLQFQLQFGWTPLAAGAMVAALFAGNLTIKPITTPLMRRFGIRTVLLVNGAASVACFGLLAVLR
PGLPVVLMAVILYISGALRSIGFTAYNSLAFSDVEGDDLTHGNTLNASVQELASGLGIAFAALLLSQLTS
YSLTFLVLGAVLALTLVETVRLPKSAGSHVSGHR*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_4980--100% (455)major facilitator superfamily protein MFS_1
M. smegmatis MC2 155MSMEG_5670-7e-3226.99% (415) efflux membrane protein
M. smegmatis MC2 155MSMEG_0827-2e-3030.07% (459) major facilitator superfamily protein MFS_1

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0805cemrB3e-4327.82% (417) multidrug resistance integral membrane efflux protein EmrB
M. gilvum PYR-GCKMflv_2018-0.073.41% (455) major facilitator transporter
M. tuberculosis H37RvRv0783cemrB3e-4327.82% (417) multidrug resistance integral membrane efflux protein EmrB
M. leprae Br4923MLBr_01562-3e-2526.82% (425) putative transmembrane efflux protein
M. abscessus ATCC 19977MAB_1396-2e-3231.30% (345) EmrB/QacA family drug resistance transporter
M. marinum MMMAR_2966-3e-4830.32% (432) integral membrane drug efflux protein
M. avium 104MAV_0730-5e-4929.73% (444) EmrB efflux protein
M. thermoresistible (build 8)TH_2729-9e-3129.83% (362) PUTATIVE putative drug resistance transporter, EmrB/QacA
M. ulcerans Agy99MUL_0542-3e-4127.93% (401) multidrug resistance integral membrane efflux protein
M. vanbaalenii PYR-1Mvan_1284-7e-4233.56% (432) major facilitator superfamily transporter

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_4980|M.smegmatis_MC2_155      ----------------------------------MPTRQQPSFPRG----
Mflv_2018|M.gilvum_PYR-GCK          ----------------------------------MPAASEPTFPRG----
Mb0805c|M.bovis_AF2122/97           ----------------------MLGNAMVEACPAEGDAPVPITPAGRPRS
Rv0783c|M.tuberculosis_H37Rv        ----------------------MLGNAMVEACPAEGDAPVPITPAGRPRS
MAV_0730|M.avium_104                MRSPSAITELAAAGAGESGLFDMLSNAMDEAPYAAAKTP-PHAPTGQPGA
MMAR_2966|M.marinum_M               -------------------------------MRRAGTPRRPRSPDTHPDN
MUL_0542|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1284|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_1396|M.abscessus_ATCC_1997      --------------------------------------MRPEYPRP----
TH_2729|M.thermoresistible__bu      --------------------------------------------------
MLBr_01562|M.leprae_Br4923          -----------MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTS
                                                                                      

MSMEG_4980|M.smegmatis_MC2_155      ----------------TALLVAGA--LFMEILDATILAPAIPLIAESFGV
Mflv_2018|M.gilvum_PYR-GCK          ----------------MALLVAGA--MFMEILDATILAPAIPAIAATFGV
Mb0805c|M.bovis_AF2122/97           -GQRSYPDRLDVGLLRTAGVCVLA--SVMAHVDVTVVSVAQRTFVADFGS
Rv0783c|M.tuberculosis_H37Rv        -GQRSYPDRLDVGLLRTAGVCVLA--SVMAHVDVTVVSVAQRTFVADFGS
MAV_0730|M.avium_104                -TEREYPDKLDAALLRISGVCILA--TVMAILDVTVVSVAQRTFIDQFSS
MMAR_2966|M.marinum_M               RHQHSYPDRLDAGLWRIAGVCVLG--SIMTMVDTSVVTVAQRTFVDTFGS
MUL_0542|M.ulcerans_Agy99           ---------------MTTATCLML--PVMVTLDTTVVNVAQRTFIEEFSS
Mvan_1284|M.vanbaalenii_PYR-1       -------------MKWILAAVATA--LFCVQIDYFAMNLALPRIAQEFGE
MAB_1396|M.abscessus_ATCC_1997      --------------WITLWVVLFG--LFMILLDSTIVSVANPAIKAGFGA
TH_2729|M.thermoresistible__bu      ----------------VLVALILT--MALVAMDTTILATAVPQVVGDLG-
MLBr_01562|M.leprae_Br4923          KYPTLLPSGRFPSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSL
                                                                   :*      *   .   :. 

MSMEG_4980|M.smegmatis_MC2_155      AAVDVNVAISAYLVTVAVLIPATGWMADRFGVRRVFISAIAVFTLASVGC
Mflv_2018|M.gilvum_PYR-GCK          AAVDVNIAISSYLLTAAVLIPASGWIADRFGIRPVFLTAIAVFTIASIGC
Mb0805c|M.bovis_AF2122/97           TQAVVAWTMTGYMLALATVIPTAGWAADRFGTRRLFMGSVLAFTLGSLLC
Rv0783c|M.tuberculosis_H37Rv        TQAVVAWTMTGYMLALATVIPTAGWAADRFGTRRLFMGSVLAFTLGSLLC
MAV_0730|M.avium_104                SQAVVAWTMTGYTLALATVIPITGWAADRFGTKRLFIGSVVAFMLGSLLC
MMAR_2966|M.marinum_M               TQAVVAWTITGYTLALAAVVPLAGWAADRFGTKRMFMGSILVFTLSSLLC
MUL_0542|M.ulcerans_Agy99           TQAVVAWTSTGYTLSLASVIPLTGWTANRLGTKRLVMGSVLLFTLGSLLC
Mvan_1284|M.vanbaalenii_PYR-1       SPSDLQWVISVYMLALGAFMVPAGRMGDIFGRRRALLTGVALFGGASVAC
MAB_1396|M.abscessus_ATCC_1997      DYSSTVWVTSAYLLGYAVPLLITGRLGDQFGPRSMYLSGLAVFTAASLWC
TH_2729|M.thermoresistible__bu      GFDQVGWVFSGYLLAQTVTIPIYGKLADLYGRRPILIFGVVAFLIGSALS
MLBr_01562|M.leprae_Br4923          SDAGRSWGITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLC
                                             : * :     :   *  .:  * :   : .:  *  .*  .

MSMEG_4980|M.smegmatis_MC2_155      ALSVSLPMLVAMRVAQGVGGAMMVPVGRLAVLRSSDK-ADLVRAIALLTW
Mflv_2018|M.gilvum_PYR-GCK          ALSATLPMLVAMRVLQGVGGAMMVPVGRLAVLRFSAK-ADLVRAIALLTW
Mb0805c|M.bovis_AF2122/97           AVAPNILLLIIFRVVQGFGGGMLTPVSFAILAREAGP-KRLGRVMAVVGI
Rv0783c|M.tuberculosis_H37Rv        AVAPNILLLIIFRVVQGFGGGMLTPVSFAILAREAGP-KRLGRVMAVVGI
MAV_0730|M.avium_104                ALAANILQLIVFRVVQGIGGGMLLPLGFMILTREAGP-RRLGRLMSILSI
MMAR_2966|M.marinum_M               AIAPNIALLIASRVVQGLGGGMLAPLALTIVNREAGP-KRVGRVMAVLGI
MUL_0542|M.ulcerans_Agy99           AMASSITLLVAFRAAQGLGGGILIPLQLIILARAAGP-ARLGRVLTISMI
Mvan_1284|M.vanbaalenii_PYR-1       ALAPSVSLLVAFRAVQGLGAALIFPVSVSVLTNAYDA-AKAGRAIGLAYG
MAB_1396|M.abscessus_ATCC_1997      GLAGSIGWLIAARVVQGIGAAMLTPQTLTVVQRVFPP-ERRGTAMGVWGA
TH_2729|M.thermoresistible__bu      AASWNMATLAIFRAIQGLGAGAISATVQTVAGDLYTV-AERGRIQGYLAS
MLBr_01562|M.leprae_Br4923          AVAWDEVTLVIARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAA
                                    . :     *   *  **.*..   .                         

MSMEG_4980|M.smegmatis_MC2_155      PALAAPVVAPVLGGAIATLGDWRWIFAVNVPIGLIGILFALRLIHGDAPA
Mflv_2018|M.gilvum_PYR-GCK          PALTAPVLAPVLGGALATLGSWRWIFIVNIPIGIVGFVLALKLIRGGPAP
Mb0805c|M.bovis_AF2122/97           PMLLGPVGGPILGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVFPRDRPA
Rv0783c|M.tuberculosis_H37Rv        PMLLGPVGGPILGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVFPRDRPA
MAV_0730|M.avium_104                PMLLAPIAGPILGGWLIDTSSWRWIFLINVPIGLLTVALAAVVFPRDHPA
MMAR_2966|M.marinum_M               PGVLAPAFGPALGGWLIDSYSWQWIFWVNLPVGVVAVGLAAVVFPRDTPA
MUL_0542|M.ulcerans_Agy99           SVLMAPIAGPILGGWLIDAFGWQWIFLINLPIGALTLILAGLVLPGDDSL
Mvan_1284|M.vanbaalenii_PYR-1       IAGLGNAAGPLVGGLLTGTVGWRWIFWLNVPLALASFVLGARHITESFDE
MAB_1396|M.abscessus_ATCC_1997      VAGIATLVGPVAGGLLVDGWGWQWIFYVNVPVGVLGIILGAIYIPRMPTH
TH_2729|M.thermoresistible__bu      VWGISAVIAPALGGFFAQYLTWRWIFLVNIPIGVFALYLIARDLHEDVVR
MLBr_01562|M.leprae_Br4923          MTAIGSVMGLVVGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKE
                                        .   .   ** :     *:  * :*:*:.   . :    :      

MSMEG_4980|M.smegmatis_MC2_155      RP-RSLDWFGLLTLGSGIAATLLALENIRVSG--THWSLVGSFGVAAVLL
Mflv_2018|M.gilvum_PYR-GCK          TP-RPFDWRGLLLLGAGIGAALVALEHIRVTG--TAWVLVGAGLVGAVAL
Mb0805c|M.bovis_AF2122/97           AS-ENFDYMGLLLLSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALI
Rv0783c|M.tuberculosis_H37Rv        AS-ENFDYMGLLLLSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALI
MAV_0730|M.avium_104                RS-ETFDAVGVLLLSPGLATFLFAVSSIPGRGTVADRHVLIPAAMGLTLI
MMAR_2966|M.marinum_M               PS-ETFDVVGMLLLSPGLPAFLYGMSEIPIYGTVADRHVWVPAGIGIALI
MUL_0542|M.ulcerans_Agy99           PA-ESLDLVGMALLSPALVLLLYGLSALPARGTIGDPQVWLPTTVGLILI
Mvan_1284|M.vanbaalenii_PYR-1       TAPRRIDITGLALVTAGIALFTLAFDRAPDWGWLSVPTLG--VFTGAVLA
MAB_1396|M.abscessus_ATCC_1997      RH--RLDLLGMALSAVGMFAFVFALQE--GESFQWAPGVWAMMAAGLVVL
TH_2729|M.thermoresistible__bu      RP-HRIDYLGAGLVLVSAGLFILGLLSG-GVHWSWTSPTSVVVFTGAALA
MLBr_01562|M.leprae_Br4923          RM--KLDAAGAILATLACTAAVFAFSMGPEKGWISLTTIG--SGLVALVA
                                         :*  *      .      ..                         

MSMEG_4980|M.smegmatis_MC2_155      LAVALRRLLTVPNPLVQLRVLRVQTLRITVSAGSLYRMVITAVPFLLPLQ
Mflv_2018|M.gilvum_PYR-GCK          LAAAVWHLRRTPTPLVRLAVLRVRTLRITVVGGSVYRLVITAVPFLLPLL
Mb0805c|M.bovis_AF2122/97           AAFVAHSWYRTEHPLIDMRLFQNRAVAQANMTMTVLSLGLFGSFLLLPSY
Rv0783c|M.tuberculosis_H37Rv        AAFVAHSWYRTEHPLIDMRLFQNRAVAQANMTMTVLSLGLFGSFLLLPSY
MAV_0730|M.avium_104                AGFVGHAWHRADHPLIDLRLFRNPVLTHANVTMLVFATAFFGAGLLLPSY
MMAR_2966|M.marinum_M               VGFMFHALYRADKPLIDLRLLTNRALTLANVAMFLYIVSTFGAGVLFPSY
MUL_0542|M.ulcerans_Agy99           GGFALHALHRGDHALIDLRLLKNRAVAAANATRFMFAVTFFGSCLLFPAY
Mvan_1284|M.vanbaalenii_PYR-1       LAVFVAVENRVRRPLIDLSLFRAGRFTILVVAGTVANVAYAVVIFLSTLE
MAB_1396|M.abscessus_ATCC_1997      GVFVWWQSANRGEPLIPLRLFADRNFSLAGVGIASMSFCVISTGLPMMFY
TH_2729|M.thermoresistible__bu      GVALLVVESRAAEPVLPLSMLTRRLTAPSFAATATAGMIVIGLSVYLPNW
MLBr_01562|M.leprae_Br4923          AIAFAVVERTAENPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLY
                                                 .:: : ::                       .     

MSMEG_4980|M.smegmatis_MC2_155      FQLQFGWTPLAAGAMVAALFAGNLTIKPITTPLMRRFGIRTVLLVNGAAS
Mflv_2018|M.gilvum_PYR-GCK          FQLEFGWSAFTAGLMVAALFIGNLTIKPLTTPLMRRFGIKRVLLVNGVVS
Mb0805c|M.bovis_AF2122/97           LQQVLHQSPMQSGVHIIPQGLGAMLAMPIAGAMMDRRGPAKIVLVGIMLI
Rv0783c|M.tuberculosis_H37Rv        LQQVLHQSPMQSGVHIIPQGLGAMLAMPIAGAMMDRRGPAKIVLVGIMLI
MAV_0730|M.avium_104                FQQVLHQTPMQAGVHMIPQGLGAMLTMRLTGPLVDRQGPGKVVLVGIALI
MMAR_2966|M.marinum_M               FQQLLDHTPLQAGMSLLPRGIGAALAVPLAGALVDRRGARGVLVIGVTLI
MUL_0542|M.ulcerans_Agy99           FQQVLGKTPLQSGLLLIPQTLAAAAVMPIVGRLMEKRGPRDVVLMGTALT
Mvan_1284|M.vanbaalenii_PYR-1       LQQVRGLDPLAAGLVFLGPSTGAAIGGVMAGRLATGRSP-----VAVMGN
MAB_1396|M.abscessus_ATCC_1997      TQLALGFSPTKAALTQAPTAIVSGILAPLAGWLVDRVRPSILIGGGIALM
TH_2729|M.thermoresistible__bu      GQTVLGLSPVAAGFVLAIMSITWPISSGFSARLYLRIGFRDTALVGASCA
MLBr_01562|M.leprae_Br4923          IQDILGYSALRAGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLL
                                     *      .  :.               .   :                 

MSMEG_4980|M.smegmatis_MC2_155      VACFG--LLAVLRPGLPVVLMAVILYISGALRSIGFTAYNSLAFSDVEGD
Mflv_2018|M.gilvum_PYR-GCK          VAWFG--VLALLEPGTPVALIAAALYVSGALRSIGFTAYNSLAFADVDGD
Mb0805c|M.bovis_AF2122/97           AAGLGTFAFGVARQADYLPILPTGLAIMGMGMGCSMMPLSGAAVQTLAPH
Rv0783c|M.tuberculosis_H37Rv        AAGLGTFAFGVARQADYLPILPTGLAIMGMGMGCSMMPLSGAAVQTLAPH
MAV_0730|M.avium_104                TAGLGAFAFGVARQAPYLPTLLAGLAITGLGMGCTMMPLSVASVQALAPH
MMAR_2966|M.marinum_M               ATGMGVFAFGVATQRDYLPMLLIGLTILGMGMGCTRMPLVAVAMQSLAPN
MUL_0542|M.ulcerans_Agy99           VVGMGIFIYGMSREHVHLPALLIGLGTFGVGTAAMMVPVSWSAVHMLNSS
Mvan_1284|M.vanbaalenii_PYR-1       TSVVAALCLAALAAGGPWWFHVAALSACGFSLGLVYAFTTVATQAVVRPE
MAB_1396|M.abscessus_ATCC_1997      IASTLWWTLLMRPETQMWQLMLPAAGIG-AAMACIWGPLATTATRNLPPS
TH_2729|M.thermoresistible__bu      VAAGTG--LVLLGPAPPVWQPVVYTALMGAGMGLLFSPLIVGLQNTVGWD
MLBr_01562|M.leprae_Br4923          MVAMLYGWAFMNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFD
                                                                    .             :   

MSMEG_4980|M.smegmatis_MC2_155      DLTHGNTLNASVQELASGLGIAFAALLLS---------------------
Mflv_2018|M.gilvum_PYR-GCK          ELTHANTLNATVQEMGAGLGIAVAALLLT---------------------
Mb0805c|M.bovis_AF2122/97           QIARGSTLISVNQQVGGSIGTALMSVLLTYQFNHSEIIATAKKVALTPES
Rv0783c|M.tuberculosis_H37Rv        QIARGSTLISVNQQVGGSIGTALMSVLLTYQFNHSEIIATAKKVALTPES
MAV_0730|M.avium_104                QIARGTTLMSVSHQVGGSMGTALMSMILTNQFNRSPNIVAANKLAALHQK
MMAR_2966|M.marinum_M               QIARGSTLIKVNQQMAAAVGTALMSVILTSQLNNGENASGASKAEILREH
MUL_0542|M.ulcerans_Agy99           EVAHGSTLFNVNHNVAASVGAALD--------------VGRTHQPIQRQR
Mvan_1284|M.vanbaalenii_PYR-1       RAGEAAGVTLTALVTAGGVGIAMAATIFEVLQ------------------
MAB_1396|M.abscessus_ATCC_1997      VAGAGSGVYNTLRQVGGVVGSSAMGALMTARLTATMPAMPPGSGSTPEAA
TH_2729|M.thermoresistible__bu      QRGTVTGGLMFSRFLGQSIGAAGFGAVANAVLRRYEPDTSAAAMG-----
MLBr_01562|M.leprae_Br4923          RIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQL
                                                   .  :  :                            

MSMEG_4980|M.smegmatis_MC2_155      -----------------------------QLTSYSLTFLVLGAVLALTLV
Mflv_2018|M.gilvum_PYR-GCK          -----------------------------VLGSYPWTFLALGAILALTLI
Mb0805c|M.bovis_AF2122/97           GAGRGAAVDPSSLPRQ---TNFAAQLLHDLSHAYAVVFVIATALVVSTLI
Rv0783c|M.tuberculosis_H37Rv        GAGRGAAVDPSSLPRQ---TNFAAQLLHDLSHAYAVVFVIATALVVSTLI
MAV_0730|M.avium_104                AAAGGTPIDQSAIPRQSLAPGFGGNVLHDLSHAYTAVFVIAVALVVCTII
MMAR_2966|M.marinum_M               RP--GVPLDQP--------------VLHELSRAYSVVFVVAVVLAVLAFI
MUL_0542|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1284|M.vanbaalenii_PYR-1       ---------------------------------REGMSPAAAIAVILGAV
MAB_1396|M.abscessus_ATCC_1997      LPPG---------------------LRAPFSAAMAQSMLLGIAALALGLV
TH_2729|M.thermoresistible__bu      -------------------------------AASHAVFVGLLVAAVATVV
MLBr_01562|M.leprae_Br4923          R---------------------------ALDHGYTYGLLWVAGAVVIVGV
                                                                                      

MSMEG_4980|M.smegmatis_MC2_155      ETVRLPKSAGSHVSGHR---------------------------------
Mflv_2018|M.gilvum_PYR-GCK          ETLRLPGSAASHVTGHR---------------------------------
Mb0805c|M.bovis_AF2122/97           PAAFLPKQQASHRRAPLLSA------------------------------
Rv0783c|M.tuberculosis_H37Rv        PAAFLPKQQASHRRAPLLSA------------------------------
MAV_0730|M.avium_104                PASFLPKKPAAETAGK----------------------------------
MMAR_2966|M.marinum_M               PLAFLPKWSALTALSQTSSLERTPEPDAAPHGRQSPPEDTRPGAGRNSSS
MUL_0542|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1284|M.vanbaalenii_PYR-1       SALLLPAGAAVLLIKAPA--------------------------------
MAB_1396|M.abscessus_ATCC_1997      AALFMRPGGSQVGAVPLDDVVSVED-------------------------
TH_2729|M.thermoresistible__bu      LLLTVPRRFPTHHVAVVD--------------------------------
MLBr_01562|M.leprae_Br4923          AALFIGYTPEQVAYAQEVKEAVDAGEL-----------------------
                                                                                      

MSMEG_4980|M.smegmatis_MC2_155      ----------
Mflv_2018|M.gilvum_PYR-GCK          ----------
Mb0805c|M.bovis_AF2122/97           ----------
Rv0783c|M.tuberculosis_H37Rv        ----------
MAV_0730|M.avium_104                ----------
MMAR_2966|M.marinum_M               NDLTPSGPDG
MUL_0542|M.ulcerans_Agy99           ----------
Mvan_1284|M.vanbaalenii_PYR-1       ----------
MAB_1396|M.abscessus_ATCC_1997      ----------
TH_2729|M.thermoresistible__bu      ----------
MLBr_01562|M.leprae_Br4923          ----------