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PTRQQPSFPRGTALLVAGALFMEILDATILAPAIPLIAESFGVAAVDVNVAISAYLVTVAVLIPATGWMA DRFGVRRVFISAIAVFTLASVGCALSVSLPMLVAMRVAQGVGGAMMVPVGRLAVLRSSDKADLVRAIALL TWPALAAPVVAPVLGGAIATLGDWRWIFAVNVPIGLIGILFALRLIHGDAPARPRSLDWFGLLTLGSGIA ATLLALENIRVSGTHWSLVGSFGVAAVLLLAVALRRLLTVPNPLVQLRVLRVQTLRITVSAGSLYRMVIT AVPFLLPLQFQLQFGWTPLAAGAMVAALFAGNLTIKPITTPLMRRFGIRTVLLVNGAASVACFGLLAVLR PGLPVVLMAVILYISGALRSIGFTAYNSLAFSDVEGDDLTHGNTLNASVQELASGLGIAFAALLLSQLTS YSLTFLVLGAVLALTLVETVRLPKSAGSHVSGHR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_4980 | - | - | 100% (455) | major facilitator superfamily protein MFS_1 |
M. smegmatis MC2 155 | MSMEG_5670 | - | 7e-32 | 26.99% (415) | efflux membrane protein |
M. smegmatis MC2 155 | MSMEG_0827 | - | 2e-30 | 30.07% (459) | major facilitator superfamily protein MFS_1 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0805c | emrB | 3e-43 | 27.82% (417) | multidrug resistance integral membrane efflux protein EmrB |
M. gilvum PYR-GCK | Mflv_2018 | - | 0.0 | 73.41% (455) | major facilitator transporter |
M. tuberculosis H37Rv | Rv0783c | emrB | 3e-43 | 27.82% (417) | multidrug resistance integral membrane efflux protein EmrB |
M. leprae Br4923 | MLBr_01562 | - | 3e-25 | 26.82% (425) | putative transmembrane efflux protein |
M. abscessus ATCC 19977 | MAB_1396 | - | 2e-32 | 31.30% (345) | EmrB/QacA family drug resistance transporter |
M. marinum M | MMAR_2966 | - | 3e-48 | 30.32% (432) | integral membrane drug efflux protein |
M. avium 104 | MAV_0730 | - | 5e-49 | 29.73% (444) | EmrB efflux protein |
M. thermoresistible (build 8) | TH_2729 | - | 9e-31 | 29.83% (362) | PUTATIVE putative drug resistance transporter, EmrB/QacA |
M. ulcerans Agy99 | MUL_0542 | - | 3e-41 | 27.93% (401) | multidrug resistance integral membrane efflux protein |
M. vanbaalenii PYR-1 | Mvan_1284 | - | 7e-42 | 33.56% (432) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_4980|M.smegmatis_MC2_155 ----------------------------------MPTRQQPSFPRG---- Mflv_2018|M.gilvum_PYR-GCK ----------------------------------MPAASEPTFPRG---- Mb0805c|M.bovis_AF2122/97 ----------------------MLGNAMVEACPAEGDAPVPITPAGRPRS Rv0783c|M.tuberculosis_H37Rv ----------------------MLGNAMVEACPAEGDAPVPITPAGRPRS MAV_0730|M.avium_104 MRSPSAITELAAAGAGESGLFDMLSNAMDEAPYAAAKTP-PHAPTGQPGA MMAR_2966|M.marinum_M -------------------------------MRRAGTPRRPRSPDTHPDN MUL_0542|M.ulcerans_Agy99 -------------------------------------------------- Mvan_1284|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1396|M.abscessus_ATCC_1997 --------------------------------------MRPEYPRP---- TH_2729|M.thermoresistible__bu -------------------------------------------------- MLBr_01562|M.leprae_Br4923 -----------MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTS MSMEG_4980|M.smegmatis_MC2_155 ----------------TALLVAGA--LFMEILDATILAPAIPLIAESFGV Mflv_2018|M.gilvum_PYR-GCK ----------------MALLVAGA--MFMEILDATILAPAIPAIAATFGV Mb0805c|M.bovis_AF2122/97 -GQRSYPDRLDVGLLRTAGVCVLA--SVMAHVDVTVVSVAQRTFVADFGS Rv0783c|M.tuberculosis_H37Rv -GQRSYPDRLDVGLLRTAGVCVLA--SVMAHVDVTVVSVAQRTFVADFGS MAV_0730|M.avium_104 -TEREYPDKLDAALLRISGVCILA--TVMAILDVTVVSVAQRTFIDQFSS MMAR_2966|M.marinum_M RHQHSYPDRLDAGLWRIAGVCVLG--SIMTMVDTSVVTVAQRTFVDTFGS MUL_0542|M.ulcerans_Agy99 ---------------MTTATCLML--PVMVTLDTTVVNVAQRTFIEEFSS Mvan_1284|M.vanbaalenii_PYR-1 -------------MKWILAAVATA--LFCVQIDYFAMNLALPRIAQEFGE MAB_1396|M.abscessus_ATCC_1997 --------------WITLWVVLFG--LFMILLDSTIVSVANPAIKAGFGA TH_2729|M.thermoresistible__bu ----------------VLVALILT--MALVAMDTTILATAVPQVVGDLG- MLBr_01562|M.leprae_Br4923 KYPTLLPSGRFPSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSL :* * . :. MSMEG_4980|M.smegmatis_MC2_155 AAVDVNVAISAYLVTVAVLIPATGWMADRFGVRRVFISAIAVFTLASVGC Mflv_2018|M.gilvum_PYR-GCK AAVDVNIAISSYLLTAAVLIPASGWIADRFGIRPVFLTAIAVFTIASIGC Mb0805c|M.bovis_AF2122/97 TQAVVAWTMTGYMLALATVIPTAGWAADRFGTRRLFMGSVLAFTLGSLLC Rv0783c|M.tuberculosis_H37Rv TQAVVAWTMTGYMLALATVIPTAGWAADRFGTRRLFMGSVLAFTLGSLLC MAV_0730|M.avium_104 SQAVVAWTMTGYTLALATVIPITGWAADRFGTKRLFIGSVVAFMLGSLLC MMAR_2966|M.marinum_M TQAVVAWTITGYTLALAAVVPLAGWAADRFGTKRMFMGSILVFTLSSLLC MUL_0542|M.ulcerans_Agy99 TQAVVAWTSTGYTLSLASVIPLTGWTANRLGTKRLVMGSVLLFTLGSLLC Mvan_1284|M.vanbaalenii_PYR-1 SPSDLQWVISVYMLALGAFMVPAGRMGDIFGRRRALLTGVALFGGASVAC MAB_1396|M.abscessus_ATCC_1997 DYSSTVWVTSAYLLGYAVPLLITGRLGDQFGPRSMYLSGLAVFTAASLWC TH_2729|M.thermoresistible__bu GFDQVGWVFSGYLLAQTVTIPIYGKLADLYGRRPILIFGVVAFLIGSALS MLBr_01562|M.leprae_Br4923 SDAGRSWGITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLC : * : : * .: * : : .: * .* . MSMEG_4980|M.smegmatis_MC2_155 ALSVSLPMLVAMRVAQGVGGAMMVPVGRLAVLRSSDK-ADLVRAIALLTW Mflv_2018|M.gilvum_PYR-GCK ALSATLPMLVAMRVLQGVGGAMMVPVGRLAVLRFSAK-ADLVRAIALLTW Mb0805c|M.bovis_AF2122/97 AVAPNILLLIIFRVVQGFGGGMLTPVSFAILAREAGP-KRLGRVMAVVGI Rv0783c|M.tuberculosis_H37Rv AVAPNILLLIIFRVVQGFGGGMLTPVSFAILAREAGP-KRLGRVMAVVGI MAV_0730|M.avium_104 ALAANILQLIVFRVVQGIGGGMLLPLGFMILTREAGP-RRLGRLMSILSI MMAR_2966|M.marinum_M AIAPNIALLIASRVVQGLGGGMLAPLALTIVNREAGP-KRVGRVMAVLGI MUL_0542|M.ulcerans_Agy99 AMASSITLLVAFRAAQGLGGGILIPLQLIILARAAGP-ARLGRVLTISMI Mvan_1284|M.vanbaalenii_PYR-1 ALAPSVSLLVAFRAVQGLGAALIFPVSVSVLTNAYDA-AKAGRAIGLAYG MAB_1396|M.abscessus_ATCC_1997 GLAGSIGWLIAARVVQGIGAAMLTPQTLTVVQRVFPP-ERRGTAMGVWGA TH_2729|M.thermoresistible__bu AASWNMATLAIFRAIQGLGAGAISATVQTVAGDLYTV-AERGRIQGYLAS MLBr_01562|M.leprae_Br4923 AVAWDEVTLVIARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAA . : * * **.*.. . MSMEG_4980|M.smegmatis_MC2_155 PALAAPVVAPVLGGAIATLGDWRWIFAVNVPIGLIGILFALRLIHGDAPA Mflv_2018|M.gilvum_PYR-GCK PALTAPVLAPVLGGALATLGSWRWIFIVNIPIGIVGFVLALKLIRGGPAP Mb0805c|M.bovis_AF2122/97 PMLLGPVGGPILGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVFPRDRPA Rv0783c|M.tuberculosis_H37Rv PMLLGPVGGPILGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVFPRDRPA MAV_0730|M.avium_104 PMLLAPIAGPILGGWLIDTSSWRWIFLINVPIGLLTVALAAVVFPRDHPA MMAR_2966|M.marinum_M PGVLAPAFGPALGGWLIDSYSWQWIFWVNLPVGVVAVGLAAVVFPRDTPA MUL_0542|M.ulcerans_Agy99 SVLMAPIAGPILGGWLIDAFGWQWIFLINLPIGALTLILAGLVLPGDDSL Mvan_1284|M.vanbaalenii_PYR-1 IAGLGNAAGPLVGGLLTGTVGWRWIFWLNVPLALASFVLGARHITESFDE MAB_1396|M.abscessus_ATCC_1997 VAGIATLVGPVAGGLLVDGWGWQWIFYVNVPVGVLGIILGAIYIPRMPTH TH_2729|M.thermoresistible__bu VWGISAVIAPALGGFFAQYLTWRWIFLVNIPIGVFALYLIARDLHEDVVR MLBr_01562|M.leprae_Br4923 MTAIGSVMGLVVGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKE . . ** : *: * :*:*:. . : : MSMEG_4980|M.smegmatis_MC2_155 RP-RSLDWFGLLTLGSGIAATLLALENIRVSG--THWSLVGSFGVAAVLL Mflv_2018|M.gilvum_PYR-GCK TP-RPFDWRGLLLLGAGIGAALVALEHIRVTG--TAWVLVGAGLVGAVAL Mb0805c|M.bovis_AF2122/97 AS-ENFDYMGLLLLSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALI Rv0783c|M.tuberculosis_H37Rv AS-ENFDYMGLLLLSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALI MAV_0730|M.avium_104 RS-ETFDAVGVLLLSPGLATFLFAVSSIPGRGTVADRHVLIPAAMGLTLI MMAR_2966|M.marinum_M PS-ETFDVVGMLLLSPGLPAFLYGMSEIPIYGTVADRHVWVPAGIGIALI MUL_0542|M.ulcerans_Agy99 PA-ESLDLVGMALLSPALVLLLYGLSALPARGTIGDPQVWLPTTVGLILI Mvan_1284|M.vanbaalenii_PYR-1 TAPRRIDITGLALVTAGIALFTLAFDRAPDWGWLSVPTLG--VFTGAVLA MAB_1396|M.abscessus_ATCC_1997 RH--RLDLLGMALSAVGMFAFVFALQE--GESFQWAPGVWAMMAAGLVVL TH_2729|M.thermoresistible__bu RP-HRIDYLGAGLVLVSAGLFILGLLSG-GVHWSWTSPTSVVVFTGAALA MLBr_01562|M.leprae_Br4923 RM--KLDAAGAILATLACTAAVFAFSMGPEKGWISLTTIG--SGLVALVA :* * . .. MSMEG_4980|M.smegmatis_MC2_155 LAVALRRLLTVPNPLVQLRVLRVQTLRITVSAGSLYRMVITAVPFLLPLQ Mflv_2018|M.gilvum_PYR-GCK LAAAVWHLRRTPTPLVRLAVLRVRTLRITVVGGSVYRLVITAVPFLLPLL Mb0805c|M.bovis_AF2122/97 AAFVAHSWYRTEHPLIDMRLFQNRAVAQANMTMTVLSLGLFGSFLLLPSY Rv0783c|M.tuberculosis_H37Rv AAFVAHSWYRTEHPLIDMRLFQNRAVAQANMTMTVLSLGLFGSFLLLPSY MAV_0730|M.avium_104 AGFVGHAWHRADHPLIDLRLFRNPVLTHANVTMLVFATAFFGAGLLLPSY MMAR_2966|M.marinum_M VGFMFHALYRADKPLIDLRLLTNRALTLANVAMFLYIVSTFGAGVLFPSY MUL_0542|M.ulcerans_Agy99 GGFALHALHRGDHALIDLRLLKNRAVAAANATRFMFAVTFFGSCLLFPAY Mvan_1284|M.vanbaalenii_PYR-1 LAVFVAVENRVRRPLIDLSLFRAGRFTILVVAGTVANVAYAVVIFLSTLE MAB_1396|M.abscessus_ATCC_1997 GVFVWWQSANRGEPLIPLRLFADRNFSLAGVGIASMSFCVISTGLPMMFY TH_2729|M.thermoresistible__bu GVALLVVESRAAEPVLPLSMLTRRLTAPSFAATATAGMIVIGLSVYLPNW MLBr_01562|M.leprae_Br4923 AIAFAVVERTAENPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLY .:: : :: . MSMEG_4980|M.smegmatis_MC2_155 FQLQFGWTPLAAGAMVAALFAGNLTIKPITTPLMRRFGIRTVLLVNGAAS Mflv_2018|M.gilvum_PYR-GCK FQLEFGWSAFTAGLMVAALFIGNLTIKPLTTPLMRRFGIKRVLLVNGVVS Mb0805c|M.bovis_AF2122/97 LQQVLHQSPMQSGVHIIPQGLGAMLAMPIAGAMMDRRGPAKIVLVGIMLI Rv0783c|M.tuberculosis_H37Rv LQQVLHQSPMQSGVHIIPQGLGAMLAMPIAGAMMDRRGPAKIVLVGIMLI MAV_0730|M.avium_104 FQQVLHQTPMQAGVHMIPQGLGAMLTMRLTGPLVDRQGPGKVVLVGIALI MMAR_2966|M.marinum_M FQQLLDHTPLQAGMSLLPRGIGAALAVPLAGALVDRRGARGVLVIGVTLI MUL_0542|M.ulcerans_Agy99 FQQVLGKTPLQSGLLLIPQTLAAAAVMPIVGRLMEKRGPRDVVLMGTALT Mvan_1284|M.vanbaalenii_PYR-1 LQQVRGLDPLAAGLVFLGPSTGAAIGGVMAGRLATGRSP-----VAVMGN MAB_1396|M.abscessus_ATCC_1997 TQLALGFSPTKAALTQAPTAIVSGILAPLAGWLVDRVRPSILIGGGIALM TH_2729|M.thermoresistible__bu GQTVLGLSPVAAGFVLAIMSITWPISSGFSARLYLRIGFRDTALVGASCA MLBr_01562|M.leprae_Br4923 IQDILGYSALRAGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLL * . :. . : MSMEG_4980|M.smegmatis_MC2_155 VACFG--LLAVLRPGLPVVLMAVILYISGALRSIGFTAYNSLAFSDVEGD Mflv_2018|M.gilvum_PYR-GCK VAWFG--VLALLEPGTPVALIAAALYVSGALRSIGFTAYNSLAFADVDGD Mb0805c|M.bovis_AF2122/97 AAGLGTFAFGVARQADYLPILPTGLAIMGMGMGCSMMPLSGAAVQTLAPH Rv0783c|M.tuberculosis_H37Rv AAGLGTFAFGVARQADYLPILPTGLAIMGMGMGCSMMPLSGAAVQTLAPH MAV_0730|M.avium_104 TAGLGAFAFGVARQAPYLPTLLAGLAITGLGMGCTMMPLSVASVQALAPH MMAR_2966|M.marinum_M ATGMGVFAFGVATQRDYLPMLLIGLTILGMGMGCTRMPLVAVAMQSLAPN MUL_0542|M.ulcerans_Agy99 VVGMGIFIYGMSREHVHLPALLIGLGTFGVGTAAMMVPVSWSAVHMLNSS Mvan_1284|M.vanbaalenii_PYR-1 TSVVAALCLAALAAGGPWWFHVAALSACGFSLGLVYAFTTVATQAVVRPE MAB_1396|M.abscessus_ATCC_1997 IASTLWWTLLMRPETQMWQLMLPAAGIG-AAMACIWGPLATTATRNLPPS TH_2729|M.thermoresistible__bu VAAGTG--LVLLGPAPPVWQPVVYTALMGAGMGLLFSPLIVGLQNTVGWD MLBr_01562|M.leprae_Br4923 MVAMLYGWAFMNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFD . : MSMEG_4980|M.smegmatis_MC2_155 DLTHGNTLNASVQELASGLGIAFAALLLS--------------------- Mflv_2018|M.gilvum_PYR-GCK ELTHANTLNATVQEMGAGLGIAVAALLLT--------------------- Mb0805c|M.bovis_AF2122/97 QIARGSTLISVNQQVGGSIGTALMSVLLTYQFNHSEIIATAKKVALTPES Rv0783c|M.tuberculosis_H37Rv QIARGSTLISVNQQVGGSIGTALMSVLLTYQFNHSEIIATAKKVALTPES MAV_0730|M.avium_104 QIARGTTLMSVSHQVGGSMGTALMSMILTNQFNRSPNIVAANKLAALHQK MMAR_2966|M.marinum_M QIARGSTLIKVNQQMAAAVGTALMSVILTSQLNNGENASGASKAEILREH MUL_0542|M.ulcerans_Agy99 EVAHGSTLFNVNHNVAASVGAALD--------------VGRTHQPIQRQR Mvan_1284|M.vanbaalenii_PYR-1 RAGEAAGVTLTALVTAGGVGIAMAATIFEVLQ------------------ MAB_1396|M.abscessus_ATCC_1997 VAGAGSGVYNTLRQVGGVVGSSAMGALMTARLTATMPAMPPGSGSTPEAA TH_2729|M.thermoresistible__bu QRGTVTGGLMFSRFLGQSIGAAGFGAVANAVLRRYEPDTSAAAMG----- MLBr_01562|M.leprae_Br4923 RIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQL . : : MSMEG_4980|M.smegmatis_MC2_155 -----------------------------QLTSYSLTFLVLGAVLALTLV Mflv_2018|M.gilvum_PYR-GCK -----------------------------VLGSYPWTFLALGAILALTLI Mb0805c|M.bovis_AF2122/97 GAGRGAAVDPSSLPRQ---TNFAAQLLHDLSHAYAVVFVIATALVVSTLI Rv0783c|M.tuberculosis_H37Rv GAGRGAAVDPSSLPRQ---TNFAAQLLHDLSHAYAVVFVIATALVVSTLI MAV_0730|M.avium_104 AAAGGTPIDQSAIPRQSLAPGFGGNVLHDLSHAYTAVFVIAVALVVCTII MMAR_2966|M.marinum_M RP--GVPLDQP--------------VLHELSRAYSVVFVVAVVLAVLAFI MUL_0542|M.ulcerans_Agy99 -------------------------------------------------- Mvan_1284|M.vanbaalenii_PYR-1 ---------------------------------REGMSPAAAIAVILGAV MAB_1396|M.abscessus_ATCC_1997 LPPG---------------------LRAPFSAAMAQSMLLGIAALALGLV TH_2729|M.thermoresistible__bu -------------------------------AASHAVFVGLLVAAVATVV MLBr_01562|M.leprae_Br4923 R---------------------------ALDHGYTYGLLWVAGAVVIVGV MSMEG_4980|M.smegmatis_MC2_155 ETVRLPKSAGSHVSGHR--------------------------------- Mflv_2018|M.gilvum_PYR-GCK ETLRLPGSAASHVTGHR--------------------------------- Mb0805c|M.bovis_AF2122/97 PAAFLPKQQASHRRAPLLSA------------------------------ Rv0783c|M.tuberculosis_H37Rv PAAFLPKQQASHRRAPLLSA------------------------------ MAV_0730|M.avium_104 PASFLPKKPAAETAGK---------------------------------- MMAR_2966|M.marinum_M PLAFLPKWSALTALSQTSSLERTPEPDAAPHGRQSPPEDTRPGAGRNSSS MUL_0542|M.ulcerans_Agy99 -------------------------------------------------- Mvan_1284|M.vanbaalenii_PYR-1 SALLLPAGAAVLLIKAPA-------------------------------- MAB_1396|M.abscessus_ATCC_1997 AALFMRPGGSQVGAVPLDDVVSVED------------------------- TH_2729|M.thermoresistible__bu LLLTVPRRFPTHHVAVVD-------------------------------- MLBr_01562|M.leprae_Br4923 AALFIGYTPEQVAYAQEVKEAVDAGEL----------------------- MSMEG_4980|M.smegmatis_MC2_155 ---------- Mflv_2018|M.gilvum_PYR-GCK ---------- Mb0805c|M.bovis_AF2122/97 ---------- Rv0783c|M.tuberculosis_H37Rv ---------- MAV_0730|M.avium_104 ---------- MMAR_2966|M.marinum_M NDLTPSGPDG MUL_0542|M.ulcerans_Agy99 ---------- Mvan_1284|M.vanbaalenii_PYR-1 ---------- MAB_1396|M.abscessus_ATCC_1997 ---------- TH_2729|M.thermoresistible__bu ---------- MLBr_01562|M.leprae_Br4923 ----------