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GLATTGPAWLFCPADRPERFEKAAAAADVVILDLEDGAGDKPAAREALLSTPLDPARTVVRINPGDSPEQ KLDLDVLSQTAYTTVMLPKCESAAQVTALAPLEVVLIVETPLGALKVDEAAAAANTWGVMWGAEDLFGFL GGTNNRFPDDSYRDVAKYVRSRSLLAAKAFGKQALDSVYIDIRNLDGLRAEVDDAVAVGFDIKVAIHPSQ VAVIREGYMPTPEQARWAREVLAAAETQPGAFAFEGMMVDAPVLRRAERIAALAPDNG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4713 | - | - | 100% (269) | HpcH/HpaI aldolase/citrate lyase family protein |
| M. smegmatis MC2 155 | MSMEG_6298 | - | 5e-19 | 32.52% (286) | malyl-CoA lyase |
| M. smegmatis MC2 155 | MSMEG_6644 | - | 5e-18 | 32.75% (287) | malyl-CoA lyase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2526c | citE | 1e-87 | 62.45% (261) | citrate (Pro-3S)-lyase beta subunit |
| M. gilvum PYR-GCK | Mflv_2556 | - | 1e-100 | 68.70% (262) | HpcH/HpaI aldolase |
| M. tuberculosis H37Rv | Rv2498c | citE | 1e-87 | 62.45% (261) | citrate (Pro-3S)-lyase beta subunit |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4378c | - | 4e-98 | 67.16% (271) | putative citrate lyase beta subunit |
| M. marinum M | MMAR_3845 | citE | 1e-92 | 64.07% (270) | citrate (pro-3s)-lyase (beta subunit) CitE |
| M. avium 104 | MAV_1674 | - | 5e-90 | 65.49% (255) | CitE protein |
| M. thermoresistible (build 8) | TH_0719 | - | 1e-111 | 74.17% (271) | HpcH/HpaI aldolase/citrate lyase family protein |
| M. ulcerans Agy99 | MUL_3776 | citE | 7e-91 | 62.96% (270) | citrate (pro-3s)-lyase (beta subunit) CitE |
| M. vanbaalenii PYR-1 | Mvan_4087 | - | 1e-106 | 72.45% (265) | HpcH/HpaI aldolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2556|M.gilvum_PYR-GCK MTL-APGTAWLFCPADRPERFEKAAAAADIVILDLEDGVAAKDRQAAREA
Mvan_4087|M.vanbaalenii_PYR-1 MTL-AAGPAWLFCPADRPERFEKAAAAADVVILDLEDGVAAKDREAARKA
TH_0719|M.thermoresistible__bu MDLSAVGPAWLFCPADRPERFEKAAAAADVVILDLEDGVAAKDRPAAREA
MAB_4378c|M.abscessus_ATCC_199 MTVATAGPGWLFCPADRPERFEKAAVAADVVILDLEDGVAAADRPAARDA
MSMEG_4713|M.smegmatis_MC2_155 MGLATTGPAWLFCPADRPERFEKAAAAADVVILDLEDG--AGDKPAAREA
Mb2526c|M.bovis_AF2122/97 MNLRAAGPGWLFCPADRPERFAKAAAAADVVILDLEDGVAEAQKPAARNA
Rv2498c|M.tuberculosis_H37Rv MNLRAAGPGWLFCPADRPERFAKAAAAADVVILDLEDGVAEAQKPAARNA
MMAR_3845|M.marinum_M MKLRTAGPAWLFCPADRPERFAKAAAAADVVILDLEDGVAEAQKPAARQA
MUL_3776|M.ulcerans_Agy99 MKLRTASPAWLFCPADRPERFAKAAAAADVVILDLEDGVAEAQKPAARQA
MAV_1674|M.avium_104 MNPHAAGPAWLFCPADRPERFAKAAAAADVVILDLEDGVAEADKPAARKA
* : ...************ ***.***:******** :: ***.*
Mflv_2556|M.gilvum_PYR-GCK LVNTPLDPARTVVRVNPTGTADHGPDLEAVARTAYTTVMLAKTEAPEQVR
Mvan_4087|M.vanbaalenii_PYR-1 LVDTPLDPSRTVVRVNPAGTPDHKLDLEALSRTSYTTVMLAKTESPQQVA
TH_0719|M.thermoresistible__bu LLSTPLDPARTVVRVNPAGTADHRLDLDALTRTPYRTVMLAKTDAAEQVR
MAB_4378c|M.abscessus_ATCC_199 LISTPLDPGRTVVRLNPAATADHALDLEALAQTEYTTVILAKSEHADQVL
MSMEG_4713|M.smegmatis_MC2_155 LLSTPLDPARTVVRINPGDSPEQKLDLDVLSQTAYTTVMLPKCESAAQVT
Mb2526c|M.bovis_AF2122/97 LRDTPLDPERTVVRINAGGTADQARDLEALAGTAYTTVMLPKAESAAQVI
Rv2498c|M.tuberculosis_H37Rv LRDTPLDPERTVVRINAGGTADQARDLEALAGTAYTTVMLPKAESAAQVI
MMAR_3845|M.marinum_M LLDTPLDPERTIVRINAGDTDEQARDLAALAGTAYTTVMLPKAESAAQLA
MUL_3776|M.ulcerans_Agy99 LLDTPLDPERTIVRINAGDTDEQARDLAALAGTAYTTVMLPKAESVAQLA
MAV_1674|M.avium_104 LLETPLDPERTVVRVNAADTDEYARDLEALAGTAYTTVMLSKTESAAQVQ
* .***** **:**:*. : : ** .:: * * **:*.* : *:
Mflv_2556|M.gilvum_PYR-GCK ALAPLDVIVLIETPLGALNVVDLARVDNAYALMWGAEDLFAELGGTANRY
Mvan_4087|M.vanbaalenii_PYR-1 ALAPLDVVVLIETPLGALAVVELARVDNALALMWGAEDLFAVLGGTANRY
TH_0719|M.thermoresistible__bu ALAPLQVVVLIETPLGALNVVESARADNAVAVMWGAEDLFAVTGGTDNRN
MAB_4378c|M.abscessus_ATCC_199 GLAPLNVVVLVETPMGALNVAELVRPGNVVAAMWGAEDLFAATWGTNNRW
MSMEG_4713|M.smegmatis_MC2_155 ALAPLEVVLIVETPLGALKVDEAAAAANTWGVMWGAEDLFGFLGGTNNRF
Mb2526c|M.bovis_AF2122/97 ELAPRDVIALVETARGAVCAAEIAAADPTVGMMWGAEDLIATLGGSSSRR
Rv2498c|M.tuberculosis_H37Rv ELAPRDVIALVETARGAVCAAEIAAADPTVGMMWGAEDLIATLGGSSSRR
MMAR_3845|M.marinum_M LLAPRDVIALVETARGALFAAEIAAADNTVGMMWGAEDLIATLGGSSSRR
MUL_3776|M.ulcerans_Agy99 LLAPRDVIALVETARGALFAAEIAAADNTVGMMWGAEDLIATLGGSSSRR
MAV_1674|M.avium_104 AMAPREVIALLETPRGAVFATEIAAAQNTVALMWGAEDLVATLGGSSSRR
:** :*: ::**. **: . : . . . *******.. *: .*
Mflv_2556|M.gilvum_PYR-GCK PDGSYREVARHVRSQTLLAAKAYGRVALDSVFLDIKNLDGLRGEVDDAVA
Mvan_4087|M.vanbaalenii_PYR-1 PDGSYREVARHVRSQTLLAAKAYGRLALDSVFLDIKNLDGLRAEVDDAVA
TH_0719|M.thermoresistible__bu PDGSYRDVARHVRSQSLLAAKAHGRLALDSVYLDIKDLDGLRAEVDDAVA
MAB_4378c|M.abscessus_ATCC_199 PDGSYRDVAQHVRSQTLLAAKAFGRIALDAVYLDIKALDGLRAEADDAVA
MSMEG_4713|M.smegmatis_MC2_155 PDDSYRDVAKYVRSRSLLAAKAFGKQALDSVYIDIRNLDGLRAEVDDAVA
Mb2526c|M.bovis_AF2122/97 ADGAYRDVARHVRSTILLAASAFGRLALDAVHLDILDVEGLQEEARDAAA
Rv2498c|M.tuberculosis_H37Rv ADGAYRDVARHVRSTILLAASAFGRLALDAVHLDILDVEGLQEEARDAAA
MMAR_3845|M.marinum_M GDGSYRDVARHVRSTTLLAASAFGRLALDAVHLDIGDIDGLHAEAIDAAT
MUL_3776|M.ulcerans_Agy99 GDGTYRDVARHVRSTILLAASAFGRLALDAVHLDIGDVDGLHAEAMDAAT
MAV_1674|M.avium_104 ADGSYRDVAHHVRSTALLTASAFGRAALDAVHLDIRDLDGLRAEAEDAVA
*.:**:**::*** **:*.*.*: ***:*.:** ::**: *. **.:
Mflv_2556|M.gilvum_PYR-GCK VGFDGKVAIHPTQLPVIRDGYTPTEAQADWARRVLAAAQAERGVFQYEGQ
Mvan_4087|M.vanbaalenii_PYR-1 VGFDVKVAIHPSQVAVIRSGYAPTDAEVDWARRVLDTARTQRGVFAFEGI
TH_0719|M.thermoresistible__bu VGFDAKVAIHPTQVAVIREGYTPTPDQVRWARHVLAAARDERGVFQFEGI
MAB_4378c|M.abscessus_ATCC_199 VGFDAKVAIHPTQVNVIRAAYEPTAKQVYWARGVLELAGRERGVFQFEGV
MSMEG_4713|M.smegmatis_MC2_155 VGFDIKVAIHPSQVAVIREGYMPTPEQARWAREVLAAAETQPGAFAFEGM
Mb2526c|M.bovis_AF2122/97 VGFDVTVCIHPSQIPVVRKAYRPSHEKLAWARRVLAASRSERGAFAFEGQ
Rv2498c|M.tuberculosis_H37Rv VGFDVTVCIHPSQIPVVRKAYRPSHEKLAWARRVLAASRSERGAFAFEGQ
MMAR_3845|M.marinum_M VGFDVTVCIHPSQVEVVRKAYRPDEEKLAWARRVLVAARTERGVFAFEGQ
MUL_3776|M.ulcerans_Agy99 VGFDVTVCIHPSQVEVVRKAYRPDEEKLAWARRVLVAARTERGVFAFEGQ
MAV_1674|M.avium_104 LGFAGTVCIHPSQVPVVRQAYRPPEEKLDWARRVLAAARSERGVFAFEGQ
:** .*.***:*: *:* .* * : *** ** : : *.* :**
Mflv_2556|M.gilvum_PYR-GCK MVDMPVLRRAERIVALAP-------
Mvan_4087|M.vanbaalenii_PYR-1 MVDAPVLRRAERIVELAPHPGA---
TH_0719|M.thermoresistible__bu MVDAPVLRRAERIVQLAPDPGR---
MAB_4378c|M.abscessus_ATCC_199 MVDAPVLRRAERIIQLSALTGGLCE
MSMEG_4713|M.smegmatis_MC2_155 MVDAPVLRRAERIAALAPDNG----
Mb2526c|M.bovis_AF2122/97 MVDSPVLTHAETMLRRAGEATSE--
Rv2498c|M.tuberculosis_H37Rv MVDSPVLTHAETMLRRAGEATSE--
MMAR_3845|M.marinum_M MVDSPVLRHAEMLLRRAGESVPA--
MUL_3776|M.ulcerans_Agy99 MVDSPVLRHAEMLLRRAGESVPA--
MAV_1674|M.avium_104 MVDSPVLKHAQMMLRRAGETDAG--
*** *** :*: : :