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VDIHSLRSTFAERLHAGGNIVAPGAYDALSAQIIARSGFEAVFIGSFGIAASAYGLPDTGLLSLDQLTEH TRNTARAVDIPVIADAEGGFFEPANMWRTVREFEDAGVCAIHIEDNLGGKHSAEPAGLLSPEAMSARIRA AADAKTDPAFQIIARTDARWVYGDVKETVRRLRAYIDAGADMVFAPGISAAELAAVRADLARPVMVLADL PTRAGEALPEDSVDDFVAAGANLIVLFYLTLGAAALGVRRVLEELTEYRDVRKLDGLFESQHAFEAAMGY DTYEARVARYGGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4393 | - | - | 100% (293) | carboxyvinyl-carboxyphosphonate phosphorylmutase |
| M. smegmatis MC2 155 | MSMEG_6855 | - | 5e-35 | 36.80% (250) | carboxyvinyl-carboxyphosphonate phosphorylmutase |
| M. smegmatis MC2 155 | MSMEG_2506 | - | 7e-29 | 34.14% (249) | carboxyvinyl-carboxyphosphonate phosphorylmutase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2021c | - | 4e-11 | 30.77% (208) | hypothetical protein Mb2021c |
| M. gilvum PYR-GCK | Mflv_0391 | - | 2e-13 | 28.57% (210) | hypothetical protein Mflv_0391 |
| M. tuberculosis H37Rv | Rv1998c | - | 5e-11 | 30.77% (208) | hypothetical protein Rv1998c |
| M. leprae Br4923 | MLBr_01985 | aceA | 2e-06 | 26.64% (229) | isocitrate lyase |
| M. abscessus ATCC 19977 | MAB_4618 | - | 7e-30 | 33.07% (257) | carboxyvinyl-carboxyphosphonate phosphorylmutase |
| M. marinum M | MMAR_1380 | - | 3e-30 | 33.86% (254) | methylisocitrate lyase 2 |
| M. avium 104 | MAV_0345 | prpB | 7e-29 | 34.03% (238) | methylisocitrate lyase |
| M. thermoresistible (build 8) | TH_1918 | - | 4e-12 | 30.14% (209) | transferase |
| M. ulcerans Agy99 | MUL_1177 | - | 1e-11 | 29.15% (223) | PEP phosphonomutase |
| M. vanbaalenii PYR-1 | Mvan_0289 | - | 4e-13 | 27.60% (221) | hypothetical protein Mvan_0289 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0391|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0289|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1918|M.thermoresistible__bu --------------------------------------------------
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb2021c|M.bovis_AF2122/97 --------------------------------------------------
Rv1998c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4393|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01985|M.leprae_Br4923 MAGIPATVVQRCNSTNLDDRLHYSPLGDRAKEERNPMAIMDTNTEVHTLF
Mflv_0391|M.gilvum_PYR-GCK ---------------------------------------MARTEDLKARA
Mvan_0289|M.vanbaalenii_PYR-1 ----------------------------------------MTNDVLKARA
TH_1918|M.thermoresistible__bu ---------------------------------------------LQKRA
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb2021c|M.bovis_AF2122/97 --------------------------------------------------
Rv1998c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1380|M.marinum_M -----------------------------------MKTVLGTAVSATEKR
MAV_0345|M.avium_104 -----------------------------------MRDMIGAARSPEQKR
MAB_4618|M.abscessus_ATCC_1997 -----------------------------------MSTLLASATDAATKR
MSMEG_4393|M.smegmatis_MC2_155 -------------------------------------------MDIHSLR
MLBr_01985|M.leprae_Br4923 TQEVAATQQYFDDPRFAGIIRLYTARQVVEQRGTIPTDYTVARDAATAFY
Mflv_0391|M.gilvum_PYR-GCK EALLALHQPGNPVILPTVWDAWSAHLAVDAGFSALTVGSHPLAD-----S
Mvan_0289|M.vanbaalenii_PYR-1 EALLALHQPGNPVILPTVWDAWSAKLATDAGFAALTVGSHPLAD-----S
TH_1918|M.thermoresistible__bu SDFLALHRPGDPVVLPTVWDAWSARLAVDAGFPALTVGSHPVAD-----S
MUL_1177|M.ulcerans_Agy99 -------------MLSTVWDAWSARLAANAGFAALTVGSHPLAD-----S
Mb2021c|M.bovis_AF2122/97 MSFHDLHHQGVPFVLPNAWDVPSALAYLAEGFTAIGTTSFGVSS-----S
Rv1998c|M.tuberculosis_H37Rv MSFHDLHHQGVPFVLPNAWDVPSALAYLAEGFTAIGTTSFGVSS-----S
MMAR_1380|M.marinum_M TGFRAALESGRLLRFPGAYSPLVARLVAEIGFDGVYVSGAALSA-----D
MAV_0345|M.avium_104 AQLRAALESGRLQRFPGAFSPLVAKLVAELGFDGVYVSGAALSA-----D
MAB_4618|M.abscessus_ATCC_1997 AAFRQGLSSGELLRLPGAFSPLVAKLIQEIGFEGVYVSGAVLSA-----D
MSMEG_4393|M.smegmatis_MC2_155 STFAERLHAGGNIVAPGAYDALSAQIIARSGFEAVFIGSFGIAAS----A
MLBr_01985|M.leprae_Br4923 ARLRELFAAGKSVTTFGPYSPGQAVSLKRMGIEAIYLGGWATSAKGSITE
:. * *: .: . :
Mflv_0391|M.gilvum_PYR-GCK IGKPDNEGMTFDDVLTRVAQITAAVDVP----------------------
Mvan_0289|M.vanbaalenii_PYR-1 VGKSDREGMTFDDVLTRVAQITAAVDVP----------------------
TH_1918|M.thermoresistible__bu LGKADNEGMTFDDVLTRVGQITAAVEVP----------------------
MUL_1177|M.ulcerans_Agy99 IGKPDNEGMSFDDVLARVAQITAAVDIP----------------------
Mb2021c|M.bovis_AF2122/97 GGHPDGHRATRGANIA-LAAALAPLQCY----------------------
Rv1998c|M.tuberculosis_H37Rv GGHPDGHRATRGANIA-LAAALAPLQCY----------------------
MMAR_1380|M.marinum_M LGLPDIGLTTLTEVSARGAQIAAASELP----------------------
MAV_0345|M.avium_104 LGLPDIGLTTLTEVSGRGAQIAAVTELP----------------------
MAB_4618|M.abscessus_ATCC_1997 LALPDIGLTTLTEVSARGRQIASVTDLP----------------------
MSMEG_4393|M.smegmatis_MC2_155 YGLPDTGLLSLDQLTEHTRNTARAVDIP----------------------
MLBr_01985|M.leprae_Br4923 DPGPDLASYPLSQVPDDAAVLVRALLAADRNQQYLRLHMTEQQRAATPAY
.* .
Mflv_0391|M.gilvum_PYR-GCK -----LSVDIESGYAE--EPGRLIDGLLSVDAVGLNIEDTVHSEGGRLRS
Mvan_0289|M.vanbaalenii_PYR-1 -----LSVDIESGYAE--APTRLIEGLLSVGAVGLNIEDTVHSEGGRLRS
TH_1918|M.thermoresistible__bu -----VSVDIESGYAE--SPERLITGLLDAGAVGLNIEDTVHSEGRRLRS
MUL_1177|M.ulcerans_Agy99 -----VSVDIESGYGL--DAQRLIEGLLNVGAVGLNIEDTVHSEGARLRS
Mb2021c|M.bovis_AF2122/97 -----VSVDIEDGYSD--EPDAIADYVAQLSTAGINIEDSSAEK------
Rv1998c|M.tuberculosis_H37Rv -----VSVDIEDGYSD--EPDAIADYVAQLSTAGINIEDSSAEK------
MMAR_1380|M.marinum_M -----TFIDADTGFGEPMSAARTVAVLEDAGLAGCHLEDQVNPK------
MAV_0345|M.avium_104 -----TLIDADTGFGEPLNAARTVTMLEYAGLAGCHLEDQVNPK------
MAB_4618|M.abscessus_ATCC_1997 -----TLIDADTGFGEPMSAARTVAVLEDSGVAGLHLEDQVNPK------
MSMEG_4393|M.smegmatis_MC2_155 -----VIADAEGGFFEPANMWRTVREFEDAGVCAIHIEDNLGGK------
MLBr_01985|M.leprae_Br4923 DYRPFIIADADTGHGGDSHVRNLIRRFVEIGVPGYHIEDQRPGT-----K
* : *. . . . ::**
Mflv_0391|M.gilvum_PYR-GCK SGEHAALVGGLRAAADAAGVHVVVNARTD------LFLRQDGDEAD-RVD
Mvan_0289|M.vanbaalenii_PYR-1 SSEHAQLVGALRAAADAAGVHVVVNARTD------LFLRQDGDESD-RVD
TH_1918|M.thermoresistible__bu VAEHAELVGALRAAADAAGVHVVVNARTD------LFLRQDGDESD-RVD
MUL_1177|M.ulcerans_Agy99 RREHAELVGALRSAADAAGVHVVLNARTD------LFLRRDGDPAD-RFE
Mb2021c|M.bovis_AF2122/97 -LIDPALAAAKIVAIKQRNPEVFVNARVDT-----YWLRQHADTTS-TIQ
Rv1998c|M.tuberculosis_H37Rv -LIDPALAAAKIVAIKQRNPEVFVNARVDT-----YWLRQHADTTS-TIQ
MMAR_1380|M.marinum_M RCGHLDGKAVVPVGVMVSRLRAAVSARRDPNFI--VCARTDAAAVE-GPS
MAV_0345|M.avium_104 RCGHLDGKAVVPVDEMVRRLRAAVSARRDPNFV--VCARTDAAAIE-GLP
MAB_4618|M.abscessus_ATCC_1997 RCGHLDGKAVVETVEMVRRLHAAVSARRDPNFV--ICARTDAAGIE-GLP
MSMEG_4393|M.smegmatis_MC2_155 --HSAEPAGLLSPEAMSARIRAAADAKTDPAFQ--IIARTDARWVYGDVK
MLBr_01985|M.leprae_Br4923 KCGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDS
.. * ..
Mflv_0391|M.gilvum_PYR-GCK RAIARLKEAADAGADVLYPVGVHPPEVMRRLTSELPLPVNA----IARPD
Mvan_0289|M.vanbaalenii_PYR-1 RAIARLKEAAAAGADVLYPVGVHPPEVMRRLTSELPLPVNA----IARPE
TH_1918|M.thermoresistible__bu RAIARLTECARAGADVLYPVGRHDPDILRRLATELPLPVNA----IAAPD
MUL_1177|M.ulcerans_Agy99 RAVAWLTEAAAAGADVLYPVGRHDPDTLRRLAAQLPLPINA----IALPD
Mb2021c|M.bovis_AF2122/97 RALR----YVDAGADGVFVPLANDPDELAELTRNIPCPVNT----LPVPG
Rv1998c|M.tuberculosis_H37Rv RALR----YVDAGADGVFVPLANDPDELAELTRNIPCPVNT----LPVPG
MMAR_1380|M.marinum_M AAIDRAKAYADAGADLIFTEALRTPAEFEQFRAAVDTPLLANMTEFGKSG
MAV_0345|M.avium_104 AAIERARAYADAGADLIFTEALQCPTEFERFRAALDTPLLANMTEFGKSP
MAB_4618|M.abscessus_ATCC_1997 AAIDRARAYADAGADLIFTEALTDIGEFEKFRAAVDIPLLANMTEFGKSE
MSMEG_4393|M.smegmatis_MC2_155 ETVRRLRAYIDAGADMVFAPGIS-AAELAAVRADLARPVMVLADLPTRAG
MLBr_01985|M.leprae_Br4923 RADERDQPFLLGATNLKIPSYKACFLALVRCFYELGVKELHGHLLYALGD
: ..:: : :
Mflv_0391|M.gilvum_PYR-GCK QSDPASYGPLGVARISFG------PFWQAALAERSK-------------E
Mvan_0289|M.vanbaalenii_PYR-1 SADPASYGPLGVARISFG------PFWQAALAERAR-------------E
TH_1918|M.thermoresistible__bu QADPASFGPLGVARISFG------PFFQAALAVRAG-------------E
MUL_1177|M.ulcerans_Agy99 QDDPASFGRLGVARISVG------PFLQAGLSGRAT-------------E
Mb2021c|M.bovis_AF2122/97 -LTIADLGELGVARVSTGSVPYSAGLYAAAHAARAVRDGEQLPRSVPYAE
Rv1998c|M.tuberculosis_H37Rv -LTIADLGELGVARVSTGSVPYSAGLYAAAHAARAVSDGEQLPRSVPYAE
MMAR_1380|M.marinum_M LLSTDQLREIGYNVVIYPVTTLRLAMYAVEAGLREIADAGTQSGLLNRMQ
MAV_0345|M.avium_104 LLGADRLADIGYNVVIYPVTTLRLAMHAVEAGLREIADTGTQSGLLDRMQ
MAB_4618|M.abscessus_ATCC_1997 LVTADRLREVGYNVVIYPVTTLRLAMYAVEQGLHEINSAGTQSGLLEQMQ
MSMEG_4393|M.smegmatis_MC2_155 EALPEDSVDDFVAAGANLIVLFYLTLGAAALGVRRVLEELTEYRDVR--K
MLBr_01985|M.leprae_Br4923 GEYAAASAWLDRQGILAQVSGTVNAWQENGKQSIDDLFEQVEYRLLAAWE
:
Mflv_0391|M.gilvum_PYR-GCK LLARWR--------------------------------------------
Mvan_0289|M.vanbaalenii_PYR-1 ILARWI--------------------------------------------
TH_1918|M.thermoresistible__bu ILARWR--------------------------------------------
MUL_1177|M.ulcerans_Agy99 LLARWR--------------------------------------------
Mb2021c|M.bovis_AF2122/97 LQARLVDY-ENRTSTT----------------------------------
Rv1998c|M.tuberculosis_H37Rv LQARLVDY-ENRTSTT----------------------------------
MMAR_1380|M.marinum_M QRSRLYEL-LRYADYQQFDSSIYNFVRQGDRP------------------
MAV_0345|M.avium_104 HRSRLYQL-LRYADYNHFDSDIYNFPR-----------------------
MAB_4618|M.abscessus_ATCC_1997 HRSRLYEL-LHYAEYNRFDTEIFNFSLDGGQ-------------------
MSMEG_4393|M.smegmatis_MC2_155 LDGLFESQ-HAFEAAMGYDTYEARVARYGGR-------------------
MLBr_01985|M.leprae_Br4923 KDAGLMTYGEAVEEMLQFGESEGELIGMSPEEWRRFVGRASLYAAREKAK
.
Mflv_0391|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0289|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1918|M.thermoresistible__bu --------------------------------------------------
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb2021c|M.bovis_AF2122/97 --------------------------------------------------
Rv1998c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4393|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01985|M.leprae_Br4923 ELGVDPGWDCELAKTPEGYYQIRGGIQYAIAKSLAAAPFADILWMETKTA
Mflv_0391|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0289|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1918|M.thermoresistible__bu --------------------------------------------------
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb2021c|M.bovis_AF2122/97 --------------------------------------------------
Rv1998c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4393|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01985|M.leprae_Br4923 DLADARQFAEAIHAEFPEQMLAYNLSPSFNWDTTGMSDEEMKRFPEELGK
Mflv_0391|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0289|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1918|M.thermoresistible__bu --------------------------------------------------
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb2021c|M.bovis_AF2122/97 --------------------------------------------------
Rv1998c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4393|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01985|M.leprae_Br4923 MGFVFNFITYGGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVESPYR
Mflv_0391|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0289|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1918|M.thermoresistible__bu --------------------------------------------------
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb2021c|M.bovis_AF2122/97 --------------------------------------------------
Rv1998c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4393|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01985|M.leprae_Br4923 TPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPKKLLEE
Mflv_0391|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0289|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1918|M.thermoresistible__bu --------------------------------------------------
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb2021c|M.bovis_AF2122/97 --------------------------------------------------
Rv1998c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4393|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01985|M.leprae_Br4923 WLALWSEHYQLGEKLRVQLRPRRAGSDVLELGIYGNGDEQLANVIVDPIK
Mflv_0391|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0289|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1918|M.thermoresistible__bu --------------------------------------------------
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb2021c|M.bovis_AF2122/97 --------------------------------------------------
Rv1998c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4393|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01985|M.leprae_Br4923 DRRGRSILQVRDQNTFAEKLRQKRLMTLIHFWLVHRFKADTVIYVTPTED
Mflv_0391|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0289|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1918|M.thermoresistible__bu --------------------------------------------------
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb2021c|M.bovis_AF2122/97 --------------------------------------------------
Rv1998c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4393|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01985|M.leprae_Br4923 NLYQTSKMKSHGIFSEVYQEVGEIIVAEVNHPRLVELLTPDRVALRRLIT
Mflv_0391|M.gilvum_PYR-GCK ---
Mvan_0289|M.vanbaalenii_PYR-1 ---
TH_1918|M.thermoresistible__bu ---
MUL_1177|M.ulcerans_Agy99 ---
Mb2021c|M.bovis_AF2122/97 ---
Rv1998c|M.tuberculosis_H37Rv ---
MMAR_1380|M.marinum_M ---
MAV_0345|M.avium_104 ---
MAB_4618|M.abscessus_ATCC_1997 ---
MSMEG_4393|M.smegmatis_MC2_155 ---
MLBr_01985|M.leprae_Br4923 KEG