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EARRKLNAQIESGTLTVAPGVYDGLTAALVKRREFNAAYMSGAAVAASLGLPDLGLTSQSEMAARVALLT GVLGDVPLIADADTGFGDIINAVRTVQLYERAGVAAIQLEDQMFPKKCGHLDSKEVVAPEDFQRKIEAVV EARTDDRMLVIARTDALASRGFDDAVARARSYVEAGADVIFIEAPQTAEQIAAIPGLISKPTLFNVVPRG KTPPVSLEMLQTAGYSIVIAPGLAFGAAADAVDHALATLRDGDTDTGSQWSPNELFRAVGLDYWDEVGKR FATPTVGV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2506 | - | - | 100% (289) | carboxyvinyl-carboxyphosphonate phosphorylmutase |
| M. smegmatis MC2 155 | MSMEG_6855 | - | 8e-73 | 49.12% (285) | carboxyvinyl-carboxyphosphonate phosphorylmutase |
| M. smegmatis MC2 155 | MSMEG_6646 | prpB | 2e-49 | 40.47% (257) | methylisocitrate lyase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0476 | icl | 7e-09 | 27.93% (222) | isocitrate lyase |
| M. gilvum PYR-GCK | Mflv_0107 | - | 2e-08 | 29.46% (258) | isocitrate lyase |
| M. tuberculosis H37Rv | Rv0467 | icl | 7e-09 | 27.93% (222) | isocitrate lyase |
| M. leprae Br4923 | MLBr_01985 | aceA | 3e-06 | 26.80% (194) | isocitrate lyase |
| M. abscessus ATCC 19977 | MAB_4618 | - | 3e-47 | 39.92% (248) | carboxyvinyl-carboxyphosphonate phosphorylmutase |
| M. marinum M | MMAR_1380 | - | 1e-49 | 42.02% (257) | methylisocitrate lyase 2 |
| M. avium 104 | MAV_0345 | prpB | 3e-53 | 42.80% (257) | methylisocitrate lyase |
| M. thermoresistible (build 8) | TH_4509 | - | 2e-09 | 27.85% (219) | PUTATIVE isocitrate lyase |
| M. ulcerans Agy99 | MUL_4536 | icl | 9e-09 | 30.38% (260) | isocitrate lyase Icl |
| M. vanbaalenii PYR-1 | Mvan_0801 | - | 1e-08 | 29.62% (260) | isocitrate lyase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0476|M.bovis_AF2122/97 ----------------------MSVVGTPKSAEQ----------------
Rv0467|M.tuberculosis_H37Rv ----------------------MSVVGTPKSAEQ----------------
Mflv_0107|M.gilvum_PYR-GCK ----------------------MSTVGMPKSPEQ----------------
Mvan_0801|M.vanbaalenii_PYR-1 ----------------------MSTVGTPKSPEQ----------------
MUL_4536|M.ulcerans_Agy99 ----------------------MSVVGTPKCAEQ----------------
TH_4509|M.thermoresistible__bu ----------------------MSNVGTPRSAEQ----------------
MLBr_01985|M.leprae_Br4923 MAGIPATVVQRCNSTNLDDRLHYSPLGDRAKEERNPMAIMDTNTEVHTLF
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2506|M.smegmatis_MC2_155 --------------------------------------------------
Mb0476|M.bovis_AF2122/97 -----IQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLW
Rv0467|M.tuberculosis_H37Rv -----IQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLW
Mflv_0107|M.gilvum_PYR-GCK -----IQHDWDHNPRWKGITRTYTPADVVALQGHVVEEHTLARRGAEVLW
Mvan_0801|M.vanbaalenii_PYR-1 -----IQHDWDHNPRWKGITRTYTPADVVALQGHVVEEHTLARRGAEVLW
MUL_4536|M.ulcerans_Agy99 -----IQHDWDHNPRWKGITRTYTPQDVVALQGHVVEEHTLARRGSEVLW
TH_4509|M.thermoresistible__bu -----IKKDWETNPRWKNVKRDYTAEDVVALQGTVVEEHTLARRGAEILW
MLBr_01985|M.leprae_Br4923 TQEVAATQQYFDDPRFAGIIRLYTARQVVEQRGTIPTDYTVARDAATAFY
MMAR_1380|M.marinum_M -------------------------------MKTVLGTAVSATEKRTGFR
MAV_0345|M.avium_104 -------------------------------MRDMIGAARSPEQKRAQLR
MAB_4618|M.abscessus_ATCC_1997 -------------------------------MSTLLASATDAATKRAAFR
MSMEG_2506|M.smegmatis_MC2_155 ------------------------------------------MEARRKLN
:
Mb0476|M.bovis_AF2122/97 EQLHDLEWVN----ALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG
Rv0467|M.tuberculosis_H37Rv EQLHDLEWVN----ALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG
Mflv_0107|M.gilvum_PYR-GCK EQLHDMDFVN----SLGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG
Mvan_0801|M.vanbaalenii_PYR-1 DQLHDMDFVN----ALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG
MUL_4536|M.ulcerans_Agy99 EQLHDMDFVN----ALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG
TH_4509|M.thermoresistible__bu NQLHDMEFVN----ALGALTGNQAVQQVRAGLKAIYLSGWQVAGDANLSG
MLBr_01985|M.leprae_Br4923 ARLRELFAAGKSVTTFGPYSPGQAVSLKRMGIEAIYLGGWATSAKGSITE
MMAR_1380|M.marinum_M AALESGRLLR----FPGAYSPLVARLVAEIGFDGVYVSGAALSADLGL--
MAV_0345|M.avium_104 AALESGRLQR----FPGAFSPLVAKLVAELGFDGVYVSGAALSADLGL--
MAB_4618|M.abscessus_ATCC_1997 QGLSSGELLR----LPGAFSPLVAKLIQEIGFEGVYVSGAVLSADLAL--
MSMEG_2506|M.smegmatis_MC2_155 AQIESGTLTV----APGVYDGLTAALVKRREFNAAYMSGAAVAASLGL--
: . * * . :.. *:.* :.. :
Mb0476|M.bovis_AF2122/97 HTYPDQSLYPANSVPQVVRRINNALQRADQIAKIE---------GDTSVE
Rv0467|M.tuberculosis_H37Rv HTYPDQSLYPANSVPQVVRRINNALQRADQIAKIE---------GDTSVE
Mflv_0107|M.gilvum_PYR-GCK HTYPDQSLYPANSVPQVIRRINNALLRADEIAKVE---------GDTSVE
Mvan_0801|M.vanbaalenii_PYR-1 HTYPDQSLYPANSVPQVVRRINNALLRADEIAKVE---------GDTSVE
MUL_4536|M.ulcerans_Agy99 HTYPDQSLYPANSVPQVVRRINNALLRADEIAKVE---------NDRSVD
TH_4509|M.thermoresistible__bu HTYPDQSLYPANSVPQVVRRINNALMRADQIAKVE---------GDTSVE
MLBr_01985|M.leprae_Br4923 DPGPDLASYPLSQVPDDAAVLVRALLAADRNQQYLRLHMTEQQRAATPAY
MMAR_1380|M.marinum_M ---PDIGLTTLTEVSARGAQIAAAS-------------------------
MAV_0345|M.avium_104 ---PDIGLTTLTEVSGRGAQIAAVT-------------------------
MAB_4618|M.abscessus_ATCC_1997 ---PDIGLTTLTEVSARGRQIASVT-------------------------
MSMEG_2506|M.smegmatis_MC2_155 ---PDLGLTSQSEMAARVALLTGVLG------------------------
** . . ..:. : .
Mb0476|M.bovis_AF2122/97 NWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHL
Rv0467|M.tuberculosis_H37Rv NWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHL
Mflv_0107|M.gilvum_PYR-GCK NWLAPIVADGEAGFGGALNVYELQKAMIAAGVAGSHWEDQLASEKKCGHL
Mvan_0801|M.vanbaalenii_PYR-1 NWLAPIVADGEAGFGGALNVYELQKAMIAAGVAGSHWEDQLASEKKCGHL
MUL_4536|M.ulcerans_Agy99 NWLVPIVADGEAGFGGALNVYELQKAMIAAGVAGSHWEDQLASEKKCGHL
TH_4509|M.thermoresistible__bu NWLVPIVADGEAGFGGALNVYELQKAMITAGVAGSHWEDQLASEKKCGHL
MLBr_01985|M.leprae_Br4923 DYRPFIIADADTGHGGDSHVRNLIRRFVEIGVPGYHIEDQRPGTKKCGHQ
MMAR_1380|M.marinum_M --ELPTFIDADTGFGEPMSAARTVAVLEDAGLAGCHLEDQVN-PKRCGHL
MAV_0345|M.avium_104 --ELPTLIDADTGFGEPLNAARTVTMLEYAGLAGCHLEDQVN-PKRCGHL
MAB_4618|M.abscessus_ATCC_1997 --DLPTLIDADTGFGEPMSAARTVAVLEDSGVAGLHLEDQVN-PKRCGHL
MSMEG_2506|M.smegmatis_MC2_155 --DVPLIADADTGFGDIINAVRTVQLYERAGVAAIQLEDQMF-PKKCGHL
. *.::*.* . . *:.. : *** *:***
Mb0476|M.bovis_AF2122/97 GGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDER
Rv0467|M.tuberculosis_H37Rv GGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDER
Mflv_0107|M.gilvum_PYR-GCK GGKVLIPTQQHIRTLTSARLAADVAGVPTVVIARTDAEAATLITSDVDER
Mvan_0801|M.vanbaalenii_PYR-1 GGKVLIPTQQHIRTLTSARLAADVAGVPTVVIARTDAEAATLITSDVDER
MUL_4536|M.ulcerans_Agy99 GGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDER
TH_4509|M.thermoresistible__bu GGKVLIPTQQHIRTLTAARLAADVADVPTVIIARTDAEAATLITSDVDER
MLBr_01985|M.leprae_Br4923 GGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDSRADER
MMAR_1380|M.marinum_M DGKAVVPVGVMVSRLRAAVSAR--RDPNFIVCARTDAAAVE---------
MAV_0345|M.avium_104 DGKAVVPVDEMVRRLRAAVSAR--RDPNFVVCARTDAAAIE---------
MAB_4618|M.abscessus_ATCC_1997 DGKAVVETVEMVRRLHAAVSAR--RDPNFVICARTDAAGIE---------
MSMEG_2506|M.smegmatis_MC2_155 DSKEVVAPEDFQRKIEAVVEAR--TDDRMLVIARTDALASR---------
..* :: : :. :: ***** .
Mb0476|M.bovis_AF2122/97 DQPFITGER-----------------------------------------
Rv0467|M.tuberculosis_H37Rv DQPFITGER-----------------------------------------
Mflv_0107|M.gilvum_PYR-GCK DQPFITGDR-----------------------------------------
Mvan_0801|M.vanbaalenii_PYR-1 DRPFITGER-----------------------------------------
MUL_4536|M.ulcerans_Agy99 DRPFITGEP-----------------------------------------
TH_4509|M.thermoresistible__bu DRPFITGER-----------------------------------------
MLBr_01985|M.leprae_Br4923 DQPFLLGATNLKIPSYKACFLALVRCFYELGVKELHGHLLYALGDGEYAA
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2506|M.smegmatis_MC2_155 --------------------------------------------------
Mb0476|M.bovis_AF2122/97 --------------------------------------------------
Rv0467|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0107|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0801|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4536|M.ulcerans_Agy99 --------------------------------------------------
TH_4509|M.thermoresistible__bu --------------------------------------------------
MLBr_01985|M.leprae_Br4923 ASAWLDRQGILAQVSGTVNAWQENGKQSIDDLFEQVEYRLLAAWEKDAGL
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2506|M.smegmatis_MC2_155 --------------------------------------------------
Mb0476|M.bovis_AF2122/97 --------------------------------------------------
Rv0467|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0107|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0801|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4536|M.ulcerans_Agy99 --------------------------------------------------
TH_4509|M.thermoresistible__bu --------------------------------------------------
MLBr_01985|M.leprae_Br4923 MTYGEAVEEMLQFGESEGELIGMSPEEWRRFVGRASLYAAREKAKELGVD
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2506|M.smegmatis_MC2_155 --------------------------------------------------
Mb0476|M.bovis_AF2122/97 ---------TREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAA
Rv0467|M.tuberculosis_H37Rv ---------TREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAA
Mflv_0107|M.gilvum_PYR-GCK ---------TAEGFYRVKNGLEPCIARAKAYAPYSDLIWMETGTPDLELA
Mvan_0801|M.vanbaalenii_PYR-1 ---------TAEGFYRVKNGLEPCIARAKAYAPYSDLIWMETGTPDLELA
MUL_4536|M.ulcerans_Agy99 ---------TKEGFYRIKNGLEPCIARAKAYAPFSDLIWMETGTPDLKLA
TH_4509|M.thermoresistible__bu ---------TKEGFYRVQNGIEPCIARAKAYAPYADLIWMETGTPDLELA
MLBr_01985|M.leprae_Br4923 PGWDCELAKTPEGYYQIRGGIQYAIAKSLAAAPFADILWMETKTADLADA
MMAR_1380|M.marinum_M -------------------GPSAAIDRAKAYADAGADLIFTEALRTPAEF
MAV_0345|M.avium_104 -------------------GLPAAIERARAYADAGADLIFTEALQCPTEF
MAB_4618|M.abscessus_ATCC_1997 -------------------GLPAAIDRARAYADAGADLIFTEALTDIGEF
MSMEG_2506|M.smegmatis_MC2_155 -------------------GFDDAVARARSYVEAGADVIFIEAPQTAEQI
* .: :: : . . : :
Mb0476|M.bovis_AF2122/97 RQFSEAVKAEYPDQMLAYNCSPSFNWKKH-LDDATIAKFQKELAAMGFKF
Rv0467|M.tuberculosis_H37Rv RQFSEAVKAEYPDQMLAYNCSPSFNWKKH-LDDATIAKFQKELAAMGFKF
Mflv_0107|M.gilvum_PYR-GCK KKFAEGVKSEFPDQMLAYNCSPSFNWKQH-LDDATIAKFQKELGAMGFKF
Mvan_0801|M.vanbaalenii_PYR-1 KKFAEGVKSEFPDQMLAYNCSPSFNWRKH-LDDATIAKFQKELGAMGFKF
MUL_4536|M.ulcerans_Agy99 KQFAEGVKAEFPDQMLAYNCSPSFNWKKH-LDDETIAKFQKELGAMGFKF
TH_4509|M.thermoresistible__bu KRFAEAVKAEFPDQMLAYNCSPSFNWRKH-LDDATIARFQKELGAMGYKF
MLBr_01985|M.leprae_Br4923 RQFAEAIHAEFPEQMLAYNLSPSFNWDTTGMSDEEMKRFPEELGKMGFVF
MMAR_1380|M.marinum_M EQFRAAVDTPLLANMTEFGKSG--------------LLSTDQLREIGYNV
MAV_0345|M.avium_104 ERFRAALDTPLLANMTEFGKSP--------------LLGADRLADIGYNV
MAB_4618|M.abscessus_ATCC_1997 EKFRAAVDIPLLANMTEFGKSE--------------LVTADRLREVGYNV
MSMEG_2506|M.smegmatis_MC2_155 AAIPGLISKPTLFNVVPRGKTP--------------PVSLEMLQTAGYSI
: : :: . : . * *: .
Mb0476|M.bovis_AF2122/97 QFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQ----------------
Rv0467|M.tuberculosis_H37Rv QFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQ----------------
Mflv_0107|M.gilvum_PYR-GCK QFITLAGFHALNYSMFDLAYGYARNQMSAYVELQ----------------
Mvan_0801|M.vanbaalenii_PYR-1 QFITLAGFHALNYSMFDLAHGYARNQMTAYVELQ----------------
MUL_4536|M.ulcerans_Agy99 QFITLAGFHALNYSMFDLAYGYARNQMSAYVELQ----------------
TH_4509|M.thermoresistible__bu QFITLAGFHALNYSMFDLAYGYARNQMTAYVDLQ----------------
MLBr_01985|M.leprae_Br4923 NFITYGGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTL
MMAR_1380|M.marinum_M VIYPVTTLRLAMYAVEAGLREIADAGTQSGLLNR----------------
MAV_0345|M.avium_104 VIYPVTTLRLAMHAVEAGLREIADTGTQSGLLDR----------------
MAB_4618|M.abscessus_ATCC_1997 VIYPVTTLRLAMYAVEQGLHEINSAGTQSGLLEQ----------------
MSMEG_2506|M.smegmatis_MC2_155 VIAPGLAFGAAADAVDHALATLRDGDTDTGSQWS----------------
: . : :
Mb0476|M.bovis_AF2122/97 ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGS
Rv0467|M.tuberculosis_H37Rv ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGS
Mflv_0107|M.gilvum_PYR-GCK ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPTSSTTALAGS
Mvan_0801|M.vanbaalenii_PYR-1 ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPTSSTTALAGS
MUL_4536|M.ulcerans_Agy99 ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPTSSTTALAGS
TH_4509|M.thermoresistible__bu ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALKGS
MLBr_01985|M.leprae_Br4923 VGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPKKLLEEWLALW
MMAR_1380|M.marinum_M ------------------MQQRSRLYELLRYADY-QQFDSSIYNFVRQGD
MAV_0345|M.avium_104 ------------------MQHRSRLYQLLRYADY-NHFDSDIYNFPR---
MAB_4618|M.abscessus_ATCC_1997 ------------------MQHRSRLYELLHYAEY-NRFDTEIFNFSLDGG
MSMEG_2506|M.smegmatis_MC2_155 ------------------PNELFRAVGLDYWDEVGKRFATPTVGV-----
. .
Mb0476|M.bovis_AF2122/97 TEEGQFH-------------------------------------------
Rv0467|M.tuberculosis_H37Rv TEEGQFH-------------------------------------------
Mflv_0107|M.gilvum_PYR-GCK TEEGQFH-------------------------------------------
Mvan_0801|M.vanbaalenii_PYR-1 TEEGQFH-------------------------------------------
MUL_4536|M.ulcerans_Agy99 TEEGQFH-------------------------------------------
TH_4509|M.thermoresistible__bu TEEDQFH-------------------------------------------
MLBr_01985|M.leprae_Br4923 SEHYQLGEKLRVQLRPRRAGSDVLELGIYGNGDEQLANVIVDPIKDRRGR
MMAR_1380|M.marinum_M RP------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 Q-------------------------------------------------
MSMEG_2506|M.smegmatis_MC2_155 --------------------------------------------------
Mb0476|M.bovis_AF2122/97 --------------------------------------------------
Rv0467|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0107|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0801|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4536|M.ulcerans_Agy99 --------------------------------------------------
TH_4509|M.thermoresistible__bu --------------------------------------------------
MLBr_01985|M.leprae_Br4923 SILQVRDQNTFAEKLRQKRLMTLIHFWLVHRFKADTVIYVTPTEDNLYQT
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2506|M.smegmatis_MC2_155 --------------------------------------------------
Mb0476|M.bovis_AF2122/97 ------------------------------------------------
Rv0467|M.tuberculosis_H37Rv ------------------------------------------------
Mflv_0107|M.gilvum_PYR-GCK ------------------------------------------------
Mvan_0801|M.vanbaalenii_PYR-1 ------------------------------------------------
MUL_4536|M.ulcerans_Agy99 ------------------------------------------------
TH_4509|M.thermoresistible__bu ------------------------------------------------
MLBr_01985|M.leprae_Br4923 SKMKSHGIFSEVYQEVGEIIVAEVNHPRLVELLTPDRVALRRLITKEG
MMAR_1380|M.marinum_M ------------------------------------------------
MAV_0345|M.avium_104 ------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 ------------------------------------------------
MSMEG_2506|M.smegmatis_MC2_155 ------------------------------------------------