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MKTVLGTAVSATEKRTGFRAALESGRLLRFPGAYSPLVARLVAEIGFDGVYVSGAALSADLGLPDIGLTT LTEVSARGAQIAAASELPTFIDADTGFGEPMSAARTVAVLEDAGLAGCHLEDQVNPKRCGHLDGKAVVPV GVMVSRLRAAVSARRDPNFIVCARTDAAAVEGPSAAIDRAKAYADAGADLIFTEALRTPAEFEQFRAAVD TPLLANMTEFGKSGLLSTDQLREIGYNVVIYPVTTLRLAMYAVEAGLREIADAGTQSGLLNRMQQRSRLY ELLRYADYQQFDSSIYNFVRQGDRP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1380 | - | - | 100% (305) | methylisocitrate lyase 2 |
| M. marinum M | MMAR_0514 | - | 2e-11 | 25.34% (221) | PEP phosphonomutase |
| M. marinum M | MMAR_2821 | aceAb | 8e-10 | 30.39% (204) | isocitrate lyase AceAb |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1950 | aceA | 4e-10 | 32.00% (175) | isocitrate lyase |
| M. gilvum PYR-GCK | Mflv_0391 | - | 9e-12 | 28.71% (202) | hypothetical protein Mflv_0391 |
| M. tuberculosis H37Rv | Rv1915 | aceAa | 3e-09 | 31.43% (175) | isocitrate lyase |
| M. leprae Br4923 | MLBr_01985 | aceA | 8e-11 | 29.15% (199) | isocitrate lyase |
| M. abscessus ATCC 19977 | MAB_4618 | - | 1e-127 | 75.50% (302) | carboxyvinyl-carboxyphosphonate phosphorylmutase |
| M. avium 104 | MAV_0345 | prpB | 1e-138 | 82.00% (300) | methylisocitrate lyase |
| M. smegmatis MC2 155 | MSMEG_6646 | prpB | 1e-130 | 77.08% (301) | methylisocitrate lyase |
| M. thermoresistible (build 8) | TH_1918 | - | 2e-12 | 30.52% (213) | transferase |
| M. ulcerans Agy99 | MUL_1177 | - | 4e-11 | 29.57% (186) | PEP phosphonomutase |
| M. vanbaalenii PYR-1 | Mvan_2977 | - | 1e-12 | 32.50% (200) | isocitrate lyase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MSMEG_6646|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0391|M.gilvum_PYR-GCK --------------------------------------------------
TH_1918|M.thermoresistible__bu --------------------------------------------------
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb1950|M.bovis_AF2122/97 ------------------------------------MAIAETDTEVHTPF
Rv1915|M.tuberculosis_H37Rv ------------------------------------MAIAETDTEVHTPF
MLBr_01985|M.leprae_Br4923 MAGIPATVVQRCNSTNLDDRLHYSPLGDRAKEERNPMAIMDTNTEVHTLF
Mvan_2977|M.vanbaalenii_PYR-1 ------------------------------------MAIIEADAFQPHAT
MMAR_1380|M.marinum_M ---------------------------------------MKTVLGTAVSA
MAV_0345|M.avium_104 ---------------------------------------MRDMIGAARSP
MSMEG_6646|M.smegmatis_MC2_155 ---------------------------------------MSGLMGSTVSA
MAB_4618|M.abscessus_ATCC_1997 ---------------------------------------MSTLLASATDA
Mflv_0391|M.gilvum_PYR-GCK -------------------------------------------MARTEDL
TH_1918|M.thermoresistible__bu -------------------------------------------------L
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb1950|M.bovis_AF2122/97 EQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVAREAA
Rv1915|M.tuberculosis_H37Rv EQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVAREAA
MLBr_01985|M.leprae_Br4923 TQ----EVAATQQYFDDPRFAGIIRLYTARQVVEQRGTIPTDYTVARDAA
Mvan_2977|M.vanbaalenii_PYR-1 GEPFERDVAETQRYFDSPRFDGITRLYTARQVAEQRGTIPADYPTAREAA
MMAR_1380|M.marinum_M TEKRTGFRAALESGRLLRFPGAYSPLVARLVAEIGFDGVYVSGAALSADL
MAV_0345|M.avium_104 EQKRAQLRAALESGRLQRFPGAFSPLVAKLVAELGFDGVYVSGAALSADL
MSMEG_6646|M.smegmatis_MC2_155 AQKRKAFRDALDSGRLQRMPGAFSPLVAKSLTDIGFDGIYVSGAVLSADL
MAB_4618|M.abscessus_ATCC_1997 ATKRAAFRQGLSSGELLRLPGAFSPLVAKLIQEIGFEGVYVSGAVLSADL
Mflv_0391|M.gilvum_PYR-GCK KARAEALLALHQPGNPVILPTVWDAWSAHLAVDAGFSALTVGSHPLADSI
TH_1918|M.thermoresistible__bu QKRASDFLALHRPGDPVVLPTVWDAWSARLAVDAGFPALTVGSHPVADSL
MUL_1177|M.ulcerans_Agy99 -----------------MLSTVWDAWSARLAANAGFAALTVGSHPLADSI
Mb1950|M.bovis_AF2122/97 GAFYERLRELFAARKSITTFGPYSPGQAVSMKRMGIEAIYLGGWATSAKG
Rv1915|M.tuberculosis_H37Rv GAFYERLRELFAARKSITTFGPYSPGQAVSMKRMGIEAIYLGGWATSAKG
MLBr_01985|M.leprae_Br4923 TAFYARLRELFAAGKSVTTFGPYSPGQAVSLKRMGIEAIYLGGWATSAKG
Mvan_2977|M.vanbaalenii_PYR-1 TAFYPHLRELFAKGKSITTFGPYSPGQAVVMKRMGIEGVYLGGWATSAKG
:.. * *: .: :.. : .
MMAR_1380|M.marinum_M GL-----PDIGLTTLTEVSARGAQIAAASELP------------------
MAV_0345|M.avium_104 GL-----PDIGLTTLTEVSGRGAQIAAVTELP------------------
MSMEG_6646|M.smegmatis_MC2_155 GL-----PDIGLTTLTEVVTRSAQIASATDLF------------------
MAB_4618|M.abscessus_ATCC_1997 AL-----PDIGLTTLTEVSARGRQIASVTDLP------------------
Mflv_0391|M.gilvum_PYR-GCK GK-----PDNEGMTFDDVLTRVAQITAAVDVP------------------
TH_1918|M.thermoresistible__bu GK-----ADNEGMTFDDVLTRVGQITAAVEVP------------------
MUL_1177|M.ulcerans_Agy99 GK-----PDNEGMSFDDVLARVAQITAAVDIP------------------
Mb1950|M.bovis_AF2122/97 SSTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSERQRAA
Rv1915|M.tuberculosis_H37Rv SSTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSERQRAA
MLBr_01985|M.leprae_Br4923 SITEDPGPDLASYPLSQVPDDAAVLVRALLAADRNQQYLRLHMTEQQRAA
Mvan_2977|M.vanbaalenii_PYR-1 SISEDPGPDLASYPLSQVPEEAASIVRALLTADRNQHYLRLQMDPEQRAA
. .* .: :* :. .
MMAR_1380|M.marinum_M ---------TFIDADTGFGEPMSAARTVAVLEDAGLAGCHLEDQVNPK--
MAV_0345|M.avium_104 ---------TLIDADTGFGEPLNAARTVTMLEYAGLAGCHLEDQVNPK--
MSMEG_6646|M.smegmatis_MC2_155 ---------TLVDADTGFGEPMSAARTVTLLEDAGLAGCHLEDQVNPK--
MAB_4618|M.abscessus_ATCC_1997 ---------TLIDADTGFGEPMSAARTVAVLEDSGVAGLHLEDQVNPK--
Mflv_0391|M.gilvum_PYR-GCK ---------LSVDIESGYAE--EPGRLIDGLLSVDAVGLNIEDTVHSEGG
TH_1918|M.thermoresistible__bu ---------VSVDIESGYAE--SPERLITGLLDAGAVGLNIEDTVHSEGR
MUL_1177|M.ulcerans_Agy99 ---------VSVDIESGYGL--DAQRLIEGLLNVGAVGLNIEDTVHSEGA
Mb1950|M.bovis_AF2122/97 TPAYDFRPFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGT-K
Rv1915|M.tuberculosis_H37Rv TPAYDFRPFIIADAGTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGT-K
MLBr_01985|M.leprae_Br4923 TPAYDYRPFIIADADTGHGGDSHVRNLIRRFVEIGVPGYHIEDQRPGT-K
Mvan_2977|M.vanbaalenii_PYR-1 APEYDYRPFIIADADTGHGGDPHVRNLIRRFVEAGVPGYHIEDQRPGT-K
* :*.. . : : . * ::**
MMAR_1380|M.marinum_M RCGHLDGKAVVPVGVMVSRLRAA--VSARRDPNFIVCARTDAAAVEGPS-
MAV_0345|M.avium_104 RCGHLDGKAVVPVDEMVRRLRAA--VSARRDPNFVVCARTDAAAIEGLP-
MSMEG_6646|M.smegmatis_MC2_155 RCGHLDGKAVVPAEDMVKRLRAA--VAARRDPNFIICARTDAAGIEGID-
MAB_4618|M.abscessus_ATCC_1997 RCGHLDGKAVVETVEMVRRLHAA--VSARRDPNFVICARTDAAGIEGLP-
Mflv_0391|M.gilvum_PYR-GCK RLRSSGEHAALVGGLRAAADAAG--VHVVVNARTDLFLRQDGDEADRVD-
TH_1918|M.thermoresistible__bu RLRSVAEHAELVGALRAAADAAG--VHVVVNARTDLFLRQDGDESDRVD-
MUL_1177|M.ulcerans_Agy99 RLRSRREHAELVGALRSAADAAG--VHVVLNARTDLFLRRDGDPADRFE-
Mb1950|M.bovis_AF2122/97 KCGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDS
Rv1915|M.tuberculosis_H37Rv KCGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDS
MLBr_01985|M.leprae_Br4923 KCGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDS
Mvan_2977|M.vanbaalenii_PYR-1 KCGHQGGKVLVPSDEQIKRLNTARFQLDIMRVPGIIVARTDAEAANLIDS
: :. : :. : * *. :
MMAR_1380|M.marinum_M AAIDRAKAYADAGADLIFTEALRTPAEFEQFRAAVDTPLLANMTEFGKSG
MAV_0345|M.avium_104 AAIERARAYADAGADLIFTEALQCPTEFERFRAALDTPLLANMTEFGKSP
MSMEG_6646|M.smegmatis_MC2_155 AAIERAKTYADAGADLIFTEALSTPEEFAAFRAAVDTPLLANMTEFGKSE
MAB_4618|M.abscessus_ATCC_1997 AAIDRARAYADAGADLIFTEALTDIGEFEKFRAAVDIPLLANMTEFGKSE
Mflv_0391|M.gilvum_PYR-GCK RAIARLKEAADAGADVLYPVGVHPPEVMRRLTSELPLPVNAIARPDQSD-
TH_1918|M.thermoresistible__bu RAIARLTECARAGADVLYPVGRHDPDILRRLATELPLPVNAIAAPDQAD-
MUL_1177|M.ulcerans_Agy99 RAVAWLTEAAAAGADVLYPVGRHDPDTLRRLAAQLPLPINAIALPDQDD-
Mb1950|M.bovis_AF2122/97 RADERDQPFLLGATKLDVPSYKSCFLAMVRRFYELGVKELNGHLLYALGD
Rv1915|M.tuberculosis_H37Rv RADERDQPFLLGATKLDVPSYKSCFLAMVRRFTNWASRSS--MVIFSMR-
MLBr_01985|M.leprae_Br4923 RADERDQPFLLGATNLKIPSYKACFLALVRCFYELGVKELHGHLLYALGD
Mvan_2977|M.vanbaalenii_PYR-1 RADERDQPFLLGATNLKIPSYKSCFLAMVRRFYEKGMTELNGHLLYALPE
* ..:.: . :
MMAR_1380|M.marinum_M LLSTDQLREIGYNVVIY---------------------------------
MAV_0345|M.avium_104 LLGADRLADIGYNVVIY---------------------------------
MSMEG_6646|M.smegmatis_MC2_155 LVNARELADIGYNVVIY---------------------------------
MAB_4618|M.abscessus_ATCC_1997 LVTADRLREVGYNVVIY---------------------------------
Mflv_0391|M.gilvum_PYR-GCK --------------------------------------------------
TH_1918|M.thermoresistible__bu --------------------------------------------------
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb1950|M.bovis_AF2122/97 SEYAAAGGWLERQGIFGLVSDAVNAWREDGQQSIDGIFDQVESRFVAAWE
Rv1915|M.tuberculosis_H37Rv --LATAS---TRRPAVGLSAKAFSAW------------------------
MLBr_01985|M.leprae_Br4923 GEYAAASAWLDRQGILAQVSGTVNAWQENGKQSIDDLFEQVEYRLLAAWE
Mvan_2977|M.vanbaalenii_PYR-1 GEYATATAWLDRQGVLNLIDETASAWQAGTESSVDAAFDRVESRFVDAWQ
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MSMEG_6646|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0391|M.gilvum_PYR-GCK --------------------------------------------------
TH_1918|M.thermoresistible__bu --------------------------------------------------
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb1950|M.bovis_AF2122/97 DDAGLMTYGEAVADVLEFGQSEGEPIGMAPEEWRAFAARASLHAARAKAK
Rv1915|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01985|M.leprae_Br4923 KDAGLMTYGEAVEEMLQFGESEGELIGMSPEEWRRFVGRASLYAAREKAK
Mvan_2977|M.vanbaalenii_PYR-1 DDAGLNTYGEAVAELLEFREREGEPSSMSVADWRMFAERAPLYTAREKAK
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MSMEG_6646|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0391|M.gilvum_PYR-GCK --------------------------------------------------
TH_1918|M.thermoresistible__bu --------------------------------------------------
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb1950|M.bovis_AF2122/97 ELGADPPWDCELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTA
Rv1915|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01985|M.leprae_Br4923 ELGVDPGWDCELAKTPEGYYQIRGGIQYAIAKSLAAAPFADILWMETKTA
Mvan_2977|M.vanbaalenii_PYR-1 ELGADVAWDCERVKTPEGYYQVRGGIPYAIAKSLAAAPFADILWMETKTA
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MSMEG_6646|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0391|M.gilvum_PYR-GCK --------------------------------------------------
TH_1918|M.thermoresistible__bu --------------------------------------------------
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb1950|M.bovis_AF2122/97 DLADARQFAEAIHAEFPDQMLAYNLSPSFNWDTTGMTDEEMRRFPEELGK
Rv1915|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01985|M.leprae_Br4923 DLADARQFAEAIHAEFPEQMLAYNLSPSFNWDTTGMSDEEMKRFPEELGK
Mvan_2977|M.vanbaalenii_PYR-1 DLADAKQFADAIHAVYPDKMLAYNLSPSFNWDTTGMSDEEMRTFPEEIGK
MMAR_1380|M.marinum_M -----------------------------------------------PVT
MAV_0345|M.avium_104 -----------------------------------------------PVT
MSMEG_6646|M.smegmatis_MC2_155 -----------------------------------------------PVT
MAB_4618|M.abscessus_ATCC_1997 -----------------------------------------------PVT
Mflv_0391|M.gilvum_PYR-GCK -----------------------------------------------PAS
TH_1918|M.thermoresistible__bu -----------------------------------------------PAS
MUL_1177|M.ulcerans_Agy99 -----------------------------------------------PAS
Mb1950|M.bovis_AF2122/97 MGFVFNFITYGGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVESPYR
Rv1915|M.tuberculosis_H37Rv ----------------------------------------------SPTR
MLBr_01985|M.leprae_Br4923 MGFVFNFITYGGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVESPYR
Mvan_2977|M.vanbaalenii_PYR-1 MGFVFNFITYGGHQVDGVASEEFATSLRQEGMLALARLQRKMRLVESPYR
*
MMAR_1380|M.marinum_M TLRLAMYAVEAG-LREIADAGTQSGLLN----------------------
MAV_0345|M.avium_104 TLRLAMHAVEAG-LREIADTGTQSGLLD----------------------
MSMEG_6646|M.smegmatis_MC2_155 TLRLAMHAVEIG-MREVFDAGTQSGLLG----------------------
MAB_4618|M.abscessus_ATCC_1997 TLRLAMYAVEQG-LHEINSAGTQSGLLE----------------------
Mflv_0391|M.gilvum_PYR-GCK YGPLGVARISFGPFWQAALAERSKELLA----------------------
TH_1918|M.thermoresistible__bu FGPLGVARISFGPFFQAALAVRAGEILA----------------------
MUL_1177|M.ulcerans_Agy99 FGRLGVARISVGPFLQAGLSGRATELLA----------------------
Mb1950|M.bovis_AF2122/97 TPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPRKLLEE
Rv1915|M.tuberculosis_H37Rv STR---GGR------TASSRSTAFSTRSSRGS------------------
MLBr_01985|M.leprae_Br4923 TPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPKKLLEE
Mvan_2977|M.vanbaalenii_PYR-1 TPQTLVGGPRSDAALAASSGRTATTKSMGKGSTQHQHLVQTEVPKKLLEE
MMAR_1380|M.marinum_M -----------------RMQQRSRLYELLRYADYQQFDSSIYNFVRQGDR
MAV_0345|M.avium_104 -----------------RMQHRSRLYQLLRYADYNHFDSDIYNFPR----
MSMEG_6646|M.smegmatis_MC2_155 -----------------SMQHRSRLYELLRYADYNQFDSDIYNFAVQEVR
MAB_4618|M.abscessus_ATCC_1997 -----------------QMQHRSRLYELLHYAEYNRFDTEIFNFSLDGGQ
Mflv_0391|M.gilvum_PYR-GCK -----------------RWR------------------------------
TH_1918|M.thermoresistible__bu -----------------RWR------------------------------
MUL_1177|M.ulcerans_Agy99 -----------------RWR------------------------------
Mb1950|M.bovis_AF2122/97 WLAMWSGHYQLKDKLRVQLRPQRAGSEVLELGIHGESDDKLANVIFQPIQ
Rv1915|M.tuberculosis_H37Rv ------------------WRPGRTTRA-----------------------
MLBr_01985|M.leprae_Br4923 WLALWSEHYQLGEKLRVQLRPRRAGSDVLELGIYGNGDEQLANVIVDPIK
Mvan_2977|M.vanbaalenii_PYR-1 WLGLWSEHYQLPERLHVQLRPRRAGSDVLDLQILGDSEEPLANVVVDPIK
:
MMAR_1380|M.marinum_M P-------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MSMEG_6646|M.smegmatis_MC2_155 A-------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0391|M.gilvum_PYR-GCK --------------------------------------------------
TH_1918|M.thermoresistible__bu --------------------------------------------------
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb1950|M.bovis_AF2122/97 DRRGRTILLVRDQNTFGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTDD
Rv1915|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01985|M.leprae_Br4923 DRRGRSILQVRDQNTFAEKLRQKRLMTLIHFWLVHRFKADTVIYVTPTED
Mvan_2977|M.vanbaalenii_PYR-1 DRHGRSILTVRDQNTFAEQMRQKRLMDLIHLWLIHRFKAEIVYYVTPTED
MMAR_1380|M.marinum_M --------------------------------------------------
MAV_0345|M.avium_104 --------------------------------------------------
MSMEG_6646|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4618|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0391|M.gilvum_PYR-GCK --------------------------------------------------
TH_1918|M.thermoresistible__bu --------------------------------------------------
MUL_1177|M.ulcerans_Agy99 --------------------------------------------------
Mb1950|M.bovis_AF2122/97 NLYQTSKMKSHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLIT
Rv1915|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01985|M.leprae_Br4923 NLYQTSKMKSHGIFSEVYQEVGEIIVAEVNHPRLVELLTPDRVALRRLIT
Mvan_2977|M.vanbaalenii_PYR-1 NIYQTEKMKSHGIFSDVYQEVGEIIVADVNQARIDELLAPDRKALIRLIN
MMAR_1380|M.marinum_M ---
MAV_0345|M.avium_104 ---
MSMEG_6646|M.smegmatis_MC2_155 ---
MAB_4618|M.abscessus_ATCC_1997 ---
Mflv_0391|M.gilvum_PYR-GCK ---
TH_1918|M.thermoresistible__bu ---
MUL_1177|M.ulcerans_Agy99 ---
Mb1950|M.bovis_AF2122/97 KEA
Rv1915|M.tuberculosis_H37Rv ---
MLBr_01985|M.leprae_Br4923 KEG
Mvan_2977|M.vanbaalenii_PYR-1 KQD