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VCTACEWAPHFTRPDADGPAPTRKPPRRSPEATAHRTGSADAHADFVFTNGRVHTVAGASPWAEAVAVRG NTITHVGRTAEVLSAAGPRTRVIDLGGRLLMPGFVEGHTHPMLGAFLSHGVDLQVPTKDDALAAIAAHAE QHPEGVVRGFGWRVDMFGPDGPSRADLDRVLPDRPGLFFAIDAHSMWANTAALQMAGIDRDTPDPVPGFS YFQRDADGEPTGYVLEVNAVLGLVDAVEPISAPGMRRMLEGWLPAAAAAGITTVFDAGVPPVGGDQAAMI ALYADLDEAGALPFRVVASYAIKSPPPGGRFEDVLAQFRAARDSVGTDLVNVDVLKIVGDGTQGGYTAWL IEPYADRPDSTGSSPFTEEQWHEMIGLFDAAGVNVHVHACGECTARVALDAIERAVAVNGPRDRRHTIAH LVFVDDADAARFAELGVVAQFSANWFSADPDTVQNMAARYGSPRKDHLYRARDILRAGGRISLGTDWPAA GYFSTHKPLDAIEIAVTRQLIGDAHAPVLSPADQRLSVAEAVHANTLGAAYQLRLDDVVGSVEVGKRADL IVLDTDIFKIDPHDIHTAEVVLTMMDGRIRHDTSRVSDAAPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4289 | - | - | 100% (602) | amidohydrolase |
| M. smegmatis MC2 155 | MSMEG_0445 | - | 3e-67 | 35.12% (561) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_1102 | - | 1e-46 | 31.25% (560) | twin-arginine translocation pathway signal |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0567 | - | 2e-48 | 31.14% (562) | hypothetical protein Mb0567 |
| M. gilvum PYR-GCK | Mflv_2930 | - | 0.0 | 64.31% (608) | amidohydrolase 3 |
| M. tuberculosis H37Rv | Rv0552 | - | 2e-48 | 31.14% (562) | hypothetical protein Rv0552 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2546 | - | 0.0 | 65.08% (610) | amidohydrolase |
| M. marinum M | MMAR_0898 | - | 5e-50 | 31.99% (569) | hypothetical protein MMAR_0898 |
| M. avium 104 | MAV_4591 | - | 7e-54 | 32.26% (561) | amidohydrolase family protein |
| M. thermoresistible (build 8) | TH_0262 | - | 6e-06 | 23.25% (357) | amidohydrolase |
| M. ulcerans Agy99 | MUL_0651 | - | 1e-50 | 31.99% (569) | hypothetical protein MUL_0651 |
| M. vanbaalenii PYR-1 | Mvan_1184 | - | 2e-57 | 32.31% (554) | amidohydrolase 3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2930|M.gilvum_PYR-GCK MCTACEWAPHFAAYGRRNPVTRRTALRAAAVTALAVTAAACATGPDSDTS
MAB_2546|M.abscessus_ATCC_1997 MCTACEWAPHFAALSAKS--TRRTALRAAVALTLAAGAAACSAGTVPAPT
MSMEG_4289|M.smegmatis_MC2_155 MCTACEWAPHFTRPDADGPAPTRKPPRRS-----------------PEAT
Mb0567|M.bovis_AF2122/97 --------------------------------------------------
Rv0552|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0898|M.marinum_M --------------------------------------------------
MUL_0651|M.ulcerans_Agy99 --------------------------------------------------
MAV_4591|M.avium_104 --------------------------------------------------
Mvan_1184|M.vanbaalenii_PYR-1 ------------------------------------------------MT
TH_0262|M.thermoresistible__bu --------------------------------------------------
Mflv_2930|M.gilvum_PYR-GCK VTSAASGAEAPDFVFHNGRVYTVTESAPWAEAVVVTGNSITFVGDNAAAR
MAB_2546|M.abscessus_ATCC_1997 TGSAGPQNTHADFVFRNGRVYTVAGPTEWAQAVAVQGNAITHVGDEAGAM
MSMEG_4289|M.smegmatis_MC2_155 AHRTGSADAHADFVFTNGRVHTVAGASPWAEAVAVRGNTITHVGRTAEVL
Mb0567|M.bovis_AF2122/97 -------MADADLVMT-GTVLTVDDARPTAEAIAVADGRVIAVGDRSEVA
Rv0552|M.tuberculosis_H37Rv -------MADADLVMT-GTVLTVDDARPTAEAIAVADGRVIAVGDRSEVA
MMAR_0898|M.marinum_M -------MADADVVIT-GTVLTVDDTRPTAEAIAVTDGRIVAVGDRSEVA
MUL_0651|M.ulcerans_Agy99 -------MADADVVIT-GTVLTVDDTRPTAEAIAVTDGRVVAVGDRSEVA
MAV_4591|M.avium_104 -----MHMGQADLVLT-GTVLTVDEARPTAEALAVADGRIVAVGTRAEIA
Mvan_1184|M.vanbaalenii_PYR-1 NDTEIAVLTAPPTLFTGGTIWTGRGD---TDAVLVDGGVVVALGDEARRR
TH_0262|M.thermoresistible__bu -------VTATTVLRAARWVDVAAGEVCSPAVVVVDGDRISAVNPVESPR
. : : . . .: * .. : :.
Mflv_2930|M.gilvum_PYR-GCK ALAGPDTEVIDLAGKLLMPGFVEGHIHPFLGSFLSTG-----VDLQVPTR
MAB_2546|M.abscessus_ATCC_1997 ALVGPNTRVVDLAGRLLMPGFVEGHIHPFFGAFLSGG-----VNLQVSTK
MSMEG_4289|M.smegmatis_MC2_155 SAAGPRTRVIDLGGRLLMPGFVEGHTHPMLGAFLSHG-----VDLQVPTK
Mb0567|M.bovis_AF2122/97 GLVGANTRVIDLGAGCVMPGFVEAHGHPLLEAVVLSDRFVDIRPVTMRDA
Rv0552|M.tuberculosis_H37Rv GLVGANTRVIDLGAGCVMPGFVEAHGHPLLEAVVLSDRFVDIRPVTMRDA
MMAR_0898|M.marinum_M GLIGEGTRTIDLGSGCLMPGFVEAHGHPLMEAIVLSGRIVDIRPVTVRDS
MUL_0651|M.ulcerans_Agy99 GLIGEGTRTIDLGSGCLMPGFVEAHGHPLMEAIVLSGRIVDIRPVTVRDS
MAV_4591|M.avium_104 AHVGPHTQTVDIGDGCVMPGFVEAHGHPLMEAVALSDRIVDIRPVTLANA
Mvan_1184|M.vanbaalenii_PYR-1 ----GGAHHVDLDGGFLMPSFADGHAHPLYGGLEAVG----PPVRRCGSV
TH_0262|M.thermoresistible__bu ----DPAVELDLGDVTLLPGLMDMELNLLIGGPGGPS---GLPSPMHGVQ
: :*: ::*.: : . : : . .
Mflv_2930|M.gilvum_PYR-GCK QDALNAIAAYATDKADGPVRGFGWR-VDMFGPQGPTRTELDSVLPDRPGF
MAB_2546|M.abscessus_ATCC_1997 EAALAAIAKYAEENPVGPVRGFGWR-VDMFGPEGPTRQELDSVLPDRPGF
MSMEG_4289|M.smegmatis_MC2_155 DDALAAIAAHAEQHPEGVVRGFGWR-VDMFGPDGPSRADLDRVLPDRPGL
Mb0567|M.bovis_AF2122/97 DDVVAAIRGEVARRGPAGAYLVGWDPLLQSGLGEPTLTWLDSLAPNGPLV
Rv0552|M.tuberculosis_H37Rv DDVVAAIRGEVARRGPAGAYLVGWDPLLQSGLGEPTLTWLDSLAPNGPLV
MMAR_0898|M.marinum_M ERVVAEICREAGERGSAGAYLIGWDPLLQPGLPEPTLAWLDDIAPNGPLV
MUL_0651|M.ulcerans_Agy99 ERVVAEICREAGERGSAGAYLIGWDPLLQPGLPEPTLAWLDDIAPNGPLV
MAV_4591|M.avium_104 DDVVAAVKSEVGKRGEAGAYLNGWDPLLQQGLPQPTLAWLDDIAPDGPLV
Mvan_1184|M.vanbaalenii_PYR-1 DEIVRAVQRYAADHPDEDWIVGASYDSSLAPEGLFDARWLDAAVPDRPVV
TH_0262|M.thermoresistible__bu DDPVYRTLRAAVN--ARTTLRAGFTTVRNLGLMVKTGGYLLDVALQRAID
: : . . * : .
Mflv_2930|M.gilvum_PYR-GCK FFAIDGHSMWANSKALEMAGISRDSEDPIPGFSYYVRDENGEPTGYVLEV
MAB_2546|M.abscessus_ATCC_1997 FFAVDAHSMWANSKSLEVAGINRETPDPVPGFSYYAKDSHGEPTGFILEI
MSMEG_4289|M.smegmatis_MC2_155 FFAIDAHSMWANTAALQMAGIDRDTPDPVPGFSYFQRDADGEPTGYVLEV
Mb0567|M.bovis_AF2122/97 IIHNSGHKAYFNSHAAWLNGLTRDTADPKG--AKYGRDGNGELDGTAEEI
Rv0552|M.tuberculosis_H37Rv IIHNSGHKAYFNSHAAWLNGLTRDTADPKG--AKYGRDGNGELDGTAEEI
MMAR_0898|M.marinum_M IIHNSGHKAYFNTHAAWLNGLTRDTPDPKG--AKYGRDANGELDGTAEET
MUL_0651|M.ulcerans_Agy99 IIHNSGHKAYFNTHAAWLNGLTRDTPDPKG--AKYGRDANGELDGTAEET
MAV_4591|M.avium_104 IIHNSGHKAFFNSRAAQRHGLNRDTPDPKG--ARYGRDADGELDGTAEET
Mvan_1184|M.vanbaalenii_PYR-1 LRAWDYHTVWCNSAALQRAGITAETPEPVLG--EIPRRADGSPLGTLREW
TH_0262|M.thermoresistible__bu QGWHDGPRIYPAGHAVTPYGGHLDP-------TVFQRLAPG-----IMPL
. : : * :. : *
Mflv_2930|M.gilvum_PYR-GCK DAVLGLVNAIEPISTDSMEQLLRAWLPKASEAGITSVFDAGVPPIGGDQG
MAB_2546|M.abscessus_ATCC_1997 SAILDLVNAIEPVTAQSLQRALEDWLPNAAAAGITSVFDAGVPAVAS-QA
MSMEG_4289|M.smegmatis_MC2_155 NAVLGLVDAVEPISAPGMRRMLEGWLPAAAAAGITTVFDAGVPPVGGDQA
Mb0567|M.bovis_AF2122/97 GAILPLLAGVADP--SNFGAMLRAECARLNRAGLTTCSEMAFDPGYRPMV
Rv0552|M.tuberculosis_H37Rv GAILPLLAGVADP--SNFGAMLRAECARLNRAGLTTCSEMAFDPGYRPMV
MMAR_0898|M.marinum_M GAVLPLLAGVTDP--SNYPAMLRAECARLNRAGLTTCSEMAFDPGFRPLV
MUL_0651|M.ulcerans_Agy99 GAVLPLLAGVTDP--SNYPAMLRAECARLNRAGLTTCLEMAFDPGFRPLV
MAV_4591|M.avium_104 GAVFPLLDGAIDT--AGYPRMLHAECARLNRAGLTTCSEMAFDPRFRPMV
Mvan_1184|M.vanbaalenii_PYR-1 GATDLVMNAMPPRDEAVRVGALGTAADYYLSRGVTWVQDAWVEPADVATY
TH_0262|M.thermoresistible__bu SVAEGIANGVDDVR------------------------------------
.. : .
Mflv_2930|M.gilvum_PYR-GCK ALIELYTNVESRGELPFRVVASYSVKSPP----VDDAVAELTGIRDRISS
MAB_2546|M.abscessus_ATCC_1997 ALIGLYGDIERRGRLPFRVVASYTVKAPP----FGDVVAKFAETRDQVST
MSMEG_4289|M.smegmatis_MC2_155 AMIALYADLDEAGALPFRVVASYAIKSPPPGGRFEDVLAQFRAARDSVGT
Mb0567|M.bovis_AF2122/97 EAVRAELTVR---------LCTYEISNAR----------MCTDATPGQGD
Rv0552|M.tuberculosis_H37Rv EAVRAELTVR---------LCTYEISNAR----------MCTDATPGQGD
MMAR_0898|M.marinum_M EQLRDELTVR---------LRTYEISNAQ----------LSTEASPGDGD
MUL_0651|M.ulcerans_Agy99 EQLRDELTVR---------LRTYEISNAQ----------LSTEASPGDGD
MAV_4591|M.avium_104 EQLRGQLTVR---------LRSYEISNPQ----------LRTDATPGEGD
Mvan_1184|M.vanbaalenii_PYR-1 VAAAGQGALRMR-------FNLALYADPRHFDAQVTQFAEQRALVEAARS
TH_0262|M.thermoresistible__bu ---------------------------------------ACVRYQIRHGA
Mflv_2930|M.gilvum_PYR-GCK DLVQVNVVKIIGDGTQEGYTAWLLEPYAD---------KPDSIGGSPFTD
MAB_2546|M.abscessus_ATCC_1997 DLVRVGAVKIMGDGTQGGYTAWLIDPYAD---------KPDSIGTSPFTE
MSMEG_4289|M.smegmatis_MC2_155 DLVNVDVLKIVGDGTQGGYTAWLIEPYAD---------RPDSTGSSPFTE
Mb0567|M.bovis_AF2122/97 DMLRQVGIKIWVDGSPWVGNIDLTFPYLDTPATRAIGVPPGSRGCANYTR
Rv0552|M.tuberculosis_H37Rv DMLRQVGIKIWVDGSPWVGNIDLTFPYLDTPATRAIGVPPGSRGCANYTR
MMAR_0898|M.marinum_M DMLRQVGIKIWVDGSPWIGNIDLSFPYLDTAATRTIGVTPGSCGCANYTR
MUL_0651|M.ulcerans_Agy99 DMLRQVGIKIWVDGSPWIGNIDLSFPYLDTAATRTIGVTPGSCGCANYTR
MAV_4591|M.avium_104 DMLRQVGIKIWVDGSPWIGNIALSFPYLDTEATRTIGVTPGSCGCANYTT
Mvan_1184|M.vanbaalenii_PYR-1 PLLTAQTVKFFADGVVENETGALLAPYCTG--------LHDHAGQHNWEG
TH_0262|M.thermoresistible__bu KLIKVSASGGVMSHS-------------------------TAPGAQQFSD
:: . * :
Mflv_2930|M.gilvum_PYR-GCK DQWRQLVREVDAAGFDVHIHACGERTARTALDSIEAAAKVNPARERRHTV
MAB_2546|M.abscessus_ATCC_1997 QEWGELVGRIDSAGIDMHVHACGERTARVALDAFEAAIANNPARDRRHTV
MSMEG_4289|M.smegmatis_MC2_155 EQWHEMIGLFDAAGVNVHVHACGECTARVALDAIERAVAVNGPRDRRHTI
Mb0567|M.bovis_AF2122/97 EQLAEIVGAYFPRGWQIACHVHGDGGVDTILDVYEEALRRNPRDDHRLRL
Rv0552|M.tuberculosis_H37Rv EQLAEIVGAYFPRGWQIACHVHGDGGVDTILDVYEEALRRNPRDDHRLRL
MMAR_0898|M.marinum_M EQLAEIVGAYFPLGWPIACHVQGDAGVDTILDVYEEALRSNPRPDHRLRL
MUL_0651|M.ulcerans_Agy99 EQLAETVGAYFPLGWPIACHVQGDAGVDTTLDVYEEALRSNPRPDHRLRL
MAV_4591|M.avium_104 EQLREIVGAYFPLGWQLACHVQGDAGVDTILDVYEEALKRHPRDDHRLRL
Mvan_1184|M.vanbaalenii_PYR-1 ESLAEAARRVDELGLQIHIHAIGDAAVRQALDAIEYVAAQNGPRDRRAVI
TH_0262|M.thermoresistible__bu EELSAIADEAHRAGVRVAAHAVGDSAIRACIRAGIDCVEHG----FLASD
:. * : *. *: :
Mflv_2930|M.gilvum_PYR-GCK AHLVYLEEPDSRRFGDLGVIAEFSANWFSADPDTVINLAARYGAPRKDNL
MAB_2546|M.abscessus_ATCC_1997 AHLIYVDDADSARFAKLGVVAQFSANWFSADPDTVVNMAARYGAPRKDNF
MSMEG_4289|M.smegmatis_MC2_155 AHLVFVDDADAARFAELGVVAQFSANWFSADPDTVQNMAARYGSPRKDHL
Mb0567|M.bovis_AF2122/97 EHVGAIRPDQLRRAAELGVTCSIFVDQIHYWGDVIV--DDLFGAQRGSRW
Rv0552|M.tuberculosis_H37Rv EHVGAIRPDQLRRAAELGVTCSIFVDQIHYWGDVIV--DDLFGAQRGSRW
MMAR_0898|M.marinum_M EHVGAIRPEQLRRAADLGVTCSIFVDQIHYWGDVIV--DGLFGPERGSRW
MUL_0651|M.ulcerans_Agy99 EHVGAIRPEQLRRAADLGVTCSIFVDQIHYWGDAIV--DGLFGPERGSRW
MAV_4591|M.avium_104 EHVGAIRPDQLQRAADLGVTCSIFVDQIHYWGDVLV--DGLFGEERGSRW
Mvan_1184|M.vanbaalenii_PYR-1 AHCQLVDRDDLDRFAALSVIPNMQPLWAQLDALMTVLTIPRLGADRADSQ
TH_0262|M.thermoresistible__bu ETLQMMADTGTFLVSTTYLTEAMAVDRIAPELRKKA--EEVFPRARS---
: . : : *
Mflv_2930|M.gilvum_PYR-GCK YRIQDVLSSGGRVSLGTDWPAAGYFSTYKPLDSIQIGVTRQLIGDPAAEV
MAB_2546|M.abscessus_ATCC_1997 YRIQDILRTGAHVALGTDWPAAGYFSTYKPLESIQIGVTRQLIGDPGAQV
MSMEG_4289|M.smegmatis_MC2_155 YRARDILRAGGRISLGTDWPAAGYFSTHKPLDAIEIAVTRQLIGDAHAPV
Mb0567|M.bovis_AF2122/97 MPAGSAVAAGMRISLHNDPPVT----PEEPLRNISVAATRVAPSGR----
Rv0552|M.tuberculosis_H37Rv MPAGSAVAAGMRISLHNDPPVT----PEEPLRNISVAATRVAPSGR----
MMAR_0898|M.marinum_M MPAGSAVATGMRISLHNDPPVT----PEEPLRNISVAATRVAPSGR----
MUL_0651|M.ulcerans_Agy99 MPAGSAVATGMRISLHNDPPVT----PEEPLRNISVAATRVAPSDR----
MAV_4591|M.avium_104 MPAGSAVATGMRISLHNDPPVT----PEEPLRNISVAATRKAPSGR----
Mvan_1184|M.vanbaalenii_PYR-1 YPIRTLDASGAPLAFGSDWPVS----SGAPLDGVAVAASRTTSDGD-PPG
TH_0262|M.thermoresistible__bu -MLPKAIAAGVRIACGTDAPAIP---HGENARELCALVDRG---------
:* :: .* *. : . *
Mflv_2930|M.gilvum_PYR-GCK LSPADQKLTVEQAVHANTLGAAYQLRLDGLVGSVETGKRADLIVVDRNIF
MAB_2546|M.abscessus_ATCC_1997 LRPHDQKLSVAEAVRANTLGAAYQIRMDNKVGSVEVGKLADLIVLDRNIL
MSMEG_4289|M.smegmatis_MC2_155 LSPADQRLSVAEAVHANTLGAAYQLRLDDVVGSVEVGKRADLIVLDTDIF
Mb0567|M.bovis_AF2122/97 VLAPEERLTVEQAIRAQTIDAAWQLFAEDAIGSLQVGKYADMVVLSADPR
Rv0552|M.tuberculosis_H37Rv VLAPEERLTVEQAIRAQTIDAAWQLFAEDAIGSLQVGKYADMVVLSADPR
MMAR_0898|M.marinum_M VLAPEERLTVEQAIRAQTIDAAWQMFADDIIGSLEVGKYADMVVLSADPR
MUL_0651|M.ulcerans_Agy99 VLAPEERLTVEQAIRAQTIDAAWQMFADDIIGSLEVGKYADMVVLSADPR
MAV_4591|M.avium_104 VLAPEERLTVEQAIRAQTLDAAWQLFADDVIGSLEVGKYADLVVLSADPR
Mvan_1184|M.vanbaalenii_PYR-1 GWTPHEILPVERALTAYTAAVAHQAFAENTWGIIEPGFSADMVWLDRDPR
TH_0262|M.thermoresistible__bu -------MTPMQAIRAATVTSAELIEAGDELGRLAPGYRADIIAVPGDP-
:. .*: * * * . * : * **:: : :
Mflv_2930|M.gilvum_PYR-GCK EIDPHDIHSAAVTLTMMDGEIRHRV---------
MAB_2546|M.abscessus_ATCC_1997 ECDPQDIHTATVLMTMMNGQVRHELQGLKS----
MSMEG_4289|M.smegmatis_MC2_155 KIDPHDIHTAEVVLTMMDGRIRHDTSRVSDAAPR
Mb0567|M.bovis_AF2122/97 TVPPEQIADLAVRATFLAGRQVYRR---------
Rv0552|M.tuberculosis_H37Rv TVPPEQIADLAVRATFLAGRQVYRR---------
MMAR_0898|M.marinum_M TVPPEEIADLEVRATFLAGRQVYRK---------
MUL_0651|M.ulcerans_Agy99 TVPPEEIADLEVRATFLAGRQVYRK---------
MAV_4591|M.avium_104 AVPPERIADLQVRATYLAGRRVYPQ---------
Mvan_1184|M.vanbaalenii_PYR-1 LTPPLELPSTSVVGTYLRGTLASPS---------
TH_0262|M.thermoresistible__bu --SRDIAATLDVRFVMKDGAVYRHDGVDRRDRG-
* . *