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IDMTIARIAEIVGGELADITPEQAAATHVTGTVEFDSRAVGPGGLFLALPGARSDGHDFAAAAVQSGAVA VLAARPVGVPAIVVRPDGGVDSASGALEHDTDGSGAAVLAALARLAAAVANELAADGLKIIGVTGSSGKT STKDLLAAVLAPLGEVVAPPGSFNNELGHPWTVLRATRDTDFLVLEMSARHPGNIAALAAIAPPSVAVVL NVGTAHLGEFGSREAIAKTKAELPQAVGPSGVVILNADDIAVAAMAEQTDARVVRISRDPGSDIDVWAGP VTLDELARPRFTLHTRDGEVDVNLAVHGDHQVSNALCAAAVALECGATPQQVADALAAAGPASRHRMQVS TRADGVTVINDAYNANPDSMRAGLKALAWMARQTAGGQPGGKRRSWAVLGEMAELGDDAITEHDAIGRFA VRLDVSRLLVVGSGRAMNAMHHGAVMEGSWGSESTMVADADAALTVLRDELQPGDVVLVKASNSVGLGAL AEALVAGEGHTEGRTPAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4231 | - | - | 100% (509) | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase |
| M. smegmatis MC2 155 | MSMEG_4226 | murC | 2e-19 | 29.12% (364) | UDP-N-acetylmuramate--L-alanine ligase |
| M. smegmatis MC2 155 | MSMEG_4232 | murE | 2e-18 | 25.59% (512) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2181c | murF | 0.0 | 74.31% (510) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diamino |
| M. gilvum PYR-GCK | Mflv_2984 | - | 0.0 | 76.82% (509) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, |
| M. tuberculosis H37Rv | Rv2157c | murF | 0.0 | 74.31% (510) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate- |
| M. leprae Br4923 | MLBr_00910 | murF | 0.0 | 74.66% (517) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, |
| M. abscessus ATCC 19977 | MAB_2002 | - | 0.0 | 71.81% (493) | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF |
| M. marinum M | MMAR_3197 | murF | 0.0 | 74.00% (523) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- |
| M. avium 104 | MAV_2332 | - | 0.0 | 75.14% (519) | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase |
| M. thermoresistible (build 8) | TH_1329 | murF | 1e-167 | 78.66% (389) | Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2, |
| M. ulcerans Agy99 | MUL_3505 | murF | 0.0 | 73.61% (523) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- |
| M. vanbaalenii PYR-1 | Mvan_3527 | - | 0.0 | 79.20% (500) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3197|M.marinum_M --------MIDYTVAEIAEIVGGTLVDISPQEAEQRRVTGTVEFDSRAVG
MUL_3505|M.ulcerans_Agy99 --------MIDYTVAEIAEIVGGTLVDISPQEAEQRRVTGTVEFDSRAVG
Mb2181c|M.bovis_AF2122/97 --------MIELTVAQIAEIVGGAVADISPQDAAHRRVTGTVEFDSRAIG
Rv2157c|M.tuberculosis_H37Rv --------MIELTVAQIAEIVGGAVADISPQDAAHRRVTGTVEFDSRAIG
MAV_2332|M.avium_104 --------MIDLTVAQIADIVGGTLADITAPDAARRRVTGTVEFDSRAVG
MLBr_00910|M.leprae_Br4923 --------MIDLTVARVTEIVGGALVDISPEEAAERRVTGSVEFDSRAVG
MAB_2002|M.abscessus_ATCC_1997 -----------MTVAEIAEIVGGRLDGISAQEARQARVTGTVEFDSRQVS
Mflv_2984|M.gilvum_PYR-GCK --------MIEMSLRRIAEIVGGRLADVSADEADRLRVTGTVEFDSRAVT
Mvan_3527|M.vanbaalenii_PYR-1 --------MIAMSLARIAEIVGGRLADVSDEDAARTVVTGTVEFDSRAVT
MSMEG_4231|M.smegmatis_MC2_155 --------MIDMTIARIAEIVGGELADITPEQAAATHVTGTVEFDSRAVG
TH_1329|M.thermoresistible__bu VTTEPGAVVSDLGQAARRSAVRTPVTAGSGGGYPRLDLTACPGLVVVAAR
. * : : :*. :
MMAR_3197|M.marinum_M PGGLFLALPGARADGHDH-----AASAVAAGAVAVLAARPVG---VP---
MUL_3505|M.ulcerans_Agy99 PGGLFLALPGARADGHDH-----AAAAVAAGAVAVLAARPVG---VS---
Mb2181c|M.bovis_AF2122/97 PGGLFLALPGARADGHDH-----AASAVAAGAAVVLAARPVG---VP---
Rv2157c|M.tuberculosis_H37Rv PGGLFLALPGARADGHDH-----AASAVAAGAAVVLAARPVG---VP---
MAV_2332|M.avium_104 PGGLFLALPGARTDGHDH-----AESAVAAGAVAVLAARPVG---VP---
MLBr_00910|M.leprae_Br4923 PGGLFLALPGARSDGHDH-----AASAIAAGAVAVLAARPVG---VP---
MAB_2002|M.abscessus_ATCC_1997 PGGLFLALPGARADGHDH-----ARGAAEAGAVAVLAARPVG---VP---
Mflv_2984|M.gilvum_PYR-GCK AGGLFLALPGARSDGHDF-----AATAVASGAVAVLAARPVG---VP---
Mvan_3527|M.vanbaalenii_PYR-1 PGGLFLALPGARSDGHDF-----AATAVAAGAVGVLAARPVG---VP---
MSMEG_4231|M.smegmatis_MC2_155 PGGLFLALPGARSDGHDF-----AAAAVQSGAVAVLAARPVG---VP---
TH_1329|M.thermoresistible__bu PDDELLGLGGAIAALVDLGVEVRVVSVCDRDATLTLTGLPALDRQIPDQR
... :*.* ** : * . . .*. .*:. *. :.
MMAR_3197|M.marinum_M ----------------AIVVSPE-PDVTADALTGVLEHDADGSGAAVLAA
MUL_3505|M.ulcerans_Agy99 ----------------AIVVSPE-PDSTADALTGVLEHDADGSGAAVLAA
Mb2181c|M.bovis_AF2122/97 ----------------AIVVPP---VAAPNVLAGVLEHDNDGSGAAVLAA
Rv2157c|M.tuberculosis_H37Rv ----------------AIVVPP---VAAPNVLAGVLEHDNDGSGAAVLAA
MAV_2332|M.avium_104 ----------------AIVAPP---VDAADALAGVLEHDADGSGAAVLAA
MLBr_00910|M.leprae_Br4923 ----------------AIVVAPD-PRTGDGGLTGVLEHDADGSGAAVLAA
MAB_2002|M.abscessus_ATCC_1997 ----------------AIVVPP---TGVARTEVSALEHDSDGSGAAVLAA
Mflv_2984|M.gilvum_PYR-GCK ----------------AVVVDPVAPQHGAGGTAGVLEHDADGSGAAVLAA
Mvan_3527|M.vanbaalenii_PYR-1 ----------------AVVVDPVRPDPAAPGTAGVLEHDVDGSGAAVLAA
MSMEG_4231|M.smegmatis_MC2_155 ----------------AIVVRP---DGGVDSASGALEHDTDGSGAAVLAA
TH_1329|M.thermoresistible__bu FDQRVAAEILGVKELHHLGLPADDLDRHAAGLADDLTELLVGPGLWCAAP
: . . * . *.* *.
MMAR_3197|M.marinum_M LAK--------LAKAVAAELVAGGLTIIGITGSSGKTSTKDLVAAVLKPL
MUL_3505|M.ulcerans_Agy99 LAK--------LAKAVAAELMAGGLTIIGITGSSGKTSTKDLVAAVLKPL
Mb2181c|M.bovis_AF2122/97 LAK--------LATAVAAQLVAGGLTIIGITGSSGKTSTKDLMAAVLAPL
Rv2157c|M.tuberculosis_H37Rv LAK--------LATAVAAQLVAGGLTIIGITGSSGKTSTKDLMAAVLAPL
MAV_2332|M.avium_104 LAK--------LARAVAAELVAGGLTIVGITGSSGKTSTKDLVAAVLAPL
MLBr_00910|M.leprae_Br4923 LAK--------LAKAVAAELVAGGLTIIGITGSSGKTSTKDLVAVVLELL
MAB_2002|M.abscessus_ATCC_1997 TAA--------LAAEVARRLTARGLRIVGITGSSGKTSTKDLIAAVLSPL
Mflv_2984|M.gilvum_PYR-GCK LAR--------LAAAVAAELVAGGLTIVGITGSSGKTSTKDLIAAVLAPL
Mvan_3527|M.vanbaalenii_PYR-1 LAR--------LASAVAAELVAGGLTIIGITGSSGKTSTKDLIAAVLAPL
MSMEG_4231|M.smegmatis_MC2_155 LAR--------LAAAVANELAADGLKIIGVTGSSGKTSTKDLLAAVLAPL
TH_1329|M.thermoresistible__bu WAGDGDPDSTVVARAAXXXLVAGGLRIVGVTGSSGKTSTKDLLAAVLAPL
* :* . * * ** *:*:************:*.** *
MMAR_3197|M.marinum_M GEVVAPPGSFNNELGHPWTVLRATRGTDYLILEMSARHPGNIAALARVAP
MUL_3505|M.ulcerans_Agy99 GEVVAPPGSFNNELGHPWTVLRATRSTDYLILEMSARHPGNIAALARVAP
Mb2181c|M.bovis_AF2122/97 GEVVAPPGSFNNELGHPWTVLRATRRTDYLILEMAARHHGNIAALAEIAP
Rv2157c|M.tuberculosis_H37Rv GEVVAPPGSFNNELGHPWTVLRATRRTDYLILEMAARHHGNIAALAEIAP
MAV_2332|M.avium_104 GEVVAPPGSFNNELGHPWTVLRATADTDYLVLEMSARHPGNIAALAEIAP
MLBr_00910|M.leprae_Br4923 GEVVAPPESFNNELGHPWTVLRATRSTDYLILEMSARRPGNIAALAAIAP
MAB_2002|M.abscessus_ATCC_1997 GEVVAPPGSFNNELGHPWTVLRATESTKFLVLELSARRPGNIAELAAIAP
Mflv_2984|M.gilvum_PYR-GCK GEVIAPPGSFNNELGHPWTVLRATESTDYLVLEMSARHPGNIAALARIAP
Mvan_3527|M.vanbaalenii_PYR-1 GEVVAPPGSFNNELGHPWTVLRATRSTDYLVLEMSARHPGNIAALARIAV
MSMEG_4231|M.smegmatis_MC2_155 GEVVAPPGSFNNELGHPWTVLRATRDTDFLVLEMSARHPGNIAALAAIAP
TH_1329|M.thermoresistible__bu GSVVAPPGSFNNELGHPWTVLRADRDTDYLVLEMSARHRGNIAALAEIAP
*.*:*** *************** *.:*:**::**: **** ** :*
MMAR_3197|M.marinum_M PAIGVVLNVGTAHLGEFGSREIIAQTKSELPQAVPASGVVILNADDPAVA
MUL_3505|M.ulcerans_Agy99 PAIGVVLNVGTAHLGEFGSREIIAQTKSELPQAVPASGVVILNADDPAVA
Mb2181c|M.bovis_AF2122/97 PSIGVVLNVGTAHLGEFGSREVIAQTKAELPQAVPHSGAVVLNADDPAVA
Rv2157c|M.tuberculosis_H37Rv PSIGVVLNVGTAHLGEFGSREVIAQTKAELPQAVPHSGAVVLNADDPAVA
MAV_2332|M.avium_104 PAVGVVLNVGTAHLGEFGSREAIARTKSELPQSVPASGVVVLNVDDPTVA
MLBr_00910|M.leprae_Br4923 PKIGVVLNVGTAHLGEFGSREAIARTKTELPQAIMQSGVVILNVDDPAVA
MAB_2002|M.abscessus_ATCC_1997 PSIGVVLNVGTAHLGEFGSRQAIADTKGELPQSLSGGGVAVLNADDAAVA
Mflv_2984|M.gilvum_PYR-GCK PSIGAVLNVGTAHLGEFGSREAIAATKSELPQAVPQSGVVILNADDPVVA
Mvan_3527|M.vanbaalenii_PYR-1 PSIAVVLNVGTAHLGEFGSREVIAATKSELPQSVPESGVVILNADDPAVA
MSMEG_4231|M.smegmatis_MC2_155 PSVAVVLNVGTAHLGEFGSREAIAKTKAELPQAVGPSGVVILNADDIAVA
TH_1329|M.thermoresistible__bu PSVGVVLNVGTAHLGEFGSRDAIAATKAELAEAVPSTGLVVLNADDPAVA
* :..***************: ** ** **.::: * .:**.** .**
MMAR_3197|M.marinum_M AMAEVTAARVVRVGRATATGAGWAGPGDVWAGPVSLDRLARPQFTMHAGD
MUL_3505|M.ulcerans_Agy99 AMAEVTAARVVRVGRATATGAGWAGPGDVWAGPVSLDRLARPQFTMHAGD
Mb2181c|M.bovis_AF2122/97 AMAKLTAARVVRVSRDN--------TGDVWAGPVSLDELARPRFTLHAHD
Rv2157c|M.tuberculosis_H37Rv AMAKLTAARVVRVSRDN--------TGDVWAGPVSLDELARPRFTLHAHD
MAV_2332|M.avium_104 AMAEVTAARVVRVSRAEHTEA---GPSDVWAGPVSLDELARPGFTLYHSH
MLBr_00910|M.leprae_Br4923 AMADATVARVIRVSRGSYSHPGSPNSPDVWTGPVSLDELARPRFTLHTRD
MAB_2002|M.abscessus_ATCC_1997 AMAAKTPARVVRTSVHH--------PADIWATEVSVDDLARARFTLHAGQ
Mflv_2984|M.gilvum_PYR-GCK AMADKTAARVVRVGRSADAR-----TLDVRADGVTLDPLARPAFTLHAGG
Mvan_3527|M.vanbaalenii_PYR-1 AMADKTAARVVRVGRGAEA-------LDVCADGVSLDALARPSFTLHTGA
MSMEG_4231|M.smegmatis_MC2_155 AMAEQTDARVVRISRDPGS------DIDVWAGPVTLDELARPRFTLHTRD
TH_1329|M.thermoresistible__bu AMAERTAARVVRVAQDPGER-----QVDVWAERVSLDELARPRFTLRTPD
*** * ***:* . *: : *::* ***. **:
MMAR_3197|M.marinum_M A----AAQVRLGVYGDHQVSNALCAGAVALECGASVSQVAAALAEAGPVS
MUL_3505|M.ulcerans_Agy99 A----AAQVRLGVYGDHQVSNALCAGAVALECGASVSQVAAALAEAGPVS
Mb2181c|M.bovis_AF2122/97 A----QAEVRLGVCGDHQVTNALCAAAVALECGASVEQVAAALTAAPPVS
Rv2157c|M.tuberculosis_H37Rv A----QAEVRLGVCGDHQVTNALCAAAVALECGASVEQVAAALTAAPPVS
MAV_2332|M.avium_104 AGGTRQARVQLGVSGDHQVGNALCAAAVALECGATVEQVVAALAGAGPVS
MLBr_00910|M.leprae_Br4923 PRAG-ATEIQLGVYGDHQVANALCAAAVGLECGASVEEVAVALAATGPVS
MAB_2002|M.abscessus_ATCC_1997 D----SVPVQLAVHGEHHVSNALAAAAVALECGATLAQVAAALAGAGPVS
Mflv_2984|M.gilvum_PYR-GCK E----QVPVTLAVHGDHQVSNALVAAAVALECGATLTQVAGALAAAGPVS
Mvan_3527|M.vanbaalenii_PYR-1 A----DVPVTLAVHGDHQVSNALCAAAVALECGATPEQVAAALATAGPVS
MSMEG_4231|M.smegmatis_MC2_155 G----EVDVNLAVHGDHQVSNALCAAAVALECGATPQQVADALAAAGPAS
TH_1329|M.thermoresistible__bu G----AVEVALTVHGEHQVSNALAAAAVALHCGATLEQVVAALAGAGPAS
. : * * *:*:* *** *.**.*.***: :*. **: : *.*
MMAR_3197|M.marinum_M RHRMQVSTRPDGVTVIDDAYNANPDSMRAGLQALAWIARGEAESTAASQP
MUL_3505|M.ulcerans_Agy99 RHRMRVSTRPDGVTVIDDAYNANPDSMRAGLQALAWIARGEAESTAASQP
Mb2181c|M.bovis_AF2122/97 RHRMQVTTRGDGVTVIDDAYNANPDSMRAGLQALAWIAH---QP------
Rv2157c|M.tuberculosis_H37Rv RHRMQVTTRGDGVTVIDDAYNANPDSMRAGLQALAWIAH---QP------
MAV_2332|M.avium_104 RHRMQVSTRGDGVTVIDDAYNANPDSMRAGLQALAWIARGGAEPG-----
MLBr_00910|M.leprae_Br4923 RHRMQVTTRADGVTVIDDTYNANPDSMRAGLQALAWIAHGGTHDKNQP--
MAB_2002|M.abscessus_ATCC_1997 RRRMEVSTRDDGVTVINDAYNANPDSMMAGLKALVSMARHGGEP------
Mflv_2984|M.gilvum_PYR-GCK RHRMQVSTRSDGVTVINDAYNANPDSMTAGLKALAWMSRQNPEG------
Mvan_3527|M.vanbaalenii_PYR-1 RHRMQVTAREDGVTVINDAYNANPDSMRAGLKALAWMSRGGASK------
MSMEG_4231|M.smegmatis_MC2_155 RHRMQVSTRADGVTVINDAYNANPDSMRAGLKALAWMARQTAGGQP----
TH_1329|M.thermoresistible__bu PRRMQVSTRSDGVTVINDAYNANPDSMRAALKSLVWMAKAGGRAG-----
:**.*::* ******:*:******** *.*::*. :::
MMAR_3197|M.marinum_M GVRPQSRRSWAVLGEMAELGADAITEHDHIGRLAVRLDVSRLVVVGTGRS
MUL_3505|M.ulcerans_Agy99 GVRPQSRRSWAVLGEMAELGADAITEHDHIGRLAVRLDVSRLVVVGTGRS
Mb2181c|M.bovis_AF2122/97 ---EATRRSWAVLGEMAELGEDAIAEHDRIGRLAVRLDVSRLVVVGTGRS
Rv2157c|M.tuberculosis_H37Rv ---EATRRSWAVLGEMAELGEDAIAEHDRIGRLAVRLDVSRLVVVGTGRS
MAV_2332|M.avium_104 ---APARRSWAVLGEMAELGDDAIAEHDRIGRLAVRLDVSRLVVVGTGRS
MLBr_00910|M.leprae_Br4923 --GSCARRSWAVLGEMAELGEDSITEHDRIGRLAVRLDVSRLVVVGGGRS
MAB_2002|M.abscessus_ATCC_1997 ------RRSWAVLGEMAELGPDAISEHDRIGRAAVRLDVSRLVVVGTGRS
Mflv_2984|M.gilvum_PYR-GCK ------SRSFAVLGEMAELGEDTITEHDRIGRLAVRLDVSRLVVVGSGRP
Mvan_3527|M.vanbaalenii_PYR-1 ------GRSWAVLGEMAELGDDAITEHDRIGRLAVRLDVSRLIVVGSGRP
MSMEG_4231|M.smegmatis_MC2_155 ---GGKRRSWAVLGEMAELGDDAITEHDAIGRFAVRLDVSRLLVVGSGRA
TH_1329|M.thermoresistible__bu ---GPPRRSWAVLGEMAELGDDAITEHDNIGRLAVRLDVSRLIVVGTGRA
**:********** *:*:*** *** *********:*** **.
MMAR_3197|M.marinum_M MSAMYHGAVMEGSWGT-----------EAVSVPDRDAALALLRAEIQPGD
MUL_3505|M.ulcerans_Agy99 MSAIYHGAVMEGSWGT-----------EAVSVPDRDAALALLRAEIQPGD
Mb2181c|M.bovis_AF2122/97 ISAMHHGAVLEGAWGSGEATADHGADRTAVNVADGDAALALLRAELRPGD
Rv2157c|M.tuberculosis_H37Rv ISAMHHGAVLEGAWGSGEATADHGADRTAVNVADGDAALALLRAELRPGD
MAV_2332|M.avium_104 VSAMHHGAVMEGSWGS--------ADKGAVNVPDAEAALELLRAELQPGD
MLBr_00910|M.leprae_Br4923 INAMHRGAVMEGSWGL-----------ETVNVADPAAALTLLRAEVRPGD
MAB_2002|M.abscessus_ATCC_1997 QRAMHAGAVMEGSWGS-----------EAVLVDDPAAAASLLASELAAGD
Mflv_2984|M.gilvum_PYR-GCK MSAMLHGAVMEGSWGS-----------EATPVADADAALALLRDELRPGD
Mvan_3527|M.vanbaalenii_PYR-1 MSAMLHGAVMEGSFGS-----------EAIPVADTDAALEILRAELRPGD
MSMEG_4231|M.smegmatis_MC2_155 MNAMHHGAVMEGSWGS-----------ESTMVADADAALTVLRDELQPGD
TH_1329|M.thermoresistible__bu MSAMHHGAVMEGSWGA-----------ESTMVSDADAALRLLRSELQAGD
*: ***:**::* : * * ** :* *: .**
MMAR_3197|M.marinum_M VVLIKASNSAGLGELADALACADAG--------------CQDRGSAHS--
MUL_3505|M.ulcerans_Agy99 VVLIKASNSAGLGELADALACADAG--------------CQDRGSAHS--
Mb2181c|M.bovis_AF2122/97 VVLVKASNAAGLGAVADALVADD------------------TCGSVRP--
Rv2157c|M.tuberculosis_H37Rv VVLVKASNAAGLGAVADALVADD------------------TCGSVRP--
MAV_2332|M.avium_104 VVLVKASNAAGLGALADALARDDREGGAAGRSGSSPLARDDSAGGTRR--
MLBr_00910|M.leprae_Br4923 VVLIKASHSVGLGALADVLVGDG---------------------AIRP--
MAB_2002|M.abscessus_ATCC_1997 VVLVKASRSAGLWVVADELLKVG---------------------DA----
Mflv_2984|M.gilvum_PYR-GCK VVLVKASNSAGLGALADALVS-----------------------EQLPGD
Mvan_3527|M.vanbaalenii_PYR-1 VVLVKASNSAGLGALADALVSDVARDGVSDVARDGVSDVARDGVSEPPRD
MSMEG_4231|M.smegmatis_MC2_155 VVLVKASNSVGLGALAEALVAGEG----------------HTEGRTPAR-
TH_1329|M.thermoresistible__bu VVLVKASNAAGLGALADALAAES--------------------GDTGR--
***:***.:.** :*: *
MMAR_3197|M.marinum_M ---
MUL_3505|M.ulcerans_Agy99 ---
Mb2181c|M.bovis_AF2122/97 ---
Rv2157c|M.tuberculosis_H37Rv ---
MAV_2332|M.avium_104 ---
MLBr_00910|M.leprae_Br4923 ---
MAB_2002|M.abscessus_ATCC_1997 ---
Mflv_2984|M.gilvum_PYR-GCK GR-
Mvan_3527|M.vanbaalenii_PYR-1 GGR
MSMEG_4231|M.smegmatis_MC2_155 ---
TH_1329|M.thermoresistible__bu ---