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IELTVAQIAEIVGGAVADISPQDAAHRRVTGTVEFDSRAIGPGGLFLALPGARADGHDHAASAVAAGAAV VLAARPVGVPAIVVPPVAAPNVLAGVLEHDNDGSGAAVLAALAKLATAVAAQLVAGGLTIIGITGSSGKT STKDLMAAVLAPLGEVVAPPGSFNNELGHPWTVLRATRRTDYLILEMAARHHGNIAALAEIAPPSIGVVL NVGTAHLGEFGSREVIAQTKAELPQAVPHSGAVVLNADDPAVAAMAKLTAARVVRVSRDNTGDVWAGPVS LDELARPRFTLHAHDAQAEVRLGVCGDHQVTNALCAAAVALECGASVEQVAAALTAAPPVSRHRMQVTTR GDGVTVIDDAYNANPDSMRAGLQALAWIAHQPEATRRSWAVLGEMAELGEDAIAEHDRIGRLAVRLDVSR LVVVGTGRSISAMHHGAVLEGAWGSGEATADHGADRTAVNVADGDAALALLRAELRPGDVVLVKASNAAG LGAVADALVADDTCGSVRP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2157c | murF | - | 100% (510) | Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate- D-alanyl-D-alanyl ligase MurF |
| M. tuberculosis H37Rv | Rv2158c | murE | 1e-22 | 27.36% (508) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
| M. tuberculosis H37Rv | Rv2152c | murC | 2e-16 | 27.47% (324) | UDP-N-acetylmuramate--L-alanine ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2181c | murF | 0.0 | 100.00% (510) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diamino |
| M. gilvum PYR-GCK | Mflv_2984 | - | 0.0 | 74.56% (515) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, |
| M. leprae Br4923 | MLBr_00910 | murF | 0.0 | 75.33% (531) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, |
| M. abscessus ATCC 19977 | MAB_2002 | - | 0.0 | 69.42% (497) | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF |
| M. marinum M | MMAR_3197 | murF | 0.0 | 78.10% (525) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- |
| M. avium 104 | MAV_2332 | - | 0.0 | 80.92% (519) | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase |
| M. smegmatis MC2 155 | MSMEG_4231 | - | 0.0 | 74.31% (510) | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase |
| M. thermoresistible (build 8) | TH_1329 | murF | 1e-152 | 72.59% (394) | Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2, |
| M. ulcerans Agy99 | MUL_3505 | murF | 0.0 | 77.14% (525) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- |
| M. vanbaalenii PYR-1 | Mvan_3527 | - | 0.0 | 76.73% (507) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2984|M.gilvum_PYR-GCK --------MIEMSLRRIAEIVGGRLADVSADEADRLRVTGTVEFDSRAVT
Mvan_3527|M.vanbaalenii_PYR-1 --------MIAMSLARIAEIVGGRLADVSDEDAARTVVTGTVEFDSRAVT
Rv2157c|M.tuberculosis_H37Rv --------MIELTVAQIAEIVGGAVADISPQDAAHRRVTGTVEFDSRAIG
Mb2181c|M.bovis_AF2122/97 --------MIELTVAQIAEIVGGAVADISPQDAAHRRVTGTVEFDSRAIG
MAV_2332|M.avium_104 --------MIDLTVAQIADIVGGTLADITAPDAARRRVTGTVEFDSRAVG
MMAR_3197|M.marinum_M --------MIDYTVAEIAEIVGGTLVDISPQEAEQRRVTGTVEFDSRAVG
MUL_3505|M.ulcerans_Agy99 --------MIDYTVAEIAEIVGGTLVDISPQEAEQRRVTGTVEFDSRAVG
MLBr_00910|M.leprae_Br4923 --------MIDLTVARVTEIVGGALVDISPEEAAERRVTGSVEFDSRAVG
MAB_2002|M.abscessus_ATCC_1997 -----------MTVAEIAEIVGGRLDGISAQEARQARVTGTVEFDSRQVS
MSMEG_4231|M.smegmatis_MC2_155 --------MIDMTIARIAEIVGGELADITPEQAAATHVTGTVEFDSRAVG
TH_1329|M.thermoresistible__bu VTTEPGAVVSDLGQAARRSAVRTPVTAGSGGGYPRLDLTACPGLVVVAAR
. * : : :*. :
Mflv_2984|M.gilvum_PYR-GCK AGGLFLALPGARSDGHDF-----AATAVASGAVAVLAARPVG---VP---
Mvan_3527|M.vanbaalenii_PYR-1 PGGLFLALPGARSDGHDF-----AATAVAAGAVGVLAARPVG---VP---
Rv2157c|M.tuberculosis_H37Rv PGGLFLALPGARADGHDH-----AASAVAAGAAVVLAARPVG---VP---
Mb2181c|M.bovis_AF2122/97 PGGLFLALPGARADGHDH-----AASAVAAGAAVVLAARPVG---VP---
MAV_2332|M.avium_104 PGGLFLALPGARTDGHDH-----AESAVAAGAVAVLAARPVG---VP---
MMAR_3197|M.marinum_M PGGLFLALPGARADGHDH-----AASAVAAGAVAVLAARPVG---VP---
MUL_3505|M.ulcerans_Agy99 PGGLFLALPGARADGHDH-----AAAAVAAGAVAVLAARPVG---VS---
MLBr_00910|M.leprae_Br4923 PGGLFLALPGARSDGHDH-----AASAIAAGAVAVLAARPVG---VP---
MAB_2002|M.abscessus_ATCC_1997 PGGLFLALPGARADGHDH-----ARGAAEAGAVAVLAARPVG---VP---
MSMEG_4231|M.smegmatis_MC2_155 PGGLFLALPGARSDGHDF-----AAAAVQSGAVAVLAARPVG---VP---
TH_1329|M.thermoresistible__bu PDDELLGLGGAIAALVDLGVEVRVVSVCDRDATLTLTGLPALDRQIPDQR
... :*.* ** : * . . .*. .*:. *. :.
Mflv_2984|M.gilvum_PYR-GCK ----------------AVVVDPVAPQHGAGGTAGVLEHDADGSGAAVLAA
Mvan_3527|M.vanbaalenii_PYR-1 ----------------AVVVDPVRPDPAAPGTAGVLEHDVDGSGAAVLAA
Rv2157c|M.tuberculosis_H37Rv ----------------AIVVPP---VAAPNVLAGVLEHDNDGSGAAVLAA
Mb2181c|M.bovis_AF2122/97 ----------------AIVVPP---VAAPNVLAGVLEHDNDGSGAAVLAA
MAV_2332|M.avium_104 ----------------AIVAPP---VDAADALAGVLEHDADGSGAAVLAA
MMAR_3197|M.marinum_M ----------------AIVVSPE-PDVTADALTGVLEHDADGSGAAVLAA
MUL_3505|M.ulcerans_Agy99 ----------------AIVVSPE-PDSTADALTGVLEHDADGSGAAVLAA
MLBr_00910|M.leprae_Br4923 ----------------AIVVAPD-PRTGDGGLTGVLEHDADGSGAAVLAA
MAB_2002|M.abscessus_ATCC_1997 ----------------AIVVPP---TGVARTEVSALEHDSDGSGAAVLAA
MSMEG_4231|M.smegmatis_MC2_155 ----------------AIVVRP---DGGVDSASGALEHDTDGSGAAVLAA
TH_1329|M.thermoresistible__bu FDQRVAAEILGVKELHHLGLPADDLDRHAAGLADDLTELLVGPGLWCAAP
: . . * . *.* *.
Mflv_2984|M.gilvum_PYR-GCK LAR--------LAAAVAAELVAGGLTIVGITGSSGKTSTKDLIAAVLAPL
Mvan_3527|M.vanbaalenii_PYR-1 LAR--------LASAVAAELVAGGLTIIGITGSSGKTSTKDLIAAVLAPL
Rv2157c|M.tuberculosis_H37Rv LAK--------LATAVAAQLVAGGLTIIGITGSSGKTSTKDLMAAVLAPL
Mb2181c|M.bovis_AF2122/97 LAK--------LATAVAAQLVAGGLTIIGITGSSGKTSTKDLMAAVLAPL
MAV_2332|M.avium_104 LAK--------LARAVAAELVAGGLTIVGITGSSGKTSTKDLVAAVLAPL
MMAR_3197|M.marinum_M LAK--------LAKAVAAELVAGGLTIIGITGSSGKTSTKDLVAAVLKPL
MUL_3505|M.ulcerans_Agy99 LAK--------LAKAVAAELMAGGLTIIGITGSSGKTSTKDLVAAVLKPL
MLBr_00910|M.leprae_Br4923 LAK--------LAKAVAAELVAGGLTIIGITGSSGKTSTKDLVAVVLELL
MAB_2002|M.abscessus_ATCC_1997 TAA--------LAAEVARRLTARGLRIVGITGSSGKTSTKDLIAAVLSPL
MSMEG_4231|M.smegmatis_MC2_155 LAR--------LAAAVANELAADGLKIIGVTGSSGKTSTKDLLAAVLAPL
TH_1329|M.thermoresistible__bu WAGDGDPDSTVVARAAXXXLVAGGLRIVGVTGSSGKTSTKDLLAAVLAPL
* :* . * * ** *:*:************:*.** *
Mflv_2984|M.gilvum_PYR-GCK GEVIAPPGSFNNELGHPWTVLRATESTDYLVLEMSARHPGNIAALARIAP
Mvan_3527|M.vanbaalenii_PYR-1 GEVVAPPGSFNNELGHPWTVLRATRSTDYLVLEMSARHPGNIAALARIAV
Rv2157c|M.tuberculosis_H37Rv GEVVAPPGSFNNELGHPWTVLRATRRTDYLILEMAARHHGNIAALAEIAP
Mb2181c|M.bovis_AF2122/97 GEVVAPPGSFNNELGHPWTVLRATRRTDYLILEMAARHHGNIAALAEIAP
MAV_2332|M.avium_104 GEVVAPPGSFNNELGHPWTVLRATADTDYLVLEMSARHPGNIAALAEIAP
MMAR_3197|M.marinum_M GEVVAPPGSFNNELGHPWTVLRATRGTDYLILEMSARHPGNIAALARVAP
MUL_3505|M.ulcerans_Agy99 GEVVAPPGSFNNELGHPWTVLRATRSTDYLILEMSARHPGNIAALARVAP
MLBr_00910|M.leprae_Br4923 GEVVAPPESFNNELGHPWTVLRATRSTDYLILEMSARRPGNIAALAAIAP
MAB_2002|M.abscessus_ATCC_1997 GEVVAPPGSFNNELGHPWTVLRATESTKFLVLELSARRPGNIAELAAIAP
MSMEG_4231|M.smegmatis_MC2_155 GEVVAPPGSFNNELGHPWTVLRATRDTDFLVLEMSARHPGNIAALAAIAP
TH_1329|M.thermoresistible__bu GSVVAPPGSFNNELGHPWTVLRADRDTDYLVLEMSARHRGNIAALAEIAP
*.*:*** *************** *.:*:**::**: **** ** :*
Mflv_2984|M.gilvum_PYR-GCK PSIGAVLNVGTAHLGEFGSREAIAATKSELPQAVPQSGVVILNADDPVVA
Mvan_3527|M.vanbaalenii_PYR-1 PSIAVVLNVGTAHLGEFGSREVIAATKSELPQSVPESGVVILNADDPAVA
Rv2157c|M.tuberculosis_H37Rv PSIGVVLNVGTAHLGEFGSREVIAQTKAELPQAVPHSGAVVLNADDPAVA
Mb2181c|M.bovis_AF2122/97 PSIGVVLNVGTAHLGEFGSREVIAQTKAELPQAVPHSGAVVLNADDPAVA
MAV_2332|M.avium_104 PAVGVVLNVGTAHLGEFGSREAIARTKSELPQSVPASGVVVLNVDDPTVA
MMAR_3197|M.marinum_M PAIGVVLNVGTAHLGEFGSREIIAQTKSELPQAVPASGVVILNADDPAVA
MUL_3505|M.ulcerans_Agy99 PAIGVVLNVGTAHLGEFGSREIIAQTKSELPQAVPASGVVILNADDPAVA
MLBr_00910|M.leprae_Br4923 PKIGVVLNVGTAHLGEFGSREAIARTKTELPQAIMQSGVVILNVDDPAVA
MAB_2002|M.abscessus_ATCC_1997 PSIGVVLNVGTAHLGEFGSRQAIADTKGELPQSLSGGGVAVLNADDAAVA
MSMEG_4231|M.smegmatis_MC2_155 PSVAVVLNVGTAHLGEFGSREAIAKTKAELPQAVGPSGVVILNADDIAVA
TH_1329|M.thermoresistible__bu PSVGVVLNVGTAHLGEFGSRDAIAATKAELAEAVPSTGLVVLNADDPAVA
* :..***************: ** ** **.::: * .:**.** .**
Mflv_2984|M.gilvum_PYR-GCK AMADKTAARVVRVGRSADAR-----TLDVRADGVTLDPLARPAFTLHAGG
Mvan_3527|M.vanbaalenii_PYR-1 AMADKTAARVVRVGRGAEA-------LDVCADGVSLDALARPSFTLHTGA
Rv2157c|M.tuberculosis_H37Rv AMAKLTAARVVRVSRDN--------TGDVWAGPVSLDELARPRFTLHAHD
Mb2181c|M.bovis_AF2122/97 AMAKLTAARVVRVSRDN--------TGDVWAGPVSLDELARPRFTLHAHD
MAV_2332|M.avium_104 AMAEVTAARVVRVSRAEHTEA---GPSDVWAGPVSLDELARPGFTLYHSH
MMAR_3197|M.marinum_M AMAEVTAARVVRVGRATATGAGWAGPGDVWAGPVSLDRLARPQFTMHAGD
MUL_3505|M.ulcerans_Agy99 AMAEVTAARVVRVGRATATGAGWAGPGDVWAGPVSLDRLARPQFTMHAGD
MLBr_00910|M.leprae_Br4923 AMADATVARVIRVSRGSYSHPGSPNSPDVWTGPVSLDELARPRFTLHTRD
MAB_2002|M.abscessus_ATCC_1997 AMAAKTPARVVRTSVHH--------PADIWATEVSVDDLARARFTLHAGQ
MSMEG_4231|M.smegmatis_MC2_155 AMAEQTDARVVRISRDPGS------DIDVWAGPVTLDELARPRFTLHTRD
TH_1329|M.thermoresistible__bu AMAERTAARVVRVAQDPGER-----QVDVWAERVSLDELARPRFTLRTPD
*** * ***:* . *: : *::* ***. **:
Mflv_2984|M.gilvum_PYR-GCK E----QVPVTLAVHGDHQVSNALVAAAVALECGATLTQVAGALAAAGPVS
Mvan_3527|M.vanbaalenii_PYR-1 A----DVPVTLAVHGDHQVSNALCAAAVALECGATPEQVAAALATAGPVS
Rv2157c|M.tuberculosis_H37Rv A----QAEVRLGVCGDHQVTNALCAAAVALECGASVEQVAAALTAAPPVS
Mb2181c|M.bovis_AF2122/97 A----QAEVRLGVCGDHQVTNALCAAAVALECGASVEQVAAALTAAPPVS
MAV_2332|M.avium_104 AGGTRQARVQLGVSGDHQVGNALCAAAVALECGATVEQVVAALAGAGPVS
MMAR_3197|M.marinum_M A----AAQVRLGVYGDHQVSNALCAGAVALECGASVSQVAAALAEAGPVS
MUL_3505|M.ulcerans_Agy99 A----AAQVRLGVYGDHQVSNALCAGAVALECGASVSQVAAALAEAGPVS
MLBr_00910|M.leprae_Br4923 PRAG-ATEIQLGVYGDHQVANALCAAAVGLECGASVEEVAVALAATGPVS
MAB_2002|M.abscessus_ATCC_1997 D----SVPVQLAVHGEHHVSNALAAAAVALECGATLAQVAAALAGAGPVS
MSMEG_4231|M.smegmatis_MC2_155 G----EVDVNLAVHGDHQVSNALCAAAVALECGATPQQVADALAAAGPAS
TH_1329|M.thermoresistible__bu G----AVEVALTVHGEHQVSNALAAAAVALHCGATLEQVVAALAGAGPAS
. : * * *:*:* *** *.**.*.***: :*. **: : *.*
Mflv_2984|M.gilvum_PYR-GCK RHRMQVSTRSDGVTVINDAYNANPDSMTAGLKALAWMSRQNPEG------
Mvan_3527|M.vanbaalenii_PYR-1 RHRMQVTAREDGVTVINDAYNANPDSMRAGLKALAWMSRGGASK------
Rv2157c|M.tuberculosis_H37Rv RHRMQVTTRGDGVTVIDDAYNANPDSMRAGLQALAWIAH---QP------
Mb2181c|M.bovis_AF2122/97 RHRMQVTTRGDGVTVIDDAYNANPDSMRAGLQALAWIAH---QP------
MAV_2332|M.avium_104 RHRMQVSTRGDGVTVIDDAYNANPDSMRAGLQALAWIARGGAEPG-----
MMAR_3197|M.marinum_M RHRMQVSTRPDGVTVIDDAYNANPDSMRAGLQALAWIARGEAESTAASQP
MUL_3505|M.ulcerans_Agy99 RHRMRVSTRPDGVTVIDDAYNANPDSMRAGLQALAWIARGEAESTAASQP
MLBr_00910|M.leprae_Br4923 RHRMQVTTRADGVTVIDDTYNANPDSMRAGLQALAWIAHGGTHDKNQP--
MAB_2002|M.abscessus_ATCC_1997 RRRMEVSTRDDGVTVINDAYNANPDSMMAGLKALVSMARHGGEP------
MSMEG_4231|M.smegmatis_MC2_155 RHRMQVSTRADGVTVINDAYNANPDSMRAGLKALAWMARQTAGGQP----
TH_1329|M.thermoresistible__bu PRRMQVSTRSDGVTVINDAYNANPDSMRAALKSLVWMAKAGGRAG-----
:**.*::* ******:*:******** *.*::*. :::
Mflv_2984|M.gilvum_PYR-GCK ------SRSFAVLGEMAELGEDTITEHDRIGRLAVRLDVSRLVVVGSGRP
Mvan_3527|M.vanbaalenii_PYR-1 ------GRSWAVLGEMAELGDDAITEHDRIGRLAVRLDVSRLIVVGSGRP
Rv2157c|M.tuberculosis_H37Rv ---EATRRSWAVLGEMAELGEDAIAEHDRIGRLAVRLDVSRLVVVGTGRS
Mb2181c|M.bovis_AF2122/97 ---EATRRSWAVLGEMAELGEDAIAEHDRIGRLAVRLDVSRLVVVGTGRS
MAV_2332|M.avium_104 ---APARRSWAVLGEMAELGDDAIAEHDRIGRLAVRLDVSRLVVVGTGRS
MMAR_3197|M.marinum_M GVRPQSRRSWAVLGEMAELGADAITEHDHIGRLAVRLDVSRLVVVGTGRS
MUL_3505|M.ulcerans_Agy99 GVRPQSRRSWAVLGEMAELGADAITEHDHIGRLAVRLDVSRLVVVGTGRS
MLBr_00910|M.leprae_Br4923 --GSCARRSWAVLGEMAELGEDSITEHDRIGRLAVRLDVSRLVVVGGGRS
MAB_2002|M.abscessus_ATCC_1997 ------RRSWAVLGEMAELGPDAISEHDRIGRAAVRLDVSRLVVVGTGRS
MSMEG_4231|M.smegmatis_MC2_155 ---GGKRRSWAVLGEMAELGDDAITEHDAIGRFAVRLDVSRLLVVGSGRA
TH_1329|M.thermoresistible__bu ---GPPRRSWAVLGEMAELGDDAITEHDNIGRLAVRLDVSRLIVVGTGRA
**:********** *:*:*** *** *********:*** **.
Mflv_2984|M.gilvum_PYR-GCK MSAMLHGAVMEGSWGS-----------EATPVADADAALALLRDELRPGD
Mvan_3527|M.vanbaalenii_PYR-1 MSAMLHGAVMEGSFGS-----------EAIPVADTDAALEILRAELRPGD
Rv2157c|M.tuberculosis_H37Rv ISAMHHGAVLEGAWGSGEATADHGADRTAVNVADGDAALALLRAELRPGD
Mb2181c|M.bovis_AF2122/97 ISAMHHGAVLEGAWGSGEATADHGADRTAVNVADGDAALALLRAELRPGD
MAV_2332|M.avium_104 VSAMHHGAVMEGSWGS--------ADKGAVNVPDAEAALELLRAELQPGD
MMAR_3197|M.marinum_M MSAMYHGAVMEGSWGT-----------EAVSVPDRDAALALLRAEIQPGD
MUL_3505|M.ulcerans_Agy99 MSAIYHGAVMEGSWGT-----------EAVSVPDRDAALALLRAEIQPGD
MLBr_00910|M.leprae_Br4923 INAMHRGAVMEGSWGL-----------ETVNVADPAAALTLLRAEVRPGD
MAB_2002|M.abscessus_ATCC_1997 QRAMHAGAVMEGSWGS-----------EAVLVDDPAAAASLLASELAAGD
MSMEG_4231|M.smegmatis_MC2_155 MNAMHHGAVMEGSWGS-----------ESTMVADADAALTVLRDELQPGD
TH_1329|M.thermoresistible__bu MSAMHHGAVMEGSWGA-----------ESTMVSDADAALRLLRSELQAGD
*: ***:**::* : * * ** :* *: .**
Mflv_2984|M.gilvum_PYR-GCK VVLVKASNSAGLGALADALVS-----------------------EQLPGD
Mvan_3527|M.vanbaalenii_PYR-1 VVLVKASNSAGLGALADALVSDVARDGVSDVARDGVSDVARDGVSEPPRD
Rv2157c|M.tuberculosis_H37Rv VVLVKASNAAGLGAVADALVADD------------------TCGSVRP--
Mb2181c|M.bovis_AF2122/97 VVLVKASNAAGLGAVADALVADD------------------TCGSVRP--
MAV_2332|M.avium_104 VVLVKASNAAGLGALADALARDDREGGAAGRSGSSPLARDDSAGGTRR--
MMAR_3197|M.marinum_M VVLIKASNSAGLGELADALACADAG--------------CQDRGSAHS--
MUL_3505|M.ulcerans_Agy99 VVLIKASNSAGLGELADALACADAG--------------CQDRGSAHS--
MLBr_00910|M.leprae_Br4923 VVLIKASHSVGLGALADVLVGDG---------------------AIRP--
MAB_2002|M.abscessus_ATCC_1997 VVLVKASRSAGLWVVADELLKVG---------------------DA----
MSMEG_4231|M.smegmatis_MC2_155 VVLVKASNSVGLGALAEALVAGEG----------------HTEGRTPAR-
TH_1329|M.thermoresistible__bu VVLVKASNAAGLGALADALAAES--------------------GDTGR--
***:***.:.** :*: *
Mflv_2984|M.gilvum_PYR-GCK GR-
Mvan_3527|M.vanbaalenii_PYR-1 GGR
Rv2157c|M.tuberculosis_H37Rv ---
Mb2181c|M.bovis_AF2122/97 ---
MAV_2332|M.avium_104 ---
MMAR_3197|M.marinum_M ---
MUL_3505|M.ulcerans_Agy99 ---
MLBr_00910|M.leprae_Br4923 ---
MAB_2002|M.abscessus_ATCC_1997 ---
MSMEG_4231|M.smegmatis_MC2_155 ---
TH_1329|M.thermoresistible__bu ---