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RLSQTVRPEFLSAQDAVDRIPDQARLLVEASGGGVIEPSGLLDALADRYRRTGEPGQLAAYFCSGIGNRS GSGMDVLALPGLLRSAIAGHWAMTPALSRMAHDGDIEAYNLPQGVLAQLLRESAAKRPGLITKVGLGTFC DPRQGGGRLNNATTTELVQVMEINSEEYLFYPSPSFDVAFIRGTTADEHGNLTMEHETAKLGVLAAATAT RNNGGLVIAQVKRVAAAHTLNPKSVVVPGHLIDIVVVQEDQWQTAINEYNPAFSGEVYVPFGRSPAMPLS ERKVVARRALDEIRPASVVNLGVGMADGVATAALEEGRLQEITLTVEQGMVGGVPERGVIFGVSWNPEAV IEHASQFDFYDGGGLDVACLGFAEVDREGNVNSSLVDGRIFGAGGFINISQSAKKVVFCGTLTAGGLTID LADGYPKVTSEGRHRKFIDKVRQITFNAHLARERGQEVIYVTERAVFTLGDDGPVLTEVAPGWTIDQVIA LMDFRPKLADDVRLMSGSLFSAATRNPDIPNIPITEEN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4168 | - | - | 100% (529) | propionate CoA-transferase |
| M. smegmatis MC2 155 | MSMEG_1898 | - | 1e-07 | 25.10% (239) | succinyl-CoA:3-ketoacid-coenzyme A transferase 1, precursor |
| M. smegmatis MC2 155 | MSMEG_1899 | - | 1e-06 | 25.65% (230) | succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2532c | scoA | 3e-08 | 23.89% (180) | succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha |
| M. gilvum PYR-GCK | Mflv_0526 | - | 5e-09 | 26.27% (236) | 3-oxoacid CoA-transferase, A subunit |
| M. tuberculosis H37Rv | Rv2504c | scoA | 3e-08 | 23.89% (180) | succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3851 | scoA | 5e-09 | 25.42% (236) | succinyl-CoA:3-ketoacid-coenzyme A transferase (alpha |
| M. avium 104 | MAV_4786 | - | 3e-20 | 24.43% (442) | succinyl-CoA:3-ketoacid-coenzyme A transferase 1 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3782 | scoA | 4e-09 | 25.42% (236) | succinyl-CoA:3-ketoacid-coenzyme a transferase (alpha |
| M. vanbaalenii PYR-1 | Mvan_4403 | - | 4e-10 | 27.92% (240) | 3-oxoacid CoA-transferase, A subunit |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3851|M.marinum_M ------MDKVVATVAEAVADIT-DGASLAVGGFGLCGIPEALIAALVD--
MUL_3782|M.ulcerans_Agy99 ------MDKVVATVAEAVADIT-DGASLAVGGFGLCGIPEALIAALVD--
Mb2532c|M.bovis_AF2122/97 ------MDKVVATAAEAVADIA-NGSSLAVGGFGLCGIPEALIAALVD--
Rv2504c|M.tuberculosis_H37Rv ------MDKVVATAAEAVADIA-NGSSLAVGGFGLCGIPEALIAALVD--
MAV_4786|M.avium_104 ------MSKVHPDAESALHGLLKDGITVAAGGFGLCGIPEKLIQALVD--
Mflv_0526|M.gilvum_PYR-GCK ----MSRTVVCDRAEDAVAGIE-DGATVLVGGFGMAGMPTTLIDALIR--
Mvan_4403|M.vanbaalenii_PYR-1 ----MSFTTIHESADDAVAEIG-DGATLLIGGFGLAGMPFDLIDALVR--
MSMEG_4168|M.smegmatis_MC2_155 MRLSQTVRPEFLSAQDAVDRIPDQARLLVEASGGGVIEPSGLLDALADRY
. .*: : :. : .. * * *: **
MMAR_3851|M.marinum_M -----SGVTDLETVSNNCGVDGVGLGVLLQHKRIRRTVSSYVGENK--EF
MUL_3782|M.ulcerans_Agy99 -----SGVTDLETVSNNCGVDGVGLGVLLQHKRIRRTVSSYVGENK--EF
Mb2532c|M.bovis_AF2122/97 -----SGVTDLETVSNNCGIDGVGLGLLLQHKRIRRTVSSYVGENK--EF
Rv2504c|M.tuberculosis_H37Rv -----SGVTDLETVSNNCGIDGVGLGLLLQHKRIRRTVSSYVGENK--EF
MAV_4786|M.avium_104 -----SGIKDLTIVGNNAGVDDFGMGLLLKGRQVKKVIASYVGENK--EF
Mflv_0526|M.gilvum_PYR-GCK -----QGAADLTIVSNNAGNGDTGLAALLAAGRVTKVICSFPRQADSYVF
Mvan_4403|M.vanbaalenii_PYR-1 -----QGSRDLTVVSNNAGNGEVGIAALLKAERVRKIVCSFPRQSDSFVF
MSMEG_4168|M.smegmatis_MC2_155 RRTGEPGQLAAYFCSGIGNRSGSGMDVLALPGLLRSAIAGHWAMTP--AL
* .. . . *: * : :... :
MMAR_3851|M.marinum_M ARQFLSGELEVELTPQGTLAERLRAGGMGIPGFYTPAGVGTQIADGGLPW
MUL_3782|M.ulcerans_Agy99 ARQFLSGELEVELTPQGTLAERLRAGGMGIPGFYTPAGVGTQIADGGLPW
Mb2532c|M.bovis_AF2122/97 ARQFLAGELEVELTPQGTLAERLRAGGMGIPAFYTPAGVGTQVADGGLPW
Rv2504c|M.tuberculosis_H37Rv ARQFLAGELEVELTPQGTLAERLRAGGMGIPAFYTPAGVGTQVADGGLPW
MAV_4786|M.avium_104 ERQVLSGELDLVLTPQGTLAEKLRAGGAGIPGFYTRTGYGTTLAEG----
Mflv_0526|M.gilvum_PYR-GCK DALYRAGKVDLEVVPQGNLAERIRAAGAGIGAFFCPTGVGTPLVEG----
Mvan_4403|M.vanbaalenii_PYR-1 DELYRTGRVELELVPQGNLAERIRAAGAGIGAFFCPTGVGTPLAEG----
MSMEG_4168|M.smegmatis_MC2_155 SRMAHDGDIEAYNLPQGVLAQLLRESAAKRPGLITKVGLGTFCDPRQGGG
* :: *** **: :* .. .: .* **
MMAR_3851|M.marinum_M RYDASGAVAVVSPPKETREFDGATYVLERGIRTDFALVHAWKGDRHGNLL
MUL_3782|M.ulcerans_Agy99 RYDASGAVAVVSPPKETREFDGATYVLERGIRTDFALVHAWKGDRHGNLL
Mb2532c|M.bovis_AF2122/97 RYDASGGVAVVSPAKETREFDGVTYVLERGIRTDFALVHAWQGDRHGNLM
Rv2504c|M.tuberculosis_H37Rv RYDASGGVAVVSPAKETREFDGVTYVLERGIRTDFALVHAWQGDRHGNLM
MAV_4786|M.avium_104 --------------KDTRVFDGVEYVLEEGIRADLAIVKAWKGDKAGNLV
Mflv_0526|M.gilvum_PYR-GCK --------------KEIRTIDGRDYVLEYPIFGDVALIGAHVADQVGNLL
Mvan_4403|M.vanbaalenii_PYR-1 --------------KESRTIGDRTYLLEYPISGDFALIAADTADSAGNLV
MSMEG_4168|M.smegmatis_MC2_155 RLNN----ATTTELVQVMEINSEEYLFYPSPSFDVAFIRGTTADEHGNLT
: :.. *:: *.*:: . .* ***
MMAR_3851|M.marinum_M YRYSAANFNPECAPAGR-----ITIAEVEHLVEPGEIDPATVHTPGVFVQ
MUL_3782|M.ulcerans_Agy99 YRYSAANFNPECAPAGR-----ITIAEVEHLVEPGEIGPATVHTPGVFVQ
Mb2532c|M.bovis_AF2122/97 YRHAAANFNPECASAGR-----ITIAEVEHLVEPGEIDPATVHTPGVFVH
Rv2504c|M.tuberculosis_H37Rv YRHAAANFNPECASAGR-----ITIAEVEHLVEPGEIDPATVHTPGVFVH
MAV_4786|M.avium_104 YRKTARNFNPMIATCAA-----VTVAEVEELVEVGDLDPDLIHTPGIYVD
Mflv_0526|M.gilvum_PYR-GCK YRKTARNFGPVMATAAL-----LTVVEVSRVVDTGQIDPETVVTPGIYVD
Mvan_4403|M.vanbaalenii_PYR-1 YRKTARNFGPVMATAAT-----TTIAQARRIVCSGQLDPEAVVTPGIYVD
MSMEG_4168|M.smegmatis_MC2_155 MEHETAKLGVLAAATATRNNGGLVIAQVKRVAAAHTLNPKSVVVPGHLID
. : ::. *. . .:.:. .:. :.* : .** :.
MMAR_3851|M.marinum_M RVVHVPNPIKRIEKETVRP-------------------------------
MUL_3782|M.ulcerans_Agy99 RVVHVPNPIKRIEKETVRP-------------------------------
Mb2532c|M.bovis_AF2122/97 RVVHVPNPAKKIERETVRQ-------------------------------
Rv2504c|M.tuberculosis_H37Rv RVVHVPNPAKKIERETVRQ-------------------------------
MAV_4786|M.avium_104 RIIQGIGYEKRIEFRTTSGGAALKNDSPIRERMAQRAAKELRDGYYVNLG
Mflv_0526|M.gilvum_PYR-GCK RVLDLSAIPETSTEAAS---------------------------------
Mvan_4403|M.vanbaalenii_PYR-1 DLVQIPRPRSPIGGAAP---------------------------------
MSMEG_4168|M.smegmatis_MC2_155 IVVVQEDQWQTAINEYNPAFSGEVYVPFGRSPAMPLSERKVVARRALDEI
:: .
MMAR_3851|M.marinum_M --------------------------------------------------
MUL_3782|M.ulcerans_Agy99 --------------------------------------------------
Mb2532c|M.bovis_AF2122/97 --------------------------------------------------
Rv2504c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4786|M.avium_104 IGIPTLVANFIPDDIQVTLQSENGLLGIGAYPSEDTVDPDLINAGKQTIT
Mflv_0526|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4403|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4168|M.smegmatis_MC2_155 RPASVVNLGVGMADGVATAALEEGRLQEITLTVEQGMVGGVPERGVIFGV
MMAR_3851|M.marinum_M --------------------------------------------------
MUL_3782|M.ulcerans_Agy99 --------------------------------------------------
Mb2532c|M.bovis_AF2122/97 --------------------------------------------------
Rv2504c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4786|M.avium_104 SLPGSSFFSSADSFAMIRGGHIDLSILGALEVASNGDLANWMVPGKMVKG
Mflv_0526|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4403|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4168|M.smegmatis_MC2_155 SWNPEAVIEHASQFDFYDGGGLDVACLGFAEVDREGNVNSSLVDG-RIFG
MMAR_3851|M.marinum_M --------------------------------------------------
MUL_3782|M.ulcerans_Agy99 --------------------------------------------------
Mb2532c|M.bovis_AF2122/97 --------------------------------------------------
Rv2504c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4786|M.avium_104 PGGAMDLVSGVKRVIVLMDHTAKDGSPKVLE-------------------
Mflv_0526|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4403|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4168|M.smegmatis_MC2_155 AGGFINISQSAKKVVFCGTLTAGGLTIDLADGYPKVTSEGRHRKFIDKVR
MMAR_3851|M.marinum_M --------------------------------------------------
MUL_3782|M.ulcerans_Agy99 --------------------------------------------------
Mb2532c|M.bovis_AF2122/97 --------------------------------------------------
Rv2504c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4786|M.avium_104 --QCTLPLTGKGVVDMIITNLCVFDVEPGRGLLLTELHPGVTVEEVRAKT
Mflv_0526|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4403|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4168|M.smegmatis_MC2_155 QITFNAHLARERGQEVIYVTERAVFTLGDDGPVLTEVAPGWTIDQVIALM
MMAR_3851|M.marinum_M ------------------------------------
MUL_3782|M.ulcerans_Agy99 ------------------------------------
Mb2532c|M.bovis_AF2122/97 ------------------------------------
Rv2504c|M.tuberculosis_H37Rv ------------------------------------
MAV_4786|M.avium_104 GCDFTVAL----------------------------
Mflv_0526|M.gilvum_PYR-GCK ------------------------------------
Mvan_4403|M.vanbaalenii_PYR-1 ------------------------------------
MSMEG_4168|M.smegmatis_MC2_155 DFRPKLADDVRLMSGSLFSAATRNPDIPNIPITEEN