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SYEDILTEVDGPVLTITINRPEAGNKFRHQTCLELFDALQKFRLDREVRAAILTGAGEKFFCIGGEHDPL TSLDQSQVLPIIDVYQAIDTIPKPVIAAVNGFAVGGGNVLHTVCDLSIASSTAVFRQVGPMVGSFDAGYG TWYLEDTIGRKRAKEMWYLNGKFTAAKAEAMGLVNEVVEPNKLMNRATEIAREISTRSPLAIGALKGAFS ARHNGVSGQARMAHDQQLTLYLQTQEAHEVSASFGERRQPNTESFWS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4114 | menB | - | 100% (258) | naphthoate synthase |
| M. smegmatis MC2 155 | MSMEG_1075 | menB | 1e-34 | 34.78% (276) | naphthoate synthase |
| M. smegmatis MC2 155 | MSMEG_5198 | - | 1e-28 | 34.92% (252) | carnitinyl-CoA dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0562c | menB | 3e-36 | 36.43% (269) | naphthoate synthase |
| M. gilvum PYR-GCK | Mflv_0025 | - | 2e-40 | 39.03% (269) | naphthoate synthase |
| M. tuberculosis H37Rv | Rv0548c | menB | 3e-36 | 36.43% (269) | naphthoate synthase |
| M. leprae Br4923 | MLBr_02263 | menB | 3e-37 | 37.17% (269) | naphthoate synthase |
| M. abscessus ATCC 19977 | MAB_3945 | - | 2e-37 | 39.15% (258) | naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) |
| M. marinum M | MMAR_0895 | menB | 5e-36 | 36.43% (269) | naphthoate synthase, MenB |
| M. avium 104 | MAV_4596 | menB | 2e-37 | 37.17% (269) | naphthoate synthase |
| M. thermoresistible (build 8) | TH_1330 | menB | 4e-36 | 36.76% (272) | PROBABLE NAPHTHOATE SYNTHASE MENB (DIHYDROXYNAPHTHOIC ACID |
| M. ulcerans Agy99 | MUL_0648 | menB | 3e-36 | 36.43% (269) | naphthoate synthase |
| M. vanbaalenii PYR-1 | Mvan_0947 | - | 4e-40 | 38.97% (272) | naphthoate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0562c|M.bovis_AF2122/97 MVAPAGEQGRSSTALSDNPFDAKAWRLVDGFDDLTDITYHRHVDD-----
Rv0548c|M.tuberculosis_H37Rv MVAPAGEQGRSSTALSDNPFDAKAWRLVDGFDDLTDITYHRHVDD-----
MLBr_02263|M.leprae_Br4923 --------------MSNNPFDAKLWRLIDGFGDLTDITYHRYVNG-----
MAV_4596|M.avium_104 ---------------------------MAGFDDLTDITYHRHVDD-----
MMAR_0895|M.marinum_M --------------MSDNPFDAGVWRLVNGFDELTDITYHRHVQD-----
MUL_0648|M.ulcerans_Agy99 --------------MSDNPFDAGVWRLVNGFDELTDITYHRHVQD-----
TH_1330|M.thermoresistible__bu --------------MSDNPFDPELWRVVDGFDDLTDITYHRHVVDGE---
Mflv_0025|M.gilvum_PYR-GCK -----------MSTPGSNPFDPSLWEPVSGFDDLTDITYHR-AVD-----
Mvan_0947|M.vanbaalenii_PYR-1 -----------MSAPGTNPFDASLWEPVAGFEDLTDITYHRHVVDGA---
MAB_3945|M.abscessus_ATCC_1997 --------MTQDDGQTANPFDPTRWQPVPGFEDLTDITYHRNVEHGSNGA
MSMEG_4114|M.smegmatis_MC2_155 ---------------------------------MSYEDILTEVDG-----
:: .
Mb0562c|M.bovis_AF2122/97 ---ATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGP
Rv0548c|M.tuberculosis_H37Rv ---ATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGP
MLBr_02263|M.leprae_Br4923 ---ATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGP
MAV_4596|M.avium_104 ---ATVRVAFDRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGP
MMAR_0895|M.marinum_M ---ATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGP
MUL_0648|M.ulcerans_Agy99 ---ATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGP
TH_1330|M.thermoresistible__bu -PQPTVRVAFNRPEVRNAFRPHTVDELYRALDHARMSPDVGVVLLTGNGP
Mflv_0025|M.gilvum_PYR-GCK --QPTVRIAFDRPEVRNAFRPHTVDELYRVLDHARMSSNVGVVLLTGNGP
Mvan_0947|M.vanbaalenii_PYR-1 -RKPTVRIAFDRPEVRNAFRPHTVDELYRVLDHARMSSDVGVVLLTGNGP
MAB_3945|M.abscessus_ATCC_1997 RQTGTVRIAFDRPEVRNAFRPHTVDELYRALDHARMTSDVGAVLLTGNGP
MSMEG_4114|M.smegmatis_MC2_155 ---PVLTITINRPEAGNKFRHQTCLELFDALQKFRLDREVRAAILTGAGE
.: ::::***. * ** :* **: .*:: *: :* ..:*** *
Mb0562c|M.bovis_AF2122/97 SPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRL
Rv0548c|M.tuberculosis_H37Rv SPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRL
MLBr_02263|M.leprae_Br4923 SPRDGVWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRL
MAV_4596|M.avium_104 SPKDGGWAFCSGGDQRIRGRSGYQYASGETADTVDPARAGRLHILEVQRL
MMAR_0895|M.marinum_M SPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDIARAGRLHILEVQRL
MUL_0648|M.ulcerans_Agy99 SPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDIARAGRLHILEVQRL
TH_1330|M.thermoresistible__bu SPKDGGWAFCSGGDQRIRGRTGYQYASGETADTVDAARAGRLHILEVQRL
Mflv_0025|M.gilvum_PYR-GCK SPKDGGWAFCSGGDQRIRGRSGYQYASGDTAETVDPARAGRLHILEVQRL
Mvan_0947|M.vanbaalenii_PYR-1 SAKDGGWAFCSGGDQRIRGRSGYQYASGETAETVDPARAGRLHILEVQRL
MAB_3945|M.abscessus_ATCC_1997 SPKDGGWAFCSGGDQRIRGRTGYQYAGGETAETVDPGRAGRLHILEVQRL
MSMEG_4114|M.smegmatis_MC2_155 K------FFCIGGEH-------------DPLTSLD--QSQVLPIIDVYQA
. ** **:: :. ::* :: * *::* :
Mb0562c|M.bovis_AF2122/97 IRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFD
Rv0548c|M.tuberculosis_H37Rv IRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFD
MLBr_02263|M.leprae_Br4923 IRFMPKVVICLVNGWAAGGGHSLHVICDLTLASREHARFKQTDADVGSFD
MAV_4596|M.avium_104 IRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREHARFKQTDADVGSFD
MMAR_0895|M.marinum_M IRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASRQHARFKQTDADVGSFD
MUL_0648|M.ulcerans_Agy99 IRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASRQHARFKQTDADVGSFD
TH_1330|M.thermoresistible__bu IRFMPKVVICLVNGWAAGGGHSLHVTCDLTLASRQHARFKQTDADVGSFD
Mflv_0025|M.gilvum_PYR-GCK IRFMPKPVICLVNGWAAGGGHSLHVVCDLTLASREHARFKQTDADVGSFD
Mvan_0947|M.vanbaalenii_PYR-1 IRFMPKPVICLVNGWAAGGGHSLHVVCDLTLASREHARFKQTDADVGSFD
MAB_3945|M.abscessus_ATCC_1997 IRFMPKVVIALVNGWAAGGGHSLHVVCDLTLASREHARFKQTDADVGSFD
MSMEG_4114|M.smegmatis_MC2_155 IDTIPKPVIAAVNGFAVGGGNVLHTVCDLSIAS-STAVFRQVGPMVGSFD
* :** **. ***:*.***: **. ***::** . * *:*... *****
Mb0562c|M.bovis_AF2122/97 GGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETV
Rv0548c|M.tuberculosis_H37Rv GGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETV
MLBr_02263|M.leprae_Br4923 GGYGSAYLARQIGQKFAREIFLLGRAYTAEQMHHMGAVNAVAEHANLETM
MAV_4596|M.avium_104 GGYGSAYLARQVGQKFAREIFFLGREYTAEQMHRMGAVNAVVEHAELERA
MMAR_0895|M.marinum_M GGYGSAYLARQVGQKFAREIFFLGRPYTAEQMHHMGAVNEVVDHAELERV
MUL_0648|M.ulcerans_Agy99 GGYGSAYLARQVGQKFAREIFFLGRPYTAEQMHHMGAVNEVVDHAELERV
TH_1330|M.thermoresistible__bu GGFGSAYLARQTGQKFAREIFFLGRAYDAETMHQMGAVNEVVDHADLERA
Mflv_0025|M.gilvum_PYR-GCK GGYGSAYLARQAGQKFAREIFFLGRPYTAEQMHAMGAVNEVVDHAELENV
Mvan_0947|M.vanbaalenii_PYR-1 GGYGSAYLASQVGQKFAREIFFLGRAYTAEQMHAMGAVNEVVDHADLENV
MAB_3945|M.abscessus_ATCC_1997 GGYGSAYLAKMVGQKFAREIFFLGRPYTAEQMHHMGAVNEVVDHAELENV
MSMEG_4114|M.smegmatis_MC2_155 AGYGTWYLEDTIGRKRAKEMWYLNGKFTAAKAEAMGLVNEVVEPNKLMNR
.*:*: ** *:* *:*:: *. : * . ** ** *.: .*
Mb0562c|M.bovis_AF2122/97 GLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATR-LAYMTDE
Rv0548c|M.tuberculosis_H37Rv GLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATR-LAYMTDE
MLBr_02263|M.leprae_Br4923 GLEWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATR-LAYMTDE
MAV_4596|M.avium_104 GIEWAREINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATR-LAYMTDE
MMAR_0895|M.marinum_M GLQWAADINAKSPQAQRMLKYAFNLLDDGLVGQQLFAGEATR-LAYMTDE
MUL_0648|M.ulcerans_Agy99 GLQWAADINAKSPQAQRMLKYAFNLLDDGLVGQQLFAGEATR-LAYMTDE
TH_1330|M.thermoresistible__bu GLQWAAEINGKSPTAIRMLKFAFNLIDDGLVGQQVFAGEATR-LAYMTDE
Mflv_0025|M.gilvum_PYR-GCK ALQWASEINGKSPQAVRMLKYAFNLLDDGLVGQQLFAGEATR-LAYMTDE
Mvan_0947|M.vanbaalenii_PYR-1 ALQWASEINGKSPQAIRMLKYAFNLPDDGLVGQQLFAGEATR-LAYMTDE
MAB_3945|M.abscessus_ATCC_1997 ALEWAAAINGKSPQAQRMLKYAFNLTDDGLVGQQLFAGEATR-LAYMTDE
MSMEG_4114|M.smegmatis_MC2_155 ATEIAREISTRSPLAIGALKGAFSARHNGVSGQARMAHDQQLTLYLQTQE
. : * *. :** * ** **. .:*: ** :* : * *:*
Mb0562c|M.bovis_AF2122/97 AVEGRDAFLQKRPPDWSPFPRYF
Rv0548c|M.tuberculosis_H37Rv AVEGRDAFLQKRPPDWSPFPRYF
MLBr_02263|M.leprae_Br4923 AVEGRDAFLQKRAPDWSSFPRYF
MAV_4596|M.avium_104 AVEGRDAFLEKRPPDYSRFPRYF
MMAR_0895|M.marinum_M AVEGRDAFLEKRAPDWSGFPRYF
MUL_0648|M.ulcerans_Agy99 AVEGRDAFLEKRAPDWSGFPRYF
TH_1330|M.thermoresistible__bu AVEGRDAFLEKRDPDWSAFPRYF
Mflv_0025|M.gilvum_PYR-GCK AVEGRDAFLEKRDPDWSPFPRYF
Mvan_0947|M.vanbaalenii_PYR-1 AVEGRDAFLEKRDPDWSPFPRYF
MAB_3945|M.abscessus_ATCC_1997 AVEGRDSFLQKREPDWSPYPWHY
MSMEG_4114|M.smegmatis_MC2_155 AHEVSASFGERRQPNTESFWS--
* * :* ::* *: . :