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SDNPFDAGVWRLVNGFDELTDITYHRHVQDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVV LLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDIARAGRLHILEVQRLIRFMPKVVICLVN GWAAGGGHSLHVVCDLTLASRQHARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRPYTAEQMH HMGAVNEVVDHAELERVGLQWAADINAKSPQAQRMLKYAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEG RDAFLEKRAPDWSGFPRYF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0648 | menB | - | 100% (300) | naphthoate synthase |
| M. ulcerans Agy99 | MUL_0972 | echA1_1 | 4e-20 | 28.72% (282) | enoyl-CoA hydratase, EchA1_1 |
| M. ulcerans Agy99 | MUL_0210 | echA8 | 3e-18 | 26.92% (260) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0562c | menB | 1e-167 | 93.67% (300) | naphthoate synthase |
| M. gilvum PYR-GCK | Mflv_0025 | - | 1e-158 | 90.24% (297) | naphthoate synthase |
| M. tuberculosis H37Rv | Rv0548c | menB | 1e-167 | 93.67% (300) | naphthoate synthase |
| M. leprae Br4923 | MLBr_02263 | menB | 1e-164 | 90.33% (300) | naphthoate synthase |
| M. abscessus ATCC 19977 | MAB_3945 | - | 1e-151 | 83.93% (305) | naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) |
| M. marinum M | MMAR_0895 | menB | 1e-178 | 100.00% (300) | naphthoate synthase, MenB |
| M. avium 104 | MAV_4596 | menB | 1e-158 | 93.03% (287) | naphthoate synthase |
| M. smegmatis MC2 155 | MSMEG_1075 | menB | 1e-155 | 86.47% (303) | naphthoate synthase |
| M. thermoresistible (build 8) | TH_1330 | menB | 1e-160 | 88.49% (304) | PROBABLE NAPHTHOATE SYNTHASE MENB (DIHYDROXYNAPHTHOIC ACID |
| M. vanbaalenii PYR-1 | Mvan_0947 | - | 1e-155 | 88.37% (301) | naphthoate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0025|M.gilvum_PYR-GCK -----------MSTPGSNPFDPSLWEPVSGFDDLTDITYHR-AVD-----
Mvan_0947|M.vanbaalenii_PYR-1 -----------MSAPGTNPFDASLWEPVAGFEDLTDITYHRHVVDGA---
MUL_0648|M.ulcerans_Agy99 --------------MSDNPFDAGVWRLVNGFDELTDITYHRHVQD-----
MMAR_0895|M.marinum_M --------------MSDNPFDAGVWRLVNGFDELTDITYHRHVQD-----
Mb0562c|M.bovis_AF2122/97 MVAPAGEQGRSSTALSDNPFDAKAWRLVDGFDDLTDITYHRHVDD-----
Rv0548c|M.tuberculosis_H37Rv MVAPAGEQGRSSTALSDNPFDAKAWRLVDGFDDLTDITYHRHVDD-----
MLBr_02263|M.leprae_Br4923 --------------MSNNPFDAKLWRLIDGFGDLTDITYHRYVNG-----
MAV_4596|M.avium_104 ---------------------------MAGFDDLTDITYHRHVDD-----
MSMEG_1075|M.smegmatis_MC2_155 ---------MSSQAASDNPFDPAMWERVPGFDDLTDITYHRHVLDGA---
TH_1330|M.thermoresistible__bu --------------MSDNPFDPELWRVVDGFDDLTDITYHRHVVDGE---
MAB_3945|M.abscessus_ATCC_1997 --------MTQDDGQTANPFDPTRWQPVPGFEDLTDITYHRNVEHGSNGA
: ** :******** .
Mflv_0025|M.gilvum_PYR-GCK --QPTVRIAFDRPEVRNAFRPHTVDELYRVLDHARMSSNVGVVLLTGNGP
Mvan_0947|M.vanbaalenii_PYR-1 -RKPTVRIAFDRPEVRNAFRPHTVDELYRVLDHARMSSDVGVVLLTGNGP
MUL_0648|M.ulcerans_Agy99 ---ATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGP
MMAR_0895|M.marinum_M ---ATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGP
Mb0562c|M.bovis_AF2122/97 ---ATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGP
Rv0548c|M.tuberculosis_H37Rv ---ATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGP
MLBr_02263|M.leprae_Br4923 ---ATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGP
MAV_4596|M.avium_104 ---ATVRVAFDRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGP
MSMEG_1075|M.smegmatis_MC2_155 -RQPTVRVAFDRPEVRNAFRPHTVDELYRVLDHARMSSDVGVILLTGNGP
TH_1330|M.thermoresistible__bu -PQPTVRVAFNRPEVRNAFRPHTVDELYRALDHARMSPDVGVVLLTGNGP
MAB_3945|M.abscessus_ATCC_1997 RQTGTVRIAFDRPEVRNAFRPHTVDELYRALDHARMTSDVGAVLLTGNGP
***:**:******************.******:.:**.:*******
Mflv_0025|M.gilvum_PYR-GCK SPKDGGWAFCSGGDQRIRGRSGYQYASGDTAETVDPARAGRLHILEVQRL
Mvan_0947|M.vanbaalenii_PYR-1 SAKDGGWAFCSGGDQRIRGRSGYQYASGETAETVDPARAGRLHILEVQRL
MUL_0648|M.ulcerans_Agy99 SPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDIARAGRLHILEVQRL
MMAR_0895|M.marinum_M SPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDIARAGRLHILEVQRL
Mb0562c|M.bovis_AF2122/97 SPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRL
Rv0548c|M.tuberculosis_H37Rv SPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRL
MLBr_02263|M.leprae_Br4923 SPRDGVWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRL
MAV_4596|M.avium_104 SPKDGGWAFCSGGDQRIRGRSGYQYASGETADTVDPARAGRLHILEVQRL
MSMEG_1075|M.smegmatis_MC2_155 SPKDGGWAFCSGGDQRIRGRTGYQYASGETAETVDPARAGRLHILEVQRL
TH_1330|M.thermoresistible__bu SPKDGGWAFCSGGDQRIRGRTGYQYASGETADTVDAARAGRLHILEVQRL
MAB_3945|M.abscessus_ATCC_1997 SPKDGGWAFCSGGDQRIRGRTGYQYAGGETAETVDPGRAGRLHILEVQRL
*.:** **************:*****.*:**:*** .*************
Mflv_0025|M.gilvum_PYR-GCK IRFMPKPVICLVNGWAAGGGHSLHVVCDLTLASREHARFKQTDADVGSFD
Mvan_0947|M.vanbaalenii_PYR-1 IRFMPKPVICLVNGWAAGGGHSLHVVCDLTLASREHARFKQTDADVGSFD
MUL_0648|M.ulcerans_Agy99 IRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASRQHARFKQTDADVGSFD
MMAR_0895|M.marinum_M IRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASRQHARFKQTDADVGSFD
Mb0562c|M.bovis_AF2122/97 IRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFD
Rv0548c|M.tuberculosis_H37Rv IRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFD
MLBr_02263|M.leprae_Br4923 IRFMPKVVICLVNGWAAGGGHSLHVICDLTLASREHARFKQTDADVGSFD
MAV_4596|M.avium_104 IRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREHARFKQTDADVGSFD
MSMEG_1075|M.smegmatis_MC2_155 IRFMPKVVICLVNGWAAGGGHSLHVTCDLTLASREHARFKQTDADVGSFD
TH_1330|M.thermoresistible__bu IRFMPKVVICLVNGWAAGGGHSLHVTCDLTLASRQHARFKQTDADVGSFD
MAB_3945|M.abscessus_ATCC_1997 IRFMPKVVIALVNGWAAGGGHSLHVVCDLTLASREHARFKQTDADVGSFD
****** **.*************** ********::**************
Mflv_0025|M.gilvum_PYR-GCK GGYGSAYLARQAGQKFAREIFFLGRPYTAEQMHAMGAVNEVVDHAELENV
Mvan_0947|M.vanbaalenii_PYR-1 GGYGSAYLASQVGQKFAREIFFLGRAYTAEQMHAMGAVNEVVDHADLENV
MUL_0648|M.ulcerans_Agy99 GGYGSAYLARQVGQKFAREIFFLGRPYTAEQMHHMGAVNEVVDHAELERV
MMAR_0895|M.marinum_M GGYGSAYLARQVGQKFAREIFFLGRPYTAEQMHHMGAVNEVVDHAELERV
Mb0562c|M.bovis_AF2122/97 GGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETV
Rv0548c|M.tuberculosis_H37Rv GGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETV
MLBr_02263|M.leprae_Br4923 GGYGSAYLARQIGQKFAREIFLLGRAYTAEQMHHMGAVNAVAEHANLETM
MAV_4596|M.avium_104 GGYGSAYLARQVGQKFAREIFFLGREYTAEQMHRMGAVNAVVEHAELERA
MSMEG_1075|M.smegmatis_MC2_155 GGFGSAYLARQTGQKFAREIFFLGRAYDAQTMHQMGAVNEVVDHADLEKA
TH_1330|M.thermoresistible__bu GGFGSAYLARQTGQKFAREIFFLGRAYDAETMHQMGAVNEVVDHADLERA
MAB_3945|M.abscessus_ATCC_1997 GGYGSAYLAKMVGQKFAREIFFLGRPYTAEQMHHMGAVNEVVDHAELENV
**:****** *********:*** * *: ** ***** *.:**:**
Mflv_0025|M.gilvum_PYR-GCK ALQWASEINGKSPQAVRMLKYAFNLLDDGLVGQQLFAGEATRLAYMTDEA
Mvan_0947|M.vanbaalenii_PYR-1 ALQWASEINGKSPQAIRMLKYAFNLPDDGLVGQQLFAGEATRLAYMTDEA
MUL_0648|M.ulcerans_Agy99 GLQWAADINAKSPQAQRMLKYAFNLLDDGLVGQQLFAGEATRLAYMTDEA
MMAR_0895|M.marinum_M GLQWAADINAKSPQAQRMLKYAFNLLDDGLVGQQLFAGEATRLAYMTDEA
Mb0562c|M.bovis_AF2122/97 GLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEA
Rv0548c|M.tuberculosis_H37Rv GLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEA
MLBr_02263|M.leprae_Br4923 GLEWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEA
MAV_4596|M.avium_104 GIEWAREINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEA
MSMEG_1075|M.smegmatis_MC2_155 GLQYAAEINGKSPQAIRMLKFAFNLIDDGLVGQQVFAGEATRLAYMTDEA
TH_1330|M.thermoresistible__bu GLQWAAEINGKSPTAIRMLKFAFNLIDDGLVGQQVFAGEATRLAYMTDEA
MAB_3945|M.abscessus_ATCC_1997 ALEWAAAINGKSPQAQRMLKYAFNLTDDGLVGQQLFAGEATRLAYMTDEA
.:::* **.*** * ****:**** ********:***************
Mflv_0025|M.gilvum_PYR-GCK VEGRDAFLEKRDPDWSPFPRYF
Mvan_0947|M.vanbaalenii_PYR-1 VEGRDAFLEKRDPDWSPFPRYF
MUL_0648|M.ulcerans_Agy99 VEGRDAFLEKRAPDWSGFPRYF
MMAR_0895|M.marinum_M VEGRDAFLEKRAPDWSGFPRYF
Mb0562c|M.bovis_AF2122/97 VEGRDAFLQKRPPDWSPFPRYF
Rv0548c|M.tuberculosis_H37Rv VEGRDAFLQKRPPDWSPFPRYF
MLBr_02263|M.leprae_Br4923 VEGRDAFLQKRAPDWSSFPRYF
MAV_4596|M.avium_104 VEGRDAFLEKRPPDYSRFPRYF
MSMEG_1075|M.smegmatis_MC2_155 VEGRDAFLEKRDPDWSRFPRYF
TH_1330|M.thermoresistible__bu VEGRDAFLEKRDPDWSAFPRYF
MAB_3945|M.abscessus_ATCC_1997 VEGRDSFLQKREPDWSPYPWHY
*****:**:** **:* :* ::