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SNWGDYENEIYGQGLVGVAPTLPMSYADWEAHAQQALPPGVLSYVAGGSGDEHTQRANVEAFKHWGLMPR MLMAATERDLSVELWGKTWAAPMFFAPIGVIALCAQDGHGDAASAQASARTGVPYITSTLAVSSLEDIRK HAGDTPAYFQLYYPEDRDLAESFIRRAEEAGYDGLVITLDTWIFGWRPRDLTISNFPFLRGLCLTNYVTD PVFQKKFKAHSGVEAEGLRDNPRLAADFWHGLFGHSVTWEDIDWVRSITKMPVILKGIQHPDDARRAVDS GVDGIYCSNHGGRQANGGLPALDCLPEVVKASGDTPVLFDSGIRTGADVVKALAMGASAVGIGRPYAWGA ALGGSKGIEHVARSLLAEADLIMAVDGYRNLKELTIDALRPTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3962 | - | - | 100% (394) | lactate 2-monooxygenase |
| M. smegmatis MC2 155 | MSMEG_2512 | - | e-143 | 62.89% (388) | lactate 2-monooxygenase |
| M. smegmatis MC2 155 | MSMEG_1424 | - | 1e-42 | 33.42% (368) | FMN-dependent dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0713 | lldD1 | 1e-46 | 34.84% (376) | L-lactate dehydrogenase (cytochrome) LldD1 |
| M. gilvum PYR-GCK | Mflv_4136 | - | 1e-142 | 60.82% (388) | FMN-dependent alpha-hydroxy acid dehydrogenase |
| M. tuberculosis H37Rv | Rv0694 | lldD1 | 1e-46 | 34.84% (376) | L-lactate dehydrogenase (cytochrome) LldD1 |
| M. leprae Br4923 | MLBr_02046 | lldD2 | 1e-45 | 31.51% (365) | L-lactate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2126 | - | 1e-104 | 49.36% (389) | putative L-lactate 2-monooxygenase |
| M. marinum M | MMAR_1816 | lldD1_1 | 1e-143 | 62.89% (388) | L-lactate dehydrogenase (cytochrome) LldD1_1 |
| M. avium 104 | MAV_3747 | - | 1e-144 | 62.37% (388) | lactate 2-monooxygenase |
| M. thermoresistible (build 8) | TH_0845 | - | 1e-146 | 64.69% (388) | lactate 2-monooxygenase |
| M. ulcerans Agy99 | MUL_0774 | lldD1 | 8e-46 | 33.69% (371) | L-lactate dehydrogenase (cytochrome) LldD1 |
| M. vanbaalenii PYR-1 | Mvan_2206 | - | 1e-145 | 62.63% (388) | FMN-dependent alpha-hydroxy acid dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4136|M.gilvum_PYR-GCK -----------MTFGNYQLEIYLQGLSGIMPAYPMDFAGWEARAQASMPP
Mvan_2206|M.vanbaalenii_PYR-1 -----------MTFGNYQLEIYLQGLSGILPNLPMDYAGWEAKAESAMPP
TH_0845|M.thermoresistible__bu -----------MAFGDYQLEIYLQGLSGVVPSLPMAFAELEARARAAMSP
MMAR_1816|M.marinum_M -----------MAFGDYQYEIYFQGLSGVVPGLPMAFAELESRAQMALPP
MAV_3747|M.avium_104 -----------MAFGDYQNEIYFRGLGGVAPSLPMAFAELESRAERAMSP
MSMEG_3962|M.smegmatis_MC2_155 ----------MSNWGDYENEIYGQGLVGVAPTLPMSYADWEAHAQQALPP
MAB_2126|M.abscessus_ATCC_1997 -----------MNFGDFQLQFYAAGALGKVSTLPFNFAELESRAEQTLGE
Mb0713|M.bovis_AF2122/97 -------------------------MAEAWFETVAIAQQR---AKRRLPK
Rv0694|M.tuberculosis_H37Rv -------------------------MAEAWFETVAIAQQR---AKRRLPK
MUL_0774|M.ulcerans_Agy99 -------------------------MADEWFETVAIAQQR---AKRRLPK
MLBr_02046|M.leprae_Br4923 MAAKRRMPRVHDLAPLIQFKRPKFGATKRRLEAALTIQDLRCIAKQRTPK
*.
Mflv_4136|M.gilvum_PYR-GCK SVWSYVAGGAGDENTQRANRTAFDRWGLMPRMLVGTTERDLTVDVFGLTL
Mvan_2206|M.vanbaalenii_PYR-1 SVWSYVVGGAGDEHTQRANRTAFDRWGLIPRMLVGATERDLTVDLFGMTL
TH_0845|M.thermoresistible__bu SVWSYVAGGAGDERTQRINVSAFDNWGLIPRMLVGATERDLSVNLFGLTL
MMAR_1816|M.marinum_M SVWSYVVGGAGDERTQRANCEAFDRWGLMPRMFVGAAERDLTVEMFGLTL
MAV_3747|M.avium_104 SVWSYVTGGAGDERTQRANREAFDRWGLIPRMFVGAAERDLSVQMFGLTL
MSMEG_3962|M.smegmatis_MC2_155 GVLSYVAGGSGDEHTQRANVEAFKHWGLMPRMLMAATERDLSVELWGKTW
MAB_2126|M.abscessus_ATCC_1997 GIFGYVRGGAGDEHTQDSNVTALRRYGLVPRMLRDRTVRDMSTSFLGRTF
Mb0713|M.bovis_AF2122/97 SVYSSLIAASEKGITVADNVAAFSELGFAPHVIGATDKRDLSTTVMGQEV
Rv0694|M.tuberculosis_H37Rv SVYSSLIAASEKGITVADNVAAFSELGFAPHVIGATDKRDLSTTVMGQEV
MUL_0774|M.ulcerans_Agy99 SVYSSLISASEKGITVADNVAAFSELGFAPHVIGAAEKRDMSTTVMGQDI
MLBr_02046|M.leprae_Br4923 AAFDYTDGAAEDELSIKRAQQAFRDIEFHPAILRDVTNVCAGWDVLGHSV
. . ..: . : *: : * :: . *
Mflv_4136|M.gilvum_PYR-GCK PSPIFMAPVGVAGICSQSGHGDLEAARAAARTGVPMAVSTLTEDPLEDVA
Mvan_2206|M.vanbaalenii_PYR-1 PSPLFMAPIGVIGICSQNGQGDLAAARAAARTGVPMTVSTLTEDPLEDVA
TH_0845|M.thermoresistible__bu PSPIFMAPIGVLGICAQDHHGDLACARAAARTGVPLVVSTLTQDPLEDIA
MMAR_1816|M.marinum_M PSPIFLAPIGVIGLCAQDGHGDLATARAAARTGVPMVVSTLTADPMEDVA
MAV_3747|M.avium_104 PSPVFMAPIGVIGICAQDGHGDLATARAAAATGVPMVVSTLTADPMEDVA
MSMEG_3962|M.smegmatis_MC2_155 AAPMFFAPIGVIALCAQDGHGDAASAQASARTGVPYITSTLAVSSLEDIR
MAB_2126|M.abscessus_ATCC_1997 TSPAFICPVGVLGAVRD--RGDLLTAAAARELDMPAMYSTLSAATLEEVA
Mb0713|M.bovis_AF2122/97 SLPVIISPTG-VQAVDP--GGEVAVARAAAARGTVMGLSSFASKPIEEVI
Rv0694|M.tuberculosis_H37Rv SLPVIISPTG-VQAVDP--GGEVAVARAAAARGTVMGLSSFASKPIEEVI
MUL_0774|M.ulcerans_Agy99 SMPVLISPTG-VQAVHP--DGEVAVARAAAARGTAMGLSSFASKTIEDVI
MLBr_02046|M.leprae_Br4923 LLPFGIAPTGFTRLMHT--EGEIAGARAAAAAGIPFSLSTLATSAIEDVV
* :.* * *: * *: . *::: .:*::
Mflv_4136|M.gilvum_PYR-GCK AEFGDTPGFFQLYTPTDRDLAASFVQRAEAAGYKAIIVTLDTWIPGWRPR
Mvan_2206|M.vanbaalenii_PYR-1 AEFGDTPGFFQLYTPTDRDLAASLVHRAEAAGYKAIIVTLDTWIPGWRPR
TH_0845|M.thermoresistible__bu AEFGDTPGFFQLYTPNDRDLAASLVRRAEKAGYKGIIVTLDTWIPGWRPR
MMAR_1816|M.marinum_M AEFGDIPGFFQLYTPKDRELAASLVQRAESAGFKGIVVTLDTWIPGWRPR
MAV_3747|M.avium_104 AQFGDTPGFFQLYTPKDRELAASLVHRAEAAGFKGIIVTLDTWIPGWRPR
MSMEG_3962|M.smegmatis_MC2_155 KHAGDTPAYFQLYYPEDRDLAESFIRRAEEAGYDGLVITLDTWIFGWRPR
MAB_2126|M.abscessus_ATCC_1997 AARGDSYGIFQLYPSSDSELTDNFIRRAEAAGYDALAVTLDTGTLGWRPR
Mb0713|M.bovis_AF2122/97 AANP--KTFFQVYWQGGRDALAERVERARQAGAVGLVVTTDWTFSHGRDW
Rv0694|M.tuberculosis_H37Rv AANP--KTFFQVYWQGGRDALAERVERARQAGAVGLVVTTDWTFSHGRDW
MUL_0774|M.ulcerans_Agy99 AANP--KIFFQIYWLGGRDAIAERVERARQAGAVGLIVTTDWTFSHGRDW
MLBr_02046|M.leprae_Br4923 AAVPQGRKWFQLYMWRDRDRSMALVERAADAGYDALLVTVDVPVAGARLR
**:* . : :.** ** .: :* * *
Mflv_4136|M.gilvum_PYR-GCK DLSTS-------NFPQLRGRCLSNYTSDPVFRGLLPQPP-----------
Mvan_2206|M.vanbaalenii_PYR-1 DLAMS-------NFPQLRGRCLANYTSDPVFRAALSQPP-----------
TH_0845|M.thermoresistible__bu DLSTS-------NFPQLRGYSLANYTSDPVFSAGLQQPP-----------
MMAR_1816|M.marinum_M DLSTA-------NFPQLRGHCLSNYTSDPVFRAGLPRPP-----------
MAV_3747|M.avium_104 DLSTA-------NFPQLRGMCLSNYTSDPVFRAALARPP-----------
MSMEG_3962|M.smegmatis_MC2_155 DLTIS-------NFPFLRGLCLTNYVTDPVFQKKFKAHSGVEAEGL----
MAB_2126|M.abscessus_ATCC_1997 DLKHG-------YLPMLHGHCLANYTSDPRFLEIAGVRSAG---------
Mb0713|M.bovis_AF2122/97 GSPK---IPEEMNLKTILRLSPEAITRPRWLWKFAKTLRPPDLRVPNQGR
Rv0694|M.tuberculosis_H37Rv GSPK---IPEEMNLKTILRLSPEAITRPRWLWKFAKTLRPPDLRVPNQGR
MUL_0774|M.ulcerans_Agy99 GSPK---IPEQMNLRTILRLSPEAIVRPRWLWKFGKTLRPPDLRVPNQGR
MLBr_02046|M.leprae_Br4923 DTRNGMSIPPALTLRTVF----DALPHPRWWIDLLTTEP---LAFASLDR
. : :
Mflv_4136|M.gilvum_PYR-GCK -EENMQATVLQWAGMFGNA-LSWDDLPWLRSLTDLPLILKGLCHPDDVRR
Mvan_2206|M.vanbaalenii_PYR-1 -EENMQAAVLQWVAQFGNA-LTWEDLPWLRSLTDLPLVLKGLCHPDDVRR
TH_0845|M.thermoresistible__bu -EQNPQAVVTRWVQLFGNS-LTWDDLPWLRSLTTLPLILKGICHPDDVRR
MMAR_1816|M.marinum_M -EEDPQGTVLRWAQLFGNP-LTWSDLAWLRELTDLPLIVKGICHPDDARR
MAV_3747|M.avium_104 -EEDPQGTVLQWISTFGNP-LTWDDLPWLRSLTDLPLIIKGICHPDDARR
MSMEG_3962|M.smegmatis_MC2_155 -RDNPRLAADFWHGLFGHS-VTWEDIDWVRSITKMPVILKGIQHPDDARR
MAB_2126|M.abscessus_ATCC_1997 -ELTPMHAGLVWASLFSHPGLTWADIDHYRSITKLPIILKGICDSDDVRQ
Mb0713|M.bovis_AF2122/97 RGEPGPPFFAAYGEWMATPPPTWEDIGWLRELWGGPFMLKGVMRVDDAKR
Rv0694|M.tuberculosis_H37Rv RGEPGPPFFAAYGEWMATPPPTWEDIGWLRELWGGPFMLKGVMRVDDAKR
MUL_0774|M.ulcerans_Agy99 RGEPGPAFFAAYGEWMGTPPPTWDDIAWLRELWGGPFMLKGVMRVDDAKR
MLBr_02046|M.leprae_Br4923 WSG----TVSDYLNTMFDPSVTFDDLAWIKTQWPGKFVVKGIQTLDDARA
: : . :: *: : .::**: **.:
Mflv_4136|M.gilvum_PYR-GCK ARDGGVDGIYCSTHGGRQANGGLPAIDCLPVVVEAADG-LPVLFDSGVRS
Mvan_2206|M.vanbaalenii_PYR-1 AKDAGVDGVYCSTHGGRQANGGLPALDCLPGVVEAADG-LPVLFDSGIRS
TH_0845|M.thermoresistible__bu AKDAGVDGIYCSNHGGRQANGGLPAIDCLPDVVAAADG-MPVLFDSGIRS
MMAR_1816|M.marinum_M AKDGGVDGIYCSTHGGRQANGGLPALDCLPGVVEAADG-LPVLFDSGIRS
MAV_3747|M.avium_104 ARDGGVDGIYCSTHGGRQANGGLPALDCLPGVVEAADG-LPVLFDSGIRS
MSMEG_3962|M.smegmatis_MC2_155 AVDSGVDGIYCSNHGGRQANGGLPALDCLPEVVKASGD-TPVLFDSGIRT
MAB_2126|M.abscessus_ATCC_1997 AVDRGVDAIAYSNHGGRQANGGVPAIDGLAAAVEAAGS-VPVTFDSGIRD
Mb0713|M.bovis_AF2122/97 AVDAGVSAISVSNHGGNNLDGTPASIRALPAVSAAVGDQVEVLLDGGIRR
Rv0694|M.tuberculosis_H37Rv AVDAGVSAISVSNHGGNNLDGTPASIRALPAVSAAVGDQVEVLLDGGIRR
MUL_0774|M.ulcerans_Agy99 AVDAGVSAISVSNHGGNNLDGTPASIRALPAVAAAVGDQVEVLLDGGIRR
MLBr_02046|M.leprae_Br4923 VVERGIDGVVLSNHGGRQLDRAPVPFHLLPTVAREFGKDTEILLDTGIMS
. : *:..: *.***.: : .: *. . . : :* *:
Mflv_4136|M.gilvum_PYR-GCK GADIVKALALGATAVGIGRPYAYGLALGGTDGLVHVLRSLLAETDLIMAV
Mvan_2206|M.vanbaalenii_PYR-1 GADIVKALALGATAVGVGRPYAYGLAIGGEDGIVHVLRSLLAEADLIMAV
TH_0845|M.thermoresistible__bu GADIVKALALGATAVGIGRPYPYGLALGGEDGVVHVLRSLLAEADLIMAV
MMAR_1816|M.marinum_M GADIIKALAMGATAVGIGRPYAYGLALGGVDGVVHVLRMLLAEADLIMAV
MAV_3747|M.avium_104 GADVVKALALGATAVGIGRPYAYGLALGGVDGIVHVLRSILAEADLIMAV
MSMEG_3962|M.smegmatis_MC2_155 GADVVKALAMGASAVGIGRPYAWGAALGGSKGIEHVARSLLAEADLIMAV
MAB_2126|M.abscessus_ATCC_1997 GIDILRAVALGASLVGVARPYVYGLALDGTNGVKHVIQSLLAEADLTMAV
Mb0713|M.bovis_AF2122/97 GSDVVKAVALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGIDSALMG
Rv0694|M.tuberculosis_H37Rv GSDVVKAVALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGIDSALMG
MUL_0774|M.ulcerans_Agy99 GSDVVKAVALGARAVLVGRAYLWGLAANGQAGVENVLDILRGGIDSALMG
MLBr_02046|M.leprae_Br4923 GADIVAAIALGARCTLVGRAYLYGLMAGGEAGVRRAIEILESGVIRTMQL
* *:: *:*:** . :.*.* :* .* *: .. : . :
Mflv_4136|M.gilvum_PYR-GCK DGYPTLADLTPDTVRRVT--------------
Mvan_2206|M.vanbaalenii_PYR-1 DGYRSLADLTPDTLRRVI--------------
TH_0845|M.thermoresistible__bu DGYPTLADLTPDALRRVT--------------
MMAR_1816|M.marinum_M DGYPTRKDLTPDTLRRVN--------------
MAV_3747|M.avium_104 DGYPTRKDLTPDTLRRVV--------------
MSMEG_3962|M.smegmatis_MC2_155 DGYRNLKELTIDALRPTR--------------
MAB_2126|M.abscessus_ATCC_1997 NCYLSLNELAVQRLS-----------------
Mb0713|M.bovis_AF2122/97 LGHASVHDLSPADILVPTGFIRDLGVPSRRDV
Rv0694|M.tuberculosis_H37Rv LGHASVHDLSPADILVPTGFIRDLGVPSRRDV
MUL_0774|M.ulcerans_Agy99 LGHSSIHDLRSDDILIPADFVRRLGR------
MLBr_02046|M.leprae_Br4923 LGVTCLEELSPR----HVTQLQRLGPIEPPA-
:*