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MNFGDFQLQFYAAGALGKVSTLPFNFAELESRAEQTLGEGIFGYVRGGAGDEHTQDSNVTALRRYGLVPR MLRDRTVRDMSTSFLGRTFTSPAFICPVGVLGAVRDRGDLLTAAAARELDMPAMYSTLSAATLEEVAAAR GDSYGIFQLYPSSDSELTDNFIRRAEAAGYDALAVTLDTGTLGWRPRDLKHGYLPMLHGHCLANYTSDPR FLEIAGVRSAGELTPMHAGLVWASLFSHPGLTWADIDHYRSITKLPIILKGICDSDDVRQAVDRGVDAIA YSNHGGRQANGGVPAIDGLAAAVEAAGSVPVTFDSGIRDGIDILRAVALGASLVGVARPYVYGLALDGTN GVKHVIQSLLAEADLTMAVNCYLSLNELAVQRLS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2126 | - | - | 100% (384) | putative L-lactate 2-monooxygenase |
| M. abscessus ATCC 19977 | MAB_3834c | - | 2e-30 | 28.49% (365) | L-lactate dehydrogenase LldD1 |
| M. abscessus ATCC 19977 | MAB_3242 | - | 6e-05 | 33.73% (83) | isopentenyl pyrophosphate isomerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1903c | lldD2 | 3e-34 | 31.23% (365) | L-lactate dehydrogenase (cytochrome) LldD2 |
| M. gilvum PYR-GCK | Mflv_4136 | - | 1e-101 | 51.05% (380) | FMN-dependent alpha-hydroxy acid dehydrogenase |
| M. tuberculosis H37Rv | Rv1872c | lldD2 | 2e-34 | 31.23% (365) | L-lactate dehydrogenase (cytochrome) LldD2 |
| M. leprae Br4923 | MLBr_02046 | lldD2 | 8e-35 | 30.81% (370) | L-lactate dehydrogenase |
| M. marinum M | MMAR_1816 | lldD1_1 | 1e-104 | 51.69% (385) | L-lactate dehydrogenase (cytochrome) LldD1_1 |
| M. avium 104 | MAV_3747 | - | 1e-103 | 51.17% (385) | lactate 2-monooxygenase |
| M. smegmatis MC2 155 | MSMEG_2512 | - | 1e-110 | 55.06% (385) | lactate 2-monooxygenase |
| M. thermoresistible (build 8) | TH_0845 | - | 1e-105 | 52.99% (385) | lactate 2-monooxygenase |
| M. ulcerans Agy99 | MUL_3002 | lldD2 | 8e-35 | 29.67% (364) | L-lactate dehydrogenase (cytochrome) LldD2 |
| M. vanbaalenii PYR-1 | Mvan_2206 | - | 1e-103 | 50.91% (385) | FMN-dependent alpha-hydroxy acid dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1816|M.marinum_M MAFG-----------DYQYEIYFQGLSGVVPGLPMAFAELESRAQMALPP
MAV_3747|M.avium_104 MAFG-----------DYQNEIYFRGLGGVAPSLPMAFAELESRAERAMSP
TH_0845|M.thermoresistible__bu MAFG-----------DYQLEIYLQGLSGVVPSLPMAFAELEARARAAMSP
Mflv_4136|M.gilvum_PYR-GCK MTFG-----------NYQLEIYLQGLSGIMPAYPMDFAGWEARAQASMPP
Mvan_2206|M.vanbaalenii_PYR-1 MTFG-----------NYQLEIYLQGLSGILPNLPMDYAGWEAKAESAMPP
MSMEG_2512|M.smegmatis_MC2_155 MAYG-----------DYQLEIYLQGLAGVLPTMPMDYATLESKAQHAMPA
MAB_2126|M.abscessus_ATCC_1997 MNFG-----------DFQLQFYAAGALGKVSTLPFNFAELESRAEQTLGE
Mb1903c|M.bovis_AF2122/97 MAVNRRVPRVRDLAPLLQFNRPQFDTSKRRLGAALTIQDLRRIAKRRTPR
Rv1872c|M.tuberculosis_H37Rv MAVNRRVPRVRDLAPLLQFNRPQFDTSKRRLGAALTIQDLRRIAKRRTPR
MUL_3002|M.ulcerans_Agy99 MAVDRRLPRVGDLAPLMQFKRPQFNRTKRRLETALTIEDLRRVAKRRTPR
MLBr_02046|M.leprae_Br4923 MAAKRRMPRVHDLAPLIQFKRPKFGATKRRLEAALTIQDLRCIAKQRTPK
* * : . .: . *.
MMAR_1816|M.marinum_M SVWSYVVGGAGDERTQRANCEAFDRWGLMPRMFVGAAERDLTVEMFGLTL
MAV_3747|M.avium_104 SVWSYVTGGAGDERTQRANREAFDRWGLIPRMFVGAAERDLSVQMFGLTL
TH_0845|M.thermoresistible__bu SVWSYVAGGAGDERTQRINVSAFDNWGLIPRMLVGATERDLSVNLFGLTL
Mflv_4136|M.gilvum_PYR-GCK SVWSYVAGGAGDENTQRANRTAFDRWGLMPRMLVGTTERDLTVDVFGLTL
Mvan_2206|M.vanbaalenii_PYR-1 SVWSYVVGGAGDEHTQRANRTAFDRWGLIPRMLVGATERDLTVDLFGMTL
MSMEG_2512|M.smegmatis_MC2_155 SIWSYVAGGAGDERTQRVNRTAFDRWGLVPRMLNAQRERDLSVDLFGLQL
MAB_2126|M.abscessus_ATCC_1997 GIFGYVRGGAGDEHTQDSNVTALRRYGLVPRMLRDRTVRDMSTSFLGRTF
Mb1903c|M.bovis_AF2122/97 AAFDYADGAAEDELSIARARQGFRDIEFHPTILRDVTTVCAGWNVLGQPT
Rv1872c|M.tuberculosis_H37Rv AAFDYADGGAEDELSIARARQGFRDIEFHPTILRDVTTVCAGWNVLGQPT
MUL_3002|M.ulcerans_Agy99 AAFDYTDGAAEDELSIERARQAFRDIEFHPTILRDVTSVRTGWDVFGKPV
MLBr_02046|M.leprae_Br4923 AAFDYTDGAAEDELSIKRAQQAFRDIEFHPAILRDVTNVCAGWDVLGHSV
. :.*. *.* ** : .: : * :: ..:*
MMAR_1816|M.marinum_M PSPIFLAPIGVIGLCAQDGHGDLATARAAARTGVPMVVSTLTADPMEDVA
MAV_3747|M.avium_104 PSPVFMAPIGVIGICAQDGHGDLATARAAAATGVPMVVSTLTADPMEDVA
TH_0845|M.thermoresistible__bu PSPIFMAPIGVLGICAQDHHGDLACARAAARTGVPLVVSTLTQDPLEDIA
Mflv_4136|M.gilvum_PYR-GCK PSPIFMAPVGVAGICSQSGHGDLEAARAAARTGVPMAVSTLTEDPLEDVA
Mvan_2206|M.vanbaalenii_PYR-1 PSPLFMAPIGVIGICSQNGQGDLAAARAAARTGVPMTVSTLTEDPLEDVA
MSMEG_2512|M.smegmatis_MC2_155 PSPLFMAPIGVLGICGQDGHGDLAGAQAAARTGVPMVVSTLTQDPLENVA
MAB_2126|M.abscessus_ATCC_1997 TSPAFICPVGVLGAVRD--RGDLLTAAAARELDMPAMYSTLSAATLEEVA
Mb1903c|M.bovis_AF2122/97 VLPFGIAPTGFTRLMHT--EGEIAGARAAAAAGIPFSLSTLATCAIEDLV
Rv1872c|M.tuberculosis_H37Rv VLPFGIAPTGFTRLMHT--EGEIAGARAAAAAGIPFSLSTLATCAIEDLV
MUL_3002|M.ulcerans_Agy99 ALPFGIAPTGFTRLMHT--EGEIAGARAAAEAGIPFSMSTLATCAIEDLQ
MLBr_02046|M.leprae_Br4923 LLPFGIAPTGFTRLMHT--EGEIAGARAAAAAGIPFSLSTLATSAIEDVV
* :.* *. .*:: * ** .:* ***: .:*::
MMAR_1816|M.marinum_M AEFGDIPGFFQLYTPKDRELAASLVQRAESAGFKGIVVTLDTWIPGWRPR
MAV_3747|M.avium_104 AQFGDTPGFFQLYTPKDRELAASLVHRAEAAGFKGIIVTLDTWIPGWRPR
TH_0845|M.thermoresistible__bu AEFGDTPGFFQLYTPNDRDLAASLVRRAEKAGYKGIIVTLDTWIPGWRPR
Mflv_4136|M.gilvum_PYR-GCK AEFGDTPGFFQLYTPTDRDLAASFVQRAEAAGYKAIIVTLDTWIPGWRPR
Mvan_2206|M.vanbaalenii_PYR-1 AEFGDTPGFFQLYTPTDRDLAASLVHRAEAAGYKAIIVTLDTWIPGWRPR
MSMEG_2512|M.smegmatis_MC2_155 AQFGDTPGFFQLYTPTDRDLAASFVRRAEAAGYKAIVVTLDTWVPGWRPR
MAB_2126|M.abscessus_ATCC_1997 AARGDSYGIFQLYPSSDSELTDNFIRRAEAAGYDALAVTLDTGTLGWRPR
Mb1903c|M.bovis_AF2122/97 IAVPQGRKWFQLYMWRDRDRSMALVRRAAAAGFDTMLVTVDVPVAGARLR
Rv1872c|M.tuberculosis_H37Rv IAVPQGRKWFQLYMWRDRDRSMALVRRVAAAGFDTMLVTVDVPVAGARLR
MUL_3002|M.ulcerans_Agy99 AAVPQGRKWFQLYMWRDRDRSMALVKRAADAGFDTMLVTVDVPVAGARLR
MLBr_02046|M.leprae_Br4923 AAVPQGRKWFQLYMWRDRDRSMALVERAADAGYDALLVTVDVPVAGARLR
: **** * : : ::.*. **:. : **:*. * * *
MMAR_1816|M.marinum_M DLSTAN--FPQLRGHCLSNYTSDPVFR------AGLPRPPEEDPQGTVLR
MAV_3747|M.avium_104 DLSTAN--FPQLRGMCLSNYTSDPVFR------AALARPPEEDPQGTVLQ
TH_0845|M.thermoresistible__bu DLSTSN--FPQLRGYSLANYTSDPVFS------AGLQQPPEQNPQAVVTR
Mflv_4136|M.gilvum_PYR-GCK DLSTSN--FPQLRGRCLSNYTSDPVFR------GLLPQPPEENMQATVLQ
Mvan_2206|M.vanbaalenii_PYR-1 DLAMSN--FPQLRGRCLANYTSDPVFR------AALSQPPEENMQAAVLQ
MSMEG_2512|M.smegmatis_MC2_155 DLSTSN--FPQLRGKCLANYTSDPVFR------AGLPQPPEENPQATVLR
MAB_2126|M.abscessus_ATCC_1997 DLKHGY--LPMLHGHCLANYTSDPRFLE----IAGVRSAGELTPMHAGLV
Mb1903c|M.bovis_AF2122/97 DVRNGMSIPPALTLRTVLDAMGHPRWWFDLLTTEPLAFASLDRWPGTVGE
Rv1872c|M.tuberculosis_H37Rv DVRNGMSIPPALTLRTVLDAMGHPRWWFDLLTTEPLAFASLDRWPGTVGE
MUL_3002|M.ulcerans_Agy99 DVRNGMSIPPALTLRTVLDALPHPHWWFDLLTTEPLAFASLDRWSGTVGE
MLBr_02046|M.leprae_Br4923 DTRNGMSIPPALTLRTVFDALPHPRWWIDLLTTEPLAFASLDRWSGTVSD
* . * * : : .* : : . .
MMAR_1816|M.marinum_M WAQLFGNP-LTWSDLAWLRELTDLPLIVKGICHPDDARRAKDGGVDGIYC
MAV_3747|M.avium_104 WISTFGNP-LTWDDLPWLRSLTDLPLIIKGICHPDDARRARDGGVDGIYC
TH_0845|M.thermoresistible__bu WVQLFGNS-LTWDDLPWLRSLTTLPLILKGICHPDDVRRAKDAGVDGIYC
Mflv_4136|M.gilvum_PYR-GCK WAGMFGNA-LSWDDLPWLRSLTDLPLILKGLCHPDDVRRARDGGVDGIYC
Mvan_2206|M.vanbaalenii_PYR-1 WVAQFGNA-LTWEDLPWLRSLTDLPLVLKGLCHPDDVRRAKDAGVDGVYC
MSMEG_2512|M.smegmatis_MC2_155 WVSQFGNP-LTWADLPWLRSLTKLPLILKGICHPDDVRRAKDEGVDGIYC
MAB_2126|M.abscessus_ATCC_1997 WASLFSHPGLTWADIDHYRSITKLPIILKGICDSDDVRQAVDRGVDAIAY
Mb1903c|M.bovis_AF2122/97 YLNTVFDPSLTFDDLAWIKSQWPGKLVVKGIQTLDDARAVVDRGVDGIVL
Rv1872c|M.tuberculosis_H37Rv YLNTVFDPSLTFDDLAWIKSQWPGKLVVKGIQTLDDARAVVDRGVDGIVL
MUL_3002|M.ulcerans_Agy99 YLNTMFDPSVTFDDLEWMKAQWPGKLVVKGIQTLDDARAVVERGADGIVL
MLBr_02046|M.leprae_Br4923 YLNTMFDPSVTFDDLAWIKTQWPGKFVVKGIQTLDDARAVVERGIDGVVL
: . .. ::: *: : :::**: **.* . : * *.:
MMAR_1816|M.marinum_M STHGGRQANGGLPALDCLPGVVEAADG-LPVLFDSGIRSGADIIKALAMG
MAV_3747|M.avium_104 STHGGRQANGGLPALDCLPGVVEAADG-LPVLFDSGIRSGADVVKALALG
TH_0845|M.thermoresistible__bu SNHGGRQANGGLPAIDCLPDVVAAADG-MPVLFDSGIRSGADIVKALALG
Mflv_4136|M.gilvum_PYR-GCK STHGGRQANGGLPAIDCLPVVVEAADG-LPVLFDSGVRSGADIVKALALG
Mvan_2206|M.vanbaalenii_PYR-1 STHGGRQANGGLPALDCLPGVVEAADG-LPVLFDSGIRSGADIVKALALG
MSMEG_2512|M.smegmatis_MC2_155 SNHGGRQANGGVPAIDCLPGVVEAADG-LPVLFDSGIRNGADIVKALALG
MAB_2126|M.abscessus_ATCC_1997 SNHGGRQANGGVPAIDGLAAAVEAAGS-VPVTFDSGIRDGIDILRAVALG
Mb1903c|M.bovis_AF2122/97 SNHGGRQLDRAPVPFHLLPHVARELGKHTEILVDTGIMSGADIVAAIALG
Rv1872c|M.tuberculosis_H37Rv SNHGGRQLDRAPVPFHLLPHVARELGKHTEILVDTGIMSGADIVAAIALG
MUL_3002|M.ulcerans_Agy99 SNHGGRQLDRAPAPFHLLPLVARELGKDTEIVVDTGIMSGADIVAAIALG
MLBr_02046|M.leprae_Br4923 SNHGGRQLDRAPVPFHLLPTVAREFGKDTEILLDTGIMSGADIVAAIALG
*.***** : . .:. *. .. . : .*:*: .* *:: *:*:*
MMAR_1816|M.marinum_M ATAVGIGRPYAYGLALGGVDGVVHVLRMLLAEADLIMAVDGYPTRKDLTP
MAV_3747|M.avium_104 ATAVGIGRPYAYGLALGGVDGIVHVLRSILAEADLIMAVDGYPTRKDLTP
TH_0845|M.thermoresistible__bu ATAVGIGRPYPYGLALGGEDGVVHVLRSLLAEADLIMAVDGYPTLADLTP
Mflv_4136|M.gilvum_PYR-GCK ATAVGIGRPYAYGLALGGTDGLVHVLRSLLAETDLIMAVDGYPTLADLTP
Mvan_2206|M.vanbaalenii_PYR-1 ATAVGVGRPYAYGLAIGGEDGIVHVLRSLLAEADLIMAVDGYRSLADLTP
MSMEG_2512|M.smegmatis_MC2_155 ATAVGVGRPYVFGLALGGVDGIVHVLRSLLAEADLIMAVDGYPSLADLTP
MAB_2126|M.abscessus_ATCC_1997 ASLVGVARPYVYGLALDGTNGVKHVIQSLLAEADLTMAVNCYLSLNELAV
Mb1903c|M.bovis_AF2122/97 ARCTLIGRAYLYGLMAGGEAGVNRAIEILQTGVIRTMRLLGVTCLEELSP
Rv1872c|M.tuberculosis_H37Rv ARCTLIGRAYLYGLMAGGEAGVNRAIEILQTGVIRTMRLLGVTCLEELSP
MUL_3002|M.ulcerans_Agy99 ARCTLIGRAYLYGLMAGGEAGVKRAIEILSAGVSRTMRLLGVTCLEELSA
MLBr_02046|M.leprae_Br4923 ARCTLVGRAYLYGLMAGGEAGVRRAIEILESGVIRTMQLLGVTCLEELSP
* . :.*.* :** .* *: :.:. : : . * : :*:
MMAR_1816|M.marinum_M DTLRRVN---------
MAV_3747|M.avium_104 DTLRRVV---------
TH_0845|M.thermoresistible__bu DALRRVT---------
Mflv_4136|M.gilvum_PYR-GCK DTVRRVT---------
Mvan_2206|M.vanbaalenii_PYR-1 DTLRRVI---------
MSMEG_2512|M.smegmatis_MC2_155 DTLRRVDA--------
MAB_2126|M.abscessus_ATCC_1997 QRLS------------
Mb1903c|M.bovis_AF2122/97 RHVTQLRRLGPIGAPT
Rv1872c|M.tuberculosis_H37Rv RHVTQLRRLGPIGAPT
MUL_3002|M.ulcerans_Agy99 KHVTQLQRLGPIPLPT
MLBr_02046|M.leprae_Br4923 RHVTQLQRLGPIEPPA
: