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EPVPYRVRERVVENRDSATLFLDPVNGALRTPRPGEFMMMYAFGIGEIAVSVSGISPEPETTVAHTVRAV GAVSTALRDAAVGSLVGLRGPFGTGWGHEVATGRELVIVAGGVGLAPLRPVIVDVLACRHMYGQVTVIAG ARSRDDFLFTPELRQWSSRGSIDVHLTVDIPVQGWPGEVGFVTEPLRRLPVRPERTTAYLCGPEPMMRAS AEVLMGKGLRASDIRVSLERNMQCGIGWCGHCQLGPLLLCRDGPVVGYDVADPLLAVKEL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3930 | - | - | 100% (271) | [NiFe] hydrogenase, gamma subunit, putative [Mycobacterium smegmatis str. MC2 155] |
| M. smegmatis MC2 155 | MSMEG_1972 | - | 3e-06 | 24.66% (219) | methane monooxygenase component C |
| M. smegmatis MC2 155 | MSMEG_0295 | - | 3e-06 | 26.27% (236) | oxidoreductase, FAD-binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1972 | - | 3e-08 | 29.58% (142) | oxygenase |
| M. gilvum PYR-GCK | Mflv_3426 | - | 7e-06 | 25.60% (250) | ferredoxin |
| M. tuberculosis H37Rv | Rv1937 | - | 3e-08 | 29.58% (142) | oxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0583c | - | 1e-06 | 25.10% (239) | putative oxidoreductase |
| M. marinum M | MMAR_3499 | - | 1e-108 | 67.53% (271) | flavodoxin oxidoreductase |
| M. avium 104 | MAV_4795 | - | 2e-05 | 31.28% (195) | oxidoreductase FAD-binding subunit |
| M. thermoresistible (build 8) | TH_1151 | dinP | 4e-49 | 79.09% (110) | DNA polymerase IV |
| M. ulcerans Agy99 | MUL_2889 | - | 3e-11 | 31.85% (157) | oxygenase |
| M. vanbaalenii PYR-1 | Mvan_1767 | - | 1e-07 | 26.62% (278) | ferredoxin |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3930|M.smegmatis_MC2_155 ------------------MEPVPYRVRERVVENRDSATLFLDPVNG----
MMAR_3499|M.marinum_M ----MTDAAAGVAAPPSAMAPVPYRVRSRVVESPDSATLCLEPVSE----
TH_1151|M.thermoresistible__bu ------VFVSGPAGHGATILHADLDAFYASVEQRDDPALRGRPVIVGGGV
Mb1972|M.bovis_AF2122/97 --MAVRQVTVGYSDGTHKTMPVRCDQTVLDAAEEHGVAIVNECQSGICGT
Rv1937|M.tuberculosis_H37Rv --MAVRQVTVGYSDGTHKTMPVRCDQTVLDAAEEHGVAIVNECQSGICGT
MUL_2889|M.ulcerans_Agy99 --MTVRHVTVGYSDGTHKTMPVRPDQSILEAAEEHGVAIVNECQSGICGT
Mvan_1767|M.vanbaalenii_PYR-1 MAKNTIKNTAKVADTVRPTIAGAKENPGWHLLRTIAGRITTPLLPDDYLK
MAB_0583c|M.abscessus_ATCC_199 -MTDVPLGKHVLEVRIAEVIEETADSRSLVFEIPDGAADKFAYAPGQYLT
Mflv_3426|M.gilvum_PYR-GCK ---------MGVLGRLRYDVTIGLADAALHGMFATSAAMRRIRPPDGVPE
MAV_4795|M.avium_104 MSLEDADALRVLRDAFAPCDAGRPGDSGDLVHRFYTHWFALDPSVRDLFP
MSMEG_3930|M.smegmatis_MC2_155 ALRTPRPGEFMMMYAFGIGEIAVSVSGISPEP-------ETTVAHTVRAV
MMAR_3499|M.marinum_M ALRRPEPGEFMMLYAFGVGEAAISISGDPSVT-------DGSITHTIRAV
TH_1151|M.thermoresistible__bu VLAASYEAKAYGVRTAMSGGQARALCPHAIVV-------PPRMAAYSQAS
Mb1972|M.bovis_AF2122/97 CVATCTAGRYQMGRTEGLSDVERAARKILTCQTFVTSDCRIELQYPVDDN
Rv1937|M.tuberculosis_H37Rv CVATCTAGRYQMGRTEGLSDVERAARKILTCQTFVTSDCRIELQYPVDDN
MUL_2889|M.ulcerans_Agy99 CVATCTAGRYDMGRTEGLSDVERAARKILTCQTLAESDCEIELQYPVDDN
Mvan_1767|M.vanbaalenii_PYR-1 LANPLWSARELRGRVLEVRRETEDSATLVIKPG-----WGFSFDYEPGQY
MAB_0583c|M.abscessus_ATCC_199 LRIPS-DRTGSVARCYSLSSSPHLDDRLAVTVKRTADGYGSNWICDNAHA
Mflv_3426|M.gilvum_PYR-GCK TFPLTVTSRRVVARDQDVVELTLSGDDLPRWHP------GAHLDLHLPSG
MAV_4795|M.avium_104 PEMGAQRVAFGHALHWVYGELVARRAQEPVAFLAQLGRDHRKYGVLPRHY
MSMEG_3930|M.smegmatis_MC2_155 GAVSTALRDAAVG-SLVGLRGPFGTGWGHEVATG----------------
MMAR_3499|M.marinum_M GAVSRALHDAAPG-SIVGVRGPFGTTWGLDEAAG----------------
TH_1151|M.thermoresistible__bu AAVFDVFRDTTPLVEPLSVDEAFLDVGGLGRLAGTPVQI-----------
Mb1972|M.bovis_AF2122/97 AALLVTGDGVVTAVELVSPSTAILRVDTSGMAGALRYRAGQFAQLQVPGT
Rv1937|M.tuberculosis_H37Rv AALLVTGDGVVTAVELVSPSTAILRVDTSGMAGALRYRAGQFAQLQVPGT
MUL_2889|M.ulcerans_Agy99 AALLVSGDGVVTGVDMVSPGTAVLRVDVSAMAGTIGYRAGQFAQLQVPGS
Mvan_1767|M.vanbaalenii_PYR-1 IGIGLLVEGRWRWRSYSLTSSPVTSKGSRTITITVKAMP-----------
MAB_0583c|M.abscessus_ATCC_199 GMHMHVLAPSGVFVPKQLDNDFLLLAGGSGVTPMMAICKS----------
Mflv_3426|M.gilvum_PYR-GCK RIRQYSLCGEPTAGHYRVAVRRIPDGGGGSVEVHDALPVG----------
MAV_4795|M.avium_104 QTLGRALLATLRSHLDAAWTDAVEDAARTSLNLITGVMSG----------
.
MSMEG_3930|M.smegmatis_MC2_155 ----------------------------------RELVIVAGGVGLAP--
MMAR_3499|M.marinum_M ----------------------------------RDLVMVAGGVGLCP--
TH_1151|M.thermoresistible__bu ------------------------------AARLRERVRAEVGLPITVG-
Mb1972|M.bovis_AF2122/97 NVWRNYSYAHPADGRGECEFIIRLLPDGVMSNYLRDRAQPGDHIALRCSK
Rv1937|M.tuberculosis_H37Rv NVWRNYSYAHPADGRGECEFIIRLLPDGVMSNYLRDRAQPGDHIALRCSK
MUL_2889|M.ulcerans_Agy99 DQWRNYSYAHPADGGGDLEFIIRLLPDGAMSNYLRDHAKQGDRIALRGSK
Mvan_1767|M.vanbaalenii_PYR-1 --------------------------EGFLSTHLVGGVAPGTIVRLAAPQ
MAB_0583c|M.abscessus_ATCC_199 ----------------------------------ALSQGSGKVVLIYANR
Mflv_3426|M.gilvum_PYR-GCK --------------------------------STVRTHGPRNAFPLAVPG
MAV_4795|M.avium_104 ----------------------------------AADADEGPAWWDGTVI
MSMEG_3930|M.smegmatis_MC2_155 -----LRPVIVDVLACRHMYGQVTVIAGARSRDD-------FLFTP----
MMAR_3499|M.marinum_M -----LRPAVLGALAQRSRYRRLTLIVGARSRAD-------FVFAA----
TH_1151|M.thermoresistible__bu ----IARTKFLAKVASQEAKPDGLLLVPPDREPA-------FLHPLP---
Mb1972|M.bovis_AF2122/97 G-SFYLRPIVRPVILVAGGTGLSAILAMAQSLDADVAHPVYLLYGVERTE
Rv1937|M.tuberculosis_H37Rv G-SFYLRPIVRPVILVAGGTGLSAILAMAQSLDADVAHPVYLLYGVERTE
MUL_2889|M.ulcerans_Agy99 G-NFYLRPIVRPVVLVAGGTGLSAILAMAQSLPADPGQPVSLLYGVTSAE
Mvan_1767|M.vanbaalenii_PYR-1 GNFVMPDPAPASVLFLTAGSGITPVMSMLRTLVRR-----GQLGDVAHVH
MAB_0583c|M.abscessus_ATCC_199 D----EQSVIFGAALRELAAKYPDRLTVIHWLESVQG----LPSQQQLAT
Mflv_3426|M.gilvum_PYR-GCK -----YGSPARRFRFIAGGIGITPILPMLALARSLG--------------
MAV_4795|M.avium_104 G----HLRVSRDLAVVRLRLDQPMPYHPGQYVNVQVPQCPRRWRYLSPAI
MSMEG_3930|M.smegmatis_MC2_155 ------ELRQWSSRGS-IDVHLTVDIPVQGWPGEVGFVTEPLRRLPVRPE
MMAR_3499|M.marinum_M ------QLEKWAQDPD-IELHVTVDVPVQGWRGEVGLVTEPLRRLALDPE
TH_1151|M.thermoresistible__bu ----VQRLXXXAADPA-LEVALTVDVPVQGWPGEVGLVTEPLRRLELDPT
Mb1972|M.bovis_AF2122/97 DLCKLDELTELRRRVGRLEVHVVVARPDPDWDGRTGLVTDLLDERMLASG
Rv1937|M.tuberculosis_H37Rv DLCKLDELTELRRRVGRLEVHVVVARPDPDWDGRTGLVTDLLDERMLASG
MUL_2889|M.ulcerans_Agy99 DLCKLDELEQLEHRVAGLQVHVTVARRDEDWSGRTGLVTDLLDEAMLAGG
Mvan_1767|M.vanbaalenii_PYR-1 SSPTEDDVMFAAELSELADRHEGYRLRVRATRTEGRLDLDRLDEVVPDWR
MAB_0583c|M.abscessus_ATCC_199 LTAPFAEHEAFICGPGPFMDASEAALKGNGMPHDR-VHIEVFRSLESDPF
Mflv_3426|M.gilvum_PYR-GCK VDWSMVYTGRSADALPFVDEVAAFGSPVEIRTDDRRGLPTAAELLGDCPA
MAV_4795|M.avium_104 PADPGCGIEFHVRLVP--GGLVSTAIVNETRPGDRWRLSSPHGGLRVDRD
MSMEG_3930|M.smegmatis_MC2_155 RTTAYLCGPEPMMRASAEVLMGKG--------------------------
MMAR_3499|M.marinum_M HTTAFLCGPEPMLRFGAEALLAKG--------------------------
TH_1151|M.thermoresistible__bu RTAAFLCGPEPMMRHSAAALLAKG--------------------------
Mb1972|M.bovis_AF2122/97 DADVYLCGPVAMVDAARTWLDHNGFHRVGLYYEKFVASGAARRRTPARLD
Rv1937|M.tuberculosis_H37Rv DADVYLCGPVAMVDAARTWLDHNGFHRVGLYYEKFVASGAARRRTPARLD
MUL_2889|M.ulcerans_Agy99 DANVYLCGPAAMVEATRTWLSANGFHRAGLYHEKFVASGAARRRTPARLD
Mvan_1767|M.vanbaalenii_PYR-1 ERQTWACGPEAMLEAAERTWKAAGIADRLHLERFAVARAAHGSGGTVEFS
MAB_0583c|M.abscessus_ATCC_199 AEVVLAEPSDDDEPPATATVELDGETHEVSWPR-----------------
Mflv_3426|M.gilvum_PYR-GCK DTSVYACGPAPMLTAVRDALVGRDDVELHFERFAAPPVVDGRPFRVAAAG
MAV_4795|M.avium_104 GGDVLMVAGSTGLAPLRALIMDLSRFAVNPRVHLFFGARYRCELYDLP--
. .
MSMEG_3930|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3499|M.marinum_M --------------------------------------------------
TH_1151|M.thermoresistible__bu --------------------------------------------------
Mb1972|M.bovis_AF2122/97 YAGVDIAEVCRRGRGTAVVIGGSIAGIAAAKMLSETFDRVIVLEKDGPHR
Rv1937|M.tuberculosis_H37Rv YAGVDIAEVCRRGRGTAVVIGGSIAGIAAAKMLSETFDRVIVLEKDGPHR
MUL_2889|M.ulcerans_Agy99 YSALDLAAVRRSGRGIAVVIGGSIAGIAAAKVCSDTFDRVIVLEKDDPHR
Mvan_1767|M.vanbaalenii_PYR-1 RSGKAATVDG----------------------------------------
MAB_0583c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3426|M.gilvum_PYR-GCK VTVDVG--------------------------------------------
MAV_4795|M.avium_104 --------------------------------------------------
MSMEG_3930|M.smegmatis_MC2_155 ------------------------------------LRASDIRVSLERNM
MMAR_3499|M.marinum_M ------------------------------------VAAQDIRVSLERNM
TH_1151|M.thermoresistible__bu ------------------------------------VPAENIRVSLERNM
Mb1972|M.bovis_AF2122/97 RREGRPGAAQGWHLHHLLTAGQIELERIFPGIVDDMVREGAFKVDMAAQY
Rv1937|M.tuberculosis_H37Rv RREGRPGAAQGWHLHHLLTAGQIELERIFPGIVDDMVREGAFKVDMAAQY
MUL_2889|M.ulcerans_Agy99 RREGRPGAAQGWHLHHLLTAGQIELERFFPGIVDDMVREGAFKVDMAAQY
Mvan_1767|M.vanbaalenii_PYR-1 ---------------------------------ATSLMDAGEAAGIQMPF
MAB_0583c|M.abscessus_ATCC_199 ---------------------------------STVLLDVLLAKGLDAPF
Mflv_3426|M.gilvum_PYR-GCK --------------------------------VDETLLAALGRAGVTTPY
MAV_4795|M.avium_104 --------------------------------TLWQIASHNPWLSVSPVS
: .:
MSMEG_3930|M.smegmatis_MC2_155 QCGIG----------------------WCGHCQLG---------------
MMAR_3499|M.marinum_M QCGVG----------------------WCGHCQLG---------------
TH_1151|M.thermoresistible__bu QCGIG----------------------WCGHCQLG---------------
Mb1972|M.bovis_AF2122/97 RIRLGGTWKKPGTSDIEIVCAGRPLLEWCVRRRLDDEPRIDFRYESEVAD
Rv1937|M.tuberculosis_H37Rv RIRLGGTWKKPGTSDIEIVCAGRPLLEWCVRRRLDDEPRIDFRYESEVAD
MUL_2889|M.ulcerans_Agy99 RIRLGGTWKKPGTSDIEIVCAGRPLLEWCVRRRLDDEPRIDFRYESEVTD
Mvan_1767|M.vanbaalenii_PYR-1 GCRMG----------------------ICQSCVVG---------------
MAB_0583c|M.abscessus_ATCC_199 SCREG----------------------HCMTCACVLK-------------
Mflv_3426|M.gilvum_PYR-GCK SCRQG----------------------FCGTCRTRVLSG-----------
MAV_4795|M.avium_104 EYRADPP--------------------WAADYPDVTPPRGLHVHQTG---
. .
MSMEG_3930|M.smegmatis_MC2_155 --------------------------------------------PLLLCR
MMAR_3499|M.marinum_M --------------------------------------------PLLLCR
TH_1151|M.thermoresistible__bu --------------------------------------------PLLLCR
Mb1972|M.bovis_AF2122/97 LAFDRANNAIVGVAVDNGDADGGDGLQVVPAEFVVDASGKNTRVPEFLER
Rv1937|M.tuberculosis_H37Rv LAFDRANNAIVGVAVDNGDADGGDGLQVVPAEFVVDASGKNTRVPEFLER
MUL_2889|M.ulcerans_Agy99 LVFDRATNAVIGVAVP---GDGGE-PEVIPAEFVLDASGKNTHVPEFLER
Mvan_1767|M.vanbaalenii_PYR-1 ----------------------------------------LLDGHVRDLR
MAB_0583c|M.abscessus_ATCC_199 ------------------------------------------DGKVRMLV
Mflv_3426|M.gilvum_PYR-GCK ----------------------------------------EVDHRDTLLT
MAV_4795|M.avium_104 ------------------------------------------RLPEVVTK
MSMEG_3930|M.smegmatis_MC2_155 DGP-----------------------------------------------
MMAR_3499|M.marinum_M DGP-----------------------------------------------
TH_1151|M.thermoresistible__bu DGP-----------------------------------------------
Mb1972|M.bovis_AF2122/97 LGVGAPEAEQDIINCFYSTMQHRVPPERRWQDKVMVICYAYRPFEDTYAA
Rv1937|M.tuberculosis_H37Rv LGVGAPEAEQDIINCFYSTMQHRVPPERRWQDKVMVICYAYRPFEDTYAA
MUL_2889|M.ulcerans_Agy99 IGIGAPEVEQDIINCFYSTMQHQVPPERQWQDKVMVICYAYRPYEDTYAA
Mvan_1767|M.vanbaalenii_PYR-1 TGVEHEPG------------------------------------------
MAB_0583c|M.abscessus_ATCC_199 NDALSQNDIDDG--------------------------------------
Mflv_3426|M.gilvum_PYR-GCK DAERAAG-------------------------------------------
MAV_4795|M.avium_104 YGGWGDRQ------------------------------------------
MSMEG_3930|M.smegmatis_MC2_155 --------------VVGYDVADPLLAVKEL--------------------
MMAR_3499|M.marinum_M --------------VVSYDVAGPLLRVKEL--------------------
TH_1151|M.thermoresistible__bu --------------VVGYDVAAPLLAVEEL--------------------
Mb1972|M.bovis_AF2122/97 QYYTDSSRTILSTSLVAYNCYSPPRTAREFRAFADLMPSPVIGENIDGLE
Rv1937|M.tuberculosis_H37Rv QYYTDSSRTILSTSLVAYNCYSPPRTAREFRAFADLMPSPVIGENIDGLE
MUL_2889|M.ulcerans_Agy99 QYYTDSSRTILSTSLVAYNCYSPLRTVREFREFADLMPSPVIGENIDGLQ
Mvan_1767|M.vanbaalenii_PYR-1 ------------TRVQTCVSAASGDCVLDV--------------------
MAB_0583c|M.abscessus_ATCC_199 -------------YILACQAVPETDDVNVTFDE-----------------
Mflv_3426|M.gilvum_PYR-GCK -------------LMLPCVSRAAEGTVLALDL------------------
MAV_4795|M.avium_104 --------------ILICGGPRMVAATKAALIAKGAAAQRIQHDPLSR--
: .
MSMEG_3930|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3499|M.marinum_M --------------------------------------------------
TH_1151|M.thermoresistible__bu --------------------------------------------------
Mb1972|M.bovis_AF2122/97 PASPIYNFRYPNMLRLRYEKKRNLPRALLAVGDAYTSADPVSGLGMSLAL
Rv1937|M.tuberculosis_H37Rv PASPIYNFRYPNMLRLRYEKKRNLPRALLAVGDAYTSADPVSGLGMSLAL
MUL_2889|M.ulcerans_Agy99 PASPIYNFRYPNMLRLHYEKKRNLPRALLAVGDAYTSADPVSGLGMSLAL
Mvan_1767|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0583c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3426|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4795|M.avium_104 --------------------------------------------------
MSMEG_3930|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3499|M.marinum_M --------------------------------------------------
TH_1151|M.thermoresistible__bu --------------------------------------------------
Mb1972|M.bovis_AF2122/97 KEVREMQALLAKYGAGHRDLPRRYYRAIAKMADTAWFVIREQNLRFDWMK
Rv1937|M.tuberculosis_H37Rv KEVREMQALLAKYGAGHRDLPRRYYRAIAKMADTAWFVIREQNLRFDWMK
MUL_2889|M.ulcerans_Agy99 KEVREMQLLLSKYGPTHRELPRKYYRTIAKMADTAWFVIREQNLRLNWLK
Mvan_1767|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0583c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3426|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4795|M.avium_104 --------------------------------------------------
MSMEG_3930|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3499|M.marinum_M --------------------------------------------------
TH_1151|M.thermoresistible__bu --------------------------------------------------
Mb1972|M.bovis_AF2122/97 DVDKKRPFYFGVLTWYMDRVLELVHDDLDAYREFLAVVHLVKPPSALMRP
Rv1937|M.tuberculosis_H37Rv DVDKKRPFYFGVLTWYMDRVLELVHDDLDAYREFLAVVHLVKPPSALMRP
MUL_2889|M.ulcerans_Agy99 DVDKKRPFYFGALTWYMDRLLELVHDDLDAYREFLAVVHLVKPPLALMKP
Mvan_1767|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0583c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3426|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4795|M.avium_104 --------------------------------------------------
MSMEG_3930|M.smegmatis_MC2_155 ----------------------------------------------
MMAR_3499|M.marinum_M ----------------------------------------------
TH_1151|M.thermoresistible__bu ----------------------------------------------
Mb1972|M.bovis_AF2122/97 RIASRVLGKWARTRLSGQKTLIARNYENHPIPAEPADQLVNA----
Rv1937|M.tuberculosis_H37Rv RIASRVLGKWARTRLSGQKTLIARNYENHPIPAEPADQLVNA----
MUL_2889|M.ulcerans_Agy99 GIASRVIGKWARTRLSGQKTLIARNYENHTAPAEPADQLVTVGDLR
Mvan_1767|M.vanbaalenii_PYR-1 ----------------------------------------------
MAB_0583c|M.abscessus_ATCC_199 ----------------------------------------------
Mflv_3426|M.gilvum_PYR-GCK ----------------------------------------------
MAV_4795|M.avium_104 ----------------------------------------------