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TFMRKSSDAGQWSRSRWMELINSVTDHRDQLVDAFMAQVDDGRRFYDSKVETADLRESSRAAFTMLLRQL RGTPTSEEDLRITRELGVRRASQGVESEKLTAAIHRDFSVLWAAFRELAEDDDAAVLAEHAEDVWRVVDG FAGRIHAAYFDEVIAIAQERSLSVQSLLAKLVTDEYPSLTFIARAGQALSIRETDGIWVAAALASEGTPL QQFAERLRRRGRLAYTYAMGQCIVAVWVADVVGSELDGVPDGCTSDPEYADLKPVRCGVSPLHRGVSQLR SAAQIACEIALSMHPDHIGPATAADVWPLVAGAALHSRLPVLEESIRGPLRDCRPAELKVLMETISVFSG NGDVSATAAELFCHRNTVMKRIRRLKELTGLDMTVPKDSARVLVALAPELAAVSD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3552 | - | - | 100% (406) | hypothetical protein MSMEG_3552 |
| M. smegmatis MC2 155 | MSMEG_3997 | - | 1e-47 | 32.56% (387) | regulatory protein |
| M. smegmatis MC2 155 | MSMEG_4324 | - | 1e-08 | 28.49% (186) | hypothetical protein MSMEG_4324 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2266 | - | 1e-06 | 32.99% (97) | hypothetical protein Mb2266 |
| M. gilvum PYR-GCK | Mflv_2780 | - | 8e-09 | 27.42% (186) | hypothetical protein Mflv_2780 |
| M. tuberculosis H37Rv | Rv2242 | - | 1e-06 | 32.99% (97) | hypothetical protein Rv2242 |
| M. leprae Br4923 | MLBr_01652 | - | 3e-07 | 26.04% (192) | hypothetical protein MLBr_01652 |
| M. abscessus ATCC 19977 | MAB_0762 | - | 7e-15 | 26.14% (329) | hypothetical protein MAB_0762 |
| M. marinum M | MMAR_3335 | - | 2e-06 | 31.96% (97) | hypothetical protein MMAR_3335 |
| M. avium 104 | MAV_2195 | - | 1e-07 | 34.02% (97) | hypothetical protein MAV_2195 |
| M. thermoresistible (build 8) | TH_1338 | - | 5e-09 | 35.35% (99) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1307 | - | 1e-06 | 31.96% (97) | hypothetical protein MUL_1307 |
| M. vanbaalenii PYR-1 | Mvan_3753 | - | 2e-08 | 36.08% (97) | hypothetical protein Mvan_3753 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2266|M.bovis_AF2122/97 MNDN-QLA-PVARP---RSPLELLDTVPDSLLRRLKQYSGRLATEAVSAM
Rv2242|M.tuberculosis_H37Rv MNDN-QLA-PVARP---RSPLELLDTVPDSLLRRLKQYSGRLATEAVSAM
MMAR_3335|M.marinum_M MNDN-QFS-AIARLGSARSPLELLETVPDSLLRRLKQYSGRLATEAVSAM
MUL_1307|M.ulcerans_Agy99 MNNN-QFS-AIARLGSARSPLELLETVPDSLLRRLKQYSGRLATEAVSAM
MAV_2195|M.avium_104 MNDN-PFAGPFAKHP--RSPLETLDTVPESVLRRLKQYSGRLATEAVSVM
MLBr_01652|M.leprae_Br4923 MNHN-HFVPAPPRR----LPLELLDTVPDSLLRRLKQYSGRLATEAVTAM
Mflv_2780|M.gilvum_PYR-GCK MPDNNRFVPPN-------STVEVLGNVPDSTLRRLKQYSGRLATEAVHAM
Mvan_3753|M.vanbaalenii_PYR-1 MTDN-RFIPPR-------STVEVLENVPESTLRRLKQYSGRLATQAVHAM
TH_1338|M.thermoresistible__bu VPDN-RFVPPQ-------STLEVLESVPESVLRRLKQYSGRLATEAVHTM
MAB_0762|M.abscessus_ATCC_1997 ------------------------------MGEQLLARVDELCAEQCRII
MSMEG_3552|M.smegmatis_MC2_155 ----MTFMRKSSDAG------QWSRSRWMELINSVTDHRDQLVDAFMAQV
. : ..* :
Mb2266|M.bovis_AF2122/97 QERLPFFADLEASQRAS-VALVVQTAVVNFVEWMHDPHSDVGYTAQAFEL
Rv2242|M.tuberculosis_H37Rv QERLPFFADLEASQRAS-VALVVQTAVVNFVEWMHDPHSDVGYTAQAFEL
MMAR_3335|M.marinum_M QERLPFFADLEASQRAS-VALVVQTAVVNFAEWMQNPRSDVSYTAQAFEL
MUL_1307|M.ulcerans_Agy99 QERLPFFADLEASQRAS-VALVVQTAVVNFAEWMQNPRSDVSYTAQAFEL
MAV_2195|M.avium_104 QDRLPFFADLEASQRAS-VSLVVQTAVVNFAEWMQDPKSNVRHTAQAFEL
MLBr_01652|M.leprae_Br4923 QERLPFFADLEASQRAS-VTLVVQTAVVNFVQWMQNPHSDVSYTAQAFEL
Mflv_2780|M.gilvum_PYR-GCK EERLPFFADMEASQRAS-VQLVVQTAVVNFVEWMRDPQSDVSYTAQAFEV
Mvan_3753|M.vanbaalenii_PYR-1 EERLPFFAELDASQRAS-VQLVVQTAVVNFAEWMRDPRSNVSYTAQAFEV
TH_1338|M.thermoresistible__bu EERLPFFADLEASQRAS-VHLVVQTAVVNFVEWMRDPRSNVTYTMQAFEV
MAB_0762|M.abscessus_ATCC_1997 RERVAAYRDPVLVTDED-LFAAGRDQMVYVLAAMGSGAPDTSAAARVGRL
MSMEG_3552|M.smegmatis_MC2_155 DDGRRFYDSKVETADLRESSRAAFTMLLRQLRGTPTSEEDLRITRELGVR
: : . . :: : : .
Mb2266|M.bovis_AF2122/97 VPQD-LTRRIALRQTVDMVRVTMEFFEEVVPLLARSEEQLTALTVGILKY
Rv2242|M.tuberculosis_H37Rv VPQD-LTRRIALRQTVDMVRVTMEFFEEVVPLLARSEEQLTALTVGILKY
MMAR_3335|M.marinum_M VPQD-LTRRIALRHTVDMVRVTMEFFEEVVPLLARSEEQLTALTVGILKY
MUL_1307|M.ulcerans_Agy99 VPQD-LTRRIALRHTVDMVRVTMEFFEEVVPLLARSEEQLTALTVGILKY
MAV_2195|M.avium_104 VPQD-LARRIALRHSVEMVRVTMEFFEEVVPLLARSEEQLTALTVGVLKY
MLBr_01652|M.leprae_Br4923 VPQD-LARRIALRHTVDMVRVTMEFFEEVVPLLARSEEQLTALTVGILKY
Mflv_2780|M.gilvum_PYR-GCK VPQD-LRRRIALRQSVEMVRTTMEYFEEVVPLLARSEDQLTALTAGILRY
Mvan_3753|M.vanbaalenii_PYR-1 VPQD-LRRRIALRQSVEMVRVTMEFFEEVVPLLARSEDQLAAMTAGILRY
TH_1338|M.thermoresistible__bu VPQD-LTRRIALRQTVEMVRTTMEFFEQVVPLLARSEEQVTALTAGILRY
MAB_0762|M.abscessus_ATCC_1997 RAEQGVPLADVMSAYRAGGQFLWDALSQAIDAAGLSRQELRAAASQAWQN
MSMEG_3552|M.smegmatis_MC2_155 RASQGVESEKLTAAIHRDFSVLWAAFRELAEDDD--AAVLAEHAEDVWRV
..: : : : : : :
Mb2266|M.bovis_AF2122/97 SRDLAFTAATAYADAAEARGTWDSRMEASVVDAVVRGDTGPELLSRAAAL
Rv2242|M.tuberculosis_H37Rv SRDLAFTAATAYADAAEARGTWDSRMEASVVDAVVRGDTGPELLSRAAAL
MMAR_3335|M.marinum_M SRDLAFTAASAYADAAEARGTWDSRMEASVVDAVVRGDTGPELLSRAAAL
MUL_1307|M.ulcerans_Agy99 SRDLAFTAASAYADAAEARGTWDSRMEASVVDAVVRGDTGPELLSRAAAL
MAV_2195|M.avium_104 SRDLAFTAATAYADAAEARGTWDSRMEASVVDAVVRGDTGPELLSRAAAL
MLBr_01652|M.leprae_Br4923 SRDLAFTAATAYADAAEARGTWDSRMEASVVDAVVRGDTGPELLSRAAAL
Mflv_2780|M.gilvum_PYR-GCK SRDLAFAAASAYADQAEARGAWDTRIESNLVDAVVRGDIGPDLQSQAAAL
Mvan_3753|M.vanbaalenii_PYR-1 SRDLAFAAATAYADQAEARGAWDTRMEANLVDAVVRGGTRPELQSQAAAL
TH_1338|M.thermoresistible__bu SRDLAFAAATAYADAAEARGAWDTRMEANVVDAVVRGAVGPELQSQAAAL
MAB_0762|M.abscessus_ATCC_1997 HDRYTDAMAEGYRDVVVEQLIQRDQERAALVSGLIDGRFPAGITAWNAAH
MSMEG_3552|M.smegmatis_MC2_155 VDGFAGRIHAAYFDEVIAIAQERSLSVQSLLAKLVTDEYPSLTFIARAGQ
: .* * . :: :: . . *.
Mb2266|M.bovis_AF2122/97 NWDTTAPATVLVGTPAPGPNGSNSDGDSERASQDVRDTAARHGRAALTDV
Rv2242|M.tuberculosis_H37Rv NWDTTAPATVLVGTPAPGPNGSNSDGDSERASQDVRDTAARHGRAALTDV
MMAR_3335|M.marinum_M NWDTTAPATVVVGTPASARDG--SDG-SERAIQDVRDAAAQHGRAALTDV
MUL_1307|M.ulcerans_Agy99 NWDTTAPATVVVGTPASARDG--SDG-SERAIQDVRDAAAQHGRAALTDV
MAV_2195|M.avium_104 NWDTTAPATVVVGTPAPGRDGSTGPGDSERASQHVRDIAAQHGRAALTDV
MLBr_01652|M.leprae_Br4923 NWDTTAPATVVVGTPTPNHDGPNGQVSSERASQEVREIAARHGRAALTDV
Mflv_2780|M.gilvum_PYR-GCK NWDATAPATVIVGTPRP--------DRTEFVVDDVHDVVKRHGRAALSDV
Mvan_3753|M.vanbaalenii_PYR-1 NWDATAPATVIVGMPRP--------DRAEFAGDDVHEVADRNGRTALSDV
TH_1338|M.thermoresistible__bu NWDATAPATVVVGLPRP--------DRLEVVSQDVHHVANRHGRTALSDV
MAB_0762|M.abscessus_ATCC_1997 QLGLPESGAFVVVAIESG-------PLDYRTLRSAEKALRDQGFASAWRV
MSMEG_3552|M.smegmatis_MC2_155 ALSIRETDGIWVAAALASEG----TPLQQFAERLRRRGRLAYTYAMGQCI
. . . * . . . : :
Mb2266|M.bovis_AF2122/97 HGTWLVAIVSGQLSPTEKFLKDLLAAFADAPVVIGPTAPMLTAAHRSASE
Rv2242|M.tuberculosis_H37Rv HGTWLVAIVSGQLSPTEKFLKDLLAAFADAPVVIGPTAPMLTAAHRSASE
MMAR_3335|M.marinum_M HGTWLVAIVSGHLSPTDKVFKDLLEAFSDGPVVIGPTAPMLTAAYHSASE
MUL_1307|M.ulcerans_Agy99 HGTWLVAIVSGHLSPTDKVFKDLLEAFSDGPVVIGPTAPMLTAAYHSASE
MAV_2195|M.avium_104 HGTWLVAIVSGQLSPTDKFLGDLLEAFSDGPVVVGPTAPMLTAAYHSASE
MLBr_01652|M.leprae_Br4923 HGTWLVAIISGQLAPTDKFFSDLLHAFSDGPVVIGPTAPMLTAAYHSASE
Mflv_2780|M.gilvum_PYR-GCK HGTWLVAIVSGNLSPTDRFLAELMSVFADGPVVIGPTAATLGGAHRSATE
Mvan_3753|M.vanbaalenii_PYR-1 HGTWLVAIISGGLSPTDRFLSELMTVFADGPVVIGPTAPTLGAAHRSATE
TH_1338|M.thermoresistible__bu HGTWLVTIVSGALSPTDRFLTDLLDVFADGPVVLGPTAPTLSAAYRSATE
MAB_0762|M.abscessus_ATCC_1997 DPDMQVGIVALPTPSRLEELGETLRNLGVRRIGVSPVYDGYPPPGPPLNY
MSMEG_3552|M.smegmatis_MC2_155 VAVWVADVVGSELDGVPDGCTSDPEYADLKPVRCGVSPLHRGVSQLRSAA
. ::. . : . .
Mb2266|M.bovis_AF2122/97 AISGMNAVAGWRGAPRPVLARELLP-ERALMGDASAIVALHTDVMRPLAD
Rv2242|M.tuberculosis_H37Rv AISGMNAVAGWRGAPRPVLARELLP-ERALMGDASAIVALHTDVMRPLAD
MMAR_3335|M.marinum_M AISGMNAVAGWRGAPRPVLARELLP-ERALMGDASAIVALHTDVMRPLAD
MUL_1307|M.ulcerans_Agy99 AISGMNAVAGWRGASRPVLARELLP-ERALMGDASAIVALHTDVMRPLAD
MAV_2195|M.avium_104 AISGMNAVGGWRGAPRPVLARELLP-ERALMGDASAIVALHTDVMGPLAD
MLBr_01652|M.leprae_Br4923 AVSGMNAVAGWSGAPRPVQARELLP-ERALMGDASAIVALHTDVMLPLAD
Mflv_2780|M.gilvum_PYR-GCK AVAGMNSVAGWPGAPRPVAARELLP-ERALLGDVTAATALEAEVMRPLAD
Mvan_3753|M.vanbaalenii_PYR-1 AIAGMNAVAGWAGAPRPVSARELLP-ERALLGDATAGAALEAEVMRPLSD
TH_1338|M.thermoresistible__bu AIAGMNAVAGWSGAPRPVPARELLP-ERALLGDQTAIAALESEVMRPLAD
MAB_0762|M.abscessus_ATCC_1997 AKAALLAAT----EDDPVVAFDANPYAVAAITDPQTMARYRDLVLGSLTE
MSMEG_3552|M.smegmatis_MC2_155 QIACEIALSMHPDHIGPATAADVWP-LVAGAALHSRLPVLEESIRGPLRD
: : *. * : * * . : .* :
Mb2266|M.bovis_AF2122/97 AG----PTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKRITDFTGR
Rv2242|M.tuberculosis_H37Rv AG----PTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKRITDFTGR
MMAR_3335|M.marinum_M AG----PTLIETLDAYLDCGGAIEACARKLFVHPNTIRYRLKRITDFTGR
MUL_1307|M.ulcerans_Agy99 AG----PTLIETLDAYLDCGGAIEACARKLFVHPNTIRYRLKRITDFTGR
MAV_2195|M.avium_104 AG----PTLIETLDAFLDSGGAIEACARKLFVHPNTVRYRLKRITDFTGR
MLBr_01652|M.leprae_Br4923 AG----PTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKRITDFTGH
Mflv_2780|M.gilvum_PYR-GCK AG----PALMDTLDAYLDSGGAIEACARKLFIHPNTVRYRLKRITDFTGR
Mvan_3753|M.vanbaalenii_PYR-1 AG----PALMETLDAYLDSGGAIEACARKLFVHPNTVRYRLKRIADFTGR
TH_1338|M.thermoresistible__bu AG----PTLTETLDAFLESGGAIEACARRLFVHPNTVRYRLRRIAEITGR
MAB_0762|M.abscessus_ATCC_1997 IGVVDRQLLVDTFRQWVDCDGSIPATARVLFCHPNTVRYRLRRLKQLTGR
MSMEG_3552|M.smegmatis_MC2_155 CRPAELKVLMETISVFSG-NGDVSATAAELFCHRNTVMKRIRRLKELTGL
* :*: : .* : * * ** * **: *::*: ::**
Mb2266|M.bovis_AF2122/97 DPTQPRDAYVLRVAATVGQLNYPTPH------------------------
Rv2242|M.tuberculosis_H37Rv DPTQPRDAYVLRVAATVGQLNYPTPH------------------------
MMAR_3335|M.marinum_M DPTQPRDAYVLRVAATVGQLNYPTPPSGAANNTITPVPLPVRRGTEGP--
MUL_1307|M.ulcerans_Agy99 DPTQPRDAYVLRVAATVGQLNYPTPPSGAANNTITPVPLPVRRGTEGP--
MAV_2195|M.avium_104 DPMQPRDAYVLRVAATVGQLNYPTHPPSAAGAAMPAVPLPVNGAARGQSG
MLBr_01652|M.leprae_Br4923 DPTLPRDAYVLRVAATVGKLNYPTHH------------------------
Mflv_2780|M.gilvum_PYR-GCK DPTVPRDAYVLRVASSLGRLTRQASQSPPLSARSGPRGGVASVTNPGTSP
Mvan_3753|M.vanbaalenii_PYR-1 DPTVPRDAYVLRVASSVGRLARQAHLSAAPAAASAQAIGVASVTSPENLG
TH_1338|M.thermoresistible__bu DPAVPRDAYVLRVAVSVSRLTRQSYQSSTVNPDLGSTAGWRGQAAGGHRA
MAB_0762|M.abscessus_ATCC_1997 DVARPRDIAELHLAVEADRRLSWA--------------------------
MSMEG_3552|M.smegmatis_MC2_155 DMTVPKDSARVLVALAPELAAVSD--------------------------
* *:* : :*
Mb2266|M.bovis_AF2122/97 -
Rv2242|M.tuberculosis_H37Rv -
MMAR_3335|M.marinum_M -
MUL_1307|M.ulcerans_Agy99 -
MAV_2195|M.avium_104 G
MLBr_01652|M.leprae_Br4923 -
Mflv_2780|M.gilvum_PYR-GCK -
Mvan_3753|M.vanbaalenii_PYR-1 T
TH_1338|M.thermoresistible__bu M
MAB_0762|M.abscessus_ATCC_1997 -
MSMEG_3552|M.smegmatis_MC2_155 -