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RECRSQEASGQLTFAKTPRTVGIEEEFHLVDLTTRRLATRAPELLPLLPDGYVAELQSCVVETNGSVVST LPELRADLTARRRVLVDTAATLGLGVVAAGAVPLSVPSEMRVTQTSRYQQMLADYQLLAREQLICGTQIH VGIDDPDESVLVAGRVAAYVPTLLALSASSPFWSDGSDTGYSSVRTLVWQRWPTTGLAPPATSAAEYDAL ISDLIATGVITDAGMSYFDVRPALRTPTLELRVCDSCPRADTIVLIAALFRALVEREIEGLRAGVPAAIV VPPLGRAALWRAARSGLEGDLVDLIHPASRPAGDVVTDLVQMLRPQLEASRDWQTVEELARRALAEGSSA ARQRRAMRMRNSLLDVVDHLIAETADVATVANDALPTQRNGSDRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3326 | - | - | 100% (396) | carboxylate-amine ligase |
| M. smegmatis MC2 155 | MSMEG_5590 | - | 2e-57 | 37.88% (359) | carboxylate-amine ligase |
| M. smegmatis MC2 155 | MSMEG_0836 | - | 6e-37 | 30.85% (376) | carboxylate-amine ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0441 | - | 9e-37 | 30.79% (380) | carboxylate-amine ligase |
| M. gilvum PYR-GCK | Mflv_1816 | - | 4e-59 | 38.06% (360) | carboxylate-amine ligase |
| M. tuberculosis H37Rv | Rv0433 | - | 9e-37 | 30.79% (380) | carboxylate-amine ligase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2558 | - | 1e-55 | 36.57% (361) | carboxylate-amine ligase |
| M. marinum M | MMAR_5020 | gcs2 | 1e-140 | 69.17% (360) | glutamate--cysteine ligase, Gcs2 |
| M. avium 104 | MAV_4721 | - | 7e-42 | 32.72% (379) | carboxylate-amine ligase |
| M. thermoresistible (build 8) | TH_0948 | - | 2e-39 | 32.11% (380) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4094 | gcs2 | 1e-138 | 68.91% (357) | glutamate--cysteine ligase, Gcs2 |
| M. vanbaalenii PYR-1 | Mvan_4929 | - | 4e-60 | 39.29% (364) | carboxylate-amine ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0441|M.bovis_AF2122/97 ---MPARRSAARIDFAGSPRPTLGVEWEFALVDSQTRD---LSNEATAVI
Rv0433|M.tuberculosis_H37Rv ---MPARRSAARIDFAGSPRPTLGVEWEFALVDSQTRD---LSNEATAVI
MAV_4721|M.avium_104 MSSVPARRGDAHIDFARSPRPTIGVEWEFALVDAQTRD---LSNEATAVI
TH_0948|M.thermoresistible__bu ---VSSPAGSTRIDFAGSPRPTLGVEWEFALVDADTRD---LSNEAAEVI
MMAR_5020|M.marinum_M --------------MRRDPPRTMGVEEEFHLVDLRSRR---LTTRAPDLL
MUL_4094|M.ulcerans_Agy99 ----------------------MGVEEEFHLVDLRSRR---LTTRAPDLL
MSMEG_3326|M.smegmatis_MC2_155 -MRECRSQEASGQLTFAKTPRTVGIEEEFHLVDLTTRR---LATRAPELL
Mflv_1816|M.gilvum_PYR-GCK ----------------MTEIPTLGVEEEFLLVDPESGAPVALNREVADLA
Mvan_4929|M.vanbaalenii_PYR-1 ----------------MTDIPTLGVEEEFLLVHPGSGAPVALNREVAARA
MAB_2558|M.abscessus_ATCC_1997 ----------------MDGHPTVGVEEEFLLVDRNTGEPVGRNRAVAQVA
:*:* ** **. : ..
Mb0441|M.bovis_AF2122/97 AEIGENPRVHKELLRNTVEIVSGICECTAEAMQDLRDTLGPARQIVRDRG
Rv0433|M.tuberculosis_H37Rv AEIGENPRVHKELLRNTVEIVSGICECTAEAMQDLRDTLGPARQIVRDRG
MAV_4721|M.avium_104 AEIGENPRVHKELLRNTVEVVSGICRTVPEAMEDLRQTLGPARRIVRDRG
TH_0948|M.thermoresistible__bu AEIGENPHVHKELLRNTVEFVTGICADTPEAIADLRATLLPARKIVRDRG
MMAR_5020|M.marinum_M AKLPED--YVAELQSCVVETNSGIVDSLDALRADLLRHRRLLVDAADEIG
MUL_4094|M.ulcerans_Agy99 AKLPED--YVAELQSCVVETNSGIVDSLDALRADLLRHRRLLVDAADEIG
MSMEG_3326|M.smegmatis_MC2_155 PLLPDG--YVAELQSCVVETNGSVVSTLPELRADLTARRRVLVDTAATLG
Mflv_1816|M.gilvum_PYR-GCK ARDGVE--LQLELTRCQVETATGVVDTTVDLREQLVHLRRTAAHAAENAG
Mvan_4929|M.vanbaalenii_PYR-1 ADMDVE--LQLELTSCQVETATAVVDDTAHLREQLLHLRRTASAAAEHAG
MAB_2558|M.abscessus_ATCC_1997 STHGVD--LQLELTSCQVETTTAVMCTSSALRTELIRLRGIASAAAASQR
. ** ** .: :* .
Mb0441|M.bovis_AF2122/97 MELFCAGTHPFARWSAQKLTDAPRYAELIKRTQWWGRQMLIWGVHVHVGI
Rv0433|M.tuberculosis_H37Rv MELFCAGTHPFARWSAQKLTDAPRYAELIKRTQWWGRQMLIWGVHVHVGI
MAV_4721|M.avium_104 MELFCAGAHPFAQWTTQKLTDAPRYAELIKRTQWWGRQMLIWGVHVHVGI
TH_0948|M.thermoresistible__bu MELFCAGTHPFAKWSAQKLTDAPRYAELIKRTQWWGRQMLIWGVHVHVGV
MMAR_5020|M.marinum_M VGVVAAGAVPLSVPAELQITQTPRYLHMLADYQLLAREQLICATHVHVGI
MUL_4094|M.ulcerans_Agy99 VGVVAAGAVPLSVPAELQITQTPRYLHMLADYQLLAREQLICATHVHVGI
MSMEG_3326|M.smegmatis_MC2_155 LGVVAAGAVPLSVPSEMRVTQTSRYQQMLADYQLLAREQLICGTQIHVGI
Mflv_1816|M.gilvum_PYR-GCK ARLLAVG-LPPTLPHEFPITDTPRYRDIGERYGMIAHEQGICGCHVHVAV
Mvan_4929|M.vanbaalenii_PYR-1 ARLLAVG-LPPTLPHEFPVTDTPRYRDIGERYGMIAHEQGICGCHVHVAV
MAB_2558|M.abscessus_ATCC_1997 AHLLAVA-LPPTVPHAFPVTPTARYRRMADEFGMLAHEQGICGCHVHVAV
:.... * : :* :.** : .:: * . ::**.:
Mb0441|M.bovis_AF2122/97 RSAHKVMPIMTSLLNYYPHLLALSASSPWWGG-EDTGYASNRAMMFQQLP
Rv0433|M.tuberculosis_H37Rv RSAHKVMPIMTSLLNYYPHLLALSASSPWWGG-EDTGYASNRAMMFQQLP
MAV_4721|M.avium_104 SSPNKVMPIMTSLLNYYPHLLALSASSPWWTG-VDTGYASNRAMMFQQLP
TH_0948|M.thermoresistible__bu SSAHKVMPIISSLLNQYPHLLALSASSPYWDG-EDTGYASNRAMMFQQLP
MMAR_5020|M.marinum_M DDRDEAIAIANRLLPCLPTLLALSASSPFWADGSDTGYASMRTLVWRRWP
MUL_4094|M.ulcerans_Agy99 DDRDEAIAIANRLLPCLPTLLALSASSPFWADGSDTGYASMRTLVWRRWP
MSMEG_3326|M.smegmatis_MC2_155 DDPDESVLVAGRVAAYVPTLLALSASSPFWSDGSDTGYSSVRTLVWQRWP
Mflv_1816|M.gilvum_PYR-GCK PDRDTAIRVGNRLRPWLPLLLGLTANSAIYRN-ADSGHASWRSVLWARWP
Mvan_4929|M.vanbaalenii_PYR-1 PDRDAAIAVSNRLRPWLPLLLALTANSAIYRN-ADTGHASWRSVLWARWP
MAB_2558|M.abscessus_ATCC_1997 PSRESAIDVSNRLRPTLHLFLALTANSAVYRK-ADSGYASYRNMLWTRWP
. . : : : :*.*:*.*. : *:*::* * ::: : *
Mb0441|M.bovis_AF2122/97 TAGLPFHFQRWAEFEGFVYDQKKTGIIDHMDEIRWDIRPSPHLGTLEVRI
Rv0433|M.tuberculosis_H37Rv TAGLPFHFQRWAEFEGFVYDQKKTGIIDHMDEIRWDIRPSPHLGTLEVRI
MAV_4721|M.avium_104 TAGLPFQFQTWAEFEGFVYDQKKTGIIDHVDEVRWDIRPSPHLGTLEMRI
TH_0948|M.thermoresistible__bu TAGLPFQFQTWAEFERFVADQKKTGIIDHMNEIRWDIRPSPHLGTIEVRV
MMAR_5020|M.marinum_M TTGLAAPVQSATEYDALVKALIASQVITDYGMIYFDLRPSSHAPTLELRV
MUL_4094|M.ulcerans_Agy99 TTGLAAPVQSATEYDALVKALIASQVITDYGMIYFDLRPSSHAPTLELRV
MSMEG_3326|M.smegmatis_MC2_155 TTGLAPPATSAAEYDALISDLIATGVITDAGMSYFDVRPALRTPTLELRV
Mflv_1816|M.gilvum_PYR-GCK GAGPPPQFESADEYDAAVQMLCDTNVIRDQGMVYWDVRPSATFPTVEVRV
Mvan_4929|M.vanbaalenii_PYR-1 SAGPPPHFDSADEYDAAVQMLSHTGVIRDDGMVYWDVRPSANFPTVEVRV
MAB_2558|M.abscessus_ATCC_1997 SSGPPPYFDSVDHYDTTVRELSRSGAVLDDGMVYWDVRPSANFPTVEVRV
:* . .:: : : : . . :*:**: *:*:*:
Mb0441|M.bovis_AF2122/97 CDGVSNLRELGALVALTHCLIVDLDRRLDAGETLPTMPPWHVQENKWRAA
Rv0433|M.tuberculosis_H37Rv CDGVSNLRELGALVALTHCLIVDLDRRLDAGETLPTMPPWHVQENKWRAA
MAV_4721|M.avium_104 CDGVSNLHELAALVALTHCLVVDLDRRLEADESLPTMPPWHHQENKWRAA
TH_0948|M.thermoresistible__bu FDGISNLRELGALVALTHCLVVDLDRRLDAGEQLPTMPPWHVQENKWRAA
MMAR_5020|M.marinum_M CDSCPSVDTIVLVAGLYRAAVAREAEAIRAGTPAPAFPSTVGSAALWRAA
MUL_4094|M.ulcerans_Agy99 CDSCPSVDTIVLVAGLYRAAVAREAEAFRAGTPAPAFPSTVGSAALWRAA
MSMEG_3326|M.smegmatis_MC2_155 CDSCPRADTIVLIAALFRALVEREIEGLRAGVPAAIVVPPLGRAALWRAA
Mflv_1816|M.gilvum_PYR-GCK SDVPATVAETVLFAAIVRGCVMTALDDEARGEPVRPLAPYVLKAAYWMAA
Mvan_4929|M.vanbaalenii_PYR-1 ADVPATVDETVLFAALVRGCVMTALEDERHGDPVLPLAPYALKAAYWKAA
MAB_2558|M.abscessus_ATCC_1997 ADVPATVAETVLLATLVRAAVMSALEAQKRGDPAPRLEDCVLRAAHWRSA
* . .. : : : . . * :*
Mb0441|M.bovis_AF2122/97 RYGLDAVIILDAD--SNERLVTDDLADVLTRLEPVAKSLNCADELAAVSD
Rv0433|M.tuberculosis_H37Rv RYGLDAVIILDAD--SNERLVTDDLADVLTRLEPVAKSLNCADELAAVSD
MAV_4721|M.avium_104 RYGLDAVIILDAD--SNERLVTEDLDDVLNRLEPVARKLQCADELAAVAD
TH_0948|M.thermoresistible__bu RYGLDAEIILDAD--SNERLVTDDLDDILNRLEPVAVSLNCADELAEVEH
MMAR_5020|M.marinum_M RSGLEGDLVDLTGPVPASRPAGDVVNDLVSSLRPQLEASGDWEMIGELTR
MUL_4094|M.ulcerans_Agy99 RSGLEGDLVDLTGPVPASRPAGDVVNDLVSSLRPQLEASGDWEMIGELTR
MSMEG_3326|M.smegmatis_MC2_155 RSGLEGDLVDLIH--PASRPAGDVVTDLVQMLRPQLEASRDWQTVEELAR
Mflv_1816|M.gilvum_PYR-GCK RSGIEGDGVDLSD--HGAAPMVELLDRLVERIGPALDASGDGELVSSGLA
Mvan_4929|M.vanbaalenii_PYR-1 RNGVDGDGVDLEN--HVPAPVSDLLGYLTERTRPALEAAGDHELVTAGLA
MAB_2558|M.abscessus_ATCC_1997 RDGLDGMAVDLVGS-SSTAPARTLLSRLIDHLRPALESLGDYDMARTELA
* *::. : : : * :
Mb0441|M.bovis_AF2122/97 IYRDGASYQRQLRVAQQHDGDLRAVVDALVAELVI---------------
Rv0433|M.tuberculosis_H37Rv IYRDGASYQRQLRVAQQHDGDLRAVVDALVAELVI---------------
MAV_4721|M.avium_104 IPRHGASYQRQRRVAEEHDGDLRAVVDALVAELEI---------------
TH_0948|M.thermoresistible__bu IYRTGASYQRQRRVAEEHDGDLRAVVDALIGELDLGEPEQQGAS------
MMAR_5020|M.marinum_M QTLLSGTSSARQRRALRRRGRLTDVVDQLIAETAGRVKPTTAAVSHDGGL
MUL_4094|M.ulcerans_Agy99 QTLLSGTSSARQRRALRRRGRLTDVVDQLIAETAGRVKPTTAAVSHDGGL
MSMEG_3326|M.smegmatis_MC2_155 RALAEGSSAARQRRAMRMRNSLLDVVDHLIAETAD-----VATVAND---
Mflv_1816|M.gilvum_PYR-GCK RVAEHGNGAARQRRAWRRRHDVADVLAESAAATVEFP-------------
Mvan_4929|M.vanbaalenii_PYR-1 RVTDLGNGATRQRRAWRRNHDVDDVLAEAAAATLEDG-------------
MAB_2558|M.abscessus_ATCC_1997 RVVAQGNGAMRQRRTWCTSGNVKDVISEIATATTDFN-------------
.. : * : : *:
Mb0441|M.bovis_AF2122/97 --------------------------------------------------
Rv0433|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4721|M.avium_104 --------------------------------------------------
TH_0948|M.thermoresistible__bu --------------------------------------------------
MMAR_5020|M.marinum_M LAAYQPTGEAGKPADDMFASYDEAVDADGRARPNYKTALKTIEGLGVDVL
MUL_4094|M.ulcerans_Agy99 LAPYQLTGEAGKPADGMFASYDEAVDADGRARPNYKTALKTIEGLGVDVL
MSMEG_3326|M.smegmatis_MC2_155 -------------------------------------ALPTQR-------
Mflv_1816|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4929|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2558|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0441|M.bovis_AF2122/97 --------------------------------------------------
Rv0433|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4721|M.avium_104 --------------------------------------------------
TH_0948|M.thermoresistible__bu --------------------------------------------------
MMAR_5020|M.marinum_M RARDRDIEQERRAGNVTFRAAGHSRVQVNPLDLVPRIVTADEWAQLSQGL
MUL_4094|M.ulcerans_Agy99 RARDRDIEQERSAGNVTFRAAGHSRVQVNPLDLVPRIVTADEWAQLSQGL
MSMEG_3326|M.smegmatis_MC2_155 NGSDRG--------------------------------------------
Mflv_1816|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4929|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2558|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0441|M.bovis_AF2122/97 --------------------------------------------------
Rv0433|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4721|M.avium_104 --------------------------------------------------
TH_0948|M.thermoresistible__bu --------------------------------------------------
MMAR_5020|M.marinum_M AQRARALDAFLRDVYSEQAILADGVLSAQVLDRSPGFRSTGRLAGDGVRA
MUL_4094|M.ulcerans_Agy99 AQRARALDAFLRDVYSEQAILADGVLSAQVLDRSPGFRSTGRLAGDGVRA
MSMEG_3326|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1816|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4929|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2558|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0441|M.bovis_AF2122/97 --------------------------------------------------
Rv0433|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4721|M.avium_104 --------------------------------------------------
TH_0948|M.thermoresistible__bu --------------------------------------------------
MMAR_5020|M.marinum_M HISGIDLVCDRAGNWMVLEDNLRIPSGVAYAIVNRRLLGKYLPELPPPGG
MUL_4094|M.ulcerans_Agy99 HISGIDLVCDRAGNWMVLEDNLRIPSGVAYAIVNRRLLGKYLPELPPPGG
MSMEG_3326|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1816|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4929|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2558|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0441|M.bovis_AF2122/97 --------------------------------------------------
Rv0433|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4721|M.avium_104 --------------------------------------------------
TH_0948|M.thermoresistible__bu --------------------------------------------------
MMAR_5020|M.marinum_M VADLDRVAHLLLETLRAAAPPHTPDQPTVTLLSAGRDDPGWFEHGFLAEE
MUL_4094|M.ulcerans_Agy99 VADLDRVAHLLLETLRAASPPHTPDQPTVTLLSAGRDDPGWFEHGFLAEE
MSMEG_3326|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1816|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4929|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2558|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0441|M.bovis_AF2122/97 --------------------------------------------------
Rv0433|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4721|M.avium_104 --------------------------------------------------
TH_0948|M.thermoresistible__bu --------------------------------------------------
MMAR_5020|M.marinum_M MGVALVAPSDLSVRDRRVFRHGGSGGSPVDVIYSRMYEDMLLSSTGHDGA
MUL_4094|M.ulcerans_Agy99 MGVALVAPSDLSVRDRRVFRHGGSGGSPVDVIYSRMYEDMLLSSTGHDGA
MSMEG_3326|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1816|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4929|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2558|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0441|M.bovis_AF2122/97 --------------------------------------------------
Rv0433|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4721|M.avium_104 --------------------------------------------------
TH_0948|M.thermoresistible__bu --------------------------------------------------
MMAR_5020|M.marinum_M PLRSGLLEALDAGNLTIVNALGNGVAEDKAVYPFVPAMIEYYLGEKPALA
MUL_4094|M.ulcerans_Agy99 PLRSGLLEALDAGNLTIVNALGNGVAEDKAVYPFVPAMIEYYLGEKPALA
MSMEG_3326|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1816|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4929|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2558|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0441|M.bovis_AF2122/97 --------------------------------------------------
Rv0433|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4721|M.avium_104 --------------------------------------------------
TH_0948|M.thermoresistible__bu --------------------------------------------------
MMAR_5020|M.marinum_M QVPTWVCAEREQRDYVLDHLGELVVKPTDGLSGSGVLIGPEATDAAIEAR
MUL_4094|M.ulcerans_Agy99 QVPTCVCAEREQRDYVLDHLGELVVKPTDGLSGSGVLIGPEATDAAIEAR
MSMEG_3326|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1816|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4929|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2558|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0441|M.bovis_AF2122/97 --------------------------------------------------
Rv0433|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4721|M.avium_104 --------------------------------------------------
TH_0948|M.thermoresistible__bu --------------------------------------------------
MMAR_5020|M.marinum_M RRELLIQPERFVAQQLVALSTHPTFDDDGLYPHHVDLRAFVHLRQAPRGP
MUL_4094|M.ulcerans_Agy99 RRELLIQPERFVAQQLVALSTHPTFADDGLYPHHVDLRAFVHLRQAPRGP
MSMEG_3326|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1816|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4929|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2558|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0441|M.bovis_AF2122/97 --------------------------------------
Rv0433|M.tuberculosis_H37Rv --------------------------------------
MAV_4721|M.avium_104 --------------------------------------
TH_0948|M.thermoresistible__bu --------------------------------------
MMAR_5020|M.marinum_M VTAKVLPAALTRVASRGSRIANSSSGAGSKDTWIFTDG
MUL_4094|M.ulcerans_Agy99 VTAKVLPAALTRVASRGSRIANSSSGAGSKDTWIFTDG
MSMEG_3326|M.smegmatis_MC2_155 --------------------------------------
Mflv_1816|M.gilvum_PYR-GCK --------------------------------------
Mvan_4929|M.vanbaalenii_PYR-1 --------------------------------------
MAB_2558|M.abscessus_ATCC_1997 --------------------------------------