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M. thermoresistible (build 8) TH_0948 ()

annotation: CONSERVED HYPOTHETICAL PROTEIN
coordinates: 1883373 - 1884530
length: 386

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0948-100% (386)CONSERVED HYPOTHETICAL PROTEIN

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0441-0.086.41% (368) carboxylate-amine ligase
M. gilvum PYR-GCKMflv_0171-0.083.42% (380) carboxylate-amine ligase
M. tuberculosis H37RvRv0433-0.086.41% (368) carboxylate-amine ligase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_4183c-1e-17278.14% (366) carboxylate-amine ligase
M. marinum MMMAR_0748-0.085.94% (377) hypothetical protein MMAR_0748
M. avium 104MAV_4721-0.082.18% (376) carboxylate-amine ligase
M. smegmatis MC2 155MSMEG_0836-0.085.64% (376) carboxylate-amine ligase
M. ulcerans Agy99MUL_1380-0.085.68% (377) carboxylate-amine ligase
M. vanbaalenii PYR-1Mvan_0736-0.085.05% (368) carboxylate-amine ligase

CLUSTAL 2.0.9 multiple sequence alignment


TH_0948|M.thermoresistible__bu      ---------VSSPAGS-------TRIDFAGSPRPTLGVEWEFALVDADTR
MSMEG_0836|M.smegmatis_MC2_155      ---------MSSLPAD-------SRIDFAGSPRPTVGVEWEFALVDAKTR
Mflv_0171|M.gilvum_PYR-GCK          ---------MSSPVPDQ---RPDSRIDFNGSVRPTLGVEWEFALVDAQTR
Mvan_0736|M.vanbaalenii_PYR-1       ---------MSSLAADQ---RADGRIDFVGSVRPTVGVEWEFALVDATTR
Mb0441|M.bovis_AF2122/97            ------------MPAR----RSAARIDFAGSPRPTLGVEWEFALVDSQTR
Rv0433|M.tuberculosis_H37Rv         ------------MPAR----RSAARIDFAGSPRPTLGVEWEFALVDSQTR
MMAR_0748|M.marinum_M               ---------MSSAPASSSAGRTANRIDFARSPRPTVGVEWEFALVDAETR
MUL_1380|M.ulcerans_Agy99           MMPVSGWRAVSSAPASSSAGRTANRIDFARSPRPTVGVEWEFALVDAETR
MAV_4721|M.avium_104                ---------MSSVPAR----RGDAHIDFARSPRPTIGVEWEFALVDAQTR
MAB_4183c|M.abscessus_ATCC_199      ---------------------MARPIEFRGSPRPTLGVEWEFALVDAQTR
                                                             *:*  * ***:**********: **

TH_0948|M.thermoresistible__bu      DLSNEAAEVIAEIGENPHVHKELLRNTVEFVTGICADTPEAIADLRATLL
MSMEG_0836|M.smegmatis_MC2_155      ELSNEAAAVIAEIGENPHVHKELLRNTVEIVTGICENSGEAMGDLCDTLS
Mflv_0171|M.gilvum_PYR-GCK          DLSNEAASVIAEIGENPRVHKELLRNTVEVVTGICDNSGQAMDDLASTLR
Mvan_0736|M.vanbaalenii_PYR-1       DLSNEAASVIAEIGENPRVHKELLRNTVEVVTGICANAGEAMEDLASTLR
Mb0441|M.bovis_AF2122/97            DLSNEATAVIAEIGENPRVHKELLRNTVEIVSGICECTAEAMQDLRDTLG
Rv0433|M.tuberculosis_H37Rv         DLSNEATAVIAEIGENPRVHKELLRNTVEIVSGICECTAEAMQDLRDTLG
MMAR_0748|M.marinum_M               DLSNEATAVIAEIGENPRVHKELLRNTVEVVSGVCGSAGEAIEDLRTTLG
MUL_1380|M.ulcerans_Agy99           DLSNEATAVIAEIGENPRVHKELLRNTVEVVSGVCGSAGEAIEDLRTTLG
MAV_4721|M.avium_104                DLSNEATAVIAEIGENPRVHKELLRNTVEVVSGICRTVPEAMEDLRQTLG
MAB_4183c|M.abscessus_ATCC_199      DLTNAASAVLAAIGETPHVHKELLRNTIEVVTGICGTVGEAMHDLQTTLA
                                    :*:* *: *:* ***.*:*********:*.*:*:*    :*: **  ** 

TH_0948|M.thermoresistible__bu      PARKIVRDRGMELFCAGTHPFAKWSAQKLTDAPRYAELIKRTQWWGRQML
MSMEG_0836|M.smegmatis_MC2_155      TVRRAVRGRGMELFCAGTHPFGKWSAAQLTDAPRYAELIKRTQWWGRQML
Mflv_0171|M.gilvum_PYR-GCK          PVREIVRERGMELFCAGTHPFADWSAQKLTDAPRYAELIKRTQWWGRQMT
Mvan_0736|M.vanbaalenii_PYR-1       PVREVVRERGMDLFCAGTHPFADWSVQKLTDAPRYAELIKRTQWWGRQML
Mb0441|M.bovis_AF2122/97            PARQIVRDRGMELFCAGTHPFARWSAQKLTDAPRYAELIKRTQWWGRQML
Rv0433|M.tuberculosis_H37Rv         PARQIVRDRGMELFCAGTHPFARWSAQKLTDAPRYAELIKRTQWWGRQML
MMAR_0748|M.marinum_M               PARRIVHARGMELFCAGTHPFAQWSTQKLTDAPRYAELIKRTQWWGRQML
MUL_1380|M.ulcerans_Agy99           PARRIVHARGMELFCEGTHPFAQWSTQKLTDAPRYAELIKRTQWWGRQML
MAV_4721|M.avium_104                PARRIVRDRGMELFCAGAHPFAQWTTQKLTDAPRYAELIKRTQWWGRQML
MAB_4183c|M.abscessus_ATCC_199      TVRPIVQSMGMELFCAGTHPFARWSAQQLTDAPRYDELIARTQWWGRQML
                                    ..*  *:  **:*** *:***. *:. :******* *** ********* 

TH_0948|M.thermoresistible__bu      IWGVHVHVGVSSAHKVMPIISSLLNQYPHLLALSASSPYWDGEDTGYASN
MSMEG_0836|M.smegmatis_MC2_155      IWGVHVHVGVSSAHKVMPIISSLLNQYPHLLALSASSPFWDGEDTGYASN
Mflv_0171|M.gilvum_PYR-GCK          IWGVHVHVGVSSAHKVMPIITSLLHQYPHLLALSASSPFWDGEDTGYASN
Mvan_0736|M.vanbaalenii_PYR-1       IWGVHVHVGVSSAHKVMPIITALLHQYPHLLALSASSPYWDGEDTGYASN
Mb0441|M.bovis_AF2122/97            IWGVHVHVGIRSAHKVMPIMTSLLNYYPHLLALSASSPWWGGEDTGYASN
Rv0433|M.tuberculosis_H37Rv         IWGVHVHVGIRSAHKVMPIMTSLLNYYPHLLALSASSPWWGGEDTGYASN
MMAR_0748|M.marinum_M               IWGVHVHVGVSSANKVMPIISALLNYYPHLLALSASSPWWGGEDTGYASN
MUL_1380|M.ulcerans_Agy99           IWGVHVHVGVSSANKVMPIISALLNYYPHLLALSASSPWWGGEDTGYASN
MAV_4721|M.avium_104                IWGVHVHVGISSPNKVMPIMTSLLNYYPHLLALSASSPWWTGVDTGYASN
MAB_4183c|M.abscessus_ATCC_199      IWGVHVHVGISSKHKVMPIVTSMLNYYPHLLALSASSPMWEGQDTGYASN
                                    *********: * :*****::::*: ************ * * *******

TH_0948|M.thermoresistible__bu      RAMMFQQLPTAGLPFQFQTWAEFERFVADQKKTGIIDHMNEIRWDIRPSP
MSMEG_0836|M.smegmatis_MC2_155      RAMMFQQLPTAGLPFQFQTWHEFEGFVHDQKKTGIIDHLSEIRWDIRPSP
Mflv_0171|M.gilvum_PYR-GCK          RAMMFQQLPTAGLPFHFQEWREWERFVSDQKKTGIIDHMNEIRWDIRPSP
Mvan_0736|M.vanbaalenii_PYR-1       RAMMFQQLPTAGLPFHFQEWREFERFVSDQKKTGIIDHMNEIRWDIRPSP
Mb0441|M.bovis_AF2122/97            RAMMFQQLPTAGLPFHFQRWAEFEGFVYDQKKTGIIDHMDEIRWDIRPSP
Rv0433|M.tuberculosis_H37Rv         RAMMFQQLPTAGLPFHFQRWAEFEGFVYDQKKTGIIDHMDEIRWDIRPSP
MMAR_0748|M.marinum_M               RAMMFQQLPTAGLPFQFQTWSEFEGFVYDQKKTGIIDHINEIRWDIRPSP
MUL_1380|M.ulcerans_Agy99           RAMMFQQLPTAGLPFQFQTWSEFEGFVYDQKKTGIIDHINEIRWDIRPSP
MAV_4721|M.avium_104                RAMMFQQLPTAGLPFQFQTWAEFEGFVYDQKKTGIIDHVDEVRWDIRPSP
MAB_4183c|M.abscessus_ATCC_199      RAMMFQQLPTAGLPFHFQAWEQFEGFVDDQMKTGIIDQLNEIRWDIRPSP
                                    ***************:** * ::* ** ** ******::.*:********

TH_0948|M.thermoresistible__bu      HLGTIEVRVFDGISNLRELGALVALTHCLVVDLDRRLDAGEQLPTMPPWH
MSMEG_0836|M.smegmatis_MC2_155      QLGTVEVRIFDGVSNVRELSALVALTHCLIVDLDRRLDAGEQLPVMPPWH
Mflv_0171|M.gilvum_PYR-GCK          HLGTIEVRIFDGVSNLHELSALVALTHCLIVDLDRRIEAGESLPVMPPWH
Mvan_0736|M.vanbaalenii_PYR-1       HLGTIEVRIFDGVSNLHELSALVALTHCLIVDLDRRLDAGESLPVMPPWH
Mb0441|M.bovis_AF2122/97            HLGTLEVRICDGVSNLRELGALVALTHCLIVDLDRRLDAGETLPTMPPWH
Rv0433|M.tuberculosis_H37Rv         HLGTLEVRICDGVSNLRELGALVALTHCLIVDLDRRLDAGETLPTMPPWH
MMAR_0748|M.marinum_M               HLGTIELRICDGVSNLRELGALVALMHCLVVDLDRRLDAGETLPTMPPWH
MUL_1380|M.ulcerans_Agy99           HLGTIELRICDGVSNLRELGALVALMHCLVVDLDRRLDAGETLPTMPPWH
MAV_4721|M.avium_104                HLGTLEMRICDGVSNLHELAALVALTHCLVVDLDRRLEADESLPTMPPWH
MAB_4183c|M.abscessus_ATCC_199      ALGTVEVRIFDGISNVAELEALVALTHCLVVDLDRKLEAGESLPTMPPWH
                                     ***:*:*: **:**: ** ***** ***:*****:::*.* **.*****

TH_0948|M.thermoresistible__bu      VQENKWRAARYGLDAEIILDADSNERLVTDDLDDILNRLEPVAVSLNCAD
MSMEG_0836|M.smegmatis_MC2_155      VQENKWRAARYGLDAVIILDADSNERLVTEDLDDLLNHLEPVAASLHCAD
Mflv_0171|M.gilvum_PYR-GCK          VQENKWRAARYGLDAIIILDADSNERLVTEDLDDLLERLQPVARKLDCVD
Mvan_0736|M.vanbaalenii_PYR-1       VQENKWRAARYGLDAIIILDADSNERLVTEDLDDLLERLQPVAKRLSCVE
Mb0441|M.bovis_AF2122/97            VQENKWRAARYGLDAVIILDADSNERLVTDDLADVLTRLEPVAKSLNCAD
Rv0433|M.tuberculosis_H37Rv         VQENKWRAARYGLDAVIILDADSNERLVTDDLADVLTRLEPVAKSLNCAD
MMAR_0748|M.marinum_M               VQENKWRAARYGLDAVIILDAESNERLVTDDLDDVLTRLEPVARSLSCAD
MUL_1380|M.ulcerans_Agy99           VQENKWRAARYGLDAVIILDAESNERLVTDDLDDVLTRLEPVARSLSCAD
MAV_4721|M.avium_104                HQENKWRAARYGLDAVIILDADSNERLVTEDLDDVLNRLEPVARKLQCAD
MAB_4183c|M.abscessus_ATCC_199      VQENKWRSARYGLDAVIILDEDSNERLVTEDLDDLLTRLQPIARLLECET
                                     ******:******* **** :*******:** *:* :*:*:*  * *  

TH_0948|M.thermoresistible__bu      ELAEVEHIYRTGASYQRQRRVAEEHDGDLRAVVDALIGELDLGEPEQQGA
MSMEG_0836|M.smegmatis_MC2_155      ELAAVEDIYRLGGSYQRQRRVAEENDGDLREVVDALIGELEL--------
Mflv_0171|M.gilvum_PYR-GCK          ELARVPDIYHNGASYQRQRRVAEEHDGDLRAVVDALVSELVL--------
Mvan_0736|M.vanbaalenii_PYR-1       ELSRVPDIYHNGASYQRQRRVAEEHDGDLRAVVDALVSELVL--------
Mb0441|M.bovis_AF2122/97            ELAAVSDIYRDGASYQRQLRVAQQHDGDLRAVVDALVAELVI--------
Rv0433|M.tuberculosis_H37Rv         ELAAVSDIYRDGASYQRQLRVAQQHDGDLRAVVDALVAELVI--------
MMAR_0748|M.marinum_M               ELAAVAEIPRVGASYQRQRRVAEEHDGDLRAVVDALIAELDI--------
MUL_1380|M.ulcerans_Agy99           ELAAVAEIPRVGASYQRQRRVAEEHDGDLRAVVDALIAELDI--------
MAV_4721|M.avium_104                ELAAVADIPRHGASYQRQRRVAEEHDGDLRAVVDALVAELEI--------
MAB_4183c|M.abscessus_ATCC_199      ELAAVEEIYRHGGSYQRQRRVAEEHDGDLGAVVDAVVNELEPVRYTDSQ-
                                    **: * .* : *.***** ***:::****  ****:: **          

TH_0948|M.thermoresistible__bu      S
MSMEG_0836|M.smegmatis_MC2_155      -
Mflv_0171|M.gilvum_PYR-GCK          -
Mvan_0736|M.vanbaalenii_PYR-1       -
Mb0441|M.bovis_AF2122/97            -
Rv0433|M.tuberculosis_H37Rv         -
MMAR_0748|M.marinum_M               -
MUL_1380|M.ulcerans_Agy99           -
MAV_4721|M.avium_104                -
MAB_4183c|M.abscessus_ATCC_199      -