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TVTADSSAARENRWSTRLLIWAAVLILANVLVDIVIGSPLMVMPQLMAHFDTDQAAWLNASAMLAGAIWA PLLAKSSDVFGKRRILVGTLVMAGVGALVCLAAPNLWIFLIGRFLQGAALAAVFLTVTLARQICAPGVAV VLVGLLTSGPSIVGIIEPFLMKPVIDAFGYRSVFVVAALLATAAAIGVRCLVPESPIRIAARIDVFGALL LGGGIGATLAYISLGQAVGWSDGRMIALLAAGAGALVWWAVCALRVDEPLIDIRALHRPILLTLLALLLA AGSFRSMLQLTSVVAQVPVELGLGYGLGHGEAIAILLAVPNLGIVVGGVCAGWVAGRGSGPARPLLGGIT IGAVATFAMLLGVSALPLAIVCATMLGVAAGAISASGYNLAIDFAAPEHQGTIAGLVSVMLALGSVVFNF AGGEVLKATRILGMAAGGAPVSTAGGVHLYVAMAGTLFALAAIPVIMLGRKRSPQAFRTGVDNAVEEACR R*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3316 | - | - | 100% (492) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_3283 | - | 4e-33 | 27.00% (474) | membrane transport protein |
| M. smegmatis MC2 155 | MSMEG_6513 | - | 1e-30 | 28.23% (457) | membrane transport protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0805c | emrB | 7e-23 | 26.74% (430) | multidrug resistance integral membrane efflux protein EmrB |
| M. gilvum PYR-GCK | Mflv_3140 | - | 8e-28 | 25.27% (467) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv0783c | emrB | 8e-23 | 26.74% (430) | multidrug resistance integral membrane efflux protein EmrB |
| M. leprae Br4923 | MLBr_01562 | - | 3e-09 | 20.20% (401) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_1396 | - | 3e-16 | 22.74% (431) | EmrB/QacA family drug resistance transporter |
| M. marinum M | MMAR_3100 | ermB_1 | 5e-21 | 26.92% (416) | integral membrane drug efflux protein, ErmB_1 |
| M. avium 104 | MAV_0729 | - | 2e-17 | 24.55% (444) | EmrB efflux protein |
| M. thermoresistible (build 8) | TH_2968 | - | 3e-27 | 26.36% (478) | PUTATIVE putative major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_0501 | - | 1e-20 | 27.70% (444) | integral membrane drug efflux protein |
| M. vanbaalenii PYR-1 | Mvan_5900 | - | 0.0 | 70.78% (462) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0805c|M.bovis_AF2122/97 --------------MLGNAMVEACPAEGDAPVPITPAGRPRSGQRSYPDR
Rv0783c|M.tuberculosis_H37Rv --------------MLGNAMVEACPAEGDAPVPITPAGRPRSGQRSYPDR
MUL_0501|M.ulcerans_Agy99 --------------MLSTAMDEAHCTPAEVAPPDTRTGTSSPGEHVYPDR
MAV_0729|M.avium_104 --------------MLSGAMEKTR--SAAFSVPLATASGPSLRDDEYPDK
MMAR_3100|M.marinum_M -------------------MEPCG------ADARATATQLSPTQDNYPDR
MSMEG_3316|M.smegmatis_MC2_155 ----------------------------------MTVTADSSAAR--ENR
Mvan_5900|M.vanbaalenii_PYR-1 ----------------------------------MTKTLDTPTPGPLQQL
Mflv_3140|M.gilvum_PYR-GCK ---------------------------------------------MQQTV
TH_2968|M.thermoresistible__bu ---------------------------------------VRRDAPSGTPV
MAB_1396|M.abscessus_ATCC_1997 -----------------------------------------------MRP
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
Mb0805c|M.bovis_AF2122/97 LDVGLLRTAGVCVLASVMAHVDVTVVSVAQRTFVADFGSTQAVVAWTMTG
Rv0783c|M.tuberculosis_H37Rv LDVGLLRTAGVCVLASVMAHVDVTVVSVAQRTFVADFGSTQAVVAWTMTG
MUL_0501|M.ulcerans_Agy99 LDAGLLRIAGVCVLASLMSVLDATVVGIAQRTFIIEFDSTQAVVAWTMTG
MAV_0729|M.avium_104 LDAALFRIAGVCGLACIMAVLDSTVVAVAQRTFIAQFGANQAIVSWTIAG
MMAR_3100|M.marinum_M LDWPTIRIAGVCLIAAIMANLDISIVTVAQRTFTVAFHSTQATVAWTVAG
MSMEG_3316|M.smegmatis_MC2_155 WSTRLLIWAAVLILANVLVDIVIGSPLMVMPQLMAHFDT--DQAAWLNAS
Mvan_5900|M.vanbaalenii_PYR-1 GRKRLILWAAVLTLANVLADVVVGSPLMVLPLLLDHFDT--DQAGWLNAS
Mflv_3140|M.gilvum_PYR-GCK RRPRLLVIGLSIVVLTVAVLQTAVVPVLGVIAEQLDEST--AAVSWAVTA
TH_2968|M.thermoresistible__bu RRPFLLVTALAVVVLTVAVLQTAVVPVLGIMAEQLHTSA--TAVSWAVTA
MAB_1396|M.abscessus_ATCC_1997 EYPRPWITLWVVLFGLFMILLDSTIVSVANPAIKAGFGADYSSTVWVTSA
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
. : * :.
Mb0805c|M.bovis_AF2122/97 YMLALATVIPTAGWAADRFGTRRLFMGSVLAFTLGSLLCAVAPNILLLII
Rv0783c|M.tuberculosis_H37Rv YMLALATVIPTAGWAADRFGTRRLFMGSVLAFTLGSLLCAVAPNILLLII
MUL_0501|M.ulcerans_Agy99 YTLALATVIPVAGWAADRFGTKRLWMGSVLAFALGSLLCALAPNILSLIF
MAV_0729|M.avium_104 YMLAFATVIPITGWAADRFGTKRLFMGSVLIFTLGSLLCAVAPNILLLIL
MMAR_3100|M.marinum_M YMLGMATATPMTGWAADRLGAKRLFMGAVATFTLGSMLCASAPNIGLLIT
MSMEG_3316|M.smegmatis_MC2_155 AMLAGAIWAPLLAKSSDVFGKRRILVGTLVMAGVGALVCLAAPNLWIFLI
Mvan_5900|M.vanbaalenii_PYR-1 AMLAGAIWSPLLAKSSDIFGKRRILTGTLLLAGVGAVVCLVAPTLWIFLV
Mflv_3140|M.gilvum_PYR-GCK NLLAAAAATPLIGRLADLYRKKRVLLVVLAVVLVGSVLAATTSSLPSLIV
TH_2968|M.thermoresistible__bu NLLAAAAATPLLGRLADLYSKRRVLLAVLVVVLAGSVLAATTASLPLLIT
MAB_1396|M.abscessus_ATCC_1997 YLLGYAVPLLITGRLGDQFGPRSMYLSGLAVFTAASLWCGLAGSIGWLIA
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI
* . . .* : : .:: . : ::
Mb0805c|M.bovis_AF2122/97 FRVVQGFGGGMLTPVSFAILAREAGP-KRLGRVMAVVGIPMLLGPVGGPI
Rv0783c|M.tuberculosis_H37Rv FRVVQGFGGGMLTPVSFAILAREAGP-KRLGRVMAVVGIPMLLGPVGGPI
MUL_0501|M.ulcerans_Agy99 FRVLQGVGGGMLMPLGFIILTRAAGP-KRLGRLMAAIGIPMLLGPIGGPI
MAV_0729|M.avium_104 FRVVQGVGGGMLLPLSFVILTREAGP-KRVGRLMAVGGIPILLGPIGGPI
MMAR_3100|M.marinum_M FRVVQGIGGGVLGPLVLAIVTHQAGP-RRLGRLLAVGAIPMLTAPMLGPI
MSMEG_3316|M.smegmatis_MC2_155 GRFLQGAA-LAAVFLTVTLARQICAP-GVAVVLVGLLTSGPSIVGIIEPF
Mvan_5900|M.vanbaalenii_PYR-1 GRFLQGAA-FAAVFLTVALARQICSP-RLAMAIVGVVTSGSSLVGIIEPF
Mflv_3140|M.gilvum_PYR-GCK ARVLQAAS-FALYPICIAILREEIDP-DRMVSAMAVLSGTLGFGGGTGLV
TH_2968|M.thermoresistible__bu ARVLQGAS-FALYPISIAILRDELPP-DRLGRAMAVMSGTLGFGGGAGLV
MAB_1396|M.abscessus_ATCC_1997 ARVVQGIGAAMLTPQTLTVVQRVFPP-ERRGTAMGVWGAVAGIATLVGPV
MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV
*.:*. . . : . .
Mb0805c|M.bovis_AF2122/97 LGGWLIG-AYGWRWIFLVNLPVGLSALVLAAIVFPRDRPAASENFDYMGL
Rv0783c|M.tuberculosis_H37Rv LGGWLIG-AYGWRWIFLVNLPVGLSALVLAAIVFPRDRPAASENFDYMGL
MUL_0501|M.ulcerans_Agy99 LGGWLIS-SFGWHWIFLVNLPIGLAAFALAAITFPADRPVPSESFDVIGV
MAV_0729|M.avium_104 LGGWLIG-AYGWKWIFLINLPIGLTAFALAALLFPKDRSAPSEALDITGA
MMAR_3100|M.marinum_M LGGWLID-SYGWQWIFLINVPAGLLAFGLAAILVPEDPPKPSERFDFIGM
MSMEG_3316|M.smegmatis_MC2_155 LMKPVID-AFGYRSVFVVAALLATAAAIGVRCLVPESPIRIAARIDVFGA
Mvan_5900|M.vanbaalenii_PYR-1 LMKPVID-MFGYRGVFVAAALLAVGAASCVRIFIPESPIRSTGRVDIGGA
Mflv_3140|M.gilvum_PYR-GCK VVGLLMHGDAGYHRVFYLTTAFTVVVIIIVATLVPNRARTTSGSIDWFGA
TH_2968|M.thermoresistible__bu VTGLLMTDGAVYQRVFWLCTAFTLAVIVIAVLIVPVRHRRATGTLDWFGA
MAB_1396|M.abscessus_ATCC_1997 AGGLLVD-GWGWQWIFYVNVPVGVLGIILGAIYIPR-MPTHRHRLDLLGM
MLBr_01562|M.leprae_Br4923 VGGALTE--VSWRLAFLVNVPIGLVMIYLARTALHETHKER-MKLDAAGA
: :: * . .* *
Mb0805c|M.bovis_AF2122/97 LLLSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALIAAFVAHSWYRT
Rv0783c|M.tuberculosis_H37Rv LLLSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALIAAFVAHSWYRT
MUL_0501|M.ulcerans_Agy99 LLLSPGLAAFLLALSLIPDRGTVADRYVLIPVIAGLSLIGGFAWHAWHRA
MAV_0729|M.avium_104 LLLSPGVAIFLCGVCSIPGRHTVADRYVLVPALVGLVLIAAFILHAWYRT
MMAR_3100|M.marinum_M LLLLPGIAMLLLGVSAIPGSGTVTDHRVWVPAISGAVLITAFALHAWYRT
MSMEG_3316|M.smegmatis_MC2_155 LLLGGGIGATLAYISLGQAVGWSDGRMIALLAAGAGALVWWAVCA--LRV
Mvan_5900|M.vanbaalenii_PYR-1 LLLGGGLGAVLAYISLGRDLGWLSGTMILLLAAGGVALAGWVLLA--LRV
Mflv_3140|M.gilvum_PYR-GCK VGLAVGLSALLLAITQGNTWGWGSPRTLACLAGGISVLIAWWMWE--KRA
TH_2968|M.thermoresistible__bu AGLALGLSLGLLAITQGSHWGWTSPSTLGAAAASVVILVGWWCWE--QRA
MAB_1396|M.abscessus_ATCC_1997 ALSAVGMFAFVFALQEGESFQWAPG--VWAMMAAGLVVLGVFVWWQSANR
MLBr_01562|M.leprae_Br4923 ILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVER--TA
. : . :
Mb0805c|M.bovis_AF2122/97 EHPLIDMRLFQNRAVAQANMTMTVLSLGLFGSFLLLPSYLQQVLHQSPMQ
Rv0783c|M.tuberculosis_H37Rv EHPLIDMRLFQNRAVAQANMTMTVLSLGLFGSFLLLPSYLQQVLHQSPMQ
MUL_0501|M.ulcerans_Agy99 DHPLIDLHLFNNSVVTQANLTLLAFAAAYFGSSLLIPTYLQQVLHQTPMQ
MAV_0729|M.avium_104 EHPLIDLRLFRNPVVTQVNVTLLVFAAASVGVGLLVPSYFQIVGHETPMQ
MMAR_3100|M.marinum_M DHPLIDLRLFTDRVVRLANLALLLYVAGAAGASLLLPSYFQQLLHQTPMR
MSMEG_3316|M.smegmatis_MC2_155 DEPLIDIRALHR-PILLT-LLALLLAAGSFRSMLQLTSVVAQVPVELGLG
Mvan_5900|M.vanbaalenii_PYR-1 DQPVIDIRALTR-PILLT-LLALVLAAGAFRSVLQLTGIIAQVPPDLGLG
Mflv_3140|M.gilvum_PYR-GCK TRPLVSTRMLARRSMLFTNLATIFVGMGLYFAFLGLTVFVQVDRSVAGYG
TH_2968|M.thermoresistible__bu AHPLVSTRMLSRRPMLLTNLATIFVGMGLYFAFLGITLFVQVPRDQAGFG
MAB_1396|M.abscessus_ATCC_1997 GEPLIPLRLFADRNFSLAGVGIASMSFCVISTGLPMMFYTQLALGFSPTK
MLBr_01562|M.leprae_Br4923 ENPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALR
.*:: : . : : :
Mb0805c|M.bovis_AF2122/97 SG--------VHIIPQGLGAMLAMPIAGAMMDR-RGPAKIVLVGIMLIAA
Rv0783c|M.tuberculosis_H37Rv SG--------VHIIPQGLGAMLAMPIAGAMMDR-RGPAKIVLVGIMLIAA
MUL_0501|M.ulcerans_Agy99 SG--------LYLIPQGLGAMLTMPIASAFMDR-RGPGKSVLLGIVLIAV
MAV_0729|M.avium_104 SG--------LHMLPIGVGAVLTMPLGGAVMDK-HGPGKIVLTGLPLMAV
MMAR_3100|M.marinum_M SG--------LMMVPIGFGAMLTMPLTGAFMDS-RGPRKVVLIGLTLIAA
MSMEG_3316|M.smegmatis_MC2_155 YGLGHGEAIAILLAVPNLGIVVGGVCAGWVAGRGSGPARPLLGGITIGAV
Mvan_5900|M.vanbaalenii_PYR-1 YGLGNGEAVAVLLAAPNLGIVIGGVCAGWLAGR-VGPALPLLVAIAVGAV
Mflv_3140|M.gilvum_PYR-GCK FGATVLEASVVYLLPGALTGFVVALISGRFIDR--YGARPVLMVAAVAGI
TH_2968|M.thermoresistible__bu FSATVLQASVVYLLPGACTGFVVALVSGRFIDR--YGARPVLMVGALAGI
MAB_1396|M.abscessus_ATCC_1997 AA--------LTQAPTAIVSGILAPLAGWLVDR-VRPSILIGGGIALMIA
MLBr_01562|M.leprae_Br4923 AG--------IGFIPFVIAMGIGLGVSSQLVSR-FSPRVLTIGGGWLLMV
. : : . . . :
Mb0805c|M.bovis_AF2122/97 GLGTFAFGVARQADYLPILPTGLAIMGMGMGCSMMPLSGAAVQTLAPHQI
Rv0783c|M.tuberculosis_H37Rv GLGTFAFGVARQADYLPILPTGLAIMGMGMGCSMMPLSGAAVQTLAPHQI
MUL_0501|M.ulcerans_Agy99 GLAMFTFGVATRAQYLPTLLVGLAIMGMGTGCTMMPLAGAAVLTLKPREI
MAV_0729|M.avium_104 GLAVFTYGVARQAAYSPVLVCGLAIMGLGIGLTTTPLSAALMQALAPHQV
MMAR_3100|M.marinum_M GTGTFVFGVANEADYLPTLLAGLTIAGMGLGCTGLLLAASVMRVLAPHQI
MSMEG_3316|M.smegmatis_MC2_155 AT----FAMLLGVSALPLAIVCATMLGVAAGAISASGY-NLAIDFAA---
Mvan_5900|M.vanbaalenii_PYR-1 GT----FAMSAGVSVLPVAVACGALLGMAAGAIGASGY-NLAISLEV---
Mflv_3140|M.gilvum_PYR-GCK AG----FVLIAFAHSAPWQVITANILANAYISLGYGALPALIVGDSD---
TH_2968|M.thermoresistible__bu GG----FVFIAVAHTHTWQVIAAAVLTNAYISLGYGALPALVVGEAP---
MAB_1396|M.abscessus_ATCC_1997 STLWWTLLMRPETQMWQLMLP-AAGIGAAMACIWGPLATTATRNLPPSVA
MLBr_01562|M.leprae_Br4923 AMLYGWAFMNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRI
. . . .
Mb0805c|M.bovis_AF2122/97 ARGSTLISVNQQVGGSIGTALMSVLLTYQFNHSEIIATAKKVALTPESGA
Rv0783c|M.tuberculosis_H37Rv ARGSTLISVNQQVGGSIGTALMSVLLTYQFNHSEIIATAKKVALTPESGA
MUL_0501|M.ulcerans_Agy99 ARGSTLISVTQQVGGSIGTALMATILTNQFNRSDNIWVANKVATLEQNAA
MAV_0729|M.avium_104 ARGTTLISVNQQVGGSIGAALMAVILTNQFNRNPALMAANEAAGMHPVTG
MMAR_3100|M.marinum_M ARGSALISVNQQISGSIGAALMSMILTNQFCRSHTISTANNMAVLRENAE
MSMEG_3316|M.smegmatis_MC2_155 PEHQGTIAGLVSVMLALGSVVFNFAGGEVLKATRILGMAAGGAPVSTAGG
Mvan_5900|M.vanbaalenii_PYR-1 PERQGAIAGLVSVVLALGSVIVNVVGAEVLKGTQIPGVFAGGAPVSTVTG
Mflv_3140|M.gilvum_PYR-GCK AGETGVATGMNAIARTVGSSMAAALVAVLLSRTTAVGTPMESSFTIIFLG
TH_2968|M.thermoresistible__bu PGATGIATGMNAIARTIGSSVAAALVAVAVAGSTTA-APSEAGFTAIFAG
MAB_1396|M.abscessus_ATCC_1997 GAGSGVYNTLRQVGGVVGSSAMGALMTARLTATMPAMPPGSGSTPEAALP
MLBr_01562|M.leprae_Br4923 GPVSAIALMLQSLGGPLVLAVIQAVIT-----SRTLYLGGTTGPVKFMND
: : . .
Mb0805c|M.bovis_AF2122/97 GRGAAVDPSSLPRQTN---FAAQLLHDLSHAYAVVFVIATALVVSTLIPA
Rv0783c|M.tuberculosis_H37Rv GRGAAVDPSSLPRQTN---FAAQLLHDLSHAYAVVFVIATALVVSTLIPA
MUL_0501|M.ulcerans_Agy99 ARGVTVDPSGLPPQALTPDFADNVMHDLSHAYTVVFGVVVVLVVSTLIPA
MAV_0729|M.avium_104 KRGLPVDPSTVPRPAMTPELAGHVSHHLSHAYTAVFVLAVVLVACTIIPA
MMAR_3100|M.marinum_M RHVVPIAPSAVPARAVGPDFLVELQHDLSHAYTLTFAVAAVLGALAYFPA
MSMEG_3316|M.smegmatis_MC2_155 VHLYVAMAGTLFALAAIPVIMLGRKRSPQAFRTGVDNAVEEACRR-----
Mvan_5900|M.vanbaalenii_PYR-1 VYLYVAMAGSLFVVAAVPALILARATTTRDVRGS----------------
Mflv_3140|M.gilvum_PYR-GCK GAATAVLMMLLIAASRPRTQSVPSEEARYESRAMNHEWG-----------
TH_2968|M.thermoresistible__bu GAVTALFAMLLIGLSRTGRPAFETVEARQESRAMNHEWG-----------
MAB_1396|M.abscessus_ATCC_1997 PGLRAPFSAAMAQSMLLGIAALALGLVAALFMRPGGSQVGAVPLDDVVSV
MLBr_01562|M.leprae_Br4923 AQLRALDHGYTYGLLWVAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDA
Mb0805c|M.bovis_AF2122/97 AFLPKQQAS-------HRRAPLLSA---
Rv0783c|M.tuberculosis_H37Rv AFLPKQQAS-------HRRAPLLSA---
MUL_0501|M.ulcerans_Agy99 ASLPKTPAAAPASFEQHHCDTQYGVHRV
MAV_0729|M.avium_104 SFLPRKPPS-----------PPAGD---
MMAR_3100|M.marinum_M AFLPAKPTT--------IAPGEVDVPG-
MSMEG_3316|M.smegmatis_MC2_155 ----------------------------
Mvan_5900|M.vanbaalenii_PYR-1 ----------------------------
Mflv_3140|M.gilvum_PYR-GCK ----------------------------
TH_2968|M.thermoresistible__bu ----------------------------
MAB_1396|M.abscessus_ATCC_1997 ED--------------------------
MLBr_01562|M.leprae_Br4923 GEL-------------------------