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TKTLDTPTPGPLQQLGRKRLILWAAVLTLANVLADVVVGSPLMVLPLLLDHFDTDQAGWLNASAMLAGAI WSPLLAKSSDIFGKRRILTGTLLLAGVGAVVCLVAPTLWIFLVGRFLQGAAFAAVFLTVALARQICSPRL AMAIVGVVTSGSSLVGIIEPFLMKPVIDMFGYRGVFVAAALLAVGAASCVRIFIPESPIRSTGRVDIGGA LLLGGGLGAVLAYISLGRDLGWLSGTMILLLAAGGVALAGWVLLALRVDQPVIDIRALTRPILLTLLALV LAAGAFRSVLQLTGIIAQVPPDLGLGYGLGNGEAVAVLLAAPNLGIVIGGVCAGWLAGRVGPALPLLVAI AVGAVGTFAMSAGVSVLPVAVACGALLGMAAGAIGASGYNLAISLEVPERQGAIAGLVSVVLALGSVIVN VVGAEVLKGTQIPGVFAGGAPVSTVTGVYLYVAMAGSLFVVAAVPALILARATTTRDVRGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5900 | - | - | 100% (482) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_3385 | - | 2e-27 | 25.67% (487) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_2691 | - | 6e-21 | 26.28% (430) | major facilitator superfamily transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0805c | emrB | 4e-24 | 27.73% (440) | multidrug resistance integral membrane efflux protein EmrB |
| M. gilvum PYR-GCK | Mflv_3140 | - | 1e-28 | 27.20% (478) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv0783c | emrB | 4e-24 | 27.73% (440) | multidrug resistance integral membrane efflux protein EmrB |
| M. leprae Br4923 | MLBr_01562 | - | 1e-12 | 22.60% (500) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_2807 | - | 7e-19 | 25.88% (371) | major facilitator transporter |
| M. marinum M | MMAR_4905 | - | 5e-22 | 26.40% (428) | integral membrane drug efflux protein |
| M. avium 104 | MAV_0730 | - | 1e-20 | 28.38% (377) | EmrB efflux protein |
| M. smegmatis MC2 155 | MSMEG_3316 | - | 0.0 | 70.78% (462) | transporter, major facilitator family protein |
| M. thermoresistible (build 8) | TH_2968 | - | 1e-30 | 28.07% (456) | PUTATIVE putative major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_0501 | - | 3e-22 | 26.40% (428) | integral membrane drug efflux protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5900|M.vanbaalenii_PYR-1 ------------------------------------------MTKTLDTP
MSMEG_3316|M.smegmatis_MC2_155 ------------------------------------------MTVTADSS
Mflv_3140|M.gilvum_PYR-GCK --------------------------------------------------
TH_2968|M.thermoresistible__bu -----------------------------------------------VRR
Mb0805c|M.bovis_AF2122/97 ----------------------MLGNAMVEACPAEGDAPVPITPAGRPRS
Rv0783c|M.tuberculosis_H37Rv ----------------------MLGNAMVEACPAEGDAPVPITPAGRPRS
MMAR_4905|M.marinum_M ----------------------MLSTAMDEAHCTPAEVAPPDTRTGTSSP
MUL_0501|M.ulcerans_Agy99 ----------------------MLSTAMDEAHCTPAEVAPPDTRTGTSSP
MAV_0730|M.avium_104 MRSPSAITELAAAGAGESGLFDMLSNAMDEAPYAAAKT-PPHAPTGQPGA
MAB_2807|M.abscessus_ATCC_1997 -------------------------------------------MTHTATE
MLBr_01562|M.leprae_Br4923 ----------MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSK
Mvan_5900|M.vanbaalenii_PYR-1 TPGPLQQLGRKRLILWAAVLTL--ANVLADVVVGSPLMVLPLLLDHFDT-
MSMEG_3316|M.smegmatis_MC2_155 AAR--ENRWSTRLLIWAAVLIL--ANVLVDIVIGSPLMVMPQLMAHFDT-
Mflv_3140|M.gilvum_PYR-GCK ---MQQTVRRPRLLVIGLSIVV--LTVAVLQTAVVPVLGVIAEQLDEST-
TH_2968|M.thermoresistible__bu DAPSGTPVRRPFLLVTALAVVV--LTVAVLQTAVVPVLGIMAEQLHTSA-
Mb0805c|M.bovis_AF2122/97 GQRSYPDRLDVGLLRTAGVCVL--ASVMAHVDVTVVSVAQRTFVADFGST
Rv0783c|M.tuberculosis_H37Rv GQRSYPDRLDVGLLRTAGVCVL--ASVMAHVDVTVVSVAQRTFVADFGST
MMAR_4905|M.marinum_M GEHVYPDRLDAGLLRIAGVCVL--ASLMSVLDATVVGVAQRTFIIEFDST
MUL_0501|M.ulcerans_Agy99 GEHVYPDRLDAGLLRIAGVCVL--ASLMSVLDATVVGIAQRTFIIEFDST
MAV_0730|M.avium_104 TEREYPDKLDAALLRISGVCIL--ATVMAILDVTVVSVAQRTFIDQFSSS
MAB_2807|M.abscessus_ATCC_1997 PGTSLPLRHRSIAIGAGSLAVL--LGALDTYVVVSVITDIMTSVGIALNN
MLBr_01562|M.leprae_Br4923 YPTLLPSGRFPSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLS
. :
Mvan_5900|M.vanbaalenii_PYR-1 -DQAGWLNASAMLAGAIWSPLLAKSSDIFGKRRILTGTLLLAGVGAVVCL
MSMEG_3316|M.smegmatis_MC2_155 -DQAAWLNASAMLAGAIWAPLLAKSSDVFGKRRILVGTLVMAGVGALVCL
Mflv_3140|M.gilvum_PYR-GCK -AAVSWAVTANLLAAAAATPLIGRLADLYRKKRVLLVVLAVVLVGSVLAA
TH_2968|M.thermoresistible__bu -TAVSWAVTANLLAAAAATPLLGRLADLYSKRRVLLAVLVVVLAGSVLAA
Mb0805c|M.bovis_AF2122/97 QAVVAWTMTGYMLALATVIPTAGWAADRFGTRRLFMGSVLAFTLGSLLCA
Rv0783c|M.tuberculosis_H37Rv QAVVAWTMTGYMLALATVIPTAGWAADRFGTRRLFMGSVLAFTLGSLLCA
MMAR_4905|M.marinum_M QAVVAWTMTGYTLALATVIPVAGWAADRFGTKRLWMGSVLAFALGSLLCA
MUL_0501|M.ulcerans_Agy99 QAVVAWTMTGYTLALATVIPVAGWAADRFGTKRLWMGSVLAFALGSLLCA
MAV_0730|M.avium_104 QAVVAWTMTGYTLALATVIPITGWAADRFGTKRLFIGSVVAFMLGSLLCA
MAB_2807|M.abscessus_ATCC_1997 IQQVTPIVTGYLLGYIAAMPLLGQASDRFGRRLILQLALAGFAIGSVITA
MLBr_01562|M.leprae_Br4923 DAGRSWGITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCA
:. * . .* : : .:::
Mvan_5900|M.vanbaalenii_PYR-1 VAPTLWIFLVGRFLQGAA-FAAVFLTVALARQICSPRLA-MAIVGVVTSG
MSMEG_3316|M.smegmatis_MC2_155 AAPNLWIFLIGRFLQGAA-LAAVFLTVTLARQICAPGVA-VVLVGLLTSG
Mflv_3140|M.gilvum_PYR-GCK TTSSLPSLIVARVLQAAS-FALYPICIAILREEIDPDRM-VSAMAVLSGT
TH_2968|M.thermoresistible__bu TTASLPLLITARVLQGAS-FALYPISIAILRDELPPDRL-GRAMAVMSGT
Mb0805c|M.bovis_AF2122/97 VAPNILLLIIFRVVQGFGGGMLTPVSFAILAREAGPKRL-GRVMAVVGIP
Rv0783c|M.tuberculosis_H37Rv VAPNILLLIIFRVVQGFGGGMLTPVSFAILAREAGPKRL-GRVMAVVGIP
MMAR_4905|M.marinum_M LAPNILSLIFFRVLQGVGGGMLMPLGFIILTRAAGPKRL-GRLMAAIGIP
MUL_0501|M.ulcerans_Agy99 LAPNILSLIFFRVLQGVGGGMLMPLGFIILTRAAGPKRL-GRLMAAIGIP
MAV_0730|M.avium_104 LAANILQLIVFRVVQGIGGGMLLPLGFMILTREAGPRRL-GRLMSILSIP
MAB_2807|M.abscessus_ATCC_1997 LSTDLTMLVSGRVIQGVASGALLPVTLALGADLWSQRNR-ATVLGGIGAA
MLBr_01562|M.leprae_Br4923 VAWDEVTLVIARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAM
: :: *.:*. . . : . .
Mvan_5900|M.vanbaalenii_PYR-1 SSLVGIIEPFLMKPVID-MFGYRGVFVAAALLAVGAASCVRIFIPESPIR
MSMEG_3316|M.smegmatis_MC2_155 PSIVGIIEPFLMKPVID-AFGYRSVFVVAALLATAAAIGVRCLVPESPIR
Mflv_3140|M.gilvum_PYR-GCK LGFGGGTGLVVVGLLMHGDAGYHRVFYLTTAFTVVVIIIVATLVPNRART
TH_2968|M.thermoresistible__bu LGFGGGAGLVVTGLLMTDGAVYQRVFWLCTAFTLAVIVIAVLIVPVRHRR
Mb0805c|M.bovis_AF2122/97 MLLGPVGGPILGGWLIG-AYGWRWIFLVNLPVGLSALVLAAIVFPRDRPA
Rv0783c|M.tuberculosis_H37Rv MLLGPVGGPILGGWLIG-AYGWRWIFLVNLPVGLSALVLAAIVFPRDRPA
MMAR_4905|M.marinum_M MLLGPIGGPILGGWLIS-SFGWHWIFLVNLPIGLAAFALAAITFPADRPV
MUL_0501|M.ulcerans_Agy99 MLLGPIGGPILGGWLIS-SFGWHWIFLVNLPIGLAAFALAAITFPADRPV
MAV_0730|M.avium_104 MLLAPIAGPILGGWLID-TSSWRWIFLINVPIGLLTVALAAVVFPRDHPA
MAB_2807|M.abscessus_ATCC_1997 QELGSVLGPLYGVLCVWLFGSWTAIFWVNVPLAIIAIVLVQFSVPAHQHD
MLBr_01562|M.leprae_Br4923 TAIGSVMGLVVGGALTE--VSWRLAFLVNVPIGLVMIYLARTALHETHKE
: . : * . . .
Mvan_5900|M.vanbaalenii_PYR-1 STG-RVDIGGALLLGGGLGAVLAYISL-GRDLGWLSGTMILLLAAGGVAL
MSMEG_3316|M.smegmatis_MC2_155 IAA-RIDVFGALLLGGGIGATLAYISL-GQAVGWSDGRMIALLAAGAGAL
Mflv_3140|M.gilvum_PYR-GCK TSG-SIDWFGAVGLAVGLSALLLAITQ-GNTWGWGSPRTLACLAGGISVL
TH_2968|M.thermoresistible__bu ATG-TLDWFGAAGLALGLSLGLLAITQ-GSHWGWTSPSTLGAAAASVVIL
Mb0805c|M.bovis_AF2122/97 ASE-NFDYMGLLLLSPGLATFLFGVSS-SPARGTMADRHVLIPAITGLAL
Rv0783c|M.tuberculosis_H37Rv ASE-NFDYMGLLLLSPGLATFLFGVSS-SPARGTMADRHVLIPAITGLAL
MMAR_4905|M.marinum_M PSE-SFDVIGVLLLSPGLAAFLLGLSL-IPDRGTVADRYVLIPVIAGLSL
MUL_0501|M.ulcerans_Agy99 PSE-SFDVIGVLLLSPGLAAFLLALSL-IPDRGTVADRYVLIPVIAGLSL
MAV_0730|M.avium_104 RSE-TFDAVGVLLLSPGLATFLFAVSS-IPGRGTVADRHVLIPAAMGLTL
MAB_2807|M.abscessus_ATCC_1997 PDRPKVDVVGGALLAVALGLLVVGLYSPDPKVSALPEWALPVLSGSGVAF
MLBr_01562|M.leprae_Br4923 RMK--LDAAGAILATLACTAAVFAFSM-GPEKGWISLTTIGSGLVALVAA
.* * . : . . :
Mvan_5900|M.vanbaalenii_PYR-1 AGWVLLA--LRVDQPVIDIRALTR-PILLT-LLALVLAAGAFRSVLQLTG
MSMEG_3316|M.smegmatis_MC2_155 VWWAVCA--LRVDEPLIDIRALHR-PILLT-LLALLLAAGSFRSMLQLTS
Mflv_3140|M.gilvum_PYR-GCK IAWWMWE--KRATRPLVSTRMLARRSMLFTNLATIFVGMGLYFAFLGLTV
TH_2968|M.thermoresistible__bu VGWWCWE--QRAAHPLVSTRMLSRRPMLLTNLATIFVGMGLYFAFLGITL
Mb0805c|M.bovis_AF2122/97 IAAFVAHSWYRTEHPLIDMRLFQNRAVAQANMTMTVLSLGLFGSFLLLPS
Rv0783c|M.tuberculosis_H37Rv IAAFVAHSWYRTEHPLIDMRLFQNRAVAQANMTMTVLSLGLFGSFLLLPS
MMAR_4905|M.marinum_M IGGFAWHAWHRADHPLIDLHLFNNSVVTQANLTLLAFAAAYFGSSLLIPT
MUL_0501|M.ulcerans_Agy99 IGGFAWHAWHRADHPLIDLHLFNNSVVTQANLTLLAFAAAYFGSSLLIPT
MAV_0730|M.avium_104 IAGFVGHAWHRADHPLIDLRLFRNPVLTHANVTMLVFATAFFGAGLLLPS
MAB_2807|M.abscessus_ATCC_1997 LAFILWES--RAKTRLIKPEGVRFGPFFAALAASLAAGAALMVTLVNIEL
MLBr_01562|M.leprae_Br4923 IAFAVVER--TAENPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGL
. :: . : . : :
Mvan_5900|M.vanbaalenii_PYR-1 IIAQVPPDLGLGYGLGNG-EAVAVLLAAPNLGIVIGG-------------
MSMEG_3316|M.smegmatis_MC2_155 VVAQVPVELGLGYGLGHG-EAIAILLAVPNLGIVVGG-------------
Mflv_3140|M.gilvum_PYR-GCK FVQVDRSVAGYGFGATVL-EASVVYLLPGALTGFVVA-------------
TH_2968|M.thermoresistible__bu FVQVPRDQAGFGFSATVL-QASVVYLLPGACTGFVVA-------------
Mb0805c|M.bovis_AF2122/97 YLQQVLHQSPMQSGVHIIPQGLGAMLAMPIAGAMMDRRGPAKIVLVGIML
Rv0783c|M.tuberculosis_H37Rv YLQQVLHQSPMQSGVHIIPQGLGAMLAMPIAGAMMDRRGPAKIVLVGIML
MMAR_4905|M.marinum_M YLQQVLHQTPMQSGLYLIPQGLGAMLTMPIASAFMDRRGPGKSVLLGIVL
MUL_0501|M.ulcerans_Agy99 YLQQVLHQTPMQSGLYLIPQGLGAMLTMPIASAFMDRRGPGKSVLLGIVL
MAV_0730|M.avium_104 YFQQVLHQTPMQAGVHMIPQGLGAMLTMRLTGPLVDRQGPGKVVLVGIAL
MAB_2807|M.abscessus_ATCC_1997 LGQG-VLQMDKADAVFLLSRFLVALPIGAVIGGWLATRFG------DRII
MLBr_01562|M.leprae_Br4923 YIQDILGYSALRAGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWL
. :
Mvan_5900|M.vanbaalenii_PYR-1 VCAGWLAGR-VGPALPLLVAIAVGAVGTFAMSAGVSVLPVAVACGALLG-
MSMEG_3316|M.smegmatis_MC2_155 VCAGWVAGRGSGPARPLLGGITIGAVATFAMLLGVSALPLAIVCATMLG-
Mflv_3140|M.gilvum_PYR-GCK LISGRFIDR--YGARPVLMVAAVAGIAGFVLIAFAHSAPWQVITANILA-
TH_2968|M.thermoresistible__bu LVSGRFIDR--YGARPVLMVGALAGIGGFVFIAVAHTHTWQVIAAAVLT-
Mb0805c|M.bovis_AF2122/97 IAAGLGTFAFGVARQADYLPILPTGLAIMGMGMGCSMMPLSGAAVQTLAP
Rv0783c|M.tuberculosis_H37Rv IAAGLGTFAFGVARQADYLPILPTGLAIMGMGMGCSMMPLSGAAVQTLAP
MMAR_4905|M.marinum_M IAVGLAMFTFGVATRAQYLPTLLVGLAIMGMGTGCTMMPLAGAAVLTLKP
MUL_0501|M.ulcerans_Agy99 IAVGLAMFTFGVATRAQYLPTLLVGLAIMGMGTGCTMMPLAGAAVLTLKP
MAV_0730|M.avium_104 ITAGLGAFAFGVARQAPYLPTLLAGLAITGLGMGCTMMPLSVASVQALAP
MAB_2807|M.abscessus_ATCC_1997 AVIGMLIAAFGYYLISGWPVDVLAAVHNFGFFTLPRLDTDLVVAGIGLG-
MLBr_01562|M.leprae_Br4923 LMVAMLYGWAFMNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVG-
. : : . :
Mvan_5900|M.vanbaalenii_PYR-1 --------------MAAGAIGASGY-NLAISLEVPERQGAIAGLVSVVLA
MSMEG_3316|M.smegmatis_MC2_155 --------------VAAGAISASGY-NLAIDFAAPEHQGTIAGLVSVMLA
Mflv_3140|M.gilvum_PYR-GCK --------------NAYISLGYGALPALIVGDSDAGETGVATGMNAIART
TH_2968|M.thermoresistible__bu --------------NAYISLGYGALPALVVGEAPPGATGIATGMNAIART
Mb0805c|M.bovis_AF2122/97 HQIARGSTLISVNQQVGGSIGTALMSVLLTYQFNHSEIIATAKKVALTPE
Rv0783c|M.tuberculosis_H37Rv HQIARGSTLISVNQQVGGSIGTALMSVLLTYQFNHSEIIATAKKVALTPE
MMAR_4905|M.marinum_M REIARGSTLISVTQQVGGSIGTALMATILTNQFNRSDNIWVANKVATLEQ
MUL_0501|M.ulcerans_Agy99 REIARGSTLISVTQQVGGSIGTALMATILTNQFNRSDNIWVANKVATLEQ
MAV_0730|M.avium_104 HQIARGTTLMSVSHQVGGSMGTALMSMILTNQFNRSPNIVAANKLAALHQ
MAB_2807|M.abscessus_ATCC_1997 -LVIGPLSSAALRVVPAAQHGIASALVVVARMTGMLIGMAALGGWGIHRF
MLBr_01562|M.leprae_Br4923 ----------------FDRIGPVSAIALMLQSLG--GPLVLAVIQAVITS
. : .
Mvan_5900|M.vanbaalenii_PYR-1 LGSVIVNVVGAEVLKGTQIPGVFAGGAPVSTVTGVYLYVAMAGSLFVVAA
MSMEG_3316|M.smegmatis_MC2_155 LGSVVFNFAGGEVLKATRILGMAAGGAPVSTAGGVHLYVAMAGTLFALAA
Mflv_3140|M.gilvum_PYR-GCK VGSSMAAALVAVLLSRTTAVGTPMESSFTIIFLGGAATAVLMMLLIAASR
TH_2968|M.thermoresistible__bu IGSSVAAALVAVAVAGSTTA-APSEAGFTAIFAGGAVTALFAMLLIGLSR
Mb0805c|M.bovis_AF2122/97 SGAGRGAAVDPSSLPRQ---TNFAAQLLHDLSHAYAVVFVIATALVVSTL
Rv0783c|M.tuberculosis_H37Rv SGAGRGAAVDPSSLPRQ---TNFAAQLLHDLSHAYAVVFVIATALVVSTL
MMAR_4905|M.marinum_M NAAARGVTVDPSGLPPQALTPDFADNVMHDLSHAYTVVFGVAVVLVVSTL
MUL_0501|M.ulcerans_Agy99 NAAARGVTVDPSGLPPQALTPDFADNVMHDLSHAYTVVFGVVVVLVVSTL
MAV_0730|M.avium_104 KAAAGGTPIDQSAIPRQSLAPGFGGNVLHDLSHAYTAVFVIAVALVVCTI
MAB_2807|M.abscessus_ATCC_1997 YQNFDALAAKEPKPTGKPNLLELQQQLLNRSITAYSEMYSEMFAITAVVC
MLBr_01562|M.leprae_Br4923 RTLYLGGTTGPVKFMNDAQLRALDHGYTYGLLWVAGAVVIVGVAALFIGY
Mvan_5900|M.vanbaalenii_PYR-1 VPALILARATTTRDVRGS-------------
MSMEG_3316|M.smegmatis_MC2_155 IPVIMLGRKRSPQAFRTGVDNAVEEACRR--
Mflv_3140|M.gilvum_PYR-GCK PRTQSVPSEEARYESRAMNHEWG--------
TH_2968|M.thermoresistible__bu TGRPAFETVEARQESRAMNHEWG--------
Mb0805c|M.bovis_AF2122/97 IPAAFLPKQQASHRRAPLLSA----------
Rv0783c|M.tuberculosis_H37Rv IPAAFLPKQQASHRRAPLLSA----------
MMAR_4905|M.marinum_M IPAAFLPKTPAAAPASF--------------
MUL_0501|M.ulcerans_Agy99 IPAASLPKTPAAAPASFEQHHCDTQYGVHRV
MAV_0730|M.avium_104 IPASFLPKKPAAETAGK--------------
MAB_2807|M.abscessus_ATCC_1997 VIAAVIAIFVGSHRKSGHEAQ----------
MLBr_01562|M.leprae_Br4923 TPEQVAYAQEVKEAVDAGEL-----------