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VIATETVSHSMDLPRPGWAEVDAEKLWWAEVCQIASKLMAQMPSGGVLAGMCVSGVGPCLVLCDDDLRPL RPAILYGIDTRASEEIEALTAEFGAEAILDRAGTVLSSQAVGPKLEWVRRHEPEVFERATGWYGSNSYIA AKLTGEYVMDHHTASQCDPLYATRRFEWNKPWAQRICGHLPLPRLVWPADVVGTVTPEAAAATGVPAGTP VSAGTVDAYSEAFSVGVRRPGDQMLMYGSTMFLVQVIDAYHSDPVLWTTAGIEHDTLALAAGTSTAGSLI NWLQSVTGGASFDELMAEAADVPPGSEGLLVLPYLAGERTPVFDPQARGVVAGLTLRHGRGHLFRAAYEG ISFGIRQILERFDDAHTASRTVAVGGGLRSPIWAQTVSDVTGRPQLVPEQAIGASYGDALLAAIGVGLVP ADTDWAKIAAEIKPDPRNHALYEDLYATWQELYPATRDQVHRLAGQPIV
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_3263 | - | - | 100% (469) | xylulose kinase |
M. smegmatis MC2 155 | MSMEG_3113 | - | 1e-51 | 29.58% (497) | carbohydrate kinase, FGGY |
M. smegmatis MC2 155 | MSMEG_3093 | - | 1e-42 | 29.74% (464) | putative sugar kinase protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0750 | xylB | 5e-37 | 29.40% (432) | D-xylulose kinase XylB |
M. gilvum PYR-GCK | Mflv_3774 | - | 5e-59 | 32.70% (474) | carbohydrate kinase, FGGY |
M. tuberculosis H37Rv | Rv0729 | xylB | 3e-36 | 29.63% (432) | D-xylulose kinase XylB |
M. leprae Br4923 | MLBr_02314 | glpK | 1e-17 | 23.33% (493) | glycerol kinase |
M. abscessus ATCC 19977 | MAB_0382 | glpK | 1e-19 | 24.60% (435) | glycerol kinase |
M. marinum M | MMAR_1066 | xylB | 1e-34 | 28.88% (457) | D-xylulose-kinase (xylulokinase), XylB |
M. avium 104 | MAV_4437 | - | 6e-40 | 30.41% (467) | carbohydrate kinase, FGGY family protein |
M. thermoresistible (build 8) | TH_0046 | xylB | 1e-15 | 25.57% (438) | xylulokinase |
M. ulcerans Agy99 | MUL_0824 | xylB | 2e-32 | 29.05% (420) | D-xylulose-kinase (xylulokinase), XylB |
M. vanbaalenii PYR-1 | Mvan_2625 | - | 9e-54 | 31.32% (479) | carbohydrate kinase, FGGY |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_3774|M.gilvum_PYR-GCK -MSR--YTIGVDIGTTGTKTVLLDT---------TSGIVATASRETALHS Mvan_2625|M.vanbaalenii_PYR-1 -MSR--YTIGVDIGTTGIKTVLLDTTAAGRASNTTAGIVATANRENTLYS Mb0750|M.bovis_AF2122/97 -MSRDDVTIGIDIGTTAVKAVAADD---------NGRVTARVRIGHQLAV Rv0729|M.tuberculosis_H37Rv -MSRDDVTIGIDIGTTAVKAVAADD---------NGRVTARVRIGHQLAV MMAR_1066|M.marinum_M -MSREDATIGIDIGTTAVKAVVADA---------DGNVTARLRIPHQLRV MUL_0824|M.ulcerans_Agy99 -MSREDATIGIDIGTTAVKALVADA---------DGNVTARLRIPHQLRV MAV_4437|M.avium_104 -MSRKDVTIGIDVGSTAVKALAADA---------DGRVMARVRIPHELRI MLBr_02314|M.leprae_Br4923 MAEFAEFIAAIDQGTTSTRCVIFDH---------NGAEVARHQLEHEQIL MAB_0382|M.abscessus_ATCC_1997 ---MADFVASIDQGTTSTRAMIFNH---------RGEEVGRHQLEHQQLL MSMEG_3263|M.smegmatis_MC2_155 -------------------------------------MIATETVSHSMDL TH_0046|M.thermoresistible__bu ----MTLVAGIDSSTQSCKVLICDA--------------DTGAVVREGRA Mflv_3774|M.gilvum_PYR-GCK PAPGFAEADTTQWHANVIDSVREVLAHSGVAPDEIGALATSGMVPAVVPI Mvan_2625|M.vanbaalenii_PYR-1 PGPGFAEADPAQWYRNVVESIREVLAVSGVAPDQIGALATSGMVPAVVAV Mb0750|M.bovis_AF2122/97 PAPDRLEHDADEAWRRGPLAALDRLVG-----PDTRALAVAAMVPSLTAV Rv0729|M.tuberculosis_H37Rv PAPDRLEHDADEAWRRGPLAALDRLVG-----PDTRALAVAAMVPSLTAV MMAR_1066|M.marinum_M GAPDQLEHDADQAWRRGPLTALERLAG-----PDIRAVAVSAMVPSMTAV MUL_0824|M.ulcerans_Agy99 GAPDQLEHDADQAWRRGPLTALERLAG-----PDIRAVAVSAMVPSMTAV MAV_4437|M.avium_104 PAPDRLEHDAEAAWRRGPSAALDELLHQ----PGVAAVAVAAMVPSMTAV MLBr_02314|M.leprae_Br4923 PRSGWVEHNPVEIWERTASVLMSVLNATNLSAKDIAALGITNQRETTLVW MAB_0382|M.abscessus_ATCC_1997 PRAGWVEHNPVEIWERTWSVLATSLNVTGLSAGDLAAVGVTNQRETTLVW MSMEG_3263|M.smegmatis_MC2_155 PRPGWAEVDAEKLWWAEVCQIASKLMAQMPSGGVLAGMCVSGVGPCLVLC TH_0046|M.thermoresistible__bu AHPDGTEIDP-AFWESAAHDAVRAAGG----LDDVAAVAVGAQQHGMVCL .. * :. .: Mflv_3774|M.gilvum_PYR-GCK D-DAGKPLRRAILQN-DARAHREVDDLAGALADVDLVTLTGSALTQQSVA Mvan_2625|M.vanbaalenii_PYR-1 D-QTGKPLRRAILQN-DARAHREVAGLAAKLASVDLVTLTGSALTQQSVA Mb0750|M.bovis_AF2122/97 D-PAGRPITPGLLYG-DARGRVPNA-------------SVARAQSVPSVG Rv0729|M.tuberculosis_H37Rv D-PAGRPITPGLLYG-DARGRVPNA-------------SVARAQSVPSVG MMAR_1066|M.marinum_M D-SGGVPITPGLLYG-DSRGWVPGA-------------ANQRAQPLPSVG MUL_0824|M.ulcerans_Agy99 D-SGGVPITPGLLYG-DSRGWVPGA-------------ANQRAQPLPSVG MAV_4437|M.avium_104 D-DSGTPITPGLLYG-DGRGRTPGG-------------PQN--QPLPALG MLBr_02314|M.leprae_Br4923 NRNTGRPYCNAIVWQ-DTRTDRIAVALDRDGRGEVIRRKAGLPPATYFSG MAB_0382|M.abscessus_ATCC_1997 NRHTGRPYCNAIVWQ-DTRTDKIAAALDRDGRGDIIRRKAGLPPATYFSG MSMEG_3263|M.smegmatis_MC2_155 D-DDLRPLRPAILYGIDTRASEEIEALTAEFGAEAILDRAGTVLSSQAVG TH_0046|M.thermoresistible__bu D-EAGKVVRDALLWNDVRSAGAAAALVDELGGPQAWAEAVGVVPLAAITV : .:: Mflv_3774|M.gilvum_PYR-GCK PTTVWLREHEP----------EVYARTAHWVGSYDWVLS-ALGADVHVEQ Mvan_2625|M.vanbaalenii_PYR-1 PTTVWLRDHEP----------GVYARTAHWIGSYDWVLS-ALGAPIHVEQ Mb0750|M.bovis_AF2122/97 ETAEFLRWTAG----------QAPDASGYWPAPAVANYA-LSGEAVIDYA Rv0729|M.tuberculosis_H37Rv ETAEFLRWTAG----------QALDASGYWPAPAVANYA-LSGEAVIDYA MMAR_1066|M.marinum_M EAAQFLRWTAA----------QAPEAAGYWPAAAVANYA-MSGEPVIDFA MUL_0824|M.ulcerans_Agy99 EAAQFLRWTAA----------QAPEAAGYWPAAAVANYA-MSGEPVIDFA MAV_4437|M.avium_104 EAAEFLRWTAA----------RAPGAAGYWPAPAVANHA-LAGQAVIDVA MLBr_02314|M.leprae_Br4923 GKLQWILENVDGVGAAAENGEALFGTPDTWLLWNLTGGP-RGGVHVTDVT MAB_0382|M.abscessus_ATCC_1997 GKLQWILENVEGVRRDAENGDALFGTPDSWVIWNLTGGV-RSGVHVTDVT MSMEG_3263|M.smegmatis_MC2_155 PKLEWVRRHEP----------EVFERATGWYGSNSYIAAKLTGEYVMDHH TH_0046|M.thermoresistible__bu AKLRWLADHEP----------QHADRTAAVCLPHDWLTWRLRGSTDIAEL :: . * Mflv_3774|M.gilvum_PYR-GCK NWALESGLFSIVGDTADAVLGAAGLDPATLAPLRRPG--------TRVGE Mvan_2625|M.vanbaalenii_PYR-1 NWALESGLFEIDGDVATDVVQAAALEPVTLAPVRRPG--------TQVGE Mb0750|M.bovis_AF2122/97 TAVTTLPLFDGTGWNATACADCG-VTVDRMPRVETFG--------VGVGQ Rv0729|M.tuberculosis_H37Rv TAVTTLPLFDGTGWNATACADCG-VTVDRMPRVETFG--------VGVGQ MMAR_1066|M.marinum_M TAITSLPLFDGTGWNPQACADCG-ASADRMPRVETFG--------TAVGQ MUL_0824|M.ulcerans_Agy99 TAITSLPLFDGTGWNPQACADCG-ASADRMPRVETFG--------TAVGQ MAV_4437|M.avium_104 TAATAFPLFDGTGWDAAACAERG-ARVEQMPRVHSMG--------AVVGQ MLBr_02314|M.leprae_Br4923 NASRTMLMDLEKLDWDDELLSFFSIPRAMLPAIASSSPLQPYGVTLADGP MAB_0382|M.abscessus_ATCC_1997 NASRTMLMNLETLDWDDELLSFFSIPRQMLPPIKASSPVEPFGFTTQLGP MSMEG_3263|M.smegmatis_MC2_155 TASQCDPLYATRRFEWNKPWAQRICGHLPLPRLVWPA--------DVVGT TH_0046|M.thermoresistible__bu TTDRSDASGTGYYDASGDDYRLDLLELGLRGRRPHLP--------AVLGP . * Mflv_3774|M.gilvum_PYR-GCK LSAAAADATGLRAGTPLVVGGADHVLSAYAAGVNGAGDALVKLGGAGDIL Mvan_2625|M.vanbaalenii_PYR-1 LSRRAADETGLRAGTALVVGGADHVLSAYAAGVNDPGDALVKLGGAGDIL Mb0750|M.bovis_AF2122/97 VRGT---------GAVLAVGAVDALCEQIVAGADRDGDVLVLCGATLIVW Rv0729|M.tuberculosis_H37Rv VRGT---------GAVLAVGAVDALCEQIVAGADRDGDVLVLCGATLIVW MMAR_1066|M.marinum_M VHGA---------DAVLGAGGIDAVCEQIVAGADHHGDVLVLCGTTLIVW MUL_0824|M.ulcerans_Agy99 VHGT---------DAVLGAGGIDAVCEQIVAGADHHGDVLVLCGTTLIVW MAV_4437|M.avium_104 LPG----------GAALATGAIDALCEQLVAGADRDGDVLVMCGTTLIVW MLBr_02314|M.leprae_Br4923 VGGEVPITG---VLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGEAI MAB_0382|M.abscessus_ATCC_1997 LGGEVPIAG---DLGDQQAAMVGQVCLNPGEAKNTYGTGNFLLLNTGEEL MSMEG_3263|M.smegmatis_MC2_155 VTPEAAAATGVPAGTPVSAGTVDAYSEAFSVGVRRPGDQMLMYGSTMFLV TH_0046|M.thermoresistible__bu SDATRG-------GDRVFGAGLGDNAAAALGLAAEPGDVIVSVGTSGVVS . . * . : Mflv_3774|M.gilvum_PYR-GCK VASDTEIVDERLYLDAHPVPGRWLPNGCMATSGSLIRWFQTLIGG---AE Mvan_2625|M.vanbaalenii_PYR-1 VASDTQVVDERLYLDAHPIPGHWLPNGCMATSGSLIRWFQALIGGPEAVE Mb0750|M.bovis_AF2122/97 TTISAARQVPGLWTIPHTAPGKSQIGGASNAGGLFLNWVDRVIGPGD--- Rv0729|M.tuberculosis_H37Rv TTISAARQVPGLWTIPHTAPGKSQIGGASNAGGLFLNWVDRVIGPGD--- MMAR_1066|M.marinum_M TTISGSRQVPGLWTIPHTAPGKSQIGGASNAGGLFLSWVDRLIGPADRDG MUL_0824|M.ulcerans_Agy99 TTISGSRQVPGLWTIPHTAPGKSQIGGASNAGGLFLSWVDRVTGPADRDG MAV_4437|M.avium_104 ATISQARQMPGLWTIPHTTPGKSQIGGASNAGGLFLGWVDRVVAQAD--- MLBr_02314|M.leprae_Br4923 VRSGNGLLTTVCYQFGDAKP-VYALEGSIAVTGSAVQWLRDQLGIIS-GA MAB_0382|M.abscessus_ATCC_1997 VHSSNGLLTTVCYQFGDNKP-VYALEGSIAVTGSAVQWLRDQLGIIS-GA MSMEG_3263|M.smegmatis_MC2_155 QVIDAYHSDPVLWTTAGIEHDTLALAAGTSTAGSLINWLQSVTGGASFDE TH_0046|M.thermoresistible__bu AVATAPVRDGTGFVAGFADGTGRHLPLVCTLNGARVLDAAAAMLQVDHAE : * : Mflv_3774|M.gilvum_PYR-GCK LTELDDEAAQRAPGEILCLPYFLGEKSPVHDPDLRGVFAGMHLGHTR-AD Mvan_2625|M.vanbaalenii_PYR-1 LTTLDDEAALRSPAEVLCLPYFLGEKSPIHDPDLRGVFAGMHLGHTR-AD Mb0750|M.bovis_AF2122/97 -PALADPRRVP-----VWLPYIRGERTPFHEPDRRAVLDGVDLSQDA-AS Rv0729|M.tuberculosis_H37Rv -PALADPRRVP-----VWLPYIRGERTPFHEPDRRAVLDGVDLSQDA-AS MMAR_1066|M.marinum_M EQDRVDPRRVP-----IWLPYIRGERTPFHDPDRRASLEGLDLTQGA-AA MUL_0824|M.ulcerans_Agy99 EQDRVDPRRVP-----IWLPYIRGERTPFHDPDRRASLEGLDLTQGA-AA MAV_4437|M.avium_104 -PASAQPGRVP-----VFAPYLRGERSPFHDPDRRGVLEALDLTHDA-AA MLBr_02314|M.leprae_Br4923 AQSESLARQVVDNGGVYFVPAFSGLFSPYWRSDARGAIVGLSRFNTN-AH MAB_0382|M.abscessus_ATCC_1997 SQSEDLARQVEDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTN-AH MSMEG_3263|M.smegmatis_MC2_155 LMAEAADVPPGSEG-LLVLPYLAGERTPVFDPQARGVVAGLTLRHGR-GH TH_0046|M.thermoresistible__bu LSRLALSAPPGSEG-LVLVPYLEGERTPNR-PNASGALHGLRVSNATPAN * : * :* .: . . .: : . Mflv_3774|M.gilvum_PYR-GCK MYRSVLEAIAFGFRHHVDVFGEI-GIPFTRVMITNGGSRSTLWKQIHADV Mvan_2625|M.vanbaalenii_PYR-1 MYRSVLEAIAFGFRHHVDVFAEI-GIPLRRVMITNGGSKSTLWKQIHADV Mb0750|M.bovis_AF2122/97 VRRAAYEASGFVVRQLIELS----GAPVARIVAAGGGTRIQPWMQAIADA Rv0729|M.tuberculosis_H37Rv VRRAAYEASGFVVRQLIELS----GAPVARIVAAGGGTRIQPWMQAIADA MMAR_1066|M.marinum_M VRRAAYEASGFVVRHLVELS----GAPVLRIVASGGGTCVQPWMQAIADV MUL_0824|M.ulcerans_Agy99 VRRAAYEVSGFVVRHLVELS----GAPVLRIVASGGGTCVRPWMQAIADV MAV_4437|M.avium_104 LRRAAYEASGFVVRQLIELS----GAPVSRIVATGGGTRVGPWLQAIADA MLBr_02314|M.leprae_Br4923 LARATLEAICYQSRDVVDAMAADSGVRLDVLKVDGGITSNDLCMQIQADV MAB_0382|M.abscessus_ATCC_1997 LARATLEAICYQSREVVEAMEADSGVRMEVLKVDGGITANKLCMQIQADT MSMEG_3263|M.smegmatis_MC2_155 LFRAAYEGISFGIRQILERFDD--AHTASRTVAVGGGLRSPIWAQTVSDV TH_0046|M.thermoresistible__bu LARAAVEGLLCALADGIAHLTG-HGIPLRRVLLIGGAARSEAVRAIAPQV : *:. * . : . .* .:. Mflv_3774|M.gilvum_PYR-GCK LGCEMNPVIGHPGASLGAAVIAAIGVGALDDWADADRFITLDAPYRPDPA Mvan_2625|M.vanbaalenii_PYR-1 LGQEMHPVRGHPGASLGAAVIAAIGVGALADWSDAARFITLDDPYIPDPA Mb0750|M.bovis_AF2122/97 TGRPVEVSRVAEGAALGAAFLGRLAAGLESSIADAARWASTDRIVEPSAD Rv0729|M.tuberculosis_H37Rv TGRPVEVSRVAEGAALGAAFLGRLAAGLESSIADAARWASTDRIVEPSAD MMAR_1066|M.marinum_M TGRPVHVSDVAEGAALGAAFLARMAAGLESSIADADRWARTDRIVEPRPD MUL_0824|M.ulcerans_Agy99 TGRPVHVSAVAEGAALGAAFLARMAAGLES-------------------- MAV_4437|M.avium_104 TGHPVEVSAVAEGAALGAAFLARMAAGLETTLTDAARWVRTERVVEPDPA MLBr_02314|M.leprae_Br4923 LGVDVVRSVVAETTALGSAYAAGLAVGFWAGPSDLRANWQEDKRWTP-TW MAB_0382|M.abscessus_ATCC_1997 LGVDVVKPVVAETTALGAAYAAGLAVGFWKDADDLRRNWQEDERWSS-SI MSMEG_3263|M.smegmatis_MC2_155 TGRPQLVPEQAIGASYGDALLAAIGVGLVPADTDWAKIAAEIK---PDPR TH_0046|M.thermoresistible__bu FGVPVLVPDPAEYVALGAARQAAWALRGTPEPPSWQPPRTDRYEADPVPA * .: * * . . Mflv_3774|M.gilvum_PYR-GCK RRHAYDDAYQTWRELGAVMTPVSHKIARTTR- Mvan_2625|M.vanbaalenii_PYR-1 RRDIYDQAYATWRELSSAMTPISHAIARTTR- Mb0750|M.bovis_AF2122/97 WAGPTKERYRRFLALSGSKLA----------- Rv0729|M.tuberculosis_H37Rv WAGPTKERYRRFLALSGSKLA----------- MMAR_1066|M.marinum_M WVGPTKDRYRRFLELSGSPLA----------- MUL_0824|M.ulcerans_Agy99 -------------------------------- MAV_4437|M.avium_104 WAAPVQDRYQRFLELGNRPCPAVVAR------ MLBr_02314|M.leprae_Br4923 GEDQRAAAYAGWRKAVQRTLDWVDVS------ MAB_0382|M.abscessus_ATCC_1997 TDEKRAEGFAGWKKAVQRTLDGVDV------- MSMEG_3263|M.smegmatis_MC2_155 NHALYEDLYATWQELYPATRDQVHRLAGQPIV TH_0046|M.thermoresistible__bu VR----ERYAEVRDLTEGVE------------