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GILLTIDLGTEGARVGAFTEDGTALGSTHRPYLTHHPRPGWAEQDPRDWWAAITAATRELLSGELCRAAG RVIAVAASTTASTVAVVDAAGTPLRPAILWMDARGAAESEQTARLCLQHPILEWSGGSDAAEWLLPKAMW LKKHDPDAYRSAARIVEAVDYLTFRLTGRWVGSQMNAVCKYNYDTLAGRFPAELYAALGMDDLIDKLPDE IVPVGGVAGPLADSAAADLGIDGRPVVAVGGIDAHVSLLACGGNVGGLVSLVSGTSSAIVTEVDRPTTSN EVWGPYPEALNPGKWLVEGGQVTSGSVLKWTGESIIGVPRDELAGLIDQAAAVDPASHGLRALDYFMGNR TPHREARLRGAVIGLTLGTTKAELYRAMVEAVACGTRSVIDSFERSGVPCSRLVFSGGIERNTLWQQVTI DVLGRPAELVIGENLTLRACAVIAATGAGIVPSLTAGSRLFAPRVRMLEPDPKRSLLYEQTFDDYQRLTA ALRPIMCDTVDGGSDAAAGARASFRVVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3093 | - | - | 100% (519) | putative sugar kinase protein |
| M. smegmatis MC2 155 | MSMEG_3113 | - | 8e-51 | 30.49% (492) | carbohydrate kinase, FGGY |
| M. smegmatis MC2 155 | MSMEG_1713 | araB | 6e-44 | 29.28% (526) | ribulokinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0750 | xylB | 1e-22 | 27.33% (472) | D-xylulose kinase XylB |
| M. gilvum PYR-GCK | Mflv_3774 | - | 2e-54 | 30.16% (494) | carbohydrate kinase, FGGY |
| M. tuberculosis H37Rv | Rv0729 | xylB | 3e-22 | 26.81% (470) | D-xylulose kinase XylB |
| M. leprae Br4923 | MLBr_02314 | glpK | 9e-16 | 23.32% (476) | glycerol kinase |
| M. abscessus ATCC 19977 | MAB_0382 | glpK | 3e-15 | 24.74% (485) | glycerol kinase |
| M. marinum M | MMAR_1066 | xylB | 5e-21 | 26.38% (470) | D-xylulose-kinase (xylulokinase), XylB |
| M. avium 104 | MAV_4437 | - | 2e-23 | 27.47% (495) | carbohydrate kinase, FGGY family protein |
| M. thermoresistible (build 8) | TH_1719 | glpK | 2e-17 | 24.15% (472) | PROBABLE GLYCEROL KINASE GLPK (ATP:GLYCEROL |
| M. ulcerans Agy99 | MUL_0824 | xylB | 3e-18 | 25.33% (454) | D-xylulose-kinase (xylulokinase), XylB |
| M. vanbaalenii PYR-1 | Mvan_2625 | - | 1e-52 | 29.70% (505) | carbohydrate kinase, FGGY |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3774|M.gilvum_PYR-GCK -MSR--YTIGVDIGTTGTKTVLLDT---------TSGIVATASRETALHS
Mvan_2625|M.vanbaalenii_PYR-1 -MSR--YTIGVDIGTTGIKTVLLDTTAAGRASNTTAGIVATANRENTLYS
Mb0750|M.bovis_AF2122/97 -MSRDDVTIGIDIGTTAVKAVAADD---------NGRVTARVRIGHQLAV
Rv0729|M.tuberculosis_H37Rv -MSRDDVTIGIDIGTTAVKAVAADD---------NGRVTARVRIGHQLAV
MMAR_1066|M.marinum_M -MSREDATIGIDIGTTAVKAVVADA---------DGNVTARLRIPHQLRV
MUL_0824|M.ulcerans_Agy99 -MSREDATIGIDIGTTAVKALVADA---------DGNVTARLRIPHQLRV
MAV_4437|M.avium_104 -MSRKDVTIGIDVGSTAVKALAADA---------DGRVMARVRIPHELRI
MLBr_02314|M.leprae_Br4923 MAEFAEFIAAIDQGTTSTRCVIFDH---------NGAEVARHQLEHEQIL
TH_1719|M.thermoresistible__bu ---VAEFVAAIDQGTTSTRCMIFDH---------AGTEVGRHQLEHQQIM
MAB_0382|M.abscessus_ATCC_1997 ---MADFVASIDQGTTSTRAMIFNH---------RGEEVGRHQLEHQQLL
MSMEG_3093|M.smegmatis_MC2_155 ----MGILLTIDLGTEGARVGAFTE---------DGTALGSTHRPYLTHH
:* *: . : . .
Mflv_3774|M.gilvum_PYR-GCK PAPGFAEADTTQWHANVIDSVREVLAHSGVAPDEIGALATSGMVPAVVPI
Mvan_2625|M.vanbaalenii_PYR-1 PGPGFAEADPAQWYRNVVESIREVLAVSGVAPDQIGALATSGMVPAVVAV
Mb0750|M.bovis_AF2122/97 PAPDRLEHDADEAWRRGPLAALDRLVG-----PDTRALAVAAMVPSLTAV
Rv0729|M.tuberculosis_H37Rv PAPDRLEHDADEAWRRGPLAALDRLVG-----PDTRALAVAAMVPSLTAV
MMAR_1066|M.marinum_M GAPDQLEHDADQAWRRGPLTALERLAG-----PDIRAVAVSAMVPSMTAV
MUL_0824|M.ulcerans_Agy99 GAPDQLEHDADQAWRRGPLTALERLAG-----PDIRAVAVSAMVPSMTAV
MAV_4437|M.avium_104 PAPDRLEHDAEAAWRRGPSAALDELLHQ----PGVAAVAVAAMVPSMTAV
MLBr_02314|M.leprae_Br4923 PRSGWVEHNPVEIWERTASVLMSVLNATNLSAKDIAALGITNQRETTLVW
TH_1719|M.thermoresistible__bu PQAGWVEHNPIEIWERTSAVIMSALNETRLSATDLAALGVTNQRETTLVW
MAB_0382|M.abscessus_ATCC_1997 PRAGWVEHNPVEIWERTWSVLATSLNVTGLSAGDLAAVGVTNQRETTLVW
MSMEG_3093|M.smegmatis_MC2_155 PRPGWAEQDPRDWWAAITAATRELLSGELCRAAGRVIAVAASTTASTVAV
.. * :. * : :
Mflv_3774|M.gilvum_PYR-GCK D-DAGKPLRRAILQNDARAHREVDDLAGALADVDLVTLTGSALTQQSVAP
Mvan_2625|M.vanbaalenii_PYR-1 D-QTGKPLRRAILQNDARAHREVAGLAAKLASVDLVTLTGSALTQQSVAP
Mb0750|M.bovis_AF2122/97 D-PAGRPITPGLLYGDARGRVPNA-------------SVARAQSVPSVGE
Rv0729|M.tuberculosis_H37Rv D-PAGRPITPGLLYGDARGRVPNA-------------SVARAQSVPSVGE
MMAR_1066|M.marinum_M D-SGGVPITPGLLYGDSRGWVPGA-------------ANQRAQPLPSVGE
MUL_0824|M.ulcerans_Agy99 D-SGGVPITPGLLYGDSRGWVPGA-------------ANQRAQPLPSVGE
MAV_4437|M.avium_104 D-DSGTPITPGLLYGDGRGRTPGG-------------PQN--QPLPALGE
MLBr_02314|M.leprae_Br4923 NRNTGRPYCNAIVWQDTRTDRIAVALDRDGRGEVIRRKAGLPPATYFSGG
TH_1719|M.thermoresistible__bu NKRTGRPYYNAIVWQDTRTDRIASALERDGRGEVIRQKAGLPPATYFSGG
MAB_0382|M.abscessus_ATCC_1997 NRHTGRPYCNAIVWQDTRTDKIAAALDRDGRGDIIRRKAGLPPATYFSGG
MSMEG_3093|M.smegmatis_MC2_155 VDAAGTPLRPAILWMDARGAAESEQTARLCLQHPILEWSGGSDAAEWLLP
* * .:: * * .
Mflv_3774|M.gilvum_PYR-GCK TTVWLREHEP----------EVYARTAHWVGSYDWVLSALGADVHVEQNW
Mvan_2625|M.vanbaalenii_PYR-1 TTVWLRDHEP----------GVYARTAHWIGSYDWVLSALGAPIHVEQNW
Mb0750|M.bovis_AF2122/97 TAEFLRWTAG----------QAPDASGYWPAPAVANYALSGEAVIDYATA
Rv0729|M.tuberculosis_H37Rv TAEFLRWTAG----------QALDASGYWPAPAVANYALSGEAVIDYATA
MMAR_1066|M.marinum_M AAQFLRWTAA----------QAPEAAGYWPAAAVANYAMSGEPVIDFATA
MUL_0824|M.ulcerans_Agy99 AAQFLRWTAA----------QAPEAAGYWPAAAVANYAMSGEPVIDFATA
MAV_4437|M.avium_104 AAEFLRWTAA----------RAPGAAGYWPAPAVANHALAGQAVIDVATA
MLBr_02314|M.leprae_Br4923 KLQWILENVDGVGAAAENGEALFGTPDTWLLWNLTGGPRGGVHVTDVTNA
TH_1719|M.thermoresistible__bu KLQWMLENVDGLRADAEKGEALFGTPDTWLVWNLTGGVRGGRHITDVTNA
MAB_0382|M.abscessus_ATCC_1997 KLQWILENVEGVRRDAENGDALFGTPDSWVIWNLTGGVRSGVHVTDVTNA
MSMEG_3093|M.smegmatis_MC2_155 KAMWLKKHDP---------DAYRSAARIVEAVDYLTFRLTGRWVGSQMNA
:: . * : .
Mflv_3774|M.gilvum_PYR-GCK ALESGLFSIVGDTADAVLGAAGLDPATLAP---LRRPGTRVGELSAAAAD
Mvan_2625|M.vanbaalenii_PYR-1 ALESGLFEIDGDVATDVVQAAALEPVTLAP---VRRPGTQVGELSRRAAD
Mb0750|M.bovis_AF2122/97 VTTLPLFDGTGWNATACADCG-VTVDRMPR---VETFGVGVGQVRGT---
Rv0729|M.tuberculosis_H37Rv VTTLPLFDGTGWNATACADCG-VTVDRMPR---VETFGVGVGQVRGT---
MMAR_1066|M.marinum_M ITSLPLFDGTGWNPQACADCG-ASADRMPR---VETFGTAVGQVHGA---
MUL_0824|M.ulcerans_Agy99 ITSLPLFDGTGWNPQACADCG-ASADRMPR---VETFGTAVGQVHGT---
MAV_4437|M.avium_104 ATAFPLFDGTGWDAAACAERG-ARVEQMPR---VHSMGAVVGQLPG----
MLBr_02314|M.leprae_Br4923 SRTMLMDLEKLDWDDELLSFFSIPRAMLPA---IASSSPLQPYGVTLADG
TH_1719|M.thermoresistible__bu SRTMLMNLETLDWDDELLSFFGIPRAMLPE---IKPSSYPQSYGITLDDG
MAB_0382|M.abscessus_ATCC_1997 SRTMLMNLETLDWDDELLSFFSIPRQMLPP---IKASSPVEPFGFTTQLG
MSMEG_3093|M.smegmatis_MC2_155 VCKYNYDTLAGRFPAELYAALGMDDLIDKLPDEIVPVGGVAGPLADSAAA
: .
Mflv_3774|M.gilvum_PYR-GCK ATGLRAGTPLVVGGADHVLSAYAAGVNGAGDALVKLGGAGDILVASDTEI
Mvan_2625|M.vanbaalenii_PYR-1 ETGLRAGTALVVGGADHVLSAYAAGVNDPGDALVKLGGAGDILVASDTQV
Mb0750|M.bovis_AF2122/97 ------GAVLAVGAVDALCEQIVAGADRDGDVLVLCGATLIVWTTISAAR
Rv0729|M.tuberculosis_H37Rv ------GAVLAVGAVDALCEQIVAGADRDGDVLVLCGATLIVWTTISAAR
MMAR_1066|M.marinum_M ------DAVLGAGGIDAVCEQIVAGADHHGDVLVLCGTTLIVWTTISGSR
MUL_0824|M.ulcerans_Agy99 ------DAVLGAGGIDAVCEQIVAGADHHGDVLVLCGTTLIVWTTISGSR
MAV_4437|M.avium_104 ------GAALATGAIDALCEQLVAGADRDGDVLVMCGTTLIVWATISQAR
MLBr_02314|M.leprae_Br4923 PVGGEVPITGVLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGEAIVR
TH_1719|M.thermoresistible__bu PVAGQVPLTGILGDQQAAMVGQVCLSAGEAKNTYGTGNFLLLNTGENIVR
MAB_0382|M.abscessus_ATCC_1997 PLGGEVPIAGDLGDQQAAMVGQVCLNPGEAKNTYGTGNFLLLNTGEELVH
MSMEG_3093|M.smegmatis_MC2_155 DLGIDGRPVVAVGGIDAHVSLLACGGNVGGLVSLVSGTSSAIVTEVDRPT
* . .. . * : .
Mflv_3774|M.gilvum_PYR-GCK VDERLYLDAHPVPG---------RWLPNGCMATSGSLIRWFQTLIGG---
Mvan_2625|M.vanbaalenii_PYR-1 VDERLYLDAHPIPG---------HWLPNGCMATSGSLIRWFQALIGGPEA
Mb0750|M.bovis_AF2122/97 QVPGLWTIPHTAPG---------KSQIGGASNAGGLFLNWVDRVIGPGD-
Rv0729|M.tuberculosis_H37Rv QVPGLWTIPHTAPG---------KSQIGGASNAGGLFLNWVDRVIGPGD-
MMAR_1066|M.marinum_M QVPGLWTIPHTAPG---------KSQIGGASNAGGLFLSWVDRLIGPADR
MUL_0824|M.ulcerans_Agy99 QVPGLWTIPHTAPG---------KSQIGGASNAGGLFLSWVDRVTGPADR
MAV_4437|M.avium_104 QMPGLWTIPHTTPG---------KSQIGGASNAGGLFLGWVDRVVAQAD-
MLBr_02314|M.leprae_Br4923 SGNGLLTTVCYQFG-----DAKPVYALEGSIAVTGSAVQWLRDQLGIIS-
TH_1719|M.thermoresistible__bu SKNGLITTVCYQFTGADGRPAEPVYALEGSIAVTGAAVQWLRDQLGIIS-
MAB_0382|M.abscessus_ATCC_1997 SSNGLLTTVCYQFG-----DNKPVYALEGSIAVTGSAVQWLRDQLGIIS-
MSMEG_3093|M.smegmatis_MC2_155 TSNEVWGPYPEALN-------PGKWLVEGGQVTSGSVLKWTGESIIGVPR
: * . * : *
Mflv_3774|M.gilvum_PYR-GCK AELTELDDEAAQRAPGEI--LCLPYFLGEKSPVHDPDLRGVFAGMHLGHT
Mvan_2625|M.vanbaalenii_PYR-1 VELTTLDDEAALRSPAEV--LCLPYFLGEKSPIHDPDLRGVFAGMHLGHT
Mb0750|M.bovis_AF2122/97 ---PALADPRRVP-------VWLPYIRGERTPFHEPDRRAVLDGVDLSQD
Rv0729|M.tuberculosis_H37Rv ---PALADPRRVP-------VWLPYIRGERTPFHEPDRRAVLDGVDLSQD
MMAR_1066|M.marinum_M DGEQDRVDPRRVP-------IWLPYIRGERTPFHDPDRRASLEGLDLTQG
MUL_0824|M.ulcerans_Agy99 DGEQDRVDPRRVP-------IWLPYIRGERTPFHDPDRRASLEGLDLTQG
MAV_4437|M.avium_104 ---PASAQPGRVP-------VFAPYLRGERSPFHDPDRRGVLEALDLTHD
MLBr_02314|M.leprae_Br4923 GAAQSESLARQVVDNGGV--YFVPAFSGLFSPYWRSDARGAIVGLSRFNT
TH_1719|M.thermoresistible__bu GAAQSESLARQVPDNGGV--YFVPAFSGLFAPYWRSDARGAIVGLSRFNT
MAB_0382|M.abscessus_ATCC_1997 GASQSEDLARQVEDNGGV--YFVPAFSGLFAPYWRSDARGAIVGLSRFNT
MSMEG_3093|M.smegmatis_MC2_155 DELAGLIDQAAAVDPASHGLRALDYFMGNRTPHREARLRGAVIGLTLGTT
: * :* . *. . .:
Mflv_3774|M.gilvum_PYR-GCK RADMYRSVLEAIAFGFRHHVDVFGEI-GIPFTRVMITNGGSRSTLWKQIH
Mvan_2625|M.vanbaalenii_PYR-1 RADMYRSVLEAIAFGFRHHVDVFAEI-GIPLRRVMITNGGSKSTLWKQIH
Mb0750|M.bovis_AF2122/97 AASVRRAAYEASGFVVRQLIELS----GAPVARIVAAGGGTRIQPWMQAI
Rv0729|M.tuberculosis_H37Rv AASVRRAAYEASGFVVRQLIELS----GAPVARIVAAGGGTRIQPWMQAI
MMAR_1066|M.marinum_M AAAVRRAAYEASGFVVRHLVELS----GAPVLRIVASGGGTCVQPWMQAI
MUL_0824|M.ulcerans_Agy99 AAAVRRAAYEVSGFVVRHLVELS----GAPVLRIVASGGGTCVRPWMQAI
MAV_4437|M.avium_104 AAALRRAAYEASGFVVRQLIELS----GAPVSRIVATGGGTRVGPWLQAI
MLBr_02314|M.leprae_Br4923 NAHLARATLEAICYQSRDVVDAMAADSGVRLDVLKVDGGITSNDLCMQIQ
TH_1719|M.thermoresistible__bu NAHIARATLEAICYQSRDVVDAMVADSGVRMESLKVDGGITANELCMQIQ
MAB_0382|M.abscessus_ATCC_1997 NAHLARATLEAICYQSREVVEAMEADSGVRMEVLKVDGGITANKLCMQIQ
MSMEG_3093|M.smegmatis_MC2_155 KAELYRAMVEAVACGTRSVIDSFERS-GVPCSRLVFSGGIERNTLWQQVT
* : *: *. * :: * : .* *
Mflv_3774|M.gilvum_PYR-GCK ADVLGCEMNPVIGHPGASLGAAVIAAIGVGALDDWADADRFITL-DAPYR
Mvan_2625|M.vanbaalenii_PYR-1 ADVLGQEMHPVRGHPGASLGAAVIAAIGVGALADWSDAARFITL-DDPYI
Mb0750|M.bovis_AF2122/97 ADATGRPVEVSRVAEGAALGAAFLGRLAAGLESSIADAARWAST-DRIVE
Rv0729|M.tuberculosis_H37Rv ADATGRPVEVSRVAEGAALGAAFLGRLAAGLESSIADAARWAST-DRIVE
MMAR_1066|M.marinum_M ADVTGRPVHVSDVAEGAALGAAFLARMAAGLESSIADADRWART-DRIVE
MUL_0824|M.ulcerans_Agy99 ADVTGRPVHVSAVAEGAALGAAFLARMAAGLES-----------------
MAV_4437|M.avium_104 ADATGHPVEVSAVAEGAALGAAFLARMAAGLETTLTDAARWVRT-ERVVE
MLBr_02314|M.leprae_Br4923 ADVLGVDVVRSVVAETTALGSAYAAGLAVGFWAGPSDLRANWQE-DKRWT
TH_1719|M.thermoresistible__bu ADVLGVDVIKPVVSETTALGAAYAAGLAVGFWEDADDLRTNWQE-GRRWT
MAB_0382|M.abscessus_ATCC_1997 ADTLGVDVVKPVVAETTALGAAYAAGLAVGFWKDADDLRRNWQE-DERWS
MSMEG_3093|M.smegmatis_MC2_155 IDVLGRPAELVIGENLTLRACAVIAATGAGIVPSLTAGSRLFAPRVRMLE
*. * : ..* . ..*
Mflv_3774|M.gilvum_PYR-GCK PDPARRHAYDDAYQTWRELGAVMTPVSHKIARTTR--------------
Mvan_2625|M.vanbaalenii_PYR-1 PDPARRDIYDQAYATWRELSSAMTPISHAIARTTR--------------
Mb0750|M.bovis_AF2122/97 PSADWAGPTKERYRRFLALSGSKLA------------------------
Rv0729|M.tuberculosis_H37Rv PSADWAGPTKERYRRFLALSGSKLA------------------------
MMAR_1066|M.marinum_M PRPDWVGPTKDRYRRFLELSGSPLA------------------------
MUL_0824|M.ulcerans_Agy99 -------------------------------------------------
MAV_4437|M.avium_104 PDPAWAAPVQDRYQRFLELGNRPCPAVVAR-------------------
MLBr_02314|M.leprae_Br4923 P-TWGEDQRAAAYAGWRKAVQRTLDWVDVS-------------------
TH_1719|M.thermoresistible__bu P-QWTDEQREAGYRGWKKAVQRTLDWVDVG-------------------
MAB_0382|M.abscessus_ATCC_1997 S-SITDEKRAEGFAGWKKAVQRTLDGVDV--------------------
MSMEG_3093|M.smegmatis_MC2_155 PDPKRSLLYEQTFDDYQRLTAALRPIMCDTVDGGSDAAAGARASFRVVR