For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VTPPGAPKYVIGVDFGTLSGRALVVRVADGAEMGSAEHTYRHGVVTEALPGHPEVRLPADYALQVPADYI DVLRFAIPEAVANAGIDPADVVGLGTDFTACTMVAATSDGTPLCQLDEFADRPHAYAKLWRHHAAQPQAD RINALAAARGETWLPRYGGLISSEWEFAKGLQILEEDPEIYAAIDRWVEGADWIVWQLTGRYVRNISTAG YKAIRQDGKYPSRAFLAELNPGFASFVEDKIEQPIGRLGEAAGALTAQAAAWTGLPEGILVAVGNIDAHV TAAAADAADPGRLIAIMGTSTCHVMNGRFLREVPGMCGVVDGGITDGLWGYEAGQSGVGDIFAWFTKNCV PKEVAIEASRRGLTLHEHLSELAAEQEVGEHGLVALDWHSGNRSVLVDHHLSGIMVGQTLDTTCVDQYRA LLEATAFGTRMIVETFQRSGVPVEELVVAGGLIKNPLLMQIYADVTGLPLSCVTSTQAPALGAAIHAAAA AGEYRDVPTASARMGGRTKNAFTPIPENVTRYNALYAAYVELHDWFGRNNPLMRRLRVMRSNAERRETVG SAQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1713 | araB | - | 100% (563) | ribulokinase |
| M. smegmatis MC2 155 | MSMEG_3093 | - | 6e-44 | 29.28% (526) | putative sugar kinase protein |
| M. smegmatis MC2 155 | MSMEG_3263 | - | 7e-27 | 28.07% (399) | xylulose kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0750 | xylB | 2e-09 | 26.55% (226) | D-xylulose kinase XylB |
| M. gilvum PYR-GCK | Mflv_3774 | - | 3e-27 | 26.70% (528) | carbohydrate kinase, FGGY |
| M. tuberculosis H37Rv | Rv0729 | xylB | 2e-09 | 26.55% (226) | D-xylulose kinase XylB |
| M. leprae Br4923 | MLBr_02314 | glpK | 2e-09 | 23.48% (511) | glycerol kinase |
| M. abscessus ATCC 19977 | MAB_0382 | glpK | 3e-09 | 37.07% (116) | glycerol kinase |
| M. marinum M | MMAR_5208 | glpK | 1e-08 | 23.37% (522) | glycerol kinase GlpK |
| M. avium 104 | MAV_4437 | - | 2e-09 | 25.56% (270) | carbohydrate kinase, FGGY family protein |
| M. thermoresistible (build 8) | TH_1719 | glpK | 5e-10 | 23.18% (522) | PROBABLE GLYCEROL KINASE GLPK (ATP:GLYCEROL |
| M. ulcerans Agy99 | MUL_4281 | glpK | 1e-09 | 23.03% (521) | glycerol kinase |
| M. vanbaalenii PYR-1 | Mvan_2625 | - | 1e-27 | 25.55% (544) | carbohydrate kinase, FGGY |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5208|M.marinum_M --MADSPDFVAAIDQGTTSTRCMIFDH-------------QGAEIARHQL
MUL_4281|M.ulcerans_Agy99 --MADSPDFVAAIDQGTTSTRCMIFDH-------------QGAEIARHQL
MLBr_02314|M.leprae_Br4923 --MAEFAEFIAAIDQGTTSTRCVIFDH-------------NGAEVARHQL
MAB_0382|M.abscessus_ATCC_1997 -----MADFVASIDQGTTSTRAMIFNH-------------RGEEVGRHQL
TH_1719|M.thermoresistible__bu -----VAEFVAAIDQGTTSTRCMIFDH-------------AGTEVGRHQL
Mb0750|M.bovis_AF2122/97 ---MSRDDVTIGIDIGTTAVKAVAADD-------------NGRVTARVRI
Rv0729|M.tuberculosis_H37Rv ---MSRDDVTIGIDIGTTAVKAVAADD-------------NGRVTARVRI
MAV_4437|M.avium_104 ---MSRKDVTIGIDVGSTAVKALAADA-------------DGRVMARVRI
Mflv_3774|M.gilvum_PYR-GCK ---MSR--YTIGVDIGTTGTKTVLLDT-------------TSGIVATASR
Mvan_2625|M.vanbaalenii_PYR-1 ---MSR--YTIGVDIGTTGIKTVLLDTTAAGRA----SNTTAGIVATANR
MSMEG_1713|M.smegmatis_MC2_155 MTPPGAPKYVIGVDFGTLSGRALVVRVADGAEMGSAEHTYRHGVVTEALP
.:* *: . : :
MMAR_5208|M.marinum_M EHEQILPRAGWVEHNPVEIWERTASVLMSVLNATDLSPKNIAALGITNQR
MUL_4281|M.ulcerans_Agy99 VHEQILPRAGWVEHNPVEIWERTASVLMSVLNATDLSPKNIAALGITNQR
MLBr_02314|M.leprae_Br4923 EHEQILPRSGWVEHNPVEIWERTASVLMSVLNATNLSAKDIAALGITNQR
MAB_0382|M.abscessus_ATCC_1997 EHQQLLPRAGWVEHNPVEIWERTWSVLATSLNVTGLSAGDLAAVGVTNQR
TH_1719|M.thermoresistible__bu EHQQIMPQAGWVEHNPIEIWERTSAVIMSALNETRLSATDLAALGVTNQR
Mb0750|M.bovis_AF2122/97 GHQLAVPAPDRLEHDADEAWRRGPLAALDRLVG-----PDTRALAVAAMV
Rv0729|M.tuberculosis_H37Rv GHQLAVPAPDRLEHDADEAWRRGPLAALDRLVG-----PDTRALAVAAMV
MAV_4437|M.avium_104 PHELRIPAPDRLEHDAEAAWRRGPSAALDELLHQ----PGVAAVAVAAMV
Mflv_3774|M.gilvum_PYR-GCK ETALHSPAPGFAEADTTQWHANVIDSVREVLAHSGVAPDEIGALATSGMV
Mvan_2625|M.vanbaalenii_PYR-1 ENTLYSPGPGFAEADPAQWYRNVVESIREVLAVSGVAPDQIGALATSGMV
MSMEG_1713|M.smegmatis_MC2_155 GHPEVRLPADYALQVPADYIDVLRFAIPEAVANAGIDPADVVGLGTDFTA
.. . : .:.
MMAR_5208|M.marinum_M ETTLVWNKR----------TGRPYYNAIVWQDTRTD---RIASALDRDGR
MUL_4281|M.ulcerans_Agy99 ETTLVWNKR----------TGRPYYNAIVWQDTRTD---RIASALDRDGR
MLBr_02314|M.leprae_Br4923 ETTLVWNRN----------TGRPYCNAIVWQDTRTD---RIAVALDRDGR
MAB_0382|M.abscessus_ATCC_1997 ETTLVWNRH----------TGRPYCNAIVWQDTRTD---KIAAALDRDGR
TH_1719|M.thermoresistible__bu ETTLVWNKR----------TGRPYYNAIVWQDTRTD---RIASALERDGR
Mb0750|M.bovis_AF2122/97 PSLTAVDP-----------AGRPITPGLLYGDARGR---VPNASVARAQS
Rv0729|M.tuberculosis_H37Rv PSLTAVDP-----------AGRPITPGLLYGDARGR---VPNASVARAQS
MAV_4437|M.avium_104 PSMTAVDD-----------SGTPITPGLLYGDGRGR---TPGG--PQNQP
Mflv_3774|M.gilvum_PYR-GCK PAVVPIDD-----------AGKPLRRAILQNDARAH---REVDDLAGALA
Mvan_2625|M.vanbaalenii_PYR-1 PAVVAVDQ-----------TGKPLRRAILQNDARAH---REVAGLAAKLA
MSMEG_1713|M.smegmatis_MC2_155 CTMVAATSDGTPLCQLDEFADRPHAYAKLWRHHAAQPQADRINALAAARG
: :. * . : .
MMAR_5208|M.marinum_M GDVIRRKAGLPPATYFSGGKLQWILENVDGVRAAAERGDALFGTPDTWVL
MUL_4281|M.ulcerans_Agy99 GDVIRRKAGLPPATYFSGGKLQWILEDVDGVRAAAERGDALFGTPDTWVL
MLBr_02314|M.leprae_Br4923 GEVIRRKAGLPPATYFSGGKLQWILENVDGVGAAAENGEALFGTPDTWLL
MAB_0382|M.abscessus_ATCC_1997 GDIIRRKAGLPPATYFSGGKLQWILENVEGVRRDAENGDALFGTPDSWVI
TH_1719|M.thermoresistible__bu GEVIRQKAGLPPATYFSGGKLQWMLENVDGLRADAEKGEALFGTPDTWLV
Mb0750|M.bovis_AF2122/97 -------------VPSVGETAEFLRWTAG----------QAPDASGYWPA
Rv0729|M.tuberculosis_H37Rv -------------VPSVGETAEFLRWTAG----------QALDASGYWPA
MAV_4437|M.avium_104 -------------LPALGEAAEFLRWTAA----------RAPGAAGYWPA
Mflv_3774|M.gilvum_PYR-GCK DVDLVTLTGSALTQQSVAPTTVWLREHEP----------EVYARTAHWVG
Mvan_2625|M.vanbaalenii_PYR-1 SVDLVTLTGSALTQQSVAPTTVWLRDHEP----------GVYARTAHWIG
MSMEG_1713|M.smegmatis_MC2_155 ETWLPRYGGLISSEWEFAKGLQILEEDPE-----IYAAIDRWVEGADWIV
. : *
MMAR_5208|M.marinum_M WNLTGGPRGGVHVTDVTNASRTMLMNLETLDWDDELLSFFSIPRAMLPAI
MUL_4281|M.ulcerans_Agy99 WNLTGGPRGGVHVTDVTNASRTMLMNLETLDWDDELLSFFSIPRAMLPAI
MLBr_02314|M.leprae_Br4923 WNLTGGPRGGVHVTDVTNASRTMLMDLEKLDWDDELLSFFSIPRAMLPAI
MAB_0382|M.abscessus_ATCC_1997 WNLTGGVRSGVHVTDVTNASRTMLMNLETLDWDDELLSFFSIPRQMLPPI
TH_1719|M.thermoresistible__bu WNLTGGVRGGRHITDVTNASRTMLMNLETLDWDDELLSFFGIPRAMLPEI
Mb0750|M.bovis_AF2122/97 PAVANYALSGEAVIDYATAVTTLPLFDGTGWNATACADCG-VTVDRMPRV
Rv0729|M.tuberculosis_H37Rv PAVANYALSGEAVIDYATAVTTLPLFDGTGWNATACADCG-VTVDRMPRV
MAV_4437|M.avium_104 PAVANHALAGQAVIDVATAATAFPLFDGTGWDAAACAERG-ARVEQMPRV
Mflv_3774|M.gilvum_PYR-GCK SYDWVLSALGADVHVEQNWALESGLFSIVGDTADAVLGAAGLDPATLAPL
Mvan_2625|M.vanbaalenii_PYR-1 SYDWVLSALGAPIHVEQNWALESGLFEIDGDVATDVVQAAALEPVTLAPV
MSMEG_1713|M.smegmatis_MC2_155 WQLTGRYVRNISTAGYKAIRQDGKYPSRAFLAELNPGFASFVEDKIEQPI
. :
MMAR_5208|M.marinum_M EPSSPLQPYGITQDTGPVGGEVPITGMLGDQHAAMVGQVCLDAGEAKNTY
MUL_4281|M.ulcerans_Agy99 EPSSPLQPYGITQDTGPVGGEVPITGMLGDQHAAMVGQVCLDAGEAKNTY
MLBr_02314|M.leprae_Br4923 ASSSPLQPYGVTLADGPVGGEVPITGVLGDQHAAMVGQVCLDAGEAKNTY
MAB_0382|M.abscessus_ATCC_1997 KASSPVEPFGFTTQLGPLGGEVPIAGDLGDQQAAMVGQVCLNPGEAKNTY
TH_1719|M.thermoresistible__bu KPSSYPQSYGITLDDGPVAGQVPLTGILGDQQAAMVGQVCLSAGEAKNTY
Mb0750|M.bovis_AF2122/97 ETFGVGVGQVRGT---------GAVLAVGAVDALCEQIVAGADRDGDVLV
Rv0729|M.tuberculosis_H37Rv ETFGVGVGQVRGT---------GAVLAVGAVDALCEQIVAGADRDGDVLV
MAV_4437|M.avium_104 HSMGAVVGQLPG----------GAALATGAIDALCEQLVAGADRDGDVLV
Mflv_3774|M.gilvum_PYR-GCK RRPGTRVGELSAAAADATGLRAGTPLVVGGADHVLSAYAAGVNGAGDALV
Mvan_2625|M.vanbaalenii_PYR-1 RRPGTQVGELSRRAADETGLRAGTALVVGGADHVLSAYAAGVNDPGDALV
MSMEG_1713|M.smegmatis_MC2_155 GRLGEAAGALTAQAAAWTGLPEGILVAVGNIDAHVTAAAADAADPGRLIA
. * . .. .
MMAR_5208|M.marinum_M GTGNFLLLNTGETIVRSSNGLLTTLCYQFGDA-----KPVYALEGSIAVT
MUL_4281|M.ulcerans_Agy99 GTGNFLLLNTGETIVRSSNGLLTTLCYQFGDA-----KPVYALEGSIAVT
MLBr_02314|M.leprae_Br4923 GTGNFLLLNTGEAIVRSGNGLLTTVCYQFGDA-----KPVYALEGSIAVT
MAB_0382|M.abscessus_ATCC_1997 GTGNFLLLNTGEELVHSSNGLLTTVCYQFGDN-----KPVYALEGSIAVT
TH_1719|M.thermoresistible__bu GTGNFLLLNTGENIVRSKNGLITTVCYQFTGADGRPAEPVYALEGSIAVT
Mb0750|M.bovis_AF2122/97 LCGATLIVWTTISAARQVPGLWTIPHTAPGKS---------QIGGASNAG
Rv0729|M.tuberculosis_H37Rv LCGATLIVWTTISAARQVPGLWTIPHTAPGKS---------QIGGASNAG
MAV_4437|M.avium_104 MCGTTLIVWATISQARQMPGLWTIPHTTPGKS---------QIGGASNAG
Mflv_3774|M.gilvum_PYR-GCK KLGGAGDILVASDTEIVDERLYLDAHPVPGRW---------LPNGCMATS
Mvan_2625|M.vanbaalenii_PYR-1 KLGGAGDILVASDTQVVDERLYLDAHPIPGHW---------LPNGCMATS
MSMEG_1713|M.smegmatis_MC2_155 IMGTSTCHVMNGRFLREVPGMCGVVDGGITDG-------LWGYEAGQSGV
* : .
MMAR_5208|M.marinum_M GSAVQWLRDQLGIISGASQSE------------ALARQVSDNGGVYFVPA
MUL_4281|M.ulcerans_Agy99 GSAVQWLRDQLGIISGASQSE------------ALARQVSDNGGVYFVPA
MLBr_02314|M.leprae_Br4923 GSAVQWLRDQLGIISGAAQSE------------SLARQVVDNGGVYFVPA
MAB_0382|M.abscessus_ATCC_1997 GSAVQWLRDQLGIISGASQSE------------DLARQVEDNGGVYFVPA
TH_1719|M.thermoresistible__bu GAAVQWLRDQLGIISGAAQSE------------SLARQVPDNGGVYFVPA
Mb0750|M.bovis_AF2122/97 GLFLNWVDRVIGP--------------------GDPALADPRRVPVWLPY
Rv0729|M.tuberculosis_H37Rv GLFLNWVDRVIGP--------------------GDPALADPRRVPVWLPY
MAV_4437|M.avium_104 GLFLGWVDRVVAQ--------------------ADPASAQPGRVPVFAPY
Mflv_3774|M.gilvum_PYR-GCK GSLIRWFQTLIGG---AELTEL-----------DDEAAQRAPGEILCLPY
Mvan_2625|M.vanbaalenii_PYR-1 GSLIRWFQALIGGPEAVELTTL-----------DDEAALRSPAEVLCLPY
MSMEG_1713|M.smegmatis_MC2_155 GDIFAWFTKNCVPKEVAIEASRRGLTLHEHLSELAAEQEVGEHGLVALDW
* . *.
MMAR_5208|M.marinum_M FSGLFAPYWRSDARGAIVGLSRFNNNAHLARATLEAICYQSRDVVDAMEA
MUL_4281|M.ulcerans_Agy99 FSGLFAPYWRSDARGAIVGLSRFNNNAHLARATLEAICYQSRDVVDAMEA
MLBr_02314|M.leprae_Br4923 FSGLFSPYWRSDARGAIVGLSRFNTNAHLARATLEAICYQSRDVVDAMAA
MAB_0382|M.abscessus_ATCC_1997 FSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLEAICYQSREVVEAMEA
TH_1719|M.thermoresistible__bu FSGLFAPYWRSDARGAIVGLSRFNTNAHIARATLEAICYQSRDVVDAMVA
Mb0750|M.bovis_AF2122/97 IRGERTPFHEPDRRAVLDGVDLSQDAASVRRAAYEASGFVVRQLIELS--
Rv0729|M.tuberculosis_H37Rv IRGERTPFHEPDRRAVLDGVDLSQDAASVRRAAYEASGFVVRQLIELS--
MAV_4437|M.avium_104 LRGERSPFHDPDRRGVLEALDLTHDAAALRRAAYEASGFVVRQLIELS--
Mflv_3774|M.gilvum_PYR-GCK FLGEKSPVHDPDLRGVFAGMHLGHTRADMYRSVLEAIAFGFRHHVDVFGE
Mvan_2625|M.vanbaalenii_PYR-1 FLGEKSPIHDPDLRGVFAGMHLGHTRADMYRSVLEAIAFGFRHHVDVFAE
MSMEG_1713|M.smegmatis_MC2_155 HSGNRSVLVDHHLSGIMVGQTLDTTCVDQYRALLEATAFGTRMIVETFQR
* : . . : . . *: ** : * ::
MMAR_5208|M.marinum_M DSGVRLEVLKVDGGITSNDLCMQIQADVLGVDVVRPVVAETTALGAAYAA
MUL_4281|M.ulcerans_Agy99 DSGVRLEVLKVDGGITSNDLCMQIQADVLGVDVVRPVVAETTALGAAYAA
MLBr_02314|M.leprae_Br4923 DSGVRLDVLKVDGGITSNDLCMQIQADVLGVDVVRSVVAETTALGSAYAA
MAB_0382|M.abscessus_ATCC_1997 DSGVRMEVLKVDGGITANKLCMQIQADTLGVDVVKPVVAETTALGAAYAA
TH_1719|M.thermoresistible__bu DSGVRMESLKVDGGITANELCMQIQADVLGVDVIKPVVSETTALGAAYAA
Mb0750|M.bovis_AF2122/97 --GAPVARIVAAGGGTRIQPWMQAIADATGRPVEVSRVAEGAALGAAFLG
Rv0729|M.tuberculosis_H37Rv --GAPVARIVAAGGGTRIQPWMQAIADATGRPVEVSRVAEGAALGAAFLG
MAV_4437|M.avium_104 --GAPVSRIVATGGGTRVGPWLQAIADATGHPVEVSAVAEGAALGAAFLA
Mflv_3774|M.gilvum_PYR-GCK I-GIPFTRVMITNGGSRSTLWKQIHADVLGCEMNPVIGHPGASLGAAVIA
Mvan_2625|M.vanbaalenii_PYR-1 I-GIPLRRVMITNGGSKSTLWKQIHADVLGQEMHPVRGHPGASLGAAVIA
MSMEG_1713|M.smegmatis_MC2_155 S-GVPVEELVVAGGLIKNPLLMQIYADVTGLPLSCVTSTQAPALGAAIHA
* . : .* * **. * : .:**:* .
MMAR_5208|M.marinum_M GLAVGFWADPSDLRANWQ--EDKRWTP-QWTDDQRAAGYAGWRKAVQRTL
MUL_4281|M.ulcerans_Agy99 GLAVGFWADPSDLRANWQ--EDKRWTP-QWTDDQRAAGYAGWRKAVQRTL
MLBr_02314|M.leprae_Br4923 GLAVGFWAGPSDLRANWQ--EDKRWTP-TWGEDQRAAAYAGWRKAVQRTL
MAB_0382|M.abscessus_ATCC_1997 GLAVGFWKDADDLRRNWQ--EDERWSS-SITDEKRAEGFAGWKKAVQRTL
TH_1719|M.thermoresistible__bu GLAVGFWEDADDLRTNWQ--EGRRWTP-QWTDEQREAGYRGWKKAVQRTL
Mb0750|M.bovis_AF2122/97 RLAAGLESSIADAARWAS--TDRIVEPSADWAGPTKERYRRFLALSGSKL
Rv0729|M.tuberculosis_H37Rv RLAAGLESSIADAARWAS--TDRIVEPSADWAGPTKERYRRFLALSGSKL
MAV_4437|M.avium_104 RMAAGLETTLTDAARWVR--TERVVEPDPAWAAPVQDRYQRFLELGNRPC
Mflv_3774|M.gilvum_PYR-GCK AIGVGALDDWADADRFIT--LDAPYRPDPARRHAYDDAYQTWRELGAVMT
Mvan_2625|M.vanbaalenii_PYR-1 AIGVGALADWSDAARFIT--LDDPYIPDPARRDIYDQAYATWRELSSAMT
MSMEG_1713|M.smegmatis_MC2_155 AAAAGEYRDVPTASARMGGRTKNAFTPIPENVTRYNALYAAYVELHDWFG
..* . : :
MMAR_5208|M.marinum_M DWVDVS--------------------
MUL_4281|M.ulcerans_Agy99 DWVDVS--------------------
MLBr_02314|M.leprae_Br4923 DWVDVS--------------------
MAB_0382|M.abscessus_ATCC_1997 DGVDV---------------------
TH_1719|M.thermoresistible__bu DWVDVG--------------------
Mb0750|M.bovis_AF2122/97 A-------------------------
Rv0729|M.tuberculosis_H37Rv A-------------------------
MAV_4437|M.avium_104 PAVVAR--------------------
Mflv_3774|M.gilvum_PYR-GCK PVSHKIARTTR---------------
Mvan_2625|M.vanbaalenii_PYR-1 PISHAIARTTR---------------
MSMEG_1713|M.smegmatis_MC2_155 RNNPLMRRLRVMRSNAERRETVGSAQ