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VSTRRNEARIEDIRAQFLTASEPGRAVPADLLESWVRSKAALGTPANVRDVPQVDEDLLDNHLVEMFQAP MARVAEDLGGSGMGLLLADAEGRILQRWSQDASAMSHLDRLGTVRGAVLAEDTVGTNGVGTVIAAGKSVQ IAGAEHFADIYRTAVCTGAPVWHPLSGKLLAVVTVSTMLSERSGLLVPLTNSVAAQLEQHVLDVAQPGAR AMLAAFLESSARHAGPVVAFGPDGLTMRSRRAGELTQTDVDTINHLCAGLRRDVQVTAELSVGPTVIDVA ALDGGAGVVAALRPAPRSSAAHSIASSSALVGQSKSWRAVAHRVSRHIATREPILVAGELGTGKTSLALG RPFSAGAADTATIVHGAERQIVGDQTWLQRVADAVEAGPVVIRGAEHVDGHVLAAVRTLIDGQRGTTPIV LTMTAALRAEAESAAGRFGVPMVWVPPLRERVSDIGVLWNSFVAQCSPGARLPLADAARQALEAAGWPGN LSDLRGAVDTVLASGKRGTVQVDDLPDTLRSRRTWTLMERTEIEAIRRALQEADGNRSKAAELLGVSRAT IHRKMKTYHLSG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3008 | - | - | 100% (572) | putative sigma 54 type regulator |
| M. smegmatis MC2 155 | MSMEG_1970 | - | 2e-50 | 28.01% (582) | sigma factor |
| M. smegmatis MC2 155 | MSMEG_5019 | - | 1e-16 | 33.33% (150) | regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_0123 | - | 6e-18 | 30.20% (245) | putative GAF sensor protein |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2793c | - | 7e-11 | 27.07% (229) | putative transcriptional regulator |
| M. marinum M | MMAR_4913 | - | 3e-10 | 26.52% (230) | putative regulatory protein |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0493 | - | 2e-10 | 26.52% (230) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4895 | - | 1e-40 | 26.67% (615) | Fis family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4913|M.marinum_M --MATMRTANEIAAARLSMPALRALRDRFVAGRVDSTYLDSTPVRR---I
MUL_0493|M.ulcerans_Agy99 MLVATMRTANEIAAARLSMPALRALRDRFVAGRVDSTYLYSTPVRR---I
MAB_2793c|M.abscessus_ATCC_199 --MATTRTSARCGPARVSLTSVRDAHELFVTGQVDGSYLESIPLPR---L
Mflv_0123|M.gilvum_PYR-GCK --MPSNVGSPLVPEPAVAVGEDPRSYARLMSAVYDATMAGDRAPARPREV
Mvan_4895|M.vanbaalenii_PYR-1 ------------------MPNSSARMLRVAAARADFLEYGGGGAAGVSEV
MSMEG_3008|M.smegmatis_MC2_155 ----------------MSTRRNEARIEDIRAQFLTASEPGRAVPAD----
. :
MMAR_4913|M.marinum_M VADSWRRSLATGVDPDRGGGQIAQLSDTVERLRSAHPLAPVLPLIRRLLI
MUL_0493|M.ulcerans_Agy99 VADSWRRSLATGVDPDRGGGQIAQLSDTVERLRSAHPLAPVLPLIRRLLI
MAB_2793c|M.abscessus_ATCC_199 VTDSWQRSLATGVDPDRGPGEAAAATQLTE-LRNSHPLARALPVIRRLLV
Mflv_0123|M.gilvum_PYR-GCK IGDSWRRIMASGIEPDE-HAEPVVETGALEMLRRSSGLMEVLDDISHGLG
Mvan_4895|M.vanbaalenii_PYR-1 VVASWERSQAAGVDIAHPNAQFTDEIDAASLLVRC-----ARPVLQQLQI
MSMEG_3008|M.smegmatis_MC2_155 LLESWVRSKAALGTPAN----VRDVPQVDEDLLDNHLVEMFQAPMARVAE
: ** * *: . . * : :
MMAR_4913|M.marinum_M DDAADSGVIVAVTSADGTLLWVDGDRRACRKAESMDFVPGADWSERGAGT
MUL_0493|M.ulcerans_Agy99 DDAADSGVIVAVTSADGTLLWVDGDRRACRKAESMDFVPGADWSERGAGT
MAB_2793c|M.abscessus_ATCC_199 DHAADSGALVGVTAADGALLWVEGDSGAGRKAAAMNFVPGADWSERAVGT
Mflv_0123|M.gilvum_PYR-GCK PLVADGENILVVADAKGRVLWRSGSPSVLMNADRLGFVEGANWGERAVGT
Mvan_4895|M.vanbaalenii_PYR-1 DTADMPLVIALTDKKARVVQRIDSSSAVARLLDRVDLAPGFSYAESTMGT
MSMEG_3008|M.smegmatis_MC2_155 DLGGSGMGLLLADAEGRILQRWSQDASAMSHLDRLGTVRGAVLAEDTVGT
: . : . . . :. . * .* **
MMAR_4913|M.marinum_M NAPGTALALDRELQIRGSEHFSRLVQPWNCTAVPVHDPSTGVLIGAIDLT
MUL_0493|M.ulcerans_Agy99 NAPGTALALDRELQIRGSEHFSRLVQPWNCTAVPVHDPSTGVLIGAIDLT
MAB_2793c|M.abscessus_ATCC_199 NAPGTALALDREVQIRGSEHFCRLVRPWSCTAVPIHDPLSGTPLGSLDLT
Mflv_0123|M.gilvum_PYR-GCK NAIGTALVSQRAVQVFSAEHFLRSHHSWTCAGAPIRDPRTGQVIGVVDVS
Mvan_4895|M.vanbaalenii_PYR-1 NGIGTVFEAGQPISVVGPEHFSENLHLFACTGAPVIDPVTGRVEGVLDIS
MSMEG_3008|M.smegmatis_MC2_155 NGVGTVIAAGKSVQIAGAEHFADIYRTAVCTGAPVWHPLSGKLLAVVTVS
*. **.: : :.: ..*** : *:..*: .* :* . : ::
MMAR_4913|M.marinum_M GGESVASPQTLALLRATGVAVESQLALLRSGAVQ----------PQPSRQ
MUL_0493|M.ulcerans_Agy99 GGESVASPQTLALLRATGVAVESQLALLRSGAVQ----------PQPSRQ
MAB_2793c|M.abscessus_ATCC_199 GGVDIASPQTLALVRATAVAVEHFIALDYPGRVQ----------VDADTG
Mflv_0123|M.gilvum_PYR-GCK GPAATVHPTTVALVDAVARLAESHLRVEHDRTLNR---------LRALTA
Mvan_4895|M.vanbaalenii_PYR-1 TLSSSWSPLMHTLVKSAAKDIGRNFLLDRGQAQRAIFETYLKVTARSDRQ
MSMEG_3008|M.smegmatis_MC2_155 TMLSERSGLLVPLTNSVAAQLEQHVLDVAQPGARAMLAAFLESSARHAGP
.* :.. . .
MMAR_4913|M.marinum_M AQLSVLGAQRPSWRVA-GMGPTMLAGRHADILVLLDRHPEGLSADHLAVL
MUL_0493|M.ulcerans_Agy99 AQLSVLGAQRPSWRVA-GMGPTMLAGRHADILVLLDRHPEGLSADHLAVL
MAB_2793c|M.abscessus_ATCC_199 PRLTLLGVGRPVLHTADGERTHRLSGRHAEILALLLRHPEGLSADHLAML
Mflv_0123|M.gilvum_PYR-GCK PILARMGSPALVVDTDGWVAAVDAMPLHHRILLPERLGPGRVRLATLGMC
Mvan_4895|M.vanbaalenii_PYR-1 AVFAFGESVFVANSAAQQMFDADEQRIMREHAMFLMAGKDRVSDTIALPG
MSMEG_3008|M.smegmatis_MC2_155 VVAFGPDGLTMRSRRAGELTQTDVDTINHLCAGLRRDVQVTAELSVGPTV
MMAR_4913|M.marinum_M LDDRELD-VVTIRAEMSRLRRVVGEQLIASRPYRLTEPIAT-DVGDVFDA
MUL_0493|M.ulcerans_Agy99 LDDRELD-VVTARAEMSRLRRVVGEHLIASRPYRLTEPIAT-DVGDVFDA
MAB_2793c|M.abscessus_ATCC_199 LDENDLD-VVTIRAEMSRLRRIVGGELIGSRPYRLLKKVRS-DMADVFSA
Mflv_0123|M.gilvum_PYR-GCK AVEPLPG-GWLVRPAGGED----GEDADEAQPSRATLDVSDPDRPSLVMV
Mvan_4895|M.vanbaalenii_PYR-1 QRLVHVR-GTRILAGVAVAGMVVIADLVTSSQPGTPDDFSEQQLPQVAIA
MSMEG_3008|M.smegmatis_MC2_155 IDVAALDGGAGVVAALRPAPRSSAAHSIASSSALVGQSKSWRAVAHRVSR
. . :
MMAR_4913|M.marinum_M V---------------------------RRGDLAEALRHYAGALLPQSVS
MUL_0493|M.ulcerans_Agy99 V---------------------------RRGDLAEALRHYAGALLPQSVS
MAB_2793c|M.abscessus_ATCC_199 L---------------------------RAGEIANAMDHYHGELLPRSAA
Mflv_0123|M.gilvum_PYR-GCK G---------------------------RSGSWRHDLSLRHAEILVALAL
Mvan_4895|M.vanbaalenii_PYR-1 TPQTSQIVGGLWRSRDSLAGGSTPAWIRACGDLRQALEQVQPALVVGEQG
MSMEG_3008|M.smegmatis_MC2_155 HIATREP-------------------ILVAGELGTGKTSLALGRPFSAGA
*.
MMAR_4913|M.marinum_M PGVARVRTELSNTLRA----------------------------------
MUL_0493|M.ulcerans_Agy99 PGIARVRTELSNTLRA----------------------------------
MAB_2793c|M.abscessus_ATCC_199 PAVARLRLELSTSLRG----------------------------------
Mflv_0123|M.gilvum_PYR-GCK SPQGRSAPQLAEDLYGDR--------------------------------
Mvan_4895|M.vanbaalenii_PYR-1 AGKFTLVAELFHSVYPGGRAISVDAGQLESGCAPSDLGSLLGDSAEPTLH
MSMEG_3008|M.smegmatis_MC2_155 ADTATIVHGAERQIVGDQTWLQRVADAVEAGPVVIRGAEHVDGHVLAAVR
. :
MMAR_4913|M.marinum_M --------------------------------------------------
MUL_0493|M.ulcerans_Agy99 --------------------------------------------------
MAB_2793c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0123|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4895|M.vanbaalenii_PYR-1 IIRDIDQASTDGVERLEAYLAAVAEVTGPVWVVATGSDSAASADLPFREL
MSMEG_3008|M.smegmatis_MC2_155 TLIDGQRGTTPIVLTMTAALRAEAESAAGRFG------------------
MMAR_4913|M.marinum_M ------------------------------------AVVASNDADLLANW
MUL_0493|M.ulcerans_Agy99 ------------------------------------AVVASNDADLLANW
MAB_2793c|M.abscessus_ATCC_199 ------------------------------------AVLASGDLHLLRRW
Mflv_0123|M.gilvum_PYR-GCK ---------------------------------SKVVTVRAEMSRLRKQF
Mvan_4895|M.vanbaalenii_PYR-1 LHHFEVSITIPPLRCRTDDLPTLTAALLRGIAPERKVRLSPEAQRVIARY
MSMEG_3008|M.smegmatis_MC2_155 ----VPMVWVPPLRERVSDIGVLWNSFVAQCSPGARLPLADAARQALEAA
:
MMAR_4913|M.marinum_M LRLPEARDDRQGWRMLYDRSPAGSPRRAQAQGHLAGLDFDLA--------
MUL_0493|M.ulcerans_Agy99 LRLPEAHDDRQGWRMLYDRSPAGSPRRAQAQGHLAGLDFDLA--------
MAB_2793c|M.abscessus_ATCC_199 LDLPEARDNREGWQGLHDHPGAGAVARSEARGHLIALDSDLA--------
Mflv_0123|M.gilvum_PYR-GCK AGILATQPYRFAGAIELSVRYPADRRMVLPPSNAPVIRAARENG------
Mvan_4895|M.vanbaalenii_PYR-1 SWPRNISQLREALVHALRRRPVGEIQESDLPGYCQTASRHALTPLEAAER
MSMEG_3008|M.smegmatis_MC2_155 GWPGNLSDLRGAVDTVLASGKRGTVQVDDLPDTLRSRRTWTLMER--TEI
* . . .
MMAR_4913|M.marinum_M ---------------------------------------
MUL_0493|M.ulcerans_Agy99 ---------------------------------------
MAB_2793c|M.abscessus_ATCC_199 ---------------------------------------
Mflv_0123|M.gilvum_PYR-GCK ---------------------------------------
Mvan_4895|M.vanbaalenii_PYR-1 DAIVAALRDTAGNRVAAAAHLGMSRSSLYRKIKTYGIVA
MSMEG_3008|M.smegmatis_MC2_155 EAIRRALQEADGNRSKAAELLGVSRATIHRKMKTYHLSG