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MHSIDYQESLREVATPAGVLRYHEAGDGPPLLLLHGSGPGVTGWRNYRGNLAVFAQHFRCLVLEFPGFGV SDDFGGHPMLDAQSSVVAFADALGLDRVDIIGNSMGGGVGINFAVNHSHRVGKLVTIGGIGVNIFSPGPS EGIRLLQEFTEDPTRQRLVDWLNSMVYDPALVTEQLIEERWELATDPETLAAARRMYGKAAFAAMMEMMR DADFPLPWATMHKVKAPTLLTWGRDDRVSPLDMALVPMRTIPNAEFHVFPNCGHWVMIEAKAAFERTVLS FLTESSAAAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4525 | - | - | 100% (290) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_1464 | - | 2e-61 | 41.85% (270) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_0627 | - | 6e-21 | 24.44% (270) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3600c | bphD | 4e-61 | 42.75% (269) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. tuberculosis H37Rv | Rv3569c | bphD | 4e-61 | 42.75% (269) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3810 | - | 1e-110 | 65.25% (282) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_5064 | bphD | 8e-62 | 43.87% (269) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. avium 104 | MAV_3016 | - | 1e-122 | 73.94% (284) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase |
| M. smegmatis MC2 155 | MSMEG_2900 | - | 1e-152 | 88.81% (286) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase |
| M. thermoresistible (build 8) | TH_3363 | - | 1e-146 | 84.51% (284) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_4140 | bphD | 1e-61 | 43.87% (269) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. vanbaalenii PYR-1 | Mvan_2898 | - | 1e-151 | 87.02% (285) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4525|M.gilvum_PYR-GCK -------MHSIDYQESLREVATPAG---VLRYHEAG---DGPP----LLL
MSMEG_2900|M.smegmatis_MC2_155 -------MQAIDYQDSLREVTTDAG---VLRFHEAG---DGPP----LLL
Mvan_2898|M.vanbaalenii_PYR-1 ---MWNHWMTVDYHETLREVSTPSG---VLRYHEAG---DGPA----LLL
TH_3363|M.thermoresistible__bu -------MRTFDYQETLREVRTPAG---VLRYHEAG---DGPP----LLL
MAV_3016|M.avium_104 --MADTPGRTGITEQDLREISTEKG---ALRYYDTGGDTGGPDSAAVLLF
MAB_3810|M.abscessus_ATCC_1997 --------MDVTYEGTKRELATDEG---TLRYHEAGTAGEGEP----LIL
Mb3600c|M.bovis_AF2122/97 ----MTATEELTFESTSRFAEVDVDGPLKLHYHEAG---VGNDQ--TVVL
Rv3569c|M.tuberculosis_H37Rv ----MTATEELTFESTSRFAEVDVDGPLKLHYHEAG---VGNDQ--TVVL
MMAR_5064|M.marinum_M MTVTQSKTAEHTFESTSRYAEVDVDGPLKLHYHEAG---VGNDQ--TVVL
MUL_4140|M.ulcerans_Agy99 MTVTQSKTAEHTFESTSRYAEVDVDGPLKLHYHEAG---VGNDQ--TVVL
. * . . *:::::* * :::
Mflv_4525|M.gilvum_PYR-GCK LHGSGPGVTGWRNYRGNLAVFAQHFRCLVLEFPGFGVSDDFGGHPMLD--
MSMEG_2900|M.smegmatis_MC2_155 LHGSGPGVTGWRNYRGNLGFFAQHFRCLVLEFPGFGVSDDFGGHPMLD--
Mvan_2898|M.vanbaalenii_PYR-1 LHGSGPGVTGWRNYRGNLDVFARHFRCLVLEFPGFGVSDDFGGHPMLD--
TH_3363|M.thermoresistible__bu LHGSGPGVTGWRNFRGNLGVFAEHFRCLVLEFPGFGVSDDFGGHPMID--
MAV_3016|M.avium_104 LHGSGPGVTGWRNFRGILPAFAAHYRCLVLEFPGFGVSDDFGGHPMVT--
MAB_3810|M.abscessus_ATCC_1997 LHGSGPGVTGWRNYRGNLGVFAKHFHTYVLEFPGFGVSDAVPGHPVLT--
Mb3600c|M.bovis_AF2122/97 LHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFNRY
Rv3569c|M.tuberculosis_H37Rv LHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFNRY
MMAR_5064|M.marinum_M LHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDKRAEHGQFNHY
MUL_4140|M.ulcerans_Agy99 LHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDKRAEHGQFNHY
***.***.:.* *: : :* ::: .:: **:* ** * .
Mflv_4525|M.gilvum_PYR-GCK AQSSVVAFADALGLDRVDIIGNSMGGGVGINFAVNHSHRVGKLVTIG--G
MSMEG_2900|M.smegmatis_MC2_155 AQRAAVVFADALGLDRVDIIGNSMGGGVGINFAINHPDRVRHLVTIG--G
Mvan_2898|M.vanbaalenii_PYR-1 AQGAVVKFVDALGLDRVDVVGNSMGGGVGINFAINHRDRIGRLVTIG--G
TH_3363|M.thermoresistible__bu AQGAALAFADALGLDRVDIIGNSMGGGVGVSLAVRHPDRVNRLVTIG--G
MAV_3016|M.avium_104 AFGTVAPFLDALGVEKVHIIGNSMGGGVGINFATHNPDRVGRLVTIG--G
MAB_3810|M.abscessus_ATCC_1997 AGASVIRFMDGLGISSAAVVGNSMGGVVGINLAIKHPDRITKLVTIG--G
Mb3600c|M.bovis_AF2122/97 AAMALKGLFDQLGLGRVPLVGNSLGGGTAVRFALDYPARAGRLVLMGPGG
Rv3569c|M.tuberculosis_H37Rv AAMALKGLFDQLGLGRVPLVGNSLGGGTAVRFALDYPARAGRLVLMGPGG
MMAR_5064|M.marinum_M AARALKELFDQLGLGRVPLVGNSLGGGTAVRFALDYPDRAGRLVLMGPGG
MUL_4140|M.ulcerans_Agy99 AARALKELFDQLGLGRVLLVGNSLGGGTAVRFALDYPDRAGRLVLMGPGG
* : : * **: . ::***:** ..: :* * :** :* *
Mflv_4525|M.gilvum_PYR-GCK IGVNIFSPGPSEGIRLLQEFTEDPTRQRLVDWLNSMVYDPALVTEQLIEE
MSMEG_2900|M.smegmatis_MC2_155 IGTNIFSPGPSEGIRLLQEFTEDPTRARLVDWLNSMVYDPALVTDELIEE
Mvan_2898|M.vanbaalenii_PYR-1 IGTNLFSPGPSEGIRLLQEFTEEPTRQRLVDWLRSMVYDPALVTEELIEE
TH_3363|M.thermoresistible__bu IGTNIFSPGPSEGIRLLQEFTDDPTRDRLIAWLNSMVYDPTLITEELIEE
MAV_3016|M.avium_104 IGTNIFSPSPSEGIRLLQEFVEDPTRQRLVDWLKSMVYDQALITEQLIEE
MAB_3810|M.abscessus_ATCC_1997 VGPNIFSPSPSEGLRLLQEFTDNPDRDKLIRWLNSMVWDPAVVTDELIEE
Mb3600c|M.bovis_AF2122/97 LSINLFAPDPTEGVKRLSKFSVAPTRENLEAFLRVMVYDKNLITPELVDQ
Rv3569c|M.tuberculosis_H37Rv LSINLFAPDPTEGVKRLSKFSVAPTRENLEAFLRVMVYDKNLITPELVDQ
MMAR_5064|M.marinum_M LSINLFAPDPTEGVKRLGKFSVAPTRENLEAFLRVMVYDQKLITPELVDQ
MUL_4140|M.ulcerans_Agy99 LSINLFAPDPTEGVKRLGKFSVAPTRENLEAFLRVMVYDQKLITPELVDQ
:. *:*:*.*:**:: * :* * * .* :*. **:* ::* :*:::
Mflv_4525|M.gilvum_PYR-GCK RWELATDPETLAAARRMYGKAAFAAMMEMMRDADFPLPWATMHKVKAPTL
MSMEG_2900|M.smegmatis_MC2_155 RWALATDPETLESARRMYGKAAFAAMMEMMRNADFPLPWSIMHKVKAPTL
Mvan_2898|M.vanbaalenii_PYR-1 RWQLATDPETLAAARRMYGKAAFAAMMEMMRKADVPMPWATMHKIAAPTL
TH_3363|M.thermoresistible__bu RWAAATDPATLAAARRMYSKAAFAAMMAMMRDSDTPPPWATMHKVQAPTL
MAV_3016|M.avium_104 RWALATDPDTLAAARRMYGKAAFSAMNAALNASDRPLPWAVMHKLTAPTL
MAB_3810|M.abscessus_ATCC_1997 RWEAAINPDAHKTAQLMYGSKAFAMQQQFLANADIPPYWAMMHKIKCPTL
Mb3600c|M.bovis_AF2122/97 RFALASTPESLTATRAMG--KSFAGADFEAG-----MMWREVYRLRQPVL
Rv3569c|M.tuberculosis_H37Rv RFALASTPESLTATRAMG--KSFAGADFEAG-----MMWREVYRLRQPVL
MMAR_5064|M.marinum_M RFELARTPESLAATRAMG--KSFAAADFELG-----MMWREVYKLRQPVL
MUL_4140|M.ulcerans_Agy99 RFELARTPESLAATRAMG--KSFAAADFELG-----MMWREVYKLRQPVL
*: * * : ::: * :*: * :::: *.*
Mflv_4525|M.gilvum_PYR-GCK LTWGRDDRVSPLDMALVPMRTIPNAEFHVFPNCGHWVMIEAKAAFERTVL
MSMEG_2900|M.smegmatis_MC2_155 LTWGRDDRVSPLDMALVPMRTIPNAELHVFPNCGHWVMIEAKSAFERTVL
Mvan_2898|M.vanbaalenii_PYR-1 LTWGRDDRVSPLDMALVPMRTIPDAELHVFPNCGHWVMIEAKAAFERTVL
TH_3363|M.thermoresistible__bu LTWGRDDRVSPLDMALLPMRTIPGAELHVFPNCGHWVMIEAKSAFERTVL
MAV_3016|M.avium_104 LTWGRDDRVSPPDMALIPMRTIPNAELHIFPNSGHWAMIEAKAAFESTVL
MAB_3810|M.abscessus_ATCC_1997 LTWGRDDRVSPPDMAIVPMRLIPNAELHIFPNSGHWVMIEAKQAFEQTVV
Mb3600c|M.bovis_AF2122/97 LIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFNKLTI
Rv3569c|M.tuberculosis_H37Rv LIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFNKLTI
MMAR_5064|M.marinum_M LIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWAQVEKFDEFNRLTI
MUL_4140|M.ulcerans_Agy99 LIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWAQVEKFDEFNRLTI
* ***:***.* * *::.:: ** *::*:* :.***. :* *: .:
Mflv_4525|M.gilvum_PYR-GCK SFLTESSAAAR
MSMEG_2900|M.smegmatis_MC2_155 SFLTQDN----
Mvan_2898|M.vanbaalenii_PYR-1 AFLTQRDA---
TH_3363|M.thermoresistible__bu AFLTDPARG--
MAV_3016|M.avium_104 AFLSRG-----
MAB_3810|M.abscessus_ATCC_1997 DFLRR------
Mb3600c|M.bovis_AF2122/97 EFLGGGR----
Rv3569c|M.tuberculosis_H37Rv EFLGGGR----
MMAR_5064|M.marinum_M DFLGGAR----
MUL_4140|M.ulcerans_Agy99 DFLGGAR----
**