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RRPTEASGSPRTHTTKPSGTGGVFGWLGDVVVRWPWLVIGCWIALAVALPPMFPTLAEATQKHPVAPIPA SAPSMVATQQMTAAFHEAGSENVLLVLLTDEHGLGPDDEQVYRTVVGRLRQDGRDVLWLQEFLGTPQLRE TLSSQDRKAWLLPIGLSGDVGSPESYAAYTRVAGIVDHAVAGSTLTAHLTGPAATLADSIEVGLRDQIKI EIAIVALLLTILVIVYRKPATILLPVLMIGVSLGVAQAVVAGAAQLGLGVSNQTITLLSGLMAGAGTDYA VFLISRYHDFLRLGADSDQAVKSALSSIGKVIAASAATVGVTFLGMTFASLELFATIGPALAIAIGVAFL AAVTLLPAIIVLAGRRGWVSPRREITARFWRRSGIRIVRRPVTNLVASLMVLLVRDPPRRVWRVLPLGRM GTWDRSHRGGIQTS*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_2677 | - | - | 100% (435) | large membrane protein |
M. smegmatis MC2 155 | MSMEG_0410 | - | e-121 | 57.74% (381) | MmpL protein |
M. smegmatis MC2 155 | MSMEG_4741 | - | e-102 | 49.08% (381) | MmpL protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3853c | mmpL8 | 1e-134 | 58.56% (403) | integral membrane transport protein |
M. gilvum PYR-GCK | Mflv_0403 | - | 1e-127 | 59.42% (382) | transport protein |
M. tuberculosis H37Rv | Rv3823c | mmpL8 | 1e-133 | 58.31% (403) | integral membrane transport protein |
M. leprae Br4923 | MLBr_01231 | mmpL10 | 1e-125 | 60.90% (376) | hypothetical protein MLBr_01231 |
M. abscessus ATCC 19977 | MAB_0937c | - | 1e-128 | 57.82% (377) | MmpL family protein |
M. marinum M | MMAR_2342 | - | 1e-100 | 48.88% (403) | MmpL family transport protein |
M. avium 104 | MAV_1761 | - | 1e-132 | 60.55% (398) | MmpL10 protein |
M. thermoresistible (build 8) | TH_2203 | mmpL8 | 1e-121 | 56.01% (391) | PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN |
M. ulcerans Agy99 | MUL_3688 | mmpL4_1 | 4e-43 | 28.38% (370) | transmembrane transport protein MmpL4_1 |
M. vanbaalenii PYR-1 | Mvan_0271 | - | 1e-125 | 59.10% (379) | transport protein |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_2342|M.marinum_M ----------------------MSDSEAARAGGFFDKLSRFVIQKPFVVI TH_2203|M.thermoresistible__bu ----------------------MGGTETPTGRGFFGRLGDFVIRFPLIVI Mflv_0403|M.gilvum_PYR-GCK ----------------------------------MRRLADVVVRWPWAVI Mvan_0271|M.vanbaalenii_PYR-1 ----------------------------------MRRLADLVVRWPWAVI MAB_0937c|M.abscessus_ATCC_199 ----------------------------------MRRLADLVVRWPWVVI MAV_1761|M.avium_104 ----------------------MSPTAPAGDEVEMRRIADFVVRWPWLVI MSMEG_2677|M.smegmatis_MC2_155 ----------MRRPTEASGSPRTHTTKPSGTGGVFGWLGDVVVRWPWLVI Mb3853c|M.bovis_AF2122/97 ---MCDVLMQPVRTPRPSTNLRSKPLRPTGDGGVFPRLGRLIVRRPWVVI Rv3823c|M.tuberculosis_H37Rv ---MCDVLMQPVRTPRPSTNLRSKPLRPTGDGGVFPRLGRLIVRRPWVVI MLBr_01231|M.leprae_Br4923 -----------------------------------------------MVI MUL_3688|M.ulcerans_Agy99 MSESNSGASISTEDTGPIEIGAATGGAPNRERGHRPVIPHTIRILAVPII :* MMAR_2342|M.marinum_M AIWISLAAIPALMFPPLMEAAAGKNNSAALPDDAPTMVASKEMAKTFEGK TH_2203|M.thermoresistible__bu GLWVGLAVVLVATVPPLAEVAAR-NPVSVLPEDAPVMVTSREMSEAFD-- Mflv_0403|M.gilvum_PYR-GCK GVWIALAVALPLSFPSLGQMAAK-NPLQILPADAPSSVTAQKMAEAFD-- Mvan_0271|M.vanbaalenii_PYR-1 AVWVAMAVALPLSFPSLGEMAQK-HPLVILPSDAPSSVTAAKMAEAFQ-- MAB_0937c|M.abscessus_ATCC_199 GAWVALAIALPLTFPSLTEMAEK-HPLAILPADAPSSVTAKKMTEAFH-- MAV_1761|M.avium_104 GFWAALAVALPLAFPSLAEMAQK-HPLAILPGNAPSNVAARQMTEAFH-- MSMEG_2677|M.smegmatis_MC2_155 GCWIALAVALPPMFPTLAEATQK-HPVAPIPASAPSMVATQQMTAAFH-- Mb3853c|M.bovis_AF2122/97 AFWVALAGLLAPTVPSLDAISQR-HPVAILPSDAPVLVSTRQMTAAFR-- Rv3823c|M.tuberculosis_H37Rv AFWVALAGLLAPTVPSLDAISQR-HPVAILPSDAPVLVSTRQMTAAFR-- MLBr_01231|M.leprae_Br4923 GCWTLLALMLPMTVPSLTELTQR-HPVVILPVDAPSSVAAKKISQAFH-- MUL_3688|M.ulcerans_Agy99 LGWVLLTVLVNVVVPSLEVVSEQ-HSAPMTPMDAPSMKAMMRLGHNFR-- * :: .*.* : : * .** : .: * MMAR_2342|M.marinum_M SNKKDAKAKPGSKPKEDPSDGSQLLVILTDENGLGPGDLAAYTKLVEKLR TH_2203|M.thermoresistible__bu ----------------DSGGDNLLLVVMTDEEGLGPEDEKAYQKLVAALR Mflv_0403|M.gilvum_PYR-GCK ----------------EPGSDNLLVVAFINESGLVPEDELTYRNVVDALR Mvan_0271|M.vanbaalenii_PYR-1 ----------------ETSNDNLLLVAFINETGLEPADEATYRKVVDALR MAB_0937c|M.abscessus_ATCC_199 ----------------ESSNDDLLLVVFINENGLGKDDADSYRKVVDALR MAV_1761|M.avium_104 ----------------ESGSDDLLLVALTDEKGLGPADEAVYRRLVDALR MSMEG_2677|M.smegmatis_MC2_155 ----------------EAGSENVLLVLLTDEHGLGPDDEQVYRTVVGRLR Mb3853c|M.bovis_AF2122/97 ----------------EAGLQSVAVVVLSDAKGLGAADERSYKELVDALR Rv3823c|M.tuberculosis_H37Rv ----------------EAGLQSVAVVVLSDAKGLGAADERSYKELVDALR MLBr_01231|M.leprae_Br4923 ----------------EVDSENVLIVLLTDDKGLGPADETVYRTLVDRLR MUL_3688|M.ulcerans_Agy99 ----------------EFDSNSTVMIVLEGQHKLGDDAHQYYDSLIRQLR : . . :: : . * * :: ** MMAR_2342|M.marinum_M AEKYS----VQDFISNPPLREVLASKDNKAWNLPVMFKTSQDDPATQSAY TH_2203|M.thermoresistible__bu AEPNGDIMMMQDFITTPQLREVVASEDGKAWYLPINLAGAWSTPEGGGAF Mflv_0403|M.gilvum_PYR-GCK DDVAD-VVSVQDFLGTPQLRQFLTSEDKTTWVLPVSLVGELGTPRAYESF Mvan_0271|M.vanbaalenii_PYR-1 DDVTD-VVSVQDFVSTPQLRQFLTSEDKTTWVLPVSLEGELGTPRAFDSF MAB_0937c|M.abscessus_ATCC_199 HDLTN-VVSVQDFIGTPELRKFLTSQDNKTWVLPVGLAGELGTPKAFESY MAV_1761|M.avium_104 RDTRD-VVMVQDFISAPPLRSAVTSKDRKAWVLPVGIAGELGTPQSYAAF MSMEG_2677|M.smegmatis_MC2_155 QDGRD-VLWLQEFLGTPQLRETLSSQDRKAWLLPIGLSGDVGSPESYAAY Mb3853c|M.bovis_AF2122/97 RDTRD-VVMLQDFVTTPPLRELMTSKDNQAWILPVGLPGDLGSTQSKQAY Rv3823c|M.tuberculosis_H37Rv RDTRD-VVMLQDFVTTPPLRELMTSKDNQAWILPVGLPGDLGSTQSKQAY MLBr_01231|M.leprae_Br4923 NDTKD-VVVLQDFLSTPPLHELLVSKDGKAWILPIVLAGELGTSASYQAY MUL_3688|M.ulcerans_Agy99 QDPEH-IQHIQDFWGDRLTAAGAQSADGKSAYVMVNLAGNQGTTLANESV : :*:* * * : : : : . . : MMAR_2342|M.marinum_M KKIKELVKE---ALAGS-------TLTAHYAGAVATVADLVTIGQEDTHI TH_2203|M.thermoresistible__bu TRVAEIVRE---ATADA-------PMTVHLTGPAATIADVTAVGQRDIHV Mflv_0403|M.gilvum_PYR-GCK NRVADVIRH---EVPDAGTG--GSSLTVHVTGPAATVADLTVAGEQDRLP Mvan_0271|M.vanbaalenii_PYR-1 NRVSDVVKH---HLGDG-------PLQVYLTGPAATVADLTVAGEQDRLP MAB_0937c|M.abscessus_ATCC_199 NRVTSLIQH---SIDGS-------PTTVHITGPAATVADLTVAGQQDRLP MAV_1761|M.avium_104 NRIAGIVKQ---TLEKHENGPAATSLTVSLTGPAATVADLTVAGERDRLP MSMEG_2677|M.smegmatis_MC2_155 TRVAGIVDH---AVAGS-------TLTAHLTGPAATLADSIEVGLRDQIK Mb3853c|M.bovis_AF2122/97 ARVADIVEH---QVAGS-------TLTANLTGPAATVADLNLTGQRDRSR Rv3823c|M.tuberculosis_H37Rv ARVADIVEH---QVAGS-------TLTANLTGPAATVADLNLTGQRDRSR MLBr_01231|M.leprae_Br4923 AGVAGIVKQTLESTAGS-------SLKANLTGPASTVADLTDAGARDRTS MUL_3688|M.ulcerans_Agy99 EAVRDVINR---THEPAG-------VKAYVTGPAALSDDMHLIGNASLAT : :: . . :*..: * * . MMAR_2342|M.marinum_M IEIGTAVSVLVILLMVYRNIVTMLVPLATIGLSLATAQGVLSGLSKI-GL TH_2203|M.thermoresistible__bu IEIATVVMVLTILLIVYRNVVTMLMPLVTIGVAFVTAQGLVGALAPL-GL Mflv_0403|M.gilvum_PYR-GCK IEIAIAVLVLGVLLLVYRNPVTMLLPLLTIGASVLIAQGVVAGYSELTGA Mvan_0271|M.vanbaalenii_PYR-1 IEIAIAVLVLGVLLLVYRSAVTMLLPLVTIGSSLVIAQAVVAGYSQLSGS MAB_0937c|M.abscessus_ATCC_199 IEIAIAVLVLAVLLLVYRSALTMMLPLVTIGSSLVIAQSVVAAYSQLTGA MAV_1761|M.avium_104 IELAIAVLVLVVLLVVYRSAVTMLLPLVTILLSLVIAQAAVAGYSQLTGS MSMEG_2677|M.smegmatis_MC2_155 IEIAIVALLLTILVIVYRKPATILLPVLMIGVSLGVAQAVVAGAAQL-GL Mb3853c|M.bovis_AF2122/97 IEFAITILLLVILLIIYRNPITMVLPLITIGMSVVVAQRLVA-IAGLAGL Rv3823c|M.tuberculosis_H37Rv IEFAITILLLVILLIIYGNPITMVLPLITIGMSVVVAQRLVA-IAGLAGL MLBr_01231|M.leprae_Br4923 IELVIAVLLLTILMIIYRNPITMLLPLITIGASLMTAQAVVSGVSVLAGL MUL_3688|M.ulcerans_Agy99 ITMFTLGAIAVMLLLVYRSIVTTVIQLFMTGIALASSRGVVAVLGYHNVF * : : :*:::* . * :: : :. :: :. . MMAR_2342|M.marinum_M DVQMQTIVFMTAVMIGAGTDYAVFLISRYHDYVRKGQDSDL----AVKNA TH_2203|M.thermoresistible__bu GVSDQTIVLMTGIMVGAGVDYAVFLISRYHDFVRRGVEHRA----AIRQA Mflv_0403|M.gilvum_PYR-GCK GVSNQSIVFLSAILAGAGTDYAVFLISRYHDYLRRGAEAGE----AVRAA Mvan_0271|M.vanbaalenii_PYR-1 GVSNQSIVFLSAIMAGAGTDYAVFLISRYHDYLRSGADFDD----AVRAA MAB_0937c|M.abscessus_ATCC_199 GVSNQSIVFLSAILAGAGTDYAVFLISRYHDYLRSGKNYDQ----AVRAA MAV_1761|M.avium_104 GVSNQSIVFLSAIMAGAGTDYAVFLISRYHDFLRRGDDFDQ----AVRKA MSMEG_2677|M.smegmatis_MC2_155 GVSNQTITLLSGLMAGAGTDYAVFLISRYHDFLRLGADSDQ----AVKSA Mb3853c|M.bovis_AF2122/97 GIANQSIIFMSGMMVGAGTDYAVFLISRYHDYLRQGADSDQ----AVKKA Rv3823c|M.tuberculosis_H37Rv GIANQSIIFMSGMMVGAGTDYAVFLISRYHDYLRQGADSDQ----AVKKA MLBr_01231|M.leprae_Br4923 AVSNQMIVLLSAMIAGAGTDYAVFLISRYHDYIRMGSGSAQDAGCAVRQA MUL_3688|M.ulcerans_Agy99 GLTTFAANILTMLAIAAGTDYGIFLVGRYQEARQAGEDRQD----AYYTT : ::: : .**.**.:**:.**:: : * * : MMAR_2342|M.marinum_M MMSIGKVIAASAATVAVTFLAMVFSKLAIFASIGPAISISIIIAFVAAIT TH_2203|M.thermoresistible__bu MGSIGKVIGASAATVAVTFFAMVFTTLSVFQTVGPAMALAIFVCFLAAVT Mflv_0403|M.gilvum_PYR-GCK MASIGKVITASASTVGITFLAMSFAEMGVFRTIGVSAAIGIGVAYLAGVT Mvan_0271|M.vanbaalenii_PYR-1 MISIGKVITASAATVGVTFLVMSFAQMGVFRTIGVSSAIGIGVAFLAGMT MAB_0937c|M.abscessus_ATCC_199 MMSIGKVITASATTVGITFLLLSFAKMGVFQTVGVSSAIGIGVAYLSGMT MAV_1761|M.avium_104 LISIGKVITASASTVGITFLLIGFARMGVFKTVGISSAIGIGVAFLAAVT MSMEG_2677|M.smegmatis_MC2_155 LSSIGKVIAASAATVGVTFLGMTFASLELFATIGPALAIAIGVAFLAAVT Mb3853c|M.bovis_AF2122/97 LTSIGKVIAASAATVAITFLGMVFTQLGILKTVGPMLGISVAVVFFAAVT Rv3823c|M.tuberculosis_H37Rv LTSIGKVIAASAATVAITFLGMVFTQLGILKTVGPMLGISVAVVFFAAVT MLBr_01231|M.leprae_Br4923 LISLGKVIAASAATVGITFLGMSFTKIRVFSTVGPALAIGIAVAFLAAVT MUL_3688|M.ulcerans_Agy99 FRGVAPVVLGSGLTIAGATYCLSFARLPWFNTMGAPVAIGMLVVVLAGLT : .:. *: .*. *:. : : *: : : ::* .:.: : .:.:* MMAR_2342|M.marinum_M LLPSILVLIGRRGWIKPRRDL-THRFWRILGTRIVRRPRVHLIGSLIVLA TH_2203|M.thermoresistible__bu FLPAMIVLAGPRGWISPRRDL-TTRFWRRSGIRIVRAPKAHLAVSLIILL Mflv_0403|M.gilvum_PYR-GCK LLPAILVLAGPRGWIKPRREL-TAQFWRRSGIRIVRRPVPHLVASALVLA Mvan_0271|M.vanbaalenii_PYR-1 LLPAILVLAGPRGWVKPRREL-TARFWRRSGIRIVRRPVPHLVASVLVLI MAB_0937c|M.abscessus_ATCC_199 LLPAILVLAGPRGWVKPRREL-TAQFWRRSGIRIVRRPIPHLVASVLVLA MAV_1761|M.avium_104 LLPAIMVLAGPRGWIRPRREL-TTGLWRRSGIRIVRRPRAHLVASVLVLI MSMEG_2677|M.smegmatis_MC2_155 LLPAIIVLAGRRGWVSPRREI-TARFWRRSGIRIVRRPVTNLVASLMVLL Mb3853c|M.bovis_AF2122/97 LLPALMVLTGRRGWIAPRRDL-TRRFWRSSGVHIVRRPKTHLLASALVLV Rv3823c|M.tuberculosis_H37Rv LLPALMVLTGRRGWIAPRRDL-TRRFWRSSGVHIVRRPKTHLLASALVLV MLBr_01231|M.leprae_Br4923 LMPALLVLAGTRGWVAPRRDR-AGAFWRRTGVRIVRRPVAYLSASMVILI MUL_3688|M.ulcerans_Agy99 LGPAVVFVGSRFHPFESKRAANRGRLWRRVGTAVVRWPAPILALSGAIVL : *:::.: . . .:* :** * :** * * * :: MMAR_2342|M.marinum_M ILASSTLLVRFNYDDLKALPEDVDSVAGYNAMDRHFPQNMMTPMMLFIKS TH_2203|M.thermoresistible__bu GLAGCALTVQFNYDDRKTLPQSVESAAGYAAMERHYPVNSNLPQYLFINS Mflv_0403|M.gilvum_PYR-GCK LLAGFAIVADFNYDDRKAVDAAAPSSVGYAALERHFPISQSIPQYILIQS Mvan_0271|M.vanbaalenii_PYR-1 LLAGCAAFATFNYDDRKAVAASAPSSVGYAALERHFPISQSIPQYILVQS MAB_0937c|M.abscessus_ATCC_199 LLGSCALLARYNYDDRKAVSPSAPSSVGYAALERHFPLSQSIPEYILIQS MAV_1761|M.avium_104 ILASCAGLVRYNYDDRKALRPSAPSSVGYAALERHFPVNQSIPEYILIRS MSMEG_2677|M.smegmatis_MC2_155 VRD----------------------------------------------P Mb3853c|M.bovis_AF2122/97 ILAGCAGLARYNYDDRKTLPASVESSIGYAALDKHFPSNLIIPEYLFIQS Rv3823c|M.tuberculosis_H37Rv ILAGCAGLARYNYDDRKTLPASVESSIGYAALDKHFPSNLIIPEYLFIQS MLBr_01231|M.leprae_Br4923 VLALCASLVRFNYDDRKQIPASDESSVGYAALESHFPVGQAIPEYLLIQS MUL_3688|M.ulcerans_Agy99 VGMVALPGFKTSYNDRYYLPASAPSNLGEAAADRHFSHARMNPDMLMVEA . MMAR_2342|M.marinum_M PHDLRSPTALADLELMVSRVSQLPNIIAIRGLTRPNGEPLEQTKVSYQAG TH_2203|M.thermoresistible__bu PRDLRSPEALADLEEMARRVSQLPEVDTVRGITRPTGEPLEQAALSYQAG Mflv_0403|M.gilvum_PYR-GCK PKDLRNPQALADLEQMASRIAQLPDVSLVSGVTRPLGEVPAEFRATFQAG Mvan_0271|M.vanbaalenii_PYR-1 PRDLRSPQALADLEQMASRIAQLPDISLVSGVTRPLGEVPREFRATFQAG MAB_0937c|M.abscessus_ATCC_199 PRDLRTPQALADLEQMASRIAQLPDVGLVSGVTRPLGEVPPEFRATYQAG MAV_1761|M.avium_104 PHDLRTPQALADLEQLADRVSQLPNVSVVSGITRPTGNVPEQFRATYQAG MSMEG_2677|M.smegmatis_MC2_155 PRRVWRVLPLG-----------------------RMGTWDRSHRGGIQTS Mb3853c|M.bovis_AF2122/97 STDLRTPKALADLEQMVQRVSQVPGVAMVRGITRPAGRSLEQARTSWQAG Rv3823c|M.tuberculosis_H37Rv STDLRTPKALADLEQMVQRVSQVPGVAMVRGITRPAGRSLEQARTSWQAG MLBr_01231|M.leprae_Br4923 PHDLRTPRALADMAELAQRVSQIPGIALVRGVTRPTGKPLEETSATYQAG MUL_3688|M.ulcerans_Agy99 EHDMRNPADMLVLDKVAKNVIRTVGIAMIQDITRPLGIPIQHSSIPFQNS : : * * . MMAR_2342|M.marinum_M EVGSKLDEASSAIEDHGGELDQLADGSNQLADALAGVRDEVTESVANAGA TH_2203|M.thermoresistible__bu EVGIRLDDASKQITDHTGDLDMLADGADQLADALGDVRGQVFQTVATTKA Mflv_0403|M.gilvum_PYR-GCK IVGDRLAAGSAQIGERSGDLTTLADGATTLADSLGDVRSQVNEIAPSLKG Mvan_0271|M.vanbaalenii_PYR-1 LVGDRLAAGSAQIGARDDDLDELTTGADTLADTLVDVRAQVNKIAPSLQT MAB_0937c|M.abscessus_ATCC_199 LVGTRLADGSNQINQRSSDLNRLTSGANTLAGSLTDLRNQLNKITPGLQS MAV_1761|M.avium_104 AIGSMLAGGSTMINDQTDDLNRLARGAGTLADNLGDVRGQVNQLAASVRE MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 EVGSKLDEGSKQIAAHTGDIDKLAGGANLMASKLGDVRAQVNRAISTVGG Rv3823c|M.tuberculosis_H37Rv EVGSKLDEGSKQIAVHTGDIDKLAGGANLMASKLGDVRAQVNRAISTVGG MLBr_01231|M.leprae_Br4923 MVGKQLGSASHLIGESTGDLNRLASGAGLLADKLGDVRIQVGQAVAGISG MUL_3688|M.ulcerans_Agy99 MQSQTMMQNMAFLKERMADMTKMADEMQVLIDTTERMYAVMRELDTTTTD MMAR_2342|M.marinum_M LVDLLVTMKKLIGGDKTLNALDQTAKLVGRMRALGDALTSNMVDVSNVVA TH_2203|M.thermoresistible__bu LVDALSTLQERFGGDRTLDDIDNAARLVSGMRELGDAIGVNVANVAGNLE Mflv_0403|M.gilvum_PYR-GCK IIDTFSSVRTEYGGDKLVRDVATAAKLVDSVNKLGLSMGINFRAVRDMFA Mvan_0271|M.vanbaalenii_PYR-1 LLDAVTRVRVEYGGDRLVRDVETAAKLVQSVNELGLSMGISFAAVRDMFG MAB_0937c|M.abscessus_ATCC_199 LLEASNSLKTKSGGDELVRNVDNAAKLVDEINALANDMGWNFSAAKDMFG MAV_1761|M.avium_104 LENAFSSTKNQYSGDALVNQVDIAARLVDHVNSLSNAMGWNFTAAKNMFA MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 LIDALAYLQDLLGGNRVLGELEGAEKLIGSMRALGDTIDADASFVANNTE Rv3823c|M.tuberculosis_H37Rv LIDALAYLQDLLGGNRVLGELEGAEKLIGSMRALGDTIDADASFVANNTE MLBr_01231|M.leprae_Br4923 LLDNLAFAQKMFGDSKTLGEIDTAGKLVSSMRALGNMFGINFSTTMNDIN MUL_3688|M.ulcerans_Agy99 MARVTAETSTITDELR--------------------------DHLAEFDD MMAR_2342|M.marinum_M WVGPIVSALNASPQCNADPACAAARSQLQALVAAQTSGSLSSITALGRTL TH_2203|M.thermoresistible__bu WAVPVLTALDTSPVCAADPRCVSAREELRQLTVAGRQGVLDRIAALGRQL Mflv_0403|M.gilvum_PYR-GCK WIGPVLTALQGNRVCDANPSCVDTRMQFEKLVSAREDGRVDEINQLAGQL Mvan_0271|M.vanbaalenii_PYR-1 WIGPVLAALHGNAVCDANPSCVNTRMQFERLMDARADGRLERINTLAGEL MAB_0937c|M.abscessus_ATCC_199 WINPVLAALQGNPICDADTSCSNTRGQFERLVGERNSGRLDEIERLAHQL MAV_1761|M.avium_104 WIGPVLAALQGNPVCDADSSCSATRATFEQLVGPRGQADLDAIDDLSHQL MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 WASPVLGALDSSPMCTADPACASARTELQRLVTARDDGTLAKISELARQL Rv3823c|M.tuberculosis_H37Rv WASPVLGALDSSPMCTADPACASARTELQRLVTARDDGTLAKISELARQL MLBr_01231|M.leprae_Br4923 WVGAVVIALDSSVLCDTNPICADARAQFHKLLTASEDGTLDNIAHLWKQL MUL_3688|M.ulcerans_Agy99 FWRPMRSYFYWEKHCFDVPICWSFRSLFDSLDG------IDKLSEKFSEL MMAR_2342|M.marinum_M QQ-TQEFQTVAQTIAKLETNLNQAVKLLRSIDG-----MQNQLNQMQQGA TH_2203|M.thermoresistible__bu EE-TRGGQTIDQTLATLTGTLTDATAALRAAGLDKPGSLQAKIATMQEGA Mflv_0403|M.gilvum_PYR-GCK QG-VDDRQSLTATVNQLNGALAQVTKAISAMGLDTPAGARAGLDDLQDGA Mvan_0271|M.vanbaalenii_PYR-1 EG-LDDTQSLNSTVKTLNAAMTNIVKAVDELGLDSPGGAQTSLRDIRQGT MAB_0937c|M.abscessus_ATCC_199 GNSPGNKATLSTTVTKLNASLLSVVNGLHAMGLDKPGGPQAGLNQLRQGA MAV_1761|M.avium_104 QAYPDKR-ALKASTDRLRNAFAKLNDVLRAMGMDRPGGLQSNLTTLQNGA MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 QA-TRAVQTLAATVSGLRGALATVIRAMGSLGMSSPGGVRSKINLVNKGV Rv3823c|M.tuberculosis_H37Rv QA-TRAVQTLAATVSGLRGALATVIRAMGSLGMSSPGGVRSKINLVNKGV MLBr_01231|M.leprae_Br4923 GS-TQSSQTIGATVSGLEKTLTAVNTSLRSLGLDNPNVMRSKMIGLQNGV MUL_3688|M.ulcerans_Agy99 TEDIQRTAGLTSQMLTLIPPMIATMKTTKALTLTMQSTFSAMLDQMDELS MMAR_2342|M.marinum_M SALAQGSRAIAQGVNELVKQTKRMGTGLDEASDFLLQMKHDANKPSMAGF TH_2203|M.thermoresistible__bu DALADASRKLADGVQLLVNQTKEMGSGLGEASSFLLAMKRDATTPAMAGF Mflv_0403|M.gilvum_PYR-GCK DRLADGSRQVAGGVDQLVEQIKVMAAGLDQAAAFLLTMRNDASSSNMAGF Mvan_0271|M.vanbaalenii_PYR-1 DRLASGSRQVAGGVDQLVEQVRVMADGLNQAAAFLLTMRHDAASANMAGF MAB_0937c|M.abscessus_ATCC_199 DRLAGGSQQVAGGVDQLVGQIKVIVNGLNQASNFLLTMKTNAADPSQAGF MAV_1761|M.avium_104 DQFAGGSRQVADAVAQLVDKVKQLGAGLSESAAFLLSLKHDAAHPAMAGF MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 NDLADGSRQLAEGVQLLVDQVKKMGFGLGEASAFLLAMKDTATTPAMAGF Rv3823c|M.tuberculosis_H37Rv NDLADGSRQLAEGVQLLVDQVKKMGFGLGEASAFLLAMKDTATTPAMAGF MLBr_01231|M.leprae_Br4923 NDLASAGRRIADGVAVLVDQTRTMGTSLARASAFLMEMGQDASQPSMAGF MUL_3688|M.ulcerans_Agy99 N------------------------------TAIVMGQSFDASKND-DFF MMAR_2342|M.marinum_M NIPPEAL------------------------AKDEFKKAAQIFISPDGHG TH_2203|M.thermoresistible__bu YIPPEVL------------------------TQEEFAKAAEIFVSPDGHG Mflv_0403|M.gilvum_PYR-GCK SIPAEVL------------------------GAVEFQKASEAFVSPDGHS Mvan_0271|M.vanbaalenii_PYR-1 SIPAEVL------------------------NAVEFQKAAEAFISPDGHS MAB_0937c|M.abscessus_ATCC_199 NIPAEVL------------------------NNPDFQRAAKAFISPDGHS MAV_1761|M.avium_104 NIPAQLL------------------------RLPQFQEAAKVFISPDGHS MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 YIPPELLSYATGESVKAETMPSEYRDLLGGLNVDQLKKVAAAFISPDGHS Rv3823c|M.tuberculosis_H37Rv YIPPELLSYATGESVKAETMPSEYRDLLGGLNVDQLKKVAAAFISPDGHS MLBr_01231|M.leprae_Br4923 NVPPQLL------------------------NTEDFKKLVQAFISPDGHS MUL_3688|M.ulcerans_Agy99 YLPPEAFD------------------------NPDFQTGLRMFLSPDGKS MMAR_2342|M.marinum_M ARYLVQSALNPFTTAAMDQVDEILDVAHDAQPNSELSDATISMVGIPTGL TH_2203|M.thermoresistible__bu VRYLVTTTLNPFSTEAMDLVNEITETARGARANTELAEADISMAGFTTTL Mflv_0403|M.gilvum_PYR-GCK VRYLVQTKLNPFSSEAMDQVNTISDIARGAQPNTMLSDASISMGGFPAAL Mvan_0271|M.vanbaalenii_PYR-1 VRYLVQTRLNPFSPEAMDQVNVINDIARGAQPNTSLADASISMGGFPAAL MAB_0937c|M.abscessus_ATCC_199 VRYLVQTKLNPFSPEAMDQVNQISDVAKGAQPNTTLADATISMGGFPTAL MAV_1761|M.avium_104 VRYLVQSKLSPFSTQAMDQVDAITATARGAQPNTALADAEVSMAGYTVGL MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 IRYLIQTDLNPFSTAAMDQIDAITAAARGAQPNTALADAKVSVVGLPVVL Rv3823c|M.tuberculosis_H37Rv IRYLIQTDLNPFSTAAMDQIDAITAAARGAQPNTALADAKVSVVGLPVVL MLBr_01231|M.leprae_Br4923 VRYFIQTDLNPFSSAAMDQVNTILNVATGAQPNTTLSDASIYLSGYTVTL MUL_3688|M.ulcerans_Agy99 ARFFITHQGDPMTPEGISRVDAERTAAQEGLKQSSLSDAKVYLGGTAATF MMAR_2342|M.marinum_M SDTRDYYNHDIQFIVFATILIVFLILVILLRAIVAPLYLIGSVLVSFLSA TH_2203|M.thermoresistible__bu RDTRDYYNNDFRLITTLTVVIVFLILVALLRAIVAPLYLIASVVISYLSA Mflv_0403|M.gilvum_PYR-GCK RDTRDYYERDIRFIIVVTLVIVMLVLMLLLRSLIAPLYLVGSVVVSYFAA Mvan_0271|M.vanbaalenii_PYR-1 RDTRDYYERDIRFIIIAALIVVLVTLSVLLRSLVAPLYLVGSVVVSYFAA MAB_0937c|M.abscessus_ATCC_199 RDTRDYYQHDIQFIIAATLIVVLLTLMVLLRAIVAPLYLVGSVVLSYFAA MAV_1761|M.avium_104 KDTRDYYQHDIKFIIAVTLLVVLLTLMALLRAIVAPLYLVATVVISYLSA MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 KDTRDYSDHDLRLIIAMTVCIVLLILIVLLRAIVAPLYLIGSVIVSYLAA Rv3823c|M.tuberculosis_H37Rv KDTRDYSDHDLRLIIAMTVCIVLLILIVLLRAIVAPLYLIGSVIVSYLAA MLBr_01231|M.leprae_Br4923 RDTRDYYDRDLQLIVIVTMIVVLLILMALLRSIVAPIYLVGSVIVSYLSA MUL_3688|M.ulcerans_Agy99 KDMADGEKYDLMIAVVSALTLIFLIMLLLTRSVVAALVIVGTAASSIAAS MMAR_2342|M.marinum_M LGLGVIVFQLILGKDLHWSLPGLSFILLVAVGADYNMLLISRIRDESPHG TH_2203|M.thermoresistible__bu LGLGVILFQYILGQELSWSVPGLTFIVLVAVGADYNMLLISRIREESPHG Mflv_0403|M.gilvum_PYR-GCK IGIGVLVFQLLLGQQLHWSVPPLAFVVLVAVGADYNMLFVSRMRDESPHS Mvan_0271|M.vanbaalenii_PYR-1 IGIGVLTFQLLLGQQLHWSVPPLAFVVLVAVGADYNMLFVSRLRDESPHS MAB_0937c|M.abscessus_ATCC_199 IGIGVLTFQYLLGEQLHWTVPPLAFVVLVAVGADYNMLFVSRMRDESASS MAV_1761|M.avium_104 VGVGVLVFQFLLGQQLHWSVPPLAFVVLVAVGADYNMLLVSRMRDESPHS MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 LGIGVIVFQFLLGQEMHWSIPGLTFVILVAVGADYNMLLISRLREEAVLG Rv3823c|M.tuberculosis_H37Rv LGIGVIVFQFLLGQEMHWSIPGLTFVILVAVGADYNMLLISRLREEAVLG MLBr_01231|M.leprae_Br4923 LGLCVLVFQVLLRQQLHWSVPGLAFVVLVAVGADYNMLLASRLRDESSHG MUL_3688|M.ulcerans_Agy99 FGLSVLIWQDLFGIKIHWIVAALSVIILLAVGSDYNLLLVSRFREEIHAG MMAR_2342|M.marinum_M VRVGVIRTVGSTGGVITSAGLIFAASMFGLLAASITTMVEAGFIIGSGIL TH_2203|M.thermoresistible__bu IRSGIIRTVGHTGGVITSAGLIFAASMFGLVFASITTMIQAGFILGVGLL Mflv_0403|M.gilvum_PYR-GCK VRFGIIRTLGSTGGVITAAGLIFAASMAGLLFSSIGIVVQGGFVIGVGIL Mvan_0271|M.vanbaalenii_PYR-1 VRYGVIRTLGSTGGVITAAGLIFAASMAGLLFSSIGIVVQGGFVIGVGIL MAB_0937c|M.abscessus_ATCC_199 VRYGIIRALNSTGGVITAAGLIFAASVGGLLFSSIGIVVQGGFVIGVGIL MAV_1761|M.avium_104 MRYGIIRTLSSTGGVITAAGLIFAASMSGLLFSSIGTVVQGGVVIGVGIL MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 VRSGVIRTVASTGGVITAAGLIMAASMYGLVFASLGSVVQGAFVLGTGLL Rv3823c|M.tuberculosis_H37Rv VRSGVIRTVASTGGVITAAGLIMAASMYGLVFASLGSVVQGAFVLGTGLL MLBr_01231|M.leprae_Br4923 LRASVIRTVRSTGGVITAAGLIFAASMFGLLLSSIATVVQAGFVLGSGIL MUL_3688|M.ulcerans_Agy99 LKTGIIRSMAGTGGVVTAAGLVFAFTMASMLGSDLRVLGQFGSTVCIGLL MMAR_2342|M.marinum_M IDTFLVRSVTVPAMAAMLGQANWWPSKIGASSTRRRVYQRAGSRKPNLLD TH_2203|M.thermoresistible__bu LDTFLVRTITVPATAVLVGRANWWPAKPPHDG------------------ Mflv_0403|M.gilvum_PYR-GCK LDTFVVRTITVPAIATLLGRANWWPSRVA---APARERVSADT------- Mvan_0271|M.vanbaalenii_PYR-1 LDTFVVRTITVPAIAALVGRANWWPSKVGPQQAAPRAVESAGSG------ MAB_0937c|M.abscessus_ATCC_199 LDTFVVRTITVPAIAALVGKANWWPSQVNARQTSSAKPSAAAPAG----- MAV_1761|M.avium_104 LDTFLVRTVTVPAIAALAGRANWWPSRIAVR----RNPVSGQP------- MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 LDTFLVRTVTVPAIAVLVGQANWWLPSSWRPATWWPLGRRRGRAQRTKRK Rv3823c|M.tuberculosis_H37Rv LDTFLVRTVTVPAIAVLVGQANWWLPSSWRPATWWPLGRRRGRAQRTKRK MLBr_01231|M.leprae_Br4923 LDTFIVRTITVPAVAALLRRASWWPARPWGNNA----------------- MUL_3688|M.ulcerans_Agy99 LDTLIVRTLLMPSIATLLGRWFWWPQVVHPRGDNARPRVAAPTH------ MMAR_2342|M.marinum_M RIKSLGPAKQRAAVTAKASTTTTKRPSTAVKKRGELVSKPGTRKRVRKPA TH_2203|M.thermoresistible__bu -------------------------------------------------- Mflv_0403|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0271|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0937c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_1761|M.avium_104 -------------------------------------------------- MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 PLLPKEEEEQSPPDDDDLIGLWLHDGLRL--------------------- Rv3823c|M.tuberculosis_H37Rv PLLPKEEEEQSPPDDDDLIGLWLHDGLRL--------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- MUL_3688|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2342|M.marinum_M WPDIPITNDDYESLQEHALPLFGSIRLPRELTPIDPALHNGDGATSNGDG TH_2203|M.thermoresistible__bu -------------------------------------------------- Mflv_0403|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0271|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0937c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_1761|M.avium_104 -------------------------------------------------- MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 -------------------------------------------------- Rv3823c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- MUL_3688|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2342|M.marinum_M TTNGSGADCKQLQLIGLGDTTEFRVPNGTTNGNGNGNGHTNGNGHTNGNG TH_2203|M.thermoresistible__bu -------------------------------------------------- Mflv_0403|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0271|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0937c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_1761|M.avium_104 -------------------------------------------------- MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 -------------------------------------------------- Rv3823c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- MUL_3688|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2342|M.marinum_M HTNGNGHTNGTNGHGTNGATNGNGHTNGTNGTNGHGTNGATNGHTNGTNG TH_2203|M.thermoresistible__bu -------------------------------------------------- Mflv_0403|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0271|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0937c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_1761|M.avium_104 -------------------------------------------------- MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 -------------------------------------------------- Rv3823c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- MUL_3688|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2342|M.marinum_M NGHTNGTNGHGTNGATNGNGHTNGTNGTNGHGTNGATNGHTNGNGNGTNG TH_2203|M.thermoresistible__bu -------------------------------------------------- Mflv_0403|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0271|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0937c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_1761|M.avium_104 -------------------------------------------------- MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 -------------------------------------------------- Rv3823c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- MUL_3688|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2342|M.marinum_M NGNGTNGHGTNGHTNGNGTNGATNGASNGATNGTNGHTNGNGNGNGTNGH TH_2203|M.thermoresistible__bu -------------------------------------------------- Mflv_0403|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0271|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0937c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_1761|M.avium_104 -------------------------------------------------- MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 -------------------------------------------------- Rv3823c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- MUL_3688|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2342|M.marinum_M TSGNGNGTNGATNGASNGATNGTNGHTNGNGNGTNGATNGHTNGNGNGTN TH_2203|M.thermoresistible__bu -------------------------------------------------- Mflv_0403|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0271|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0937c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_1761|M.avium_104 -------------------------------------------------- MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 -------------------------------------------------- Rv3823c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- MUL_3688|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2342|M.marinum_M GHTSGNGNGTNGATNGASNGATNGTNGHTNGNGNGNGTNGATNEHGTNGS TH_2203|M.thermoresistible__bu -------------------------------------------------- Mflv_0403|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0271|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0937c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_1761|M.avium_104 -------------------------------------------------- MSMEG_2677|M.smegmatis_MC2_155 -------------------------------------------------- Mb3853c|M.bovis_AF2122/97 -------------------------------------------------- Rv3823c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01231|M.leprae_Br4923 -------------------------------------------------- MUL_3688|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2342|M.marinum_M TNGDIDDADEGHALPLFGPSNQRDLLIKR TH_2203|M.thermoresistible__bu ----------------------------- Mflv_0403|M.gilvum_PYR-GCK ----------------------------- Mvan_0271|M.vanbaalenii_PYR-1 ----------------------------- MAB_0937c|M.abscessus_ATCC_199 ----------------------------- MAV_1761|M.avium_104 ----------------------------- MSMEG_2677|M.smegmatis_MC2_155 ----------------------------- Mb3853c|M.bovis_AF2122/97 ----------------------------- Rv3823c|M.tuberculosis_H37Rv ----------------------------- MLBr_01231|M.leprae_Br4923 ----------------------------- MUL_3688|M.ulcerans_Agy99 -----------------------------