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VRLANRVAIITGAAQGIGRIYAERFAEEGAAVVVADINEPKATEVASSITSLGGRAIAAAVDVSDVESVN RMVDSAVEAFGTVDILVNNAAIFSTLKMKPFEEISGDEWDKLFAVNAKGTFLCCQAVSPVMRKNQYGRII NISSSVVVTGRPNYAHYIASKGAVWALTHALATEMGTDGITVNTVSPHGIITEIPRETISEEGWRRNLEE QALKRKGDASDLVGILLYLASDESKFMTGQTVALDAGLRFT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2536 | - | - | 100% (251) | 3-oxoacyl- |
| M. smegmatis MC2 155 | MSMEG_4117 | - | 3e-42 | 37.80% (246) | 2-deoxy-D-gluconate 3-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5858 | - | 2e-41 | 40.98% (244) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0792 | - | 4e-42 | 42.62% (244) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1601 | - | 7e-44 | 43.62% (243) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0769 | - | 1e-42 | 43.03% (244) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-24 | 34.74% (190) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1219 | - | 2e-42 | 40.74% (243) | short chain dehydrogenase |
| M. marinum M | MMAR_4927 | - | 5e-41 | 41.39% (244) | dehydrogenase/reductase |
| M. avium 104 | MAV_1395 | - | 6e-43 | 39.34% (244) | 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3037 | - | 2e-44 | 43.03% (244) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0478 | - | 2e-40 | 41.39% (244) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5156 | - | 8e-44 | 43.62% (243) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4927|M.marinum_M --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1601|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5156|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3037|M.thermoresistible__bu --------------------------------------------------
MSMEG_2536|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MMAR_4927|M.marinum_M --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1601|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5156|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3037|M.thermoresistible__bu --------------------------------------------------
MSMEG_2536|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MMAR_4927|M.marinum_M --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1601|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5156|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3037|M.thermoresistible__bu --------------------------------------------------
MSMEG_2536|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MMAR_4927|M.marinum_M --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1601|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5156|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3037|M.thermoresistible__bu --------------------------------------------------
MSMEG_2536|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MMAR_4927|M.marinum_M --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1601|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5156|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3037|M.thermoresistible__bu --------------------------------------------------
MSMEG_2536|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MMAR_4927|M.marinum_M --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1601|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5156|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3037|M.thermoresistible__bu --------------------------------------------------
MSMEG_2536|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MMAR_4927|M.marinum_M ------------------MG----QFENKVAIVTGAAQGIGQAYADALAR
MUL_0478|M.ulcerans_Agy99 ------------------MG----QFENKVAIVTGAAQGIGQAYADALAR
Mb0792|M.bovis_AF2122/97 ------------------------MFDSKVAIVTGAAQGIGQAYAQALAR
Rv0769|M.tuberculosis_H37Rv ------------------------MFDSKVAIVTGAAQGIGQAYAQALAR
MAB_1219|M.abscessus_ATCC_1997 ------------------MG----EFDNKVAIVTGAAQGIGEAYAHALAR
Mflv_1601|M.gilvum_PYR-GCK ------------------MGLYGDQFNEKVAIVTGAGGGIGQAYAEALAR
Mvan_5156|M.vanbaalenii_PYR-1 ------------------MGLYGDQFKEKVAIVTGAGGGIGQAYAEALAR
TH_3037|M.thermoresistible__bu ------------------MG----QFDDKVAIVTGAGGGIGQAYAEALAR
MSMEG_2536|M.smegmatis_MC2_155 -----------------------MRLANRVAIITGAAQGIGRIYAERFAE
MAV_1395|M.avium_104 -----------------------------MAVVTGGGSGIGRAIVERLAH
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
:. :**.. ***. . :*.
MMAR_4927|M.marinum_M EGARVVVADINAEAAEKTAKQIVADGGTAIHVPVDVSDEESARAMADRTV
MUL_0478|M.ulcerans_Agy99 EGARVVVADINAEAAEKTAKQIVADGGTAIHVPVDVSDEESARAMADRTV
Mb0792|M.bovis_AF2122/97 EGASVVVADINADGAAAVAKQIVADGGTVIHVPVDVSDEDSAKAMVDRAV
Rv0769|M.tuberculosis_H37Rv EGASVVVADINADGAAAVAKQIVADGGTAIHVPVDVSDEDSAKAMVDRAV
MAB_1219|M.abscessus_ATCC_1997 EGAAVVVADINAEMGEGVAKQIVADGGRAIFAGVDVSDPDSAIAMADKAV
Mflv_1601|M.gilvum_PYR-GCK EGAAVVVADINVEGAQKVADGIKGEGGNALAVRVDVSDPDSAKEMAAQAL
Mvan_5156|M.vanbaalenii_PYR-1 EGAAVVVADINTEGAQKVADGIKGEGGNALAVRVDVSDPESAKGMAAQTL
TH_3037|M.thermoresistible__bu EGAAVVVADINTEGAQKVADGIKGEGGDALAVPVDVSDPESAEEMAAQTV
MSMEG_2536|M.smegmatis_MC2_155 EGAAVVVADINEPKATEVASSITSLGGRAIAAAVDVSDVESVNRMVDSAV
MAV_1395|M.avium_104 DGHRVAVLDVNEEAAEKVAARVAADGAHAIAVPTDVAESASVAAAFESVR
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
* *.* *:: . .* : . *. . **:: :. .
MMAR_4927|M.marinum_M SEFGGIDYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAV
MUL_0478|M.ulcerans_Agy99 SEFGGIDYLVNNAAIYGGMKLDLQLTVPLDYYKKFMSVNHDGVLVCTRAV
Mb0792|M.bovis_AF2122/97 GAFGGIDYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAV
Rv0769|M.tuberculosis_H37Rv GAFGGIDYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAV
MAB_1219|M.abscessus_ATCC_1997 SEFGGIDYLVNNAAIYGGMKLDLLLSVPWDYYKKFMSVNQDGALVCTRAV
Mflv_1601|M.gilvum_PYR-GCK SEFGGIDYLVNNAAIFGGMKLDFLITVDWDYYKKFMSVNLDGALVCTRAV
Mvan_5156|M.vanbaalenii_PYR-1 SEFGGIDYLVNNAAIFGGMKLDFLITVDWDYYKKFMSVNMDGALVCTRAV
TH_3037|M.thermoresistible__bu SEFGGIDYLVNNAAIFGGMKLDFLITVDWDYYKRFMSVNLDGALVCTRAV
MSMEG_2536|M.smegmatis_MC2_155 EAFGTVDILVNNAAIFSTLKMKPFEEISGDEWDKLFAVNAKGTFLCCQAV
MAV_1395|M.avium_104 RALGSVQVLVTSAAITG---FKPFAEITIEDWNRHLAVNLTGTFLCLQAA
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVNNAGIGQAG---RFLDTPPEEFDRVLAVNLGGVVNCCRAF
* : :*..*.* : :.: ::** *.. * :*
MMAR_4927|M.marinum_M YKHMAKRGGG-AIVNQSS---TAAWLYSNFYGLAKVGVNGLTQQLSRELG
MUL_0478|M.ulcerans_Agy99 YKHMAKRGGG-AIVNQSS---TAAWLYSNFYGLAKVGVNGLTQQLSRELG
Mb0792|M.bovis_AF2122/97 YKHMAKRGGG-AIVNQSS---TAAWLYSNFYGLAKVGVNGLTQQLARELG
Rv0769|M.tuberculosis_H37Rv YKHMAKRGGG-AIVNQSS---TAAWLYSNFYGLAKVGVNGLTQQLARELG
MAB_1219|M.abscessus_ATCC_1997 YKHIAQRGGG-AIVNQSS---TAAWLYSGFYGLAKVGINGLTQQLSRELG
Mflv_1601|M.gilvum_PYR-GCK YRKMAKRGGG-AIVNQSS---TAAWLYSNFYGLAKVGINGLTQQLATELG
Mvan_5156|M.vanbaalenii_PYR-1 YRKMAKRGGG-AIVNQSS---TAAWLYSNFYGLAKVGINGLTQQLATELG
TH_3037|M.thermoresistible__bu YKKMAKRGGG-AIVNQSS---TAAWLYSNYYGLAKAGLNSLTQQLATELG
MSMEG_2536|M.smegmatis_MC2_155 SPVMRKNQYG-RIINISSSVVVTGRPNYAHYIASKGAVWALTHALATEMG
MAV_1395|M.avium_104 LPDMVEAGWG-RVVTISSTAAQTGSPRQGHYSASKGGVIALTRTIALEYA
MLBr_00862|M.leprae_Br4923 GQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELD
: : * ::. ** : * :* . :: : *
MMAR_4927|M.marinum_M GMKIRINAIAPGPIDTEATRTVTPG----------EFVKDMVKQIPLSRM
MUL_0478|M.ulcerans_Agy99 GMKIRINAIAPGPIDTEATRTVTPG----------EFVKDMVKQIPLSRM
Mb0792|M.bovis_AF2122/97 GMKIRINAIAPGPIDTEATRTVTPA----------ELVKNMVQTIPLSRM
Rv0769|M.tuberculosis_H37Rv GMKIRINAIAPGPIDTEATRTVTPA----------ELVKNMVQTIPLSRM
MAB_1219|M.abscessus_ATCC_1997 GQKIRINAIAPGPTDTEATRGTVPE----------QFRSELVKNIPLSRM
Mflv_1601|M.gilvum_PYR-GCK GQNIRVNAIAPGPIDTEANRTTTPQ----------EMVADIVKGIPLSRM
Mvan_5156|M.vanbaalenii_PYR-1 GQNIRVNAIAPGPIDTEANRTTTPQ----------EMVADIVKGIPLSRM
TH_3037|M.thermoresistible__bu GQNIRVNAIAPGPIDTEANRSTTPK----------EMVDDIVKRIPLSRL
MSMEG_2536|M.smegmatis_MC2_155 TDGITVNTVSPHGIITEIPRETISE----------EGWRRNLEEQALKRK
MAV_1395|M.avium_104 AHGITANTVPPFSVDTPMLRAAQEAG-------NLPPVKYLAKASPVGRL
MLBr_00862|M.leprae_Br4923 AVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRRY
: .:: * * : . : *
MMAR_4927|M.marinum_M GTPEDLVGMCLFLLGDQ--------------ASWITGQIFNVDGGQIIRS
MUL_0478|M.ulcerans_Agy99 GTPEDLVGMCLFLLGDQ--------------ASRITGQIFNVDGGQIIRS
Mb0792|M.bovis_AF2122/97 GTPEDLVGMCLFLLSDS--------------ASWITGQIFNVDGGQIIRS
Rv0769|M.tuberculosis_H37Rv GTPEDLVGMCLFLLSDS--------------ASWITGQIFNVDGGQIIRS
MAB_1219|M.abscessus_ATCC_1997 GTVDDMVGMCLFLLSDK--------------ASWITGQVFNVDGGQIIRS
Mflv_1601|M.gilvum_PYR-GCK GQPDDLVGMLLFLLSDQ--------------AKWVTGQIFNVDGGQIIR-
Mvan_5156|M.vanbaalenii_PYR-1 GEPEDLVGMLLFLLSDQ--------------AKWITGQIFNVDGGQIIRS
TH_3037|M.thermoresistible__bu GEPEDLVGMCLFLLSDQ--------------AKWITGQIFNVDGGQIIR-
MSMEG_2536|M.smegmatis_MC2_155 GDASDLVGILLYLASDE--------------SKFMTGQTVALDAGLRFT-
MAV_1395|M.avium_104 GTGEDIAAACAFLCSDE--------------AGYITGQIIGVNGGEVI--
MLBr_00862|M.leprae_Br4923 GPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI-
* . : :. : * . . .