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MKQLILTKFGDPEDTVRLVDTPEPVAGPGKVLVRLEAAAINPSDLLLLKGKYLVHPELPAGVGAEGVGIV EAVGPEVDSNLVGKRVIVLPTYTYGTWSEKVVAAAHDVIEVPDADPQQLAMLSINPPTAHLLLDRFVNLQ VGDWVGQTAANSAVGRYVTTLARRRGLKTLNIVRREDAVEDVRAAGGDVVVVSGPNLADDIKQALGGDRL SLVIDPLGGSAASDLIGALEFGGTAVAYASLTGTPMSVSSADLFGREVRLTGFWLGNWYASEPRHEIVDT LDYLARLIAEGVLHAPVEATYHLDDYLKAFTHARTAKRGGKILFTFE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2155 | - | - | 100% (327) | trans-2-enoyl-CoA reductase |
| M. smegmatis MC2 155 | MSMEG_4064 | - | 2e-26 | 34.84% (244) | zinc-binding alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4032 | - | 7e-26 | 34.43% (244) | zinc-binding alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3165 | fadB4 | 2e-20 | 26.69% (326) | NADPH quinone oxidoreductase |
| M. gilvum PYR-GCK | Mflv_2449 | - | 3e-23 | 27.81% (320) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3141 | fadB4 | 2e-20 | 26.69% (326) | NADPH quinone oxidoreductase |
| M. leprae Br4923 | MLBr_00118 | - | 7e-15 | 24.44% (311) | putative oxidireductase |
| M. abscessus ATCC 19977 | MAB_4603c | - | 2e-24 | 27.47% (324) | oxidoreductase |
| M. marinum M | MMAR_5313 | - | 2e-23 | 27.83% (327) | quinone oxidoreductase |
| M. avium 104 | MAV_0308 | - | 2e-26 | 29.36% (327) | alcohol dehydrogenase, zinc-binding |
| M. thermoresistible (build 8) | TH_3440 | - | 2e-21 | 31.98% (247) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_4387 | - | 4e-22 | 27.74% (328) | quinone oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4202 | - | 2e-28 | 29.36% (327) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3165|M.bovis_AF2122/97 -----------------------------------------------MRA
Rv3141|M.tuberculosis_H37Rv -----------------------------------------------MRA
MAB_4603c|M.abscessus_ATCC_199 -----------------------------------------------MKA
Mflv_2449|M.gilvum_PYR-GCK -----------------------------------------------MRA
Mvan_4202|M.vanbaalenii_PYR-1 -----------------------------------------------MRA
MMAR_5313|M.marinum_M -----------------------------------------------MRA
MUL_4387|M.ulcerans_Agy99 -----------------------------------------------MRA
MAV_0308|M.avium_104 -----------------------------------------------MRA
TH_3440|M.thermoresistible__bu VQTAAAQRRDEIGVIGVALRAVRTTGQNDPRMEHIRAGELHTGMIGAMKA
MLBr_00118|M.leprae_Br4923 -----------------------------------------------MHA
MSMEG_2155|M.smegmatis_MC2_155 -----------------------------------------------MKQ
*:
Mb3165|M.bovis_AF2122/97 VRVTRLEGPD-AVEVAEVEEPTSAG--VVIEVHAAGVAFPDALLTRGRYQ
Rv3141|M.tuberculosis_H37Rv VRVTRLEGPD-AVEVAEVEEPTSAG--VVIEVHAAGVAFPDALLTRGRYQ
MAB_4603c|M.abscessus_ATCC_199 IQAQSLSGPE-GLVYTDVETPGAGPNVVVVDVKAAGVCFPDYLMTKGEYQ
Mflv_2449|M.gilvum_PYR-GCK AMCREYGPPE-VVRVEDVAEPVAGPGQIGVRVDAAAVNFPDVLLVAGTYQ
Mvan_4202|M.vanbaalenii_PYR-1 AVCPQYGPPE-VVRVEERPEPSAGPGQVVVRVEAAAVNFPDVLLVADSYQ
MMAR_5313|M.marinum_M IVCNAYGPPE-DLVLDEVPDPVPAPGQVLVRVRAAAVNFPDVLFIAGKYQ
MUL_4387|M.ulcerans_Agy99 IVCDAYGPPE-DLVLDEVPDPVPAPGQVLVRVRAVAVNFPDVLFIAGKYQ
MAV_0308|M.avium_104 VVCRSYGTPE-DLVLDEVPDPVPGPGQLLVRVRAAAVNFPDVLFIAGKYQ
TH_3440|M.thermoresistible__bu IEVRETGGPE-VLTYVDVPEPTPGPGQVLIKAEAIGVNFIDTYFRSGLYP
MLBr_00118|M.leprae_Br4923 IVAESAN----QMVWREVPDVTAGPGEVLIEVAASGVNRADVLQVAGKYP
MSMEG_2155|M.smegmatis_MC2_155 LILTKFGDPEDTVRLVDTPEPVAGPGKVLVRLEAAAINPSDLLLLKGKYL
: : .. : : * .: * . *
Mb3165|M.bovis_AF2122/97 YRPEPPFVLGAEIAGVVRSAPDNSQVRSGDR--VVGLTMLTGGMAEVAVL
Rv3141|M.tuberculosis_H37Rv YRPEPPFVLGAEIAGVVRSAPDNSQVRSGDR--VVGLTMLTGGMAEVAVL
MAB_4603c|M.abscessus_ATCC_199 LKMEPPFVPGIETAGVVRSAPEGSGIKPGDR--VMAFNFIGG-YAERVAV
Mflv_2449|M.gilvum_PYR-GCK ISVPPPFVPGSEFAGVVDEIGPGTEGFTIGD--RVSGTAMFGAFAERTVV
Mvan_4202|M.vanbaalenii_PYR-1 VSVAPPFVPGSEFTGVVDEIGPHTTGFTVGE--RVAGTGMFGAFAERVVA
MMAR_5313|M.marinum_M IKIPPPFIPGNEIAGEVVSVGAGVT-LVPGQ--RVFGT-TFGAFAELALL
MUL_4387|M.ulcerans_Agy99 IKIPPPFVPGNEIAGEVVGAGAGVI-LVPGQ--RVFGT-TFGAFAELALL
MAV_0308|M.avium_104 VKIPPPFIPGNEIAGEVIAAGEGAR-FLPGQ--RVAGT-TFGAFAEQALL
TH_3440|M.thermoresistible__bu R--EVPFIVGTEVCGTVEAVGDGVAALRVGD--RVLTDKANGAYAEYTVA
MLBr_00118|M.leprae_Br4923 HPPGASAIIGMEVAGVVAAVSSGVTEWSVGQ--EVCALLAGGGYAEYVAV
MSMEG_2155|M.smegmatis_MC2_155 VHPELPAGVGAEGVGIVEAVGPEVDSNLVGKRVIVLPTYTYGTWSEKVVA
. * * * * . : * :* .
Mb3165|M.bovis_AF2122/97 SPERVFKLPDNMTFEAGAGVLFNDLTVYFALAVRGRLQAGETVLVHGAAG
Rv3141|M.tuberculosis_H37Rv SPERVFKLPDNMTFEAGAGVLFNDLTVYFALAVRGRLQAGETVLVHGAAG
MAB_4603c|M.abscessus_ATCC_199 APSNILPTPPQLDDAEAVALIANYHTMYFAYARRGQLRAGETVLVLGAAG
Mflv_2449|M.gilvum_PYR-GCK DAAALAPIPDGVDARTAAAFGVAYRTAYHTLRSVARVSEGDELVVLGAGG
Mvan_4202|M.vanbaalenii_PYR-1 DAAGLTPVPDGVDARTAAAFGVAHRTAYHALRSTARLSAGDELVVLGAGG
MMAR_5313|M.marinum_M DGAAAEPIPDDADFASAAAFGVTYRTAYHALRSVAQVSQGDWVVVLGAAG
MUL_4387|M.ulcerans_Agy99 DGAAAQPIPDDADFASAAAFGVTYRTAYHALRSVAQVSQGDWVVVLGAAG
MAV_0308|M.avium_104 DADQAEPIPDDADFASAAAFGVTYRTAYHALRSTAGVTAGDWVVVLGAAG
TH_3440|M.thermoresistible__bu PADYVAYVPDGVAPDTVASALLKGMTAHYLIKSVYEVQRGDTILVHAGAG
MLBr_00118|M.leprae_Br4923 PASQVMPIPKGVNVVDSAGIPEVACTVWSNLVMAAHLSAGQLLLLHGGTS
MSMEG_2155|M.smegmatis_MC2_155 AAHDVIEVPD-ADPQQLAMLSINPPTAHLLLDRFVNLQVGDWVGQTAANS
* . * : *: : .. .
Mb3165|M.bovis_AF2122/97 GIGTSTLRLAPALGASRTVAVVSTQEKAELATVAGATDVV-LAEGF---K
Rv3141|M.tuberculosis_H37Rv GIGTSTLRLAPALGASRTVAVVSTQEKAELATVAGATDVV-LAEGF---K
MAB_4603c|M.abscessus_ATCC_199 GIGTAAIQIAKGMGA-KVIAVVNRTAATEFVKSVGADIVLPLEEGW---A
Mflv_2449|M.gilvum_PYR-GCK GVGLAAVQLGVALGA-NVTAVASSAEKLAAAAEYGAAHLVDHREQD---L
Mvan_4202|M.vanbaalenii_PYR-1 GVGLATVQLGVALGA-RVTAVASSNEKLAVAGGYGAATLINHRDGE---L
MMAR_5313|M.marinum_M GVGLAAVDLAVAMGA-RVLAAASSPEKLGLCRQRGAEAVVDYDQED---L
MUL_4387|M.ulcerans_Agy99 GVGLAAVDLAVAMGA-RVLAAASSPEKLGLCRQRGAEAVVDYDQED---L
MAV_0308|M.avium_104 GVGLAAVDLAVAMQA-RVLAAASSPEKLELCRRRGAEATVDYDRED---L
TH_3440|M.thermoresistible__bu GVGLILTQWATHLGA-RVITTVSTPQKAELSRKAGAAEVLDYPTDPEEFG
MLBr_00118|M.leprae_Br4923 GIGSHGIQVARALGA-KVAVTAGSEEKLEFCRALGAQITINYRDED----
MSMEG_2155|M.smegmatis_MC2_155 AVGRYVTTLARRRGL-KTLNIVRREDAVEDVRAAGGDVVVVSGPNL---A
.:* . .. . *. :
Mb3165|M.bovis_AF2122/97 DAVQELTNGRGVDIVVDPVGGDRFTDSLRSLAAGGRLLVIGFTGGEIPTV
Rv3141|M.tuberculosis_H37Rv DAVQELTNGRGVDIVVDPVGGDRFTDSLRSLAAGGRLLVIGFTGGEIPTV
MAB_4603c|M.abscessus_ATCC_199 KAVREATGGAGVDMVVDPIGGPAFDDAVRTLASEGRLLVVGFAAGGIPTI
Mflv_2449|M.gilvum_PYR-GCK RAALRTAVPDGADVVIDPVGGRLSEPALRSLGRGGRFVTVGFASGEIPRI
Mvan_4202|M.vanbaalenii_PYR-1 RQALRQAIPDGADVVVDPVGGDVSEPALRSLGRGGRFVSVGFASGVIPRI
MMAR_5313|M.marinum_M KLRIRELTGESARVVLDPVGGSYAEPALRGLARGGMFVTLGYAAGSIPAI
MUL_4387|M.ulcerans_Agy99 KLRIRELTGESARVVLDPVGGSYAEPALRGLARGGIFVTLGYAAGSIPAI
MAV_0308|M.avium_104 KTRIRDLTGDRARVVLDPVGGPYSEPALRGLARGGTFVTLGYASGTIPAI
TH_3440|M.thermoresistible__bu ARIRDLTGGEGVPVVYDGVGRSTFDASLASLAVRGTLALFGAASGPVPPF
MLBr_00118|M.leprae_Br4923 FVARLQQQNGGADVILDIMGAAYLDRNIDALAIDGQLIVIGLQGGVKGEL
MSMEG_2155|M.smegmatis_MC2_155 DDIKQALGGDRLSLVIDPLGGSAASDLIGALEFGGTAVAYASLTGTPMSV
:: * :* : * * . * .
Mb3165|M.bovis_AF2122/97 KVNRLLLNNIDVVGVGWGAWSLTHPDALAQQWSQLER----LLRSGKLPP
Rv3141|M.tuberculosis_H37Rv KVNRLLLNNIDVVGVGWGAWSLTHPDALAQQWSQLER----LLRSGKLPP
MAB_4603c|M.abscessus_ATCC_199 KVNRLLLRNASLIGVAWGEFLRTHADYLYETQAGLEK----LVAEG-MRP
Mflv_2449|M.gilvum_PYR-GCK PLNLVLLKGVQVLGFQFQDVPGD---EFVRNDHELRA----LLSARRVTP
Mvan_4202|M.vanbaalenii_PYR-1 PLNLVLIKGVHVLGFQFQDVPAD---EFTRNEVELRE----LLVSGRVKP
MMAR_5313|M.marinum_M PLNLVMLKNLTIRGMEIRTFMGDYPNECARDVAELSQ----MFAAGKIRP
MUL_4387|M.ulcerans_Agy99 PLNLVMLKNLTIRGMEIRTFMGDYPDECARDVAELSQ----MFAAGKIRP
MAV_0308|M.avium_104 PLNLVLLKDICVRGMEIRTFMTDRPDDAVRDLTELSQ----MFAAGTVRP
TH_3440|M.thermoresistible__bu DPQRLNAAGSVYLTRPSLVHFTRTPDEFGWRAGEFLS----AVADGTLTI
MLBr_00118|M.leprae_Br4923 NLGKVLSKRARIIGSTLRARPVNGPNSKSEIVAAVTASIWPMIADGSVRP
MSMEG_2155|M.smegmatis_MC2_155 SSADLFGREVRLTGFWLGNWYASEPRHEIVDTLDYLAR---LIAEGVLHA
: . :
Mb3165|M.bovis_AF2122/97 PEPVVYPLDQAAAAIASLENRTAKGKVVLRVRD-----------
Rv3141|M.tuberculosis_H37Rv PEPVVYPLDQAAAAIASLENRTAKGKVVLRVRD-----------
MAB_4603c|M.abscessus_ATCC_199 PVSARIPLSEGRQALQDFADGKVYGKMVLVP-------------
Mflv_2449|M.gilvum_PYR-GCK HVGAVYPLEEVAAALRHVGEGRAIGKVLIDVPA-----------
Mvan_4202|M.vanbaalenii_PYR-1 HVGAVYSLDDTVAALRHVSDGRAIGKVVIDLS------------
MMAR_5313|M.marinum_M HIGARFPLADTPAALRYVAERKVLGKVVIDVV------------
MUL_4387|M.ulcerans_Agy99 HIGARFPLADTPAALRYVAERKVLGKVVIDVA------------
MAV_0308|M.avium_104 YIGARFPLARTAAALRHVADRKVLGKVVIDVA------------
TH_3440|M.thermoresistible__bu TVGERYPLAEAERAHRDLEGRKTVGSVVLLP-------------
MLBr_00118|M.leprae_Br4923 IIGARMAVQQAADAHQLLLSGKVSGKIVLTVAGSGTETLLSRHH
MSMEG_2155|M.smegmatis_MC2_155 PVEATYHLDDYLKAFTHARTAKRGGKILFTFE------------
: * *.:::