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M. smegmatis MC2 155 MSMEG_2148 (-)

annotation: HNH endonuclease domain-containing protein
coordinates: 2222742 - 2224376
length: 544

VWFSWPFRSLAVLCAVAVAIGGLHLVQPTPSERVEQGAAAVSAAQKFADAATAAFTESAVGSDLTVSPEQ
RRTGLPTDPVTGLTSQTAAGPVQIVLPGGLGRAEHTPGGQVVYPNAGAGFDLLAENTATGTRTVARIAGP
GGPRMVTTFVRTPADTVMLAHTNGYLTINKATPTAETVGMFAPAETRDATGGPVPSSYLVKQLAPQLYVL
AEVIDPRPDTAWPVYVDPPLHLTGAGGAPLGLLDSFADSVSSLANTATSAVKTAASATVSGAKAVGSFVK
ENPLESAMLVGGVALAVTGVGGPAGAAAIAAATVNLSSAGLDIAAAAMPDNQALGMAANVMAAASMVTPQ
GAAKKVIKEGVEQAGEQLAKHTDDVIERWPKNHPTPPAQLADEVAAASTAKPPVSPGVSPKAPNAPPAKA
PEPTQPASSAGPPGASTPGVRPGNLPRSQRVPPATKAQRDAAYEASAARNGGKPQCVYCGSSDGPFHIDH
VVPRAKGGTNAPSNHAPACATTCNLAKSDKRPEDFLKELDARESKKHHPKPKGK
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_2148--100% (544)HNH endonuclease domain-containing protein
M. smegmatis MC2 155MSMEG_4606-1e-4857.73% (194) hypothetical protein MSMEG_4606
M. smegmatis MC2 155MSMEG_4608-2e-0760.42% (48) hypothetical protein MSMEG_4608

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1188c-5e-0627.27% (242) hypothetical protein Mb1188c
M. gilvum PYR-GCKMflv_3843-8e-0728.08% (292) hypothetical protein Mflv_3843
M. tuberculosis H37RvRv1157c-5e-0627.27% (242) hypothetical protein Rv1157c
M. leprae Br4923MLBr_01254-1e-0546.67% (45) hypothetical protein MLBr_01254
M. abscessus ATCC 19977MAB_4293-3e-0825.94% (293) putative Fe-S oxidoreductase
M. marinum MMMAR_1894infB6e-0628.00% (200) translation initiation factor IF-2 InfB
M. avium 104MAV_3693infB6e-0729.58% (142) translation initiation factor IF-2
M. thermoresistible (build 8)TH_0510-8e-0528.00% (125) SECRETED PROLINE RICH PROTEIN MTC28 (PROLINE RICH 28 KDA
M. ulcerans Agy99MUL_2122infB6e-0728.22% (202) translation initiation factor IF-2
M. vanbaalenii PYR-1Mvan_0085-7e-0825.89% (336) hypothetical protein Mvan_0085

CLUSTAL 2.0.9 multiple sequence alignment


Mb1188c|M.bovis_AF2122/97           --------------------------------------------------
Rv1157c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1894|M.marinum_M               ----------------------------------------MAGKARVHEL
MUL_2122|M.ulcerans_Agy99           ----------------------------------------MAGKARVHEL
MAV_3693|M.avium_104                ----------------------------------------MAGKARVHEL
Mflv_3843|M.gilvum_PYR-GCK          ------MSRTKKSIVVVMMGSAGLFLSAPLLGPAANATPTRGGVPCVGIL
TH_0510|M.thermoresistible__bu      --------------------------------------------------
Mvan_0085|M.vanbaalenii_PYR-1       ----------------------------------------MGISKNVGEY
MSMEG_2148|M.smegmatis_MC2_155      -----------------------------------MWFSWPFRSLAVLCA
MLBr_01254|M.leprae_Br4923          --------------------------------------------------
MAB_4293|M.abscessus_ATCC_1997      MSTATITLGIIGVIFSLVAWGSFFGGVVKMVRVILSGQPDRTRFRPFLPR
                                                                                      

Mb1188c|M.bovis_AF2122/97           MRRLTNTEHRENTTVASTWSVCKGLAAVVITSAAAFALCPNAAADPATPQ
Rv1157c|M.tuberculosis_H37Rv        MRRLTNTEHRENTTVASTWSVCKGLAAVVITSAAAFALCPNAAADPATPQ
MMAR_1894|M.marinum_M               AKELGVTSKEVLARLSEQGEFVKSASSTVEAPVARRLRESFGGGKSAPAK
MUL_2122|M.ulcerans_Agy99           AKELGVTSKEVLARLSEQGEFVKSASSTVEAPVARRLRESFGGGKSAPAK
MAV_3693|M.avium_104                AKELGVTSKEVLARLNEQGEFVKSASSTVEAPVARRLRESFGGGK--AAE
Mflv_3843|M.gilvum_PYR-GCK          QQIVTRPGEIPQALTDTARSFTEPPKPAPPVVRPPASSSSSAGTPPVPGR
TH_0510|M.thermoresistible__bu      --------------------VAAGLTGILGFAGSTASAQPLVPQPPPPPA
Mvan_0085|M.vanbaalenii_PYR-1       VEEMTEPAGWPHVDEDHLYTRASGFVDKVTQLIAVRDSWQQQQARLFGGG
MSMEG_2148|M.smegmatis_MC2_155      VAVAIGGLHLVQPTPSERVEQGAAAVSAAQKFADAATAAFTESAVGSDLT
MLBr_01254|M.leprae_Br4923          --------MVQRKNRRSHRSSGAAANLIRAANPSSLHNVDIHPSTCYESG
MAB_4293|M.abscessus_ATCC_1997      LKQLIVEVVAHTRMNKFRTVGWAHWLVMVGFLGGFPLYFESYGQTFNPEF
                                                                                      

Mb1188c|M.bovis_AF2122/97           PNPTQQLPGLPALAQLSPIIQQAAMNPAQATQLLMAAASAFAGN------
Rv1157c|M.tuberculosis_H37Rv        PNPTQQLPGLPALAQLSPIIQQAAMNPAQATQLLMAAASAFAGN------
MMAR_1894|M.marinum_M               GSDTGAAKGVAKAPQKVPGVSPAAKAPDRSLDAALDKAVGNGAPAPVPAP
MUL_2122|M.ulcerans_Agy99           GSDTGAAKGVAKAPQKVSGASPAAKAPDRSLDAALDKAVGNGAPAPVPAP
MAV_3693|M.avium_104                GAAKAPAKAAAKGDAKTAAKG-DVKAPDKALDAALDNAIKAGGNGEAAAP
Mflv_3843|M.gilvum_PYR-GCK          PPASVVTPSSGATPPVPPSPGTPASTSTRGGTPPVPPAPPAPAGTPASGA
TH_0510|M.thermoresistible__bu      PATVTQTVTVAAAPVAPVAPVTPVGPVNRTPPVAVDPATGVAIG------
Mvan_0085|M.vanbaalenii_PYR-1       AWSGAAANAAETAIQARVSEMISLINHLEKAIAWYTMTARTIAQTKATIN
MSMEG_2148|M.smegmatis_MC2_155      VSPEQRRTGLPTDPVTGLTSQTAAGPVQIVLPGGLGRAEHTPGGQ-----
MLBr_01254|M.leprae_Br4923          SIWNRRRVLLLNSTYEPLTALPTRRAIIMVICGKADVVHVDPAG------
MAB_4293|M.abscessus_ATCC_1997      HWPIIGDTFLWHLWDELLGIGTVIGIVTLIIIRQLNHPRKPERLSRFGGS
                                                                                      

Mb1188c|M.bovis_AF2122/97           -----------PAVPTESKNVASS------VNQFVAEPTNPDSAALGVP-
Rv1157c|M.tuberculosis_H37Rv        -----------PAVPTESKNVASS------VNQFVAEPTNPDSAALGVP-
MMAR_1894|M.marinum_M               APAPTPAPAPAPAQPADSGVAPPA-ATPAAPAAS-AAPAPPKAPLPGQRP
MUL_2122|M.ulcerans_Agy99           APAPT--PAPAPAQPADSGVAPPA-ATPAAPAAS-AAPAPPKAPLPGQRP
MAV_3693|M.avium_104                -----------PAQPGGTATTPAAQATPEAPARPGPAAARPSAPAPGQPK
Mflv_3843|M.gilvum_PYR-GCK          TPPAPPVPGVPAVTSTGGGTPPVPPVPGAPVGAPVANPGLPTPPVPGAPV
TH_0510|M.thermoresistible__bu      ------------TAPAAGTTPALP--------------------------
Mvan_0085|M.vanbaalenii_PYR-1       QNLETS----YSFIASIRASPELDEVEKDGIIQSWVQSQRAVNTVTVLTA
MSMEG_2148|M.smegmatis_MC2_155      -----------VVYPNAGAGFDLLAENTATGTRTVARIAGPGGPRMVTT-
MLBr_01254|M.leprae_Br4923          -----------PVVHSATRSITVP--------------------------
MAB_4293|M.abscessus_ATCC_1997      NFFAAYTIEMIVLVEGLGMVLVKSGKIATFHNSHPSSDFFTMNVAQLLPE
                                                                                      

Mb1188c|M.bovis_AF2122/97           -----------APHGV---------ALPEAIPVP-----------HVPPL
Rv1157c|M.tuberculosis_H37Rv        -----------APHGV---------ALPEAIPVP-----------HVPPL
MMAR_1894|M.marinum_M               APTPGKPAAPQAPHPG---------MAPGARPGP-----------VPKPG
MUL_2122|M.ulcerans_Agy99           APTPGKPAAPQAPHPG---------MAPGARPGP-----------VPKQG
MAV_3693|M.avium_104                PPAPG-----QPPRPG---------ATPGPRPGP-----------APKPA
Mflv_3843|M.gilvum_PYR-GCK          FGDGGAVLPPLPPAPAGPAGGPAGLVAPPAPPVPGGPAAVPAGVALPPAP
TH_0510|M.thermoresistible__bu      ------------------------VAVPRETIVP----------------
Mvan_0085|M.vanbaalenii_PYR-1       AGDVAAFDSWQPPPSP--------QRIPATLSPPE---------SVSAPS
MSMEG_2148|M.smegmatis_MC2_155      -----------------------FVRTPADTVMLAHTN------GYLTIN
MLBr_01254|M.leprae_Br4923          --------------------------------------------------
MAB_4293|M.abscessus_ATCC_1997      SPIMVSVFAFIKMMSGGLFLLLVGRKLVWGVAWHRFAAFFNIYFKRNADG
                                                                                      

Mb1188c|M.bovis_AF2122/97           GAEPGVQAHLPTGIDPSHAAGPAPAVAPTVTP------------------
Rv1157c|M.tuberculosis_H37Rv        GAEPGVQAHLPTGIDPSHAAGPAPAVAPTVTP------------------
MMAR_1894|M.marinum_M               VRTPRVGNNPFSSAQPVDRPIPRPQAPRPGAP------------------
MUL_2122|M.ulcerans_Agy99           VRTPRVGNNPFSSAQPVDRPIPRPQAPRPGAP------------------
MAV_3693|M.avium_104                ARTPRVGNNPFSSAQPVDRPIPRP-VPRPGAP------------------
Mflv_3843|M.gilvum_PYR-GCK          PGAPGAPVFGEAGAAPSGAAAPVAPAAGSGGAGGAGGGSGIGGPGGGGAP
TH_0510|M.thermoresistible__bu      ---ARSGTLRDFFTERGVKMEPQAADGFTALN------------------
Mvan_0085|M.vanbaalenii_PYR-1       GPEPPKQNVGYFGPTRPPAAEPRGGSAGLSAK------------------
MSMEG_2148|M.smegmatis_MC2_155      KATPTAETVGMFAPAETRDATGGPVPSSYLVK------------------
MLBr_01254|M.leprae_Br4923          ----SVIQLRSYVRVPYRARVPMTRAALMHRDR-----------------
MAB_4293|M.abscessus_ATCC_1997      SVALGAAKPMMSGGKVLEMESADPDVDAFGAG-----------KVEDFSW
                                                                                      

Mb1188c|M.bovis_AF2122/97           --------PVAAPPASAPAPAPDAAQPV------AVPGP--PPAPPAPRA
Rv1157c|M.tuberculosis_H37Rv        --------PVAAPPASAPAPAPDAAQPV------AVPGP--PPAPPAPRA
MMAR_1894|M.marinum_M               --------RPGAPRPGGASPGNMPPRPG------GASGGPRPPRTGAPRP
MUL_2122|M.ulcerans_Agy99           --------RPGAPRPGGASSGNMPPRPG------GASGGPRPPRTGAPRP
MAV_3693|M.avium_104                --------RPGAPRPG-ASPGNMPPRPG------GVGGPGRPARPGAPRP
Mflv_3843|M.gilvum_PYR-GCK          VEGTGGAVPAGAPLAAAGGEVPPPAPPIPGAPVIGEAGVVPPPAPPAPAP
TH_0510|M.thermoresistible__bu      ---------IVLPMPRGWAHVPDPNVPD-------------AFAVIADRV
Mvan_0085|M.vanbaalenii_PYR-1       -------AANDAYMAQGPSASADQPVPIS-----QSSGGGSPGSPGGLGS
MSMEG_2148|M.smegmatis_MC2_155      ---------QLAPQLYVLAEVIDPRPDT--------AWPVYVDPPLHLTG
MLBr_01254|M.leprae_Br4923          ---------FCCAYCGAKADTVDHVVPR----------------------
MAB_4293|M.abscessus_ATCC_1997      KDLLDVTTCTECGRCQSQCPAWNTGKPLSPKLLITSLRDHTYAKAPYLLA
                                                                                      

Mb1188c|M.bovis_AF2122/97           AAPAPASAAP-------------APAAAPAPASGFG--------------
Rv1157c|M.tuberculosis_H37Rv        AAPAPASAAP-------------APAAAPAPASGFG--------------
MMAR_1894|M.marinum_M               GGGRPGGPGGGRSDGGGGNYRGGGGGVGAAPGGGFRGRPGGGGGGGRPGQ
MUL_2122|M.ulcerans_Agy99           GGGRPGGPGGGRSDGGGGNYRGGGGGVGAAPGGGFRGRPGGGGGGGRPGQ
MAV_3693|M.avium_104                GGGRPGGPGG--RDGGGGNYRGGGVGAPPGGGGGFRGRPGGGGGG-RPGQ
Mflv_3843|M.gilvum_PYR-GCK          PAGGLGGAVPPPVPGAPGVPVVDEAGVVTPPAPGGPGVPTGGEGGVVTPP
TH_0510|M.thermoresistible__bu      GGGFYTSNAQ---------------VVVYKLIGDFD--------------
Mvan_0085|M.vanbaalenii_PYR-1       PGSPSSSTSGSSPISTSGGSSSGSGASSSGSGSGSGG-------------
MSMEG_2148|M.smegmatis_MC2_155      AGGAPLGLLDSFADSVSSLANTATSAVKTAASATVSG-------------
MLBr_01254|M.leprae_Br4923          SRGGDHSWEN---------------CVACCSTCNHR--------------
MAB_4293|M.abscessus_ATCC_1997      GEDKSKLSEAEIAEGERQLVGGEGAVIDHEVLWSCTTCG-----------
                                                                                      

Mb1188c|M.bovis_AF2122/97           -----------------------ADAPPTQD-------------------
Rv1157c|M.tuberculosis_H37Rv        -----------------------ADAPPTQD-------------------
MMAR_1894|M.marinum_M               RGGAAGAFGRPGGAPRRGRKSKRAKRAEYEN-------------------
MUL_2122|M.ulcerans_Agy99           RGGAAGAFGRPGGAPRRGRKSKRAKRAEYEN-------------------
MAV_3693|M.avium_104                RGGAAGAFGRPGGAPRRGRKSKRQKRQEYDS-------------------
Mflv_3843|M.gilvum_PYR-GCK          APGAPGVPVVDEAGVVTPPAPGGPGVPTGGEGGVVTPPAPGAPGAPVVDE
TH_0510|M.thermoresistible__bu      -----------------------PKEAISHG-------------------
Mvan_0085|M.vanbaalenii_PYR-1       ---------------------SSSAAASSSG-------------------
MSMEG_2148|M.smegmatis_MC2_155      --------------------AKAVGSFVKENP------------------
MLBr_01254|M.leprae_Br4923          --------------------------------------------------
MAB_4293|M.abscessus_ATCC_1997      --------------------ACVEQCPVDIEH------------------
                                                                                      

Mb1188c|M.bovis_AF2122/97           ---FMYPSIGPNCVADGSN-------------------------------
Rv1157c|M.tuberculosis_H37Rv        ---FMYPSIGPNCVADGSN-------------------------------
MMAR_1894|M.marinum_M               ---MQAPVVGGVRLPHGNGETIRLARGASLSDFADKINANPAALVQALFN
MUL_2122|M.ulcerans_Agy99           ---MQAPVVGGVRLPHGNGETIRLARGASLSDFADKINANPAALVQALFN
MAV_3693|M.avium_104                ---MQAPVVGGVRLPHGNGETIRLARGASLSDFAEKIDANPASLVQALFN
Mflv_3843|M.gilvum_PYR-GCK          AGVVTPPAPGGPGVPAVGDTAVVTPPAPGAPGTPAVNSVETFSPPAPPAA
TH_0510|M.thermoresistible__bu      -------YIDSLQLPAWRT-------------------------------
Mvan_0085|M.vanbaalenii_PYR-1       ----TSPTSGGQSATGAAG---------GQPTAASPASAAKAQPSPMQQM
MSMEG_2148|M.smegmatis_MC2_155      --LESAMLVGGVALAVTGVG-----------------------GPAGAAA
MLBr_01254|M.leprae_Br4923          --------------------------------------------------
MAB_4293|M.abscessus_ATCC_1997      ----VDHIIDMRRYQVLIESEFPGELAGLFKNLENKGNPWGQNAKDRLNW
                                                                                      

Mb1188c|M.bovis_AF2122/97           --SIATALSVAGPAKIPLPGPGP---------------------------
Rv1157c|M.tuberculosis_H37Rv        --SIATALSVAGPAKIPLPGPGP---------------------------
MMAR_1894|M.marinum_M               LGEMVTATQSVGDETLELLGSEMNYNVQVVSPEDEDRELLESFDLTYGED
MUL_2122|M.ulcerans_Agy99           LGEMVTATQSVGDETLELLGSEMNYNVQVVSPEDEDRELLESFDLTYGED
MAV_3693|M.avium_104                LGEMVTATQSVGDETLELLGSEMNYNVQVVSPEDEDRELLESFDLTYGED
Mflv_3843|M.gilvum_PYR-GCK          TPPSSGSVETFSPPAPPAPGTGTNSTVEISTPPPPGTPGLPSEGSTTYTT
TH_0510|M.thermoresistible__bu      --TAQSMADHHGWPSSLIEGTYRD--------------------------
Mvan_0085|M.vanbaalenii_PYR-1       VNQAPPPLASSAPATSPAPAPAPS--------------------------
MSMEG_2148|M.smegmatis_MC2_155      IAAATVNLSSAGLDIAAAAMPDNQ--------------------------
MLBr_01254|M.leprae_Br4923          --KGDKLLTELGWVLRRTPVLPTG--------------------------
MAB_4293|M.abscessus_ATCC_1997      IEEVDFDVPVFGQDVDSFADFEYLFWVGCAG-------------------
                                               .                                      

Mb1188c|M.bovis_AF2122/97           --------------------------------------------------
Rv1157c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1894|M.marinum_M               SGDESELQTRPPVVTVMGHVDHGKTRLLDTIRKANVREGEAGGIT-----
MUL_2122|M.ulcerans_Agy99           SGDESELQTRPPVVTVMGHVDHGKTRLLDTIRKANVREGEAGGIT-----
MAV_3693|M.avium_104                EGTEEDLQTRPPVVTVMGHVDHGKTRLLDTIRKANVREAEQ---------
Mflv_3843|M.gilvum_PYR-GCK          PPTPEITLNPANSGIDIATPPAPGLPGAPLEATANITTPGTPGVPGAPVN
TH_0510|M.thermoresistible__bu      --------------------------------------------------
Mvan_0085|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2148|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_01254|M.leprae_Br4923          --------------------------------------------------
MAB_4293|M.abscessus_ATCC_1997      --------------------------------------------------
                                                                                      

Mb1188c|M.bovis_AF2122/97           ---------------------------------GQTAYVFTAVGTPGPAD
Rv1157c|M.tuberculosis_H37Rv        ---------------------------------GQTAYVFTAVGTPGPAD
MMAR_1894|M.marinum_M               ---------------------QHIGAYQVSVDHDGTERLITFIDTPGHEA
MUL_2122|M.ulcerans_Agy99           ---------------------QHIGAYQVSVDHDGTERLITFIDTPGHEA
MAV_3693|M.avium_104                ----------------------------VTVEHDGVERPITFIDTPGHEA
Mflv_3843|M.gilvum_PYR-GCK          SSIDVATPGEVGVPAAPIERSMTVTTPDTPGAPGAPANAAVDVATPPAPG
TH_0510|M.thermoresistible__bu      ---------------------------------NSVTLNTSRRHVIATSG
Mvan_0085|M.vanbaalenii_PYR-1       --------------------------------QPAAAPSAAAGAGPSSGG
MSMEG_2148|M.smegmatis_MC2_155      -------------------------------ALGMAANVMAAASMVTPQG
MLBr_01254|M.leprae_Br4923          ----------------------------------QHWRLLSTVKELDPAW
MAB_4293|M.abscessus_ATCC_1997      -----------------------------AYEDRAKKTTKAVAELLALAG
                                                                                      

Mb1188c|M.bovis_AF2122/97           VQRLPLN-------------------------------------------
Rv1157c|M.tuberculosis_H37Rv        VQRLPLN-------------------------------------------
MMAR_1894|M.marinum_M               FTAMRARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAVNKI
MUL_2122|M.ulcerans_Agy99           FTAMRARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAVNKI
MAV_3693|M.avium_104                FTAMRARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAVNKI
Mflv_3843|M.gilvum_PYR-GCK          VPGAPVVGEAGVTTPGAPGAPGAPANAAVDVATPPAPGVPGAPVVGEAAV
TH_0510|M.thermoresistible__bu      SDRYLVS-------------------------------------------
Mvan_0085|M.vanbaalenii_PYR-1       VGGISASAG-----------------------------------------
MSMEG_2148|M.smegmatis_MC2_155      AAKKVIKEG-----------------------------------------
MLBr_01254|M.leprae_Br4923          ARYLGGGAA-----------------------------------------
MAB_4293|M.abscessus_ATCC_1997      TKFLVLGADETCTGDSARRAGNEFLFQQLAMQNIELLN------------
                                                                                      

Mb1188c|M.bovis_AF2122/97           ---------------------------VTWVNLTTGK-------------
Rv1157c|M.tuberculosis_H37Rv        ---------------------------VTWVNLTTGK-------------
MMAR_1894|M.marinum_M               DKEGADPAKIRGQLTEYGLVAEDFGGDTMFVDISAKQGTNIEALEEAVLL
MUL_2122|M.ulcerans_Agy99           DKEGADPAKIRGQLTEYGLVAEDFGGDTMFVDISAKQGTNIEALEEAVLL
MAV_3693|M.avium_104                DVEGADPQKIRGQLTEYGLVPEEFGGDTMFVDISAKQGTNIDQLLEAVLL
Mflv_3843|M.gilvum_PYR-GCK          TTPGAPGVPGVPAGGDAGVVTPPAPGVPGAPVVGEAGVTTPGAPGVPGVP
TH_0510|M.thermoresistible__bu      --------------------------------------------------
Mvan_0085|M.vanbaalenii_PYR-1       ------------------------SAPVGAAPPSGAPPAPPVPLGPPTSP
MSMEG_2148|M.smegmatis_MC2_155      --------------------------VEQAGEQLAKHTDDVIERWPKNHP
MLBr_01254|M.leprae_Br4923          --------------------------------------------------
MAB_4293|M.abscessus_ATCC_1997      -----------SVFEGVEQKQRKIVVTCAHCFNALGNEYPQVGGDYQVVH
                                                                                      

Mb1188c|M.bovis_AF2122/97           --SGSATLRPRSDINPDGPTTLTVIADTGSGS---IMSTIFGQVTTKDRQ
Rv1157c|M.tuberculosis_H37Rv        --SGSATLRPRSDINPDGPTTLTVIADTGSGS---IMSTIFGQVTTKDRQ
MMAR_1894|M.marinum_M               TADAALDLRANPDMEAQG-VAIEAHLDRGRGP---VATVLVQRGTLRVGD
MUL_2122|M.ulcerans_Agy99           TADAALDLRANPDMEAQG-VAIEAHLDRGRGP---VATVLVQRGTLRVGD
MAV_3693|M.avium_104                TADAALDLRANPDMEAQG-VAIEAHLDRGRGP---VATVLIQRGTLRVGD
Mflv_3843|M.gilvum_PYR-GCK          AGGDAGVVTPPAPGVPGAPAATEAGLATPPGPGAPGAPVVGDAGVATPPG
TH_0510|M.thermoresistible__bu      -----LSVTTEVDQAVAAAEATDAIVN--------GFKVTSPTRPSAPPA
Mvan_0085|M.vanbaalenii_PYR-1       APPGPVPPTGTPGTAPGGAMGPGVAPMSTTGTAGGAAPAPIPVSTARAER
MSMEG_2148|M.smegmatis_MC2_155      TPPAQLADEVAAASTAKPPVSPGVSPKAPNAPPAKAPEPTQPASSAGPPG
MLBr_01254|M.leprae_Br4923          --------------------------------------------------
MAB_4293|M.abscessus_ATCC_1997      HTQLLNRLVRDKKLVPVAPVSQDVTYHDPCYLGRHNKVYTAPRELIGASG
                                                                                      

Mb1188c|M.bovis_AF2122/97           ---------------------------CQFMPTIGSTVVP----------
Rv1157c|M.tuberculosis_H37Rv        ---------------------------CQFMPTIGSTVVP----------
MMAR_1894|M.marinum_M               SVVAGDAYGRVRRMVDEHGEDVEEALPSRPVQVIGFTSVPGAGDNFLVVD
MUL_2122|M.ulcerans_Agy99           SVVAGDAYGRVRRMVDEHGEDVEEALPSRPVQVIGFTSVPGAGDNFLVVD
MAV_3693|M.avium_104                SIVAGDAYGRVRRMVDEHGDDVEEALPSRPVQVIGFTSVPGAGDNLLVVD
Mflv_3843|M.gilvum_PYR-GCK          PGVPGAPIVDEAGLATPPAPVAPVEGAGGAVPPAGPPPAPVFGDAGAPVE
TH_0510|M.thermoresistible__bu      P---------------------------VRAPSAAPVSLPASGAGLPAAQ
Mvan_0085|M.vanbaalenii_PYR-1       DAIAAASTAG-----------------ALRRKTNGADPLQQARHIAAALN
MSMEG_2148|M.smegmatis_MC2_155      ----------------------------ASTPGVRPGNLPRSQRVPPATK
MLBr_01254|M.leprae_Br4923          --------------------------------------------------
MAB_4293|M.abscessus_ATCC_1997      AAITEMPRHGERSMCCGAGGARMWMEEQLGKRINIDRVDEALSTPASKIA
                                                                                      

Mb1188c|M.bovis_AF2122/97           --------------------------------------------------
Rv1157c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1894|M.marinum_M               EDRIARQIADRRSARKRNALAARSRKRIS---------------------
MUL_2122|M.ulcerans_Agy99           EDRIARQIADRRSARKRNALAARSRKRIS---------------------
MAV_3693|M.avium_104                EDRIARQIADKRSARKRNALAARSRKRIS---------------------
Mflv_3843|M.gilvum_PYR-GCK          AAAGGAPVEAAAGVTGGGSVAGAGAGGGAGGAAGGAGVEGASGAVGAAGG
TH_0510|M.thermoresistible__bu      P-------------------------------------------------
Mvan_0085|M.vanbaalenii_PYR-1       VGIMDFGFFWVTGVTMEGTIVVANSYGLAY--------------------
MSMEG_2148|M.smegmatis_MC2_155      AQRDAAYEASAARNGGKPQCVYCGS-------------------------
MLBr_01254|M.leprae_Br4923          --------------------------------------------------
MAB_4293|M.abscessus_ATCC_1997      TGCPFCRVMLTDGVTARDDSAAVEVVDVAQLLLESVG---------RTED
                                                                                      

Mb1188c|M.bovis_AF2122/97           --------------------------------------------------
Rv1157c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1894|M.marinum_M               ------LEDLDSALKETSQLNLILKGDNAGTVEALEEALMGIEVDDEVAL
MUL_2122|M.ulcerans_Agy99           ------LEDLDSALKETSQLNLILKGDNAGTVEALEEALMGIEVDDEVAL
MAV_3693|M.avium_104                ------LEDLDSALKETSQLNLILKGDNAGTVEALEEALMGIQIDDEVAL
Mflv_3843|M.gilvum_PYR-GCK          PGAGAAPAAAGGAAPGGAPGGPVAGGGPVGGPGALPAPGAPIVGEAGVVS
TH_0510|M.thermoresistible__bu      --------------------------------------------------
Mvan_0085|M.vanbaalenii_PYR-1       -------IPAGVALPDQVRMATADESIPAGERAKWATYPILAVQGWAQHH
MSMEG_2148|M.smegmatis_MC2_155      ---------SDGPFHIDHVVPRAKGGTNAPSNHAPACATTCNLAKSDKRP
MLBr_01254|M.leprae_Br4923          --------------------------------------------------
MAB_4293|M.abscessus_ATCC_1997      IRKALPAKGTAAAAAAERAATKTAEPEPVVAEEEAPATTKAEAAAPAAEA
                                                                                      

Mb1188c|M.bovis_AF2122/97           --------------------------------------------------
Rv1157c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1894|M.marinum_M               RVIDRGVGGITETNVNLASASDAIIIGFNVRAEG----------------
MUL_2122|M.ulcerans_Agy99           RVIDRGVGGITETNVNLASASDAIIIGFNVRAEG----------------
MAV_3693|M.avium_104                RVIDRGVGGITETNVNLASASDAVIIGFNVRAEG----------------
Mflv_3843|M.gilvum_PYR-GCK          PPAPGVPGGAAAVPAGAVTPPAPGVPGAPVFGEAGVVTPPAPGVPGGAAA
TH_0510|M.thermoresistible__bu      --------------------------------------------------
Mvan_0085|M.vanbaalenii_PYR-1       NQQLRAVVATEEQFANFDPGVAKIILTQDDIPES----------------
MSMEG_2148|M.smegmatis_MC2_155      EDFLKELDARESKKHHPKPKGK----------------------------
MLBr_01254|M.leprae_Br4923          --------------------------------------------------
MAB_4293|M.abscessus_ATCC_1997      KPVSGLGMATGAKRPGAKKTAAENSTAEASTATPTAEAAPAAPVKGLGMA
                                                                                      

Mb1188c|M.bovis_AF2122/97           --------------------------------------------------
Rv1157c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1894|M.marinum_M               KATELANREGVEIRYYSVIYQAIDEIEKALRGMLKPIYEEVELGRAEIR-
MUL_2122|M.ulcerans_Agy99           KATELANREGVEIRYYSVIYQAIDEIEKALRGMLKPIYEEVELGRAEIR-
MAV_3693|M.avium_104                KATELANREGVEIRYYSVIYQAIDEIEKALRGMLKPIYEENQLGRAEIR-
Mflv_3843|M.gilvum_PYR-GCK          VPAGVVTPPAPGVPGGAAAVPAGAVTPPAPGVPGAPVFGDAGVATPPVPG
TH_0510|M.thermoresistible__bu      --------------------------------------------------
Mvan_0085|M.vanbaalenii_PYR-1       --GQMQGRSRLEVIAPEAAQRLSAVSDFGLNDLLPPATADLEPP------
MSMEG_2148|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_01254|M.leprae_Br4923          --------------------------------------------------
MAB_4293|M.abscessus_ATCC_1997      AGAKRPGAKKATAETSAATPPAASASPPASQAPAAAAAPAPPVKGLGMAA
                                                                                      

Mb1188c|M.bovis_AF2122/97           --------------------------------------------------
Rv1157c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1894|M.marinum_M               ----------ALFRSSKVGLIAGCMISSGVVRRNAKARLLRDNIVVVENL
MUL_2122|M.ulcerans_Agy99           ----------ALFRSSKVGLIAGCMISSGVVRRNAKARLLRDNIVVVENL
MAV_3693|M.avium_104                ----------AIFRSSKVGIIAGCMITSGVVRRNAKARLLRDNVVVSENL
Mflv_3843|M.gilvum_PYR-GCK          VPGGGTTVPAASVTPPAPGVPGGASTVPGNAGTPSTPGLPPGSTDTYINY
TH_0510|M.thermoresistible__bu      --------------------------------------------------
Mvan_0085|M.vanbaalenii_PYR-1       -------------ADDSARLWFEVAKPLMSTNPQRSGPHLQAFVAYAKHA
MSMEG_2148|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_01254|M.leprae_Br4923          --------------------------------------------------
MAB_4293|M.abscessus_ATCC_1997      GAKRPGAKKTAPAAPAAPAPEAAAVPSESEAPTATETSAVAEPPVKGLGI
                                                                                      

Mb1188c|M.bovis_AF2122/97           --------------------------------------------------
Rv1157c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1894|M.marinum_M               SIHSLRREKDDVTEVREGFECGMTLGYS--DLKEGDFIESYELVQKDRS-
MUL_2122|M.ulcerans_Agy99           SIRSLRREKDDVTEVREGFECGMTLGYS--DLKEGDFIESYELVQKDRS-
MAV_3693|M.avium_104                TINSLRREKDDVTEVREGFECGMTLGYS--DIKEGDVIESYELVQKERT-
Mflv_3843|M.gilvum_PYR-GCK          PAPPVPPTPPNSTGVSAGTPGSPAPGTPGSTLTLTDLLTPPGIARTLQNT
TH_0510|M.thermoresistible__bu      --------------------------------------------------
Mvan_0085|M.vanbaalenii_PYR-1       QELALHKAHNAAEPGDQRLAIADWVYWQHLEVLLTDAVSTDAAV------
MSMEG_2148|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_01254|M.leprae_Br4923          --------------------------------------------------
MAB_4293|M.abscessus_ATCC_1997      AAGARRPGAKKAAPATESAPEPAQPATAPEPTEPATSAPKDEAPETSSTP
                                                                                      

Mb1188c|M.bovis_AF2122/97           --------------------------------------------------
Rv1157c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1894|M.marinum_M               --------------------------------------------------
MUL_2122|M.ulcerans_Agy99           --------------------------------------------------
MAV_3693|M.avium_104                --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK          ASSVMGATPPGTPPVPGGSGSVSLAVPGTPSPIAPLAATGLSNLVSPPSL
TH_0510|M.thermoresistible__bu      --------------------------------------------------
Mvan_0085|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2148|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_01254|M.leprae_Br4923          --------------------------------------------------
MAB_4293|M.abscessus_ATCC_1997      EPPVKGLGIAPGARRPGRRN------------------------------
                                                                                      

Mb1188c|M.bovis_AF2122/97           --------------------------------------------------
Rv1157c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1894|M.marinum_M               --------------------------------------------------
MUL_2122|M.ulcerans_Agy99           --------------------------------------------------
MAV_3693|M.avium_104                --------------------------------------------------
Mflv_3843|M.gilvum_PYR-GCK          TIPSIPGLPVPLPNTVPVPSDLLCVGTDWSASQGDSAATPPAAEVPRVVT
TH_0510|M.thermoresistible__bu      --------------------------------------------------
Mvan_0085|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2148|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_01254|M.leprae_Br4923          --------------------------------------------------
MAB_4293|M.abscessus_ATCC_1997      --------------------------------------------------
                                                                                      

Mb1188c|M.bovis_AF2122/97           ---------------
Rv1157c|M.tuberculosis_H37Rv        ---------------
MMAR_1894|M.marinum_M               ---------------
MUL_2122|M.ulcerans_Agy99           ---------------
MAV_3693|M.avium_104                ---------------
Mflv_3843|M.gilvum_PYR-GCK          GAAPTGDRRDRWGNR
TH_0510|M.thermoresistible__bu      ---------------
Mvan_0085|M.vanbaalenii_PYR-1       ---------------
MSMEG_2148|M.smegmatis_MC2_155      ---------------
MLBr_01254|M.leprae_Br4923          ---------------
MAB_4293|M.abscessus_ATCC_1997      ---------------