For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
PKFLDALAGFAVTLGSMFKKPITEGYPEKPGPVAPRYHGRHQLNRYPDGLEKCIGCELCAWACPADAIYV EGADNTADERYSPGERYGRVYQINYLRCIGCGLCIEACPTRALTMTTEYEMADDNRADLIWGKDKLLAPL QEGMQAPPHDMAPGKTDDDYYLGNVTPITPVPSGTEDAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2055 | nuoI | - | 100% (180) | NADH dehydrogenase subunit I |
| M. smegmatis MC2 155 | MSMEG_0161 | - | 3e-05 | 28.16% (103) | formate dehydrogenase, alpha subunit |
| M. smegmatis MC2 155 | MSMEG_5681 | - | 8e-05 | 26.21% (103) | ferredoxin/ferredoxin--NADP reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3177 | nuoI | 3e-84 | 84.85% (165) | NADH dehydrogenase subunit I |
| M. gilvum PYR-GCK | Mflv_4489 | - | 8e-89 | 83.33% (180) | NADH dehydrogenase subunit I |
| M. tuberculosis H37Rv | Rv3153 | nuoI | 8e-84 | 84.24% (165) | NADH dehydrogenase subunit I |
| M. leprae Br4923 | MLBr_02134 | fprB | 2e-05 | 31.34% (67) | ferredoxin, ferredoxin-NADP reductase |
| M. abscessus ATCC 19977 | MAB_2142 | - | 3e-81 | 83.85% (161) | NADH dehydrogenase subunit I |
| M. marinum M | MMAR_1475 | nuoI | 5e-85 | 84.85% (165) | NADH dehydrogenase I (chain I) NuoI (NADH- ubiquinone |
| M. avium 104 | MAV_4041 | - | 6e-85 | 85.45% (165) | NADH dehydrogenase subunit I |
| M. thermoresistible (build 8) | TH_1087 | nuoI | 5e-90 | 85.88% (170) | PROBABLE NADH DEHYDROGENASE I (CHAIN I) NUOI |
| M. ulcerans Agy99 | MUL_2467 | nuoI | 3e-85 | 84.85% (165) | NADH dehydrogenase subunit I |
| M. vanbaalenii PYR-1 | Mvan_1877 | - | 9e-91 | 87.50% (168) | NADH dehydrogenase subunit I |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3177|M.bovis_AF2122/97 --------------------------------------------------
Rv3153|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1475|M.marinum_M --------------------------------------------------
MUL_2467|M.ulcerans_Agy99 --------------------------------------------------
MAV_4041|M.avium_104 --------------------------------------------------
MSMEG_2055|M.smegmatis_MC2_155 --------------------------------------------------
TH_1087|M.thermoresistible__bu --------------------------------------------------
Mflv_4489|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1877|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2142|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02134|M.leprae_Br4923 MPYIITQSCCNDGSCVFACPVNCIHPTPDEPGFATSEMLYIDPVACVDCG
Mb3177|M.bovis_AF2122/97 --------------------------------MANTDRPALPHKRAVPPS
Rv3153|M.tuberculosis_H37Rv --------------------------------MANTDRPALPHKRAVPPS
MMAR_1475|M.marinum_M --------------------------------------------------
MUL_2467|M.ulcerans_Agy99 --------------------------------------------------
MAV_4041|M.avium_104 --------------------------------------------------
MSMEG_2055|M.smegmatis_MC2_155 --------------------------------------------------
TH_1087|M.thermoresistible__bu --------------------------------------------------
Mflv_4489|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1877|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2142|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02134|M.leprae_Br4923 ACVSACPVGAIASDTRLAPKQLPFIEINASYYPARPIDLKLPPTSKLAPV
Mb3177|M.bovis_AF2122/97 RADSGPRRRRTKLLDAVAGFG----VTLGSMFKKT-----VTEEYPERPG
Rv3153|M.tuberculosis_H37Rv RADSGPRRRRTKLLDAVAGFG----VTLGSMFKKT-----VTEEYPERPG
MMAR_1475|M.marinum_M ---------MAKFLDSIAGFG----VTFGSMFKKT-----VTEEYPEKPG
MUL_2467|M.ulcerans_Agy99 ---------MAKFLDSIAGFG----VTFGSMFKKT-----VTEEYPEKPG
MAV_4041|M.avium_104 ---------MAKFLDAVAGFG----VTFASMFKKH-----VTEEYPEKPG
MSMEG_2055|M.smegmatis_MC2_155 ---------MPKFLDALAGFA----VTLGSMFKKP-----ITEGYPEKPG
TH_1087|M.thermoresistible__bu ---------LSRFLEAIAGFG----VTLGAMFKKP-----LTEQYPEQPG
Mflv_4489|M.gilvum_PYR-GCK ---------MPKFLDAVAGFG----VTFGSMFKKP-----VTEEYPEKPG
Mvan_1877|M.vanbaalenii_PYR-1 ---------MPKFLDAVAGFG----VTFGSMFKKP-----VTEEYPEKPG
MAB_2142|M.abscessus_ATCC_1997 -----MPDLLRRSADAMAGFW----VTFSSMFKKR-----LTEQYPEKKQ
MLBr_02134|M.leprae_Br4923 IPAAQVHVRRRPLTVAIVGSGPAAMYAADELLTQPGVWVNVFEKLPTPYG
::.* : ::.: : * *
Mb3177|M.bovis_AF2122/97 PVAARYHGRHQ--------LNRYPDG------LEKCIG------------
Rv3153|M.tuberculosis_H37Rv PVAARYHGRHQ--------LNRYPDG------LEKCIG------------
MMAR_1475|M.marinum_M PVAPRYHGRHQ--------LNRYPDG------LEKCIG------------
MUL_2467|M.ulcerans_Agy99 PVAPRYHGRHQ--------LNRYPDG------LEKCIG------------
MAV_4041|M.avium_104 PVAPRYHGRHQ--------LNRYPDG------LEKCIG------------
MSMEG_2055|M.smegmatis_MC2_155 PVAPRYHGRHQ--------LNRYPDG------LEKCIG------------
TH_1087|M.thermoresistible__bu PVAPRYHGRHQ--------LNRYPDG------LEKCIG------------
Mflv_4489|M.gilvum_PYR-GCK PVAKRYHGRHQ--------LNRYADG------LEKCIG------------
Mvan_1877|M.vanbaalenii_PYR-1 PVAKRYHGRHQ--------LNRYPDG------LEKCIG------------
MAB_2142|M.abscessus_ATCC_1997 PTAPRYHGRHQ--------LNRYADG------LEKCIG------------
MLBr_02134|M.leprae_Br4923 LVRAGLAPDHQNTKKVTELFDRVAEHRRFRFFLNVEIGRHLSHDELLAHH
. ** ::* .: *: **
Mb3177|M.bovis_AF2122/97 ----------------------------CELCAWACP-------------
Rv3153|M.tuberculosis_H37Rv ----------------------------CELCAWACP-------------
MMAR_1475|M.marinum_M ----------------------------CELCAWACP-------------
MUL_2467|M.ulcerans_Agy99 ----------------------------CELCAWACP-------------
MAV_4041|M.avium_104 ----------------------------CELCAWACP-------------
MSMEG_2055|M.smegmatis_MC2_155 ----------------------------CELCAWACP-------------
TH_1087|M.thermoresistible__bu ----------------------------CELCAWACP-------------
Mflv_4489|M.gilvum_PYR-GCK ----------------------------CELCAWACP-------------
Mvan_1877|M.vanbaalenii_PYR-1 ----------------------------CELCAWACP-------------
MAB_2142|M.abscessus_ATCC_1997 ----------------------------CELCAWACP-------------
MLBr_02134|M.leprae_Br4923 HAVLYAVGAPDDRRLNIDGMGIPGTGTATELVAWINAHPDFAYLPVDLSH
** ** .
Mb3177|M.bovis_AF2122/97 --------------------------------------------------
Rv3153|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1475|M.marinum_M --------------------------------------------------
MUL_2467|M.ulcerans_Agy99 --------------------------------------------------
MAV_4041|M.avium_104 --------------------------------------------------
MSMEG_2055|M.smegmatis_MC2_155 --------------------------------------------------
TH_1087|M.thermoresistible__bu --------------------------------------------------
Mflv_4489|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1877|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2142|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02134|M.leprae_Br4923 ERVVVIGNGNVALDVARLLTADPDNLARTDISEFALHVLGGSAVREVVVA
Mb3177|M.bovis_AF2122/97 ----------------------------ADAIYVEG--------------
Rv3153|M.tuberculosis_H37Rv ----------------------------ADAIYVEG--------------
MMAR_1475|M.marinum_M ----------------------------ADAIYVEG--------------
MUL_2467|M.ulcerans_Agy99 ----------------------------ADAIYVEG--------------
MAV_4041|M.avium_104 ----------------------------ADAIYVEG--------------
MSMEG_2055|M.smegmatis_MC2_155 ----------------------------ADAIYVEG--------------
TH_1087|M.thermoresistible__bu ----------------------------ADAIYVEG--------------
Mflv_4489|M.gilvum_PYR-GCK ----------------------------ADAIFVEG--------------
Mvan_1877|M.vanbaalenii_PYR-1 ----------------------------ADAIFVEG--------------
MAB_2142|M.abscessus_ATCC_1997 ----------------------------ADAIFVEG--------------
MLBr_02134|M.leprae_Br4923 ARRGPAHSAFTLPELIGLKATSEVVLDAGDRKLVEGDFATVSDSLTRKKL
.* ***
Mb3177|M.bovis_AF2122/97 ---ADNTEEERFSPGERYGRVYQINYLRCIG----CGLCIEACPTR----
Rv3153|M.tuberculosis_H37Rv ---ADNTEEERFSPGERYGRVYQINYLRCIG----CGLCIEACPTR----
MMAR_1475|M.marinum_M ---ADNTDEQRFSPGERYGRVYQINYLRCIG----CGLCIEACPTR----
MUL_2467|M.ulcerans_Agy99 ---ADNTDEQRFSPGERYGRVYQINYLRCIG----CGLCIEACPTR----
MAV_4041|M.avium_104 ---ADNTEELRYSPGERYGRVYQINYLRCIG----CGLCVEACPTR----
MSMEG_2055|M.smegmatis_MC2_155 ---ADNTADERYSPGERYGRVYQINYLRCIG----CGLCIEACPTR----
TH_1087|M.thermoresistible__bu ---ADNTEAQRYSPGERYGRVYQINYLRCIG----CGLCIEACPTR----
Mflv_4489|M.gilvum_PYR-GCK ---ADNTEAERYSPGERYGRVYQINYLRCIG----CGLCIEACPTR----
Mvan_1877|M.vanbaalenii_PYR-1 ---ADNTESERYSPGERYGRVYQINYLRCIG----CGLCIEACPTR----
MAB_2142|M.abscessus_ATCC_1997 ---ADNSEEERFSPGERYGRVYQINYLRCIG----CGLCIEACPTR----
MLBr_02134|M.leprae_Br4923 EVLSSLVDSSKPTSRRRIRLAYQLTPKRVLGNQRATGVEFSVTGTEESRR
:. : :. .* .**:. * :* *: ... *.
Mb3177|M.bovis_AF2122/97 --ALTMTYDYELADDNRADLIYEKDRLLAPLLPEMAAPPHPRAPG-----
Rv3153|M.tuberculosis_H37Rv --ALTMTYDYELADDNRADLIYEKDRLLAPLLPEMAAPPHPRTPG-----
MMAR_1475|M.marinum_M --ALTMTNDYELADDNRADLIYEKDRLLAPLQPEMTAPPHPRAAG-----
MUL_2467|M.ulcerans_Agy99 --ALTMTNDYELADDNRADLIYEKDRLLAPLQPEMTAPPHPRAAG-----
MAV_4041|M.avium_104 --ALTMTNDYEMADDNRADLIYEKDRLLAPLLPEMTAPPHPRAPG-----
MSMEG_2055|M.smegmatis_MC2_155 --ALTMTTEYEMADDNRADLIWGKDKLLAPLQEGMQAPPHDMAPG-----
TH_1087|M.thermoresistible__bu --ALTMTNDYEMADDNRADLIWGKDKLLAPLQPGMVPPPHPMAVG-----
Mflv_4489|M.gilvum_PYR-GCK --ALTMTNDYEMADDNRADLIYGKDKLLAPLEPGMGAPPHAMAPG-----
Mvan_1877|M.vanbaalenii_PYR-1 --ALTMTNDYEMADDNRSDLIYGKDKLLAPLEPGMEAPPHAMAPD-----
MAB_2142|M.abscessus_ATCC_1997 --ALTMTNDYEMADDNRADLIYGKDKLLAPLQPGMTAPPHAMYPG-----
MLBr_02134|M.leprae_Br4923 FDAGLVLTSVGYRGKRIRDLPFDEEAAVIPNDGGRVVDPSRGRPMPGAYV
* : . ... ** : :: : * *
Mb3177|M.bovis_AF2122/97 ------------------------ATDKDYYLGNVTAEGLRGVRESQTTG
Rv3153|M.tuberculosis_H37Rv ------------------------ATDKDYYLGNVTAEGLRGVRESQTTG
MMAR_1475|M.marinum_M ------------------------ATDKDYYLGNVTAEGLR---ETQKTG
MUL_2467|M.ulcerans_Agy99 ------------------------ATDKDYYLGNVTAEGLR---ETQKTG
MAV_4041|M.avium_104 ------------------------ATDKDYYLGNVTAHGLR---EAQRAG
MSMEG_2055|M.smegmatis_MC2_155 ------------------------KTDDDYYLGNVTPITPVP----SGTE
TH_1087|M.thermoresistible__bu ------------------------ATDEDYYLGRVSPIT----------E
Mflv_4489|M.gilvum_PYR-GCK ------------------------ATDEDYYRGTVSPSAEA---------
Mvan_1877|M.vanbaalenii_PYR-1 ------------------------STDDDYYLGNIKP-AAR---------
MAB_2142|M.abscessus_ATCC_1997 ------------------------ATDTDYYLGNLPKAG----------E
MLBr_02134|M.leprae_Br4923 AGWIKRGPTGFIGTNKLCSVQTVQAVVADFNAGWLTDPVAEPAELAKLVH
. *: * :
Mb3177|M.bovis_AF2122/97 DSR-----------------------------------------------
Rv3153|M.tuberculosis_H37Rv DSR-----------------------------------------------
MMAR_1475|M.marinum_M ESR-----------------------------------------------
MUL_2467|M.ulcerans_Agy99 ESR-----------------------------------------------
MAV_4041|M.avium_104 EPR-----------------------------------------------
MSMEG_2055|M.smegmatis_MC2_155 DAR-----------------------------------------------
TH_1087|M.thermoresistible__bu DVR-----------------------------------------------
Mflv_4489|M.gilvum_PYR-GCK DAR-----------------------------------------------
Mvan_1877|M.vanbaalenii_PYR-1 DAR-----------------------------------------------
MAB_2142|M.abscessus_ATCC_1997 EVR-----------------------------------------------
MLBr_02134|M.leprae_Br4923 ARQPDTVDSVGWRAIDAAEIAQGSTEGRPRRKFTDVADMLAVAAGAPPLR
:
Mb3177|M.bovis_AF2122/97 -----
Rv3153|M.tuberculosis_H37Rv -----
MMAR_1475|M.marinum_M -----
MUL_2467|M.ulcerans_Agy99 -----
MAV_4041|M.avium_104 -----
MSMEG_2055|M.smegmatis_MC2_155 -----
TH_1087|M.thermoresistible__bu -----
Mflv_4489|M.gilvum_PYR-GCK -----
Mvan_1877|M.vanbaalenii_PYR-1 -----
MAB_2142|M.abscessus_ATCC_1997 -----
MLBr_02134|M.leprae_Br4923 LRALS