For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
FVVATAGHVDHGKSTLVHRLTGMWPDRLAEEQRRGLTIDLGFAWTTLEGRDIAFVDVPGHERFVGNMLAG VGPVPATMFVVAATEGWMPQSEEHLAALEALGVRHTLVVISKADLADPARAIAQVRDRIPDARVVLGTDL GSVQAELVALVDRLPAPATDSDVRLWVDRSFTVRGAGTVVTGTLAAGTIRVGDQLERDGRLVTVRGLQSL GRDRDAVSAVARVAVNLRGVERESLRRGDAVRTPGAWLDTSEVDVVLRSAGKLHQKLTLHIGSASVPVHV RPLGDVGARLRLTRALPLRIGDIGLLRDPGAHRIVAGVEVLDVRPAPLRRRGDARARAAALATGRVTPPV CARAKDLRAMGFEVVGERIGDWVVSPEWWAERRRLALAAVEQWAAEHDIAAGMPFETLRQRVGLPAVELV PALLDGTGLQLRDGLVQRPGVALPPRVDKAVQTVREWLAAEPFRAPEAAELAELNLGPKELAAAVRAGRF VRVADGVVLGPDAFDRAAEVLVGLPQPFTVAEAKRALNTTRRVAVPLLEQLDARGVTTRADDGTRTVRVS RAGDTGQAD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1849 | selB | - | 100% (570) | selenocysteine-specific translation elongation factor |
| M. smegmatis MC2 155 | MSMEG_1401 | tuf | 1e-30 | 31.29% (294) | elongation factor Tu |
| M. smegmatis MC2 155 | MSMEG_4978 | cysNC | 4e-14 | 26.25% (301) | bifunctional sulfate adenylyltransferase subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0704 | tuf | 6e-32 | 31.97% (294) | elongation factor Tu |
| M. gilvum PYR-GCK | Mflv_5075 | - | 2e-32 | 32.65% (294) | elongation factor Tu |
| M. tuberculosis H37Rv | Rv0685 | tuf | 6e-32 | 31.97% (294) | elongation factor Tu |
| M. leprae Br4923 | MLBr_01877 | tuf | 6e-32 | 30.61% (294) | elongation factor Tu |
| M. abscessus ATCC 19977 | MAB_3848c | - | 1e-30 | 31.19% (295) | elongation factor Tu |
| M. marinum M | MMAR_5191 | selB | 0.0 | 71.02% (566) | selenocysteine-specific translation elongation factor, SelB |
| M. avium 104 | MAV_0417 | - | 0.0 | 73.19% (567) | elongation factor Tu GTP binding domain-containing protein |
| M. thermoresistible (build 8) | TH_4394 | - | 5e-31 | 29.93% (294) | PUTATIVE translation elongation factor 1A (EF-1A/EF-Tu) |
| M. ulcerans Agy99 | MUL_0766 | tuf | 1e-30 | 31.29% (294) | elongation factor Tu |
| M. vanbaalenii PYR-1 | Mvan_1282 | - | 2e-31 | 32.28% (285) | elongation factor Tu |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0704|M.bovis_AF2122/97 MAKAKFQRTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKFPDLNETKAFD
Rv0685|M.tuberculosis_H37Rv MAKAKFQRTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKFPDLNETKAFD
MLBr_01877|M.leprae_Br4923 MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKFPNLNESRAFD
MUL_0766|M.ulcerans_Agy99 MAKAKFQRTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKYPELNESRAFD
Mflv_5075|M.gilvum_PYR-GCK MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAITKVLHDQYPDLNESRAFD
Mvan_1282|M.vanbaalenii_PYR-1 MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKYPDLNESRAFD
MAB_3848c|M.abscessus_ATCC_199 MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKYPDLNEASAFD
TH_4394|M.thermoresistible__bu VAKAKFERTKPHVNIGTIGHVDHGKTTTTAAITKVLHDKYPELNESRAFE
MMAR_5191|M.marinum_M -----------MFVIATAGHVDHGKSTLVHRLTDMWPDR-----------
MAV_0417|M.avium_104 -----------MFVLATAGHVDHGKSTLLHRLTGMWPDR-----------
MSMEG_1849|M.smegmatis_MC2_155 -----------MFVVATAGHVDHGKSTLVHRLTGMWPDR-----------
. :.* *******:* :* : *:
Mb0704|M.bovis_AF2122/97 QIDNAPEERQRGITINIAHVEYQTDKRHYAHVDAPGHADYIKNMITGAAQ
Rv0685|M.tuberculosis_H37Rv QIDNAPEERQRGITINIAHVEYQTDKRHYAHVDAPGHADYIKNMITGAAQ
MLBr_01877|M.leprae_Br4923 QIDNAPEERQRGITINISHVEYQTEKRHYAHVDAPGHADYIKNMITGAAQ
MUL_0766|M.ulcerans_Agy99 QIDNAPEERQRGITINISHVEYQTEKRHYAHVDAPGHADYIKNMITGAAQ
Mflv_5075|M.gilvum_PYR-GCK QIDNAPEERQRGITINISHVEYQTEKRHYAHVDAPGHADYIKNMITGAAQ
Mvan_1282|M.vanbaalenii_PYR-1 QIDNAPEERQRGITINISHVEYQTDKRHYAHVDAPGHADYIKNMITGAAQ
MAB_3848c|M.abscessus_ATCC_199 QIDNAPEEKARGITINISHVEYQTEKRHYAHVDAPGHADYIKNMITGAAQ
TH_4394|M.thermoresistible__bu QIDNAPEERQRGITINISHVEYQTEKRHYAHVDAPGHADYIKNMITGAAQ
MMAR_5191|M.marinum_M ----LAEEQRRGLTIDLGFAWTELDGRQLAFVDVPGHERFVTNMLAGSGA
MAV_0417|M.avium_104 ----LAEEQRRGLTIDLGFVWTELAGRRLAFVDVPGHERFVANMLAGVGP
MSMEG_1849|M.smegmatis_MC2_155 ----LAEEQRRGLTIDLGFAWTTLEGRDIAFVDVPGHERFVGNMLAGVGP
.**: **:**::... * *.**.*** :: **::* .
Mb0704|M.bovis_AF2122/97 MDG---AILVVAATDGPMPQTREHVLLARQVGVPYILVALNKADAVD---
Rv0685|M.tuberculosis_H37Rv MDG---AILVVAATDGPMPQTREHVLLARQVGVPYILVALNKADAVD---
MLBr_01877|M.leprae_Br4923 MDG---AILVVAATDGPMPQTREHVLLARQVGVPYILVALNKSDAVD---
MUL_0766|M.ulcerans_Agy99 MDG---AILVVAATDGPMPQTREHVLLARQVGVPYILVALNKSDAVD---
Mflv_5075|M.gilvum_PYR-GCK MDG---AILVVAATDGPMPQTREHVLLARQVGVPYILVALNKADMVD---
Mvan_1282|M.vanbaalenii_PYR-1 MDG---AILVVAATDGPMPQTREHVLLARQVGVPYILVALNKADMVD---
MAB_3848c|M.abscessus_ATCC_199 MDG---AILVVAATDGPMPQTREHVLLARQVGVPYILVALNKSDMVD---
TH_4394|M.thermoresistible__bu MDG---AILVVAATDGPMPQTREHVLLARQVGVPYILVALNKADMVD---
MMAR_5191|M.marinum_M MPPDSPVLFVVAATEGWMPQSEEHLAALDALRVRHALLVISKADLADPGP
MAV_0417|M.avium_104 VP---AVVFVVAATEGWMPQSEEHLAALDALRVRHGLLVISKADLADPGP
MSMEG_1849|M.smegmatis_MC2_155 VP---ATMFVVAATEGWMPQSEEHLAALEALGVRHTLVVISKADLADPAR
: .::*****:* ***:.**: : * : *:.:.*:* .*
Mb0704|M.bovis_AF2122/97 -------------------------DEELLELVEMEVRELLAAQEFD---
Rv0685|M.tuberculosis_H37Rv -------------------------DEELLELVEMEVRELLAAQEFD---
MLBr_01877|M.leprae_Br4923 -------------------------DEELLELVEMEVRELLAAQEFD---
MUL_0766|M.ulcerans_Agy99 -------------------------DEELLELVEMEVRELLAAQEFD---
Mflv_5075|M.gilvum_PYR-GCK -------------------------DEELIELVEMEVRELLAAQDFD---
Mvan_1282|M.vanbaalenii_PYR-1 -------------------------DEELIELVEMEVRELLAAQDFD---
MAB_3848c|M.abscessus_ATCC_199 -------------------------DEELLELVEMEVRELLSSQDFDG--
TH_4394|M.thermoresistible__bu -------------------------DPELLELVEMEVRELLASQEFD---
MMAR_5191|M.marinum_M AIRAASERFATTSMADPFVALGTELDQVRTKLLALTDRLPEPDRDADVRL
MAV_0417|M.avium_104 AVAQATERFAATSLAGAPVAIGTDLERVRAELVALTDRLPPPDPHADVRL
MSMEG_1849|M.smegmatis_MC2_155 AIAQVRDR-----IPDARVVLGTDLGSVQAELVALVDRLPAPATDSDVRL
:*: : * . . *
Mb0704|M.bovis_AF2122/97 -------------------------------EDAPVVRVSALKALEGDAK
Rv0685|M.tuberculosis_H37Rv -------------------------------EDAPVVRVSALKALEGDAK
MLBr_01877|M.leprae_Br4923 -------------------------------EDAPVVRVSALKALEGDAK
MUL_0766|M.ulcerans_Agy99 -------------------------------EDAPVVRVSALKALEGDPK
Mflv_5075|M.gilvum_PYR-GCK -------------------------------EDAPVVKVSALKALEGDEK
Mvan_1282|M.vanbaalenii_PYR-1 -------------------------------EEAPVVKVSALKALEGDEK
MAB_3848c|M.abscessus_ATCC_199 -------------------------------DNAPVVRVSALKALEGDAE
TH_4394|M.thermoresistible__bu -------------------------------ENAPVIPISALKALEGDPK
MMAR_5191|M.marinum_M WVDRAFTVRGAGTVVTGTLSAGTIRVGDELEHAGQRVTVRGLQSLGRDHT
MAV_0417|M.avium_104 WVDRSFTVRGAGTVVTGTLAAGTVRVGDELEHAGRRVTVRGLQSLGRNEI
MSMEG_1849|M.smegmatis_MC2_155 WVDRSFTVRGAGTVVTGTLAAGTIRVGDQLERDGRLVTVRGLQSLGRDRD
. : : .*::* :
Mb0704|M.bovis_AF2122/97 WVASVEELMNAVDESIPDPVR-----ETDKPFLMPVEDVFTITG---RGT
Rv0685|M.tuberculosis_H37Rv WVASVEELMNAVDESIPDPVR-----ETDKPFLMPVEDVFTITG---RGT
MLBr_01877|M.leprae_Br4923 WVESVTQLMDAVDESIPAPVR-----ETDKPFLMPVEDVFTITG---RGT
MUL_0766|M.ulcerans_Agy99 WVESVEQLMDAVDESIPDPVR-----ETDRPFLMPVEDVFTITG---RGT
Mflv_5075|M.gilvum_PYR-GCK WVKSVQELMAAVDESIPDPVR-----ETDKPFLMPVEDVFTITG---RGT
Mvan_1282|M.vanbaalenii_PYR-1 WVKSVEELMEAVDESIPDPVR-----ETDKPFLMPVEDVFTITG---RGT
MAB_3848c|M.abscessus_ATCC_199 WGKTVADLMDAVDESIPDPVR-----ETEKPFLMPVEDVFTITG---RGT
TH_4394|M.thermoresistible__bu WVKSVEDLMEAVDESIPDPVR-----DTDKPFLMPIEDVFTITG---RGT
MMAR_5191|M.marinum_M EVAAVARVALNLRGVDRRHIARGDTVRTPGAWLDTTEIDVSLR----SAV
MAV_0417|M.avium_104 RVGAVARVALNLRGVDRRDIGRGDTVRTPGAWRDTAEIDVALRGPGTAED
MSMEG_1849|M.smegmatis_MC2_155 AVSAVARVAVNLRGVERESLRRGDAVRTPGAWLDTSEVDVVLR----SAG
:* : : : * .: . * . :
Mb0704|M.bovis_AF2122/97 VVTGRVERGVINVNEEVEIVGIRPSTTKTTVTG-----VEMFRKLLDQGQ
Rv0685|M.tuberculosis_H37Rv VVTGRVERGVINVNEEVEIVGIRPSTTKTTVTG-----VEMFRKLLDQGQ
MLBr_01877|M.leprae_Br4923 VVTGRVERGVVNVNEEVEIVGIRQTTTKTTVTG-----VEMFRKLLDQGQ
MUL_0766|M.ulcerans_Agy99 VVTGRVERGIINVNEEVEIVGIRPTSTKTTVTG-----VEMFRKLLDQGQ
Mflv_5075|M.gilvum_PYR-GCK VVTGRVERGVINVNEEVEIVGIRPTVTKTTVTG-----VEMFRKLLDQGQ
Mvan_1282|M.vanbaalenii_PYR-1 VVTGRVERGIINVNEEVEIVGIRPDTTKTTVTG-----VEMFRKLLDQGQ
MAB_3848c|M.abscessus_ATCC_199 VVTGRVERGVINVNEDVEIVGIKDTTTKTTVTG-----VEMFRKLLDQGQ
TH_4394|M.thermoresistible__bu VVTGRIERGVINVNDEVEIVGIRPETTKTTVTG-----VEMFRKLLDQGQ
MMAR_5191|M.marinum_M KLHRELVAHLGSAAVPVYVRALGAEAARLRLSRPLPLRVGDIGLLRDPGQ
MAV_0417|M.avium_104 TLHSQLVLHVGSAAVPVRVRRLGPAAARLRLARPLPLRVADVGLLRDPGQ
MSMEG_1849|M.smegmatis_MC2_155 KLHQKLTLHIGSASVPVHVRPLGDVGARLRLTRALPLRIGDIGLLRDPGA
: .: : .. * : : :: :: : . * * *
Mb0704|M.bovis_AF2122/97 AGDNVGLLLRGVKREDVER-------GQVVTKPGTTTPHTEFEGQVYILS
Rv0685|M.tuberculosis_H37Rv AGDNVGLLLRGVKREDVER-------GQVVTKPGTTTPHTEFEGQVYILS
MLBr_01877|M.leprae_Br4923 AGDNVGLLLRGIKREDVER-------GQVVIKPGTTTPHTEFEGQVYILS
MUL_0766|M.ulcerans_Agy99 AGDNVGLLLRGIKREDVER-------GQVVVKPGTTTPHTEFEGQVYILS
Mflv_5075|M.gilvum_PYR-GCK AGDNVGLLVRGIKREDVER-------GQVVVKPGTTTPHTEFEGSVYILS
Mvan_1282|M.vanbaalenii_PYR-1 AGDNVGLLLRGIKREDVER-------GQVVVKPGTTTPHTDFEGSVYILS
MAB_3848c|M.abscessus_ATCC_199 AGDNVGLLVRGVKREDVER-------GQVVVKPGTTTPHTEFEGSVYILS
TH_4394|M.thermoresistible__bu AGDNVGLLLRGIKREDVER-------GQVVVQPGTTTPHTEFEGSVYILS
MMAR_5191|M.marinum_M HRIAAGIEVLDVAPPSLRRRGAARERAQELAGGRIRPPQCARAAVLRAMG
MAV_0417|M.avium_104 HRIAAGVEVLDVRPPELRRRGAARLRAAELATGSAPAPHIVRADDLRAMG
MSMEG_1849|M.smegmatis_MC2_155 HRIVAGVEVLDVRPAPLRRRGDARARAAALATGRVTPPVCARAKDLRAMG
.*: : .: :.* . : .* : :.
Mb0704|M.bovis_AF2122/97 KDEGGR-------HTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDN
Rv0685|M.tuberculosis_H37Rv KDEGGR-------HTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDN
MLBr_01877|M.leprae_Br4923 KDEGGR-------HTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDN
MUL_0766|M.ulcerans_Agy99 KDEGGR-------HTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDN
Mflv_5075|M.gilvum_PYR-GCK KDEGGR-------HTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDN
Mvan_1282|M.vanbaalenii_PYR-1 KDEGGR-------HTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDN
MAB_3848c|M.abscessus_ATCC_199 KDEGGR-------HTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDN
TH_4394|M.thermoresistible__bu KDEGGR-------HTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDN
MMAR_5191|M.marinum_M LPLAGLRVGDWLVDPQWWAARREHAAATVTHWAADHDVAAGMPLETLRQQ
MAV_0417|M.avium_104 VPARGQRVGDWVVDPQWWAERRDEAAAQVRRWAGEHDIAAGMPLETLRRQ
MSMEG_1849|M.smegmatis_MC2_155 FEVVGERIGDWVVSPEWWAERRRLALAAVEQWAAEHDIAAGMPFETLRQR
* . :: * . :. :. * : .
Mb0704|M.bovis_AF2122/97 TNISVKLIQPVAMDEG----------------------------------
Rv0685|M.tuberculosis_H37Rv TNISVKLIQPVAMDEG----------------------------------
MLBr_01877|M.leprae_Br4923 TNISVTLIQPVAMDEG----------------------------------
MUL_0766|M.ulcerans_Agy99 TNISVKLIQPVAMDDG----------------------------------
Mflv_5075|M.gilvum_PYR-GCK TDIAVKLIQPVAMDEG----------------------------------
Mvan_1282|M.vanbaalenii_PYR-1 TDISVKLIQPVAMDEG----------------------------------
MAB_3848c|M.abscessus_ATCC_199 TDISVKLIQPVAMDEG----------------------------------
TH_4394|M.thermoresistible__bu TDISVKLIQPVAMEEG----------------------------------
MMAR_5191|M.marinum_M VGLPAAELVPPLLVGTGLDVADGLVRPPGAGLPARVDAAVRTLEGRLAAE
MAV_0417|M.avium_104 VGLPAAELVPKLLQGTGFEVADGLVRAPGAGLPARVDKAVREVEAWLAAE
MSMEG_1849|M.smegmatis_MC2_155 VGLPAVELVPALLDGTGLQLRDGLVQRPGVALPPRVDKAVQTVREWLAAE
..:.. : * :
Mb0704|M.bovis_AF2122/97 ------------LRFAIREGGRTVGAGRVTKIIK----------------
Rv0685|M.tuberculosis_H37Rv ------------LRFAIREGGRTVGAGRVTKIIK----------------
MLBr_01877|M.leprae_Br4923 ------------LRFAIREGGRTVGAGRVVKIIK----------------
MUL_0766|M.ulcerans_Agy99 ------------LRFAIREGGRTVGAGRVVKIIK----------------
Mflv_5075|M.gilvum_PYR-GCK ------------LRFAIREGGRTVGAGRVTKIIK----------------
Mvan_1282|M.vanbaalenii_PYR-1 ------------LRFAIREGGRTVGAGRVTKIIK----------------
MAB_3848c|M.abscessus_ATCC_199 ------------LRFAIREGGRTVGAGRVTKIIK----------------
TH_4394|M.thermoresistible__bu ------------LRFAIREGGRTVGAGRVTKIIK----------------
MMAR_5191|M.marinum_M PFRAPEADELGELRLGARELAAAVRAGRLTRVADAIVLGPDAFERAAEIL
MAV_0417|M.avium_104 PFRAPEADELAGLGLGPRELAAAVRAGRLTRIADGVVLGPDALARAAGVL
MSMEG_1849|M.smegmatis_MC2_155 PFRAPEAAELAELNLGPKELAAAVRAGRFVRVADGVVLGPDAFDRAAEVL
* :. :* . :* ***..:: .
Mb0704|M.bovis_AF2122/97 --------------------------------------------------
Rv0685|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01877|M.leprae_Br4923 --------------------------------------------------
MUL_0766|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5075|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1282|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3848c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4394|M.thermoresistible__bu --------------------------------------------------
MMAR_5191|M.marinum_M ATLPQPFTVSQARRVLGTTRRVAVPLLEQLDALGITRRGEAGTRTLLTTP
MAV_0417|M.avium_104 AGLPQPFTVSEARRALGTTRRVAVPLLEQLDARRVTRRASDGTRVLIAD-
MSMEG_1849|M.smegmatis_MC2_155 VGLPQPFTVAEAKRALNTTRRVAVPLLEQLDARGVTTRADDGTRTVRVSR
Mb0704|M.bovis_AF2122/97 --------
Rv0685|M.tuberculosis_H37Rv --------
MLBr_01877|M.leprae_Br4923 --------
MUL_0766|M.ulcerans_Agy99 --------
Mflv_5075|M.gilvum_PYR-GCK --------
Mvan_1282|M.vanbaalenii_PYR-1 --------
MAB_3848c|M.abscessus_ATCC_199 --------
TH_4394|M.thermoresistible__bu --------
MMAR_5191|M.marinum_M G-------
MAV_0417|M.avium_104 --------
MSMEG_1849|M.smegmatis_MC2_155 AGDTGQAD