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VSQVQRPPTLSTGAMVSSSHPAASFAGARVLADGGNAIDATLAMAAVTWLTLPGQCGIGGDAFAVVAEPD GRVWTVNGSGFGPDGGTTDFYRDIQGGRSGIPLTGALGVAVPGAPAALAALHSHGARMSLAELWEPAARM AENGLACTAKTVTDVREAFDAIRADDGLAAVYTPDGAVPAVGQRLPQPDLARTIRRLATAPGDFYTGEFA ERAVAVLCAAGAPFSGDEWAAGAVVAPEAPLTGGYAGATIHQTPLPTPGWMVLQQAALCDGTLGAAPWLG AEAIDRMARAARLAFQDRFALCGSDGAGVREVLDANRIAEQRRALDASAEQRMSFSVAGGDTTCTVAVDA DGRAVSFIHSLGFTFGAKLTVPGTGVVLNNRLGRGAYLIPGHPNEVAPRRKPLNTLNAWIATGADGELLA LGSIPGGDGQVQWNMQLLSYLFDHGLDPAEAVSAPRFTVFPGSDADVIGRPDELRVEARIPDDVRSELQD MGHRVVVQPDFGAGGSAQVIRRDARGVLSGAADPRQEGIAIGVE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1463 | - | - | 100% (534) | gamma-glutamyltranspeptidase |
| M. smegmatis MC2 155 | MSMEG_1615 | ggt | 5e-48 | 33.27% (526) | gamma-glutamyltranspeptidase |
| M. smegmatis MC2 155 | MSMEG_3076 | ggt | 8e-30 | 27.04% (577) | gamma-glutamyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0796c | ggtA | 3e-60 | 31.89% (530) | bifunctional cephalosporin |
| M. gilvum PYR-GCK | Mflv_3716 | - | 4e-32 | 27.82% (568) | gamma-glutamyltransferase |
| M. tuberculosis H37Rv | Rv0773c | ggtA | 3e-60 | 31.89% (530) | bifunctional cephalosporin |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2788 | - | 4e-28 | 25.30% (577) | gamma-glutamyltranspeptidase (GgtB) |
| M. marinum M | MMAR_4920 | ggtA | 1e-55 | 31.76% (529) | bifunctional acylase, GgtA |
| M. avium 104 | MAV_0717 | ggt | 2e-56 | 30.19% (530) | gamma-glutamyltransferase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0486 | ggtA | 2e-37 | 30.46% (417) | bifunctional acylase, GgtA |
| M. vanbaalenii PYR-1 | Mvan_1330 | - | 0.0 | 70.22% (534) | gamma-glutamyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0796c|M.bovis_AF2122/97 --------------------------------------------------
Rv0773c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0717|M.avium_104 --------------------------------------------------
MMAR_4920|M.marinum_M --------------------------------------------------
MUL_0486|M.ulcerans_Agy99 --------------------------------------------------
Mflv_3716|M.gilvum_PYR-GCK MAVMWATRRTTTSALRVLLGLSLILTGCTARQDTPAAPPGPCDIVANGTP
MAB_2788|M.abscessus_ATCC_1997 ---MRALTRALAIASIALLASAGCAGDMTSR---PGGAAEPCGITANGVP
MSMEG_1463|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1330|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0796c|M.bovis_AF2122/97 ------------------------------MPILATNVVCTSQPLAAQAG
Rv0773c|M.tuberculosis_H37Rv ------------------------------MPILATNVVCTSQPLAAQAG
MAV_0717|M.avium_104 ---------MNQPFG------WDFPYAWPRKPVLADNVVCTSQPLAAQAG
MMAR_4920|M.marinum_M ---------MTSSAGSASPFGWTFPYAWPHTPILAANAVCTSQPLAAQAG
MUL_0486|M.ulcerans_Agy99 ---------MQRSGG---------------------DLICR---------
Mflv_3716|M.gilvum_PYR-GCK VSSDGG------RSDDTAPETATGYRSDMTAVHTRSYAVATANPLATRAA
MAB_2788|M.abscessus_ATCC_1997 ITKTAATQAATERNISTNPEVATGYRTGMTAVRTASYAAATANPLATQAA
MSMEG_1463|M.smegmatis_MC2_155 -----------------------MSQVQRPPTLSTGAMVSSSHPAASFAG
Mvan_1330|M.vanbaalenii_PYR-1 -----------------------MATAQRPPALSANAMVSSSHPAASLAG
.
Mb0796c|M.bovis_AF2122/97 LRMLADGGNAVDAAVATAITLTVVEPVSNGIGSDAFSIVWDGQKLHGLNA
Rv0773c|M.tuberculosis_H37Rv LRMLADGGNAVDAAVATAITLTVVEPVSNGIGSDAFSIVWDGQKLHGLNA
MAV_0717|M.avium_104 LRMLAEGGSAVDAAIATAITLTIVEPVSNGMGSDAFAIVWDGEKVHGLNA
MMAR_4920|M.marinum_M LRMLAEGGNAVDAAIATAITLTLVEPVSNGIGSDAFAIVWDGQQLHGLNA
MUL_0486|M.ulcerans_Agy99 ----------IRLALRLDLSVRMAAHAHPGR-----------QRRVHLTA
Mflv_3716|M.gilvum_PYR-GCK CEVLRDGGTAADALVTAQAVLGLVEPQSSGLGGGGFLLYYDAAAQSVQAF
MAB_2788|M.abscessus_ATCC_1997 CKVLRDGGSAADALVAAQAVLGLVEPQSSGIGGGGFLVYYDAASGAVQTY
MSMEG_1463|M.smegmatis_MC2_155 ARVLADGGNAIDATLAMAAVTWLTLPGQCGIGGDAFAVVAEPDGRVWTVN
Mvan_1330|M.vanbaalenii_PYR-1 ARVLADGGNAIDATLAMAALTWLTLPGQCGIGGDAFAVVREPDGRVWTVN
: :. *
Mb0796c|M.bovis_AF2122/97 SGRSPSAWTPEYFGG-----------NAVPVLGWNSVTVPGAVSAWVELH
Rv0773c|M.tuberculosis_H37Rv SGRSPSAWTPEYFGG-----------NAVPVLGWNSVTVPGAVSAWVELH
MAV_0717|M.avium_104 SGRSPAAWTPEYFGG-----------NAVPVLGWNSVTVPGAVSAWTELH
MMAR_4920|M.marinum_M SGRSPAAWTPEYFCG-----------KDVPILGWNSVTVPGAVSAWVDLH
MUL_0486|M.ulcerans_Agy99 AGRP--SGSSDACRR-----------RERRRRRYRHRHHP----------
Mflv_3716|M.gilvum_PYR-GCK DGRETAPAAATENSLRWISDTDRTEPKPDARASGRSIGVPGIVAMLAQVH
MAB_2788|M.abscessus_ATCC_1997 DGREVAPAAATENYLRWVDDADRTAPRPDVRSSGRSIGVPGILRMLYDVH
MSMEG_1463|M.smegmatis_MC2_155 GSGFGPDGGTTDFYR-----DIQGGRSGIPLTGALGVAVPGAPAALAALH
Mvan_1330|M.vanbaalenii_PYR-1 GSGYGPDGGTPEFY-------AAQGLSSIPLDGPLAVAVPGAVAALRALH
. . *
Mb0796c|M.bovis_AF2122/97 ARFGRLPFETLFEPAISYGRNGFLVSPTVAAQWAAQVPLFASQPGFADAF
Rv0773c|M.tuberculosis_H37Rv ARFGRLPFETLFEPAISYGRNGFLVSPTVAAQWAAQVPLFASQPGFADAF
MAV_0717|M.avium_104 ARFGKLPFERLFAPAISYGRNGFPVSPVVAEQWVAQVPLFAGQPGFAEAF
MMAR_4920|M.marinum_M AKFGKLPFERLFGPAIAYGRNGFLVSPKVSAQWQAQVALFADQPGFAEAF
MUL_0486|M.ulcerans_Agy99 -HPGGTGFQRLFGPAITYGRNGFLVSPKVSAQWQAQVALFADQPGFAEAF
Mflv_3716|M.gilvum_PYR-GCK AEHGRTPWRDLFSPAVTLADDGFDVSARLAAAIAAAAPKLALDDDAAAYF
MAB_2788|M.abscessus_ATCC_1997 AEHGAAPWRELFTPAVQLADDGFEISPRLAAAITDSAASLALDPEADLYL
MSMEG_1463|M.smegmatis_MC2_155 SHGARMSLAELWEPAARMAENGLACTAKTVTDVREAFDAIRADDGLAAVY
Mvan_1330|M.vanbaalenii_PYR-1 LGGATRELEQLWEPAARIAGDGLPCSARTAGDVVTALG------------
. *: ** . :*: :.
Mb0796c|M.bovis_AF2122/97 MPGGRAPK-PGELFTFPDHAATLEKIAATNGEEFYRGELAAKLEAHSAAN
Rv0773c|M.tuberculosis_H37Rv MPGGRAPK-PGELFTFPDHAATLEKIAATNGEEFYRGELAAKLEAHSAAN
MAV_0717|M.avium_104 APEGRAPR-PGERFRLPAHADTLEAIAASRGEAFYRGALAARVAEHAAAN
MMAR_4920|M.marinum_M LPGGRAPR-PGELFTFPDHADTLEKIAASTGAAFYRGELADKLEAHARAN
MUL_0486|M.ulcerans_Agy99 LPGGRAPK-PGELFTFPDHADTLEKIAASTGAAFYRGELADKLEAHARAN
Mflv_3716|M.gilvum_PYR-GCK LNADRTPKSAGTTLTNPAYAKTLGAVAAD-PEAFYTGDIARAIVASVTDP
MAB_2788|M.abscessus_ATCC_1997 LNTDGSAKPAGTKITNPAYAKTLGAVAADGPDAFYRGAIAEAIVAAAADT
MSMEG_1463|M.smegmatis_MC2_155 TPDGAVPA-VGQRLPQPDLARTIRRLATA-PGDFYTGEFAERAVAVLCAA
Mvan_1330|M.vanbaalenii_PYR-1 ---DSAPA-VGSRVPQPELAATIRRLARD-PEGFYTGEFAQRAVAALQAG
. . * . * * *: :* ** * :*
Mb0796c|M.bovis_AF2122/97 -----GGVMRADDLAAHRVDWVDTITGTYRGYTIHQIP-PNGQGIVALIA
Rv0773c|M.tuberculosis_H37Rv -----GGVMRADDLAAHRVDWVDTITGTYRGYTIHQIP-PNGQGIVALIA
MAV_0717|M.avium_104 -----GGAMTADDLAAHRADWVETITGDYRGYTVHEIP-PNGHGIVALIA
MMAR_4920|M.marinum_M -----DAALRASDLAAHRTDWVGTISTNYRDYTIHEIP-PNGQGIVALIA
MUL_0486|M.ulcerans_Agy99 -----DAALRASDLAAHRTDWVGTISTNYRDYTIHEIP-PNGQGIVALIA
Mflv_3716|M.gilvum_PYR-GCK SGGRTPGLMTVEDLADYTVKQRDPLCTPYRGKEICGMPPPSSGGIAVAAT
MAB_2788|M.abscessus_ATCC_1997 SSGRTPSLMTTADLSGYTAKRRAALCTTYRDHEICGMPAPSSGGIAVAAT
MSMEG_1463|M.smegmatis_MC2_155 G----APFSGDEWAAGAVVAPEAPLTGGYAGATIHQTPLPTPGWMVLQQA
Mvan_1330|M.vanbaalenii_PYR-1 G----APFSGDEWTAGAEVNPEPAITGRYAGAVVHQTPLPTPGWMVLQQA
: . .: * . : * *. :. :
Mb0796c|M.bovis_AF2122/97 LGILEHFDMSSWSVDSAES---------VHVQIEALKLAFADAQACVADI
Rv0773c|M.tuberculosis_H37Rv LGILEHFDMSSWSVDSAES---------VHVQIEALKLAFADAQACVADI
MAV_0717|M.avium_104 LGILERFDMASLPVDSADS---------VHLQIEAVKLAFADAQAYLADI
MMAR_4920|M.marinum_M LGILDQFDMSCYPVDSADS---------VHLQIEALKLAFSDAQHQLADI
MUL_0486|M.ulcerans_Agy99 LGILDQFDMSCYPVDSADS---------VHLQIEALKLAFSDAQHQLADI
Mflv_3716|M.gilvum_PYR-GCK LGMLERFPMADHAPTDVDLNGGRPSVMGVHLISEAERLAYADRDRYVADT
MAB_2788|M.abscessus_ATCC_1997 LGILQNFPMASFRPTDIDLDGGKPTVDGVHYIAEAERLAYADRDKYVADT
MSMEG_1463|M.smegmatis_MC2_155 ALCDGTLGAAPWLGAEAIDR-----------MARAARLAFQDR-FALCGS
Mvan_1330|M.vanbaalenii_PYR-1 ALCDGVVGFSGWLSAEAIDR-----------LARAARLTFADR-LALCAS
. : . .* :*:: * :.
Mb0796c|M.bovis_AF2122/97 DYMPVH---PKRLLDKEYLRQRATLIDPKRAMPAATG------------I
Rv0773c|M.tuberculosis_H37Rv DYMPVH---PKRLLDKEYLRQRATLIDPKRAMPAATG------------I
MAV_0717|M.avium_104 EHMPLR---PEHLLDTEYLERRAALIDPARAKPVSAG------------A
MMAR_4920|M.marinum_M DHMTVG---PDQLLDKEYLRGRAALIDLKQAKPASAG------------T
MUL_0486|M.ulcerans_Agy99 DHMTVG---PDQLLDKEYLRGRAALIDLKQAKPASAG------------T
Mflv_3716|M.gilvum_PYR-GCK DFVALPGGSPDTLLGNDYLAGRAALISPDRSMGTAEPGNFGPPTAPVPPT
MAB_2788|M.abscessus_ATCC_1997 DFVALPGNSPDTLLNPTYLAGRARLISGDTTMGVAKPGEFNIPASAAVST
MSMEG_1463|M.smegmatis_MC2_155 DGAGVR-----EVLDANRIAEQRRALDASAEQRMSFS------------V
Mvan_1330|M.vanbaalenii_PYR-1 DNDGSR-----YVLTPDRIEAQRRDLDCGTEARGPVE------------V
: :* : : :. .
Mb0796c|M.bovis_AF2122/97 PRGGTVYLAAADAAGMMVSMIQSNYLGFGSGVVVPGTGISLHNRGS-DFT
Rv0773c|M.tuberculosis_H37Rv PRGGTVYLAAADAAGMMVSMIQSNYLGFGSGVVVPGTGISLHNRGS-DFT
MAV_0717|M.avium_104 PAGGTVYLTAADAAGMMVSMIQSNYMGFGSGVVVPGTGISLQNRGA-NFT
MMAR_4920|M.marinum_M PKGGTIYLTAADADGLMVSMIQSNYMGFGSGVVVPGTGISLQNRGS-GFV
MUL_0486|M.ulcerans_Agy99 PKGGTIYLTAADADGLMVSMIQSNYMGFGSGVVVPGTGISLQNRGS-GFV
Mflv_3716|M.gilvum_PYR-GCK PEHGTSHVSVVDRDGNAASLTTTVESAFGSFHMVDG--FLLNNQLT-DFS
MAB_2788|M.abscessus_ATCC_1997 PEHGTSQVTVVDARGNAASLTTTVESAFGSFHMVDG--FFLNNQLT-DFS
MSMEG_1463|M.smegmatis_MC2_155 AGGDTTCTVAVDADGRAVSFIHSLGFTFGAKLTVPGTGVVLNNRLGRGAY
Mvan_1330|M.vanbaalenii_PYR-1 RAGDTTSTVVVDAEGRAVSFIHSLAFTFGAKFTVPGTGVILNNRLARGAY
.* ..* * .*: : **: * * . *:*: .
Mb0796c|M.bovis_AF2122/97 VVPRHP------NRVGPRKRPYHTIIPGFVTRDG------APVMSFGVMG
Rv0773c|M.tuberculosis_H37Rv VVPRHP------NRVGPRKRPYHTIIPGFVTRDG------APVMSFGVMG
MAV_0717|M.avium_104 AGLGHP------NSVGPNKRPYHTIIPGFVTKGG------APVMSFGVMG
MMAR_4920|M.marinum_M ATPGHP------NQVGPRKRPYHTIIPGFVTKDG------APVLSFGVMG
MUL_0486|M.ulcerans_Agy99 ATPGHP------NQVGPRKRPYHTIIPGFVTKDG------APVLSFGVMG
Mflv_3716|M.gilvum_PYR-GCK AEPAGPDGAPVANRLEPGKRPRSTMAPTLIFDTSGPDRR--LYAVAGSPG
MAB_2788|M.abscessus_ATCC_1997 AEPVGKDGLPVANRLQPGKRPRSSMAPTLVFERAESGKRGALLLALGSPG
MSMEG_1463|M.smegmatis_MC2_155 LIPGHP------NEVAPRRKPLNTLNAWIATGADG-----ELLALGSIPG
Mvan_1330|M.vanbaalenii_PYR-1 LIPGHP------NEVAPRRKPLHTLNAWVVTDDAG-----ALLHVGNTPG
* : * ::* :: . . . *
Mb0796c|M.bovis_AF2122/97 GMMQPQGHVQVLVRIADYGQNPQAACDGPRFRWVNGMRVSF---------
Rv0773c|M.tuberculosis_H37Rv GMMQPQGHVQVLVRIADYGQNPQAACDGPRFRWVNGMRVSF---------
MAV_0717|M.avium_104 GMMQPQGHVQVMVRIADHGQNPQAACDGPRFRWVQGTQVSC---------
MMAR_4920|M.marinum_M AQMQPQGHVQMMVRIADYGQNPQAACDGPRFRWVQGLKVSC---------
MUL_0486|M.ulcerans_Agy99 AQMQPQGHVQMMVRIADYGQNPQAACDGPRFRWVQELKVSC---------
Mflv_3716|M.gilvum_PYR-GCK GSTIIQFVVKTVVGMLDWGLDPQQAVSMVDFGADNSPETNVGGEHPVIDT
MAB_2788|M.abscessus_ATCC_1997 GSVIIQFVVKTLVGILDWGLDPQQAVSMVDFGANNSPKTNVGGEHPSIDA
MSMEG_1463|M.smegmatis_MC2_155 GDGQVQWNMQLLSYLFDHGLDPAEAVSAPRFTVFPGSDADVIG-RPDELR
Mvan_1330|M.vanbaalenii_PYR-1 GDGQVQWNMQLLSHVLDHGLDPAEAVSAPRFTVFPGSDADVVG-SPDELR
. * :: : : * * :* * . * ..
Mb0796c|M.bovis_AF2122/97 -ENGFPDSTLDELRQRGHDLVAVADYSQFGSCQAIWRLDDGYLA-ASDPR
Rv0773c|M.tuberculosis_H37Rv -ENGFPDSTLDELRQRGHDLVAVADYSQFGSCQAIWRLDDGYLA-ASDPR
MAV_0717|M.avium_104 -ENGFPAATLDELRRRGHDLVAVDDYNQFGSCQAIWRMDTGYVA-ASDPR
MMAR_4920|M.marinum_M -EKGFPPSTLDELRRRGHDLVTVEDYNEFGSCQAIWRLEHGYLA-ASDPR
MUL_0486|M.ulcerans_Agy99 -EKGFPPSTLDELRRRGHDLVTVEDYNEFGSCQAIWRLEHGYLA-GSDPR
Mflv_3716|M.gilvum_PYR-GCK ADDGADDPLVRGLRELGHKVDLADQSSGLS---AIVRAGDGWVG-GADPR
MAB_2788|M.abscessus_ATCC_1997 RDNGADDPLIQRLRARGHIVDVADQSSGLS---ALVRRGPGWIG-GADPR
MSMEG_1463|M.smegmatis_MC2_155 VEARIPDDVRSELQDMGHRVVVQPDFGAGGSAQVIRRDARGVLSGAADPR
Mvan_1330|M.vanbaalenii_PYR-1 VEQSLPAGVRRQLAAAGHRVVDQPALGGGGSAQLISVDERGVLAGAADPR
: * ** : . . : * :. .:***
Mb0796c|M.bovis_AF2122/97 RDGQAAAC------
Rv0773c|M.tuberculosis_H37Rv RDGQAAAC------
MAV_0717|M.avium_104 RDGQAAAF------
MMAR_4920|M.marinum_M RDGQAAAF------
MUL_0486|M.ulcerans_Agy99 RDGQAAAF------
Mflv_3716|M.gilvum_PYR-GCK REGAVMGDGDAPVS
MAB_2788|M.abscessus_ATCC_1997 REGLVMGDTG----
MSMEG_1463|M.smegmatis_MC2_155 QEGIAIGVE-----
Mvan_1330|M.vanbaalenii_PYR-1 QEGVALGVD-----
::* . .