For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VTSSAGSASPFGWTFPYAWPHTPILAANAVCTSQPLAAQAGLRMLAEGGNAVDAAIATAITLTLVEPVSN GIGSDAFAIVWDGQQLHGLNASGRSPAAWTPEYFCGKDVPILGWNSVTVPGAVSAWVDLHAKFGKLPFER LFGPAIAYGRNGFLVSPKVSAQWQAQVALFADQPGFAEAFLPGGRAPRPGELFTFPDHADTLEKIAASTG AAFYRGELADKLEAHARANDAALRASDLAAHRTDWVGTISTNYRDYTIHEIPPNGQGIVALIALGILDQF DMSCYPVDSADSVHLQIEALKLAFSDAQHQLADIDHMTVGPDQLLDKEYLRGRAALIDLKQAKPASAGTP KGGTIYLTAADADGLMVSMIQSNYMGFGSGVVVPGTGISLQNRGSGFVATPGHPNQVGPRKRPYHTIIPG FVTKDGAPVLSFGVMGAQMQPQGHVQMMVRIADYGQNPQAACDGPRFRWVQGLKVSCEKGFPPSTLDELR RRGHDLVTVEDYNEFGSCQAIWRLEHGYLAASDPRRDGQAAAF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4920 | ggtA | - | 100% (533) | bifunctional acylase, GgtA |
| M. marinum M | MMAR_3713 | ggtB | 2e-48 | 29.81% (577) | gamma-glutamyltranspeptidase precursor GgtB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0796c | ggtA | 0.0 | 80.00% (510) | bifunctional cephalosporin |
| M. gilvum PYR-GCK | Mflv_3716 | - | 1e-46 | 29.72% (562) | gamma-glutamyltransferase |
| M. tuberculosis H37Rv | Rv0773c | ggtA | 0.0 | 80.00% (510) | bifunctional cephalosporin |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2788 | - | 4e-54 | 32.34% (569) | gamma-glutamyltranspeptidase (GgtB) |
| M. avium 104 | MAV_0717 | ggt | 0.0 | 79.20% (524) | gamma-glutamyltransferase |
| M. smegmatis MC2 155 | MSMEG_1615 | ggt | 4e-59 | 32.95% (516) | gamma-glutamyltranspeptidase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0486 | ggtA | 0.0 | 97.28% (404) | bifunctional acylase, GgtA |
| M. vanbaalenii PYR-1 | Mvan_1330 | - | 3e-48 | 30.23% (526) | gamma-glutamyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3716|M.gilvum_PYR-GCK MAVMWATRRTTTSALRVLLGLSLILTGCTARQDTPAAPPGPCDIVANGTP
MAB_2788|M.abscessus_ATCC_1997 ---MRALTRALAIASIALLASAGCAGDMTSR---PGGAAEPCGITANGVP
MMAR_4920|M.marinum_M --------------------------------------------------
MUL_0486|M.ulcerans_Agy99 --------------------------------------------------
Mb0796c|M.bovis_AF2122/97 --------------------------------------------------
Rv0773c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0717|M.avium_104 --------------------------------------------------
MSMEG_1615|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1330|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3716|M.gilvum_PYR-GCK VSSDGG------RSDDTAPETATGYRSDMTAVHTRSYAVATANPLATRAA
MAB_2788|M.abscessus_ATCC_1997 ITKTAATQAATERNISTNPEVATGYRTGMTAVRTASYAAATANPLATQAA
MMAR_4920|M.marinum_M ---------MTSSAGSASPFGWTFPYAWPHTPILAANAVCTSQPLAAQAG
MUL_0486|M.ulcerans_Agy99 ---------MQRSGG---------------------DLICR---------
Mb0796c|M.bovis_AF2122/97 ------------------------------MPILATNVVCTSQPLAAQAG
Rv0773c|M.tuberculosis_H37Rv ------------------------------MPILATNVVCTSQPLAAQAG
MAV_0717|M.avium_104 ---------MNQPFG------WDFPYAWPRKPVLADNVVCTSQPLAAQAG
MSMEG_1615|M.smegmatis_MC2_155 -------------------------------MSTFTGALASPHALATEAG
Mvan_1330|M.vanbaalenii_PYR-1 -----------------------MATAQRPPALSANAMVSSSHPAASLAG
.
Mflv_3716|M.gilvum_PYR-GCK CEVLRDGGTAADALVTAQAVLGLVEPQSSGLGGGGFLLYYDAAAQSVQA-
MAB_2788|M.abscessus_ATCC_1997 CKVLRDGGSAADALVAAQAVLGLVEPQSSGIGGGGFLVYYDAASGAVQT-
MMAR_4920|M.marinum_M LRMLAEGGNAVDAAIATAITLTLVEPVSNGIGSDAFAIVWDGQQLHGLN-
MUL_0486|M.ulcerans_Agy99 ----------IRLALRLDLSVRMAAHAHPGR-----------QRRVHLT-
Mb0796c|M.bovis_AF2122/97 LRMLADGGNAVDAAVATAITLTVVEPVSNGIGSDAFSIVWDGQKLHGLN-
Rv0773c|M.tuberculosis_H37Rv LRMLADGGNAVDAAVATAITLTVVEPVSNGIGSDAFSIVWDGQKLHGLN-
MAV_0717|M.avium_104 LRMLAEGGSAVDAAIATAITLTIVEPVSNGMGSDAFAIVWDGEKVHGLN-
MSMEG_1615|M.smegmatis_MC2_155 MAAFAEGGNAIDAAISAAAVLTVVYPHNVALGGDLIALVRTPDGIIRCVN
Mvan_1330|M.vanbaalenii_PYR-1 ARVLADGGNAIDATLAMAALTWLTLPGQCGIGGDAFAVVREPDGRVWTVN
: :. .
Mflv_3716|M.gilvum_PYR-GCK FDGRETAPAAATENSLRWISDTDRTEPKPDARASGRSIGVPGIVAMLAQV
MAB_2788|M.abscessus_ATCC_1997 YDGREVAPAAATENYLRWVDDADRTAPRPDVRSSGRSIGVPGILRMLYDV
MMAR_4920|M.marinum_M ASGRSPAAWTPEYFCG-----------KDVPILGWNSVTVPGAVSAWVDL
MUL_0486|M.ulcerans_Agy99 AAGRP--SGSSDACRR-----------RERRRRRYRHRHHP---------
Mb0796c|M.bovis_AF2122/97 ASGRSPSAWTPEYFGG-----------NAVPVLGWNSVTVPGAVSAWVEL
Rv0773c|M.tuberculosis_H37Rv ASGRSPSAWTPEYFGG-----------NAVPVLGWNSVTVPGAVSAWVEL
MAV_0717|M.avium_104 ASGRSPAAWTPEYFGG-----------NAVPVLGWNSVTVPGAVSAWTEL
MSMEG_1615|M.smegmatis_MC2_155 ASGWSGAQATAERMRTRH--------GRSLPARHADSVTVPGGVRGWEAL
Mvan_1330|M.vanbaalenii_PYR-1 GSGYGPDGGTPEFYAAQG--------LSSIPLDGPLAVAVPGAVAALRAL
* :. *
Mflv_3716|M.gilvum_PYR-GCK HAEHGRTPWRDLFSPAVTLADDGFDVSARLAAAIAAAAPKLALDDDAAAY
MAB_2788|M.abscessus_ATCC_1997 HAEHGAAPWRELFTPAVQLADDGFEISPRLAAAITDSAASLALDPEADLY
MMAR_4920|M.marinum_M HAKFGKLPFERLFGPAIAYGRNGFLVSPKVSAQWQAQVALFADQPGFAEA
MUL_0486|M.ulcerans_Agy99 --HPGGTGFQRLFGPAITYGRNGFLVSPKVSAQWQAQVALFADQPGFAEA
Mb0796c|M.bovis_AF2122/97 HARFGRLPFETLFEPAISYGRNGFLVSPTVAAQWAAQVPLFASQPGFADA
Rv0773c|M.tuberculosis_H37Rv HARFGRLPFETLFEPAISYGRNGFLVSPTVAAQWAAQVPLFASQPGFADA
MAV_0717|M.avium_104 HARFGKLPFERLFAPAISYGRNGFPVSPVVAEQWVAQVPLFAGQPGFAEA
MSMEG_1615|M.smegmatis_MC2_155 RSLGCRISWAQTLAPAQRVAEAGVAVAKSLAHHIADPENADLAESEDFCR
Mvan_1330|M.vanbaalenii_PYR-1 HLGGATRELEQLWEPAARIAGDGLPCSARTAGDVVT--------------
** . *. : :
Mflv_3716|M.gilvum_PYR-GCK FLNADRTPKSAGTTLTNPAYAKTLGAVAAD-PEAFYTGDIARAIVASVTD
MAB_2788|M.abscessus_ATCC_1997 LLNTDGSAKPAGTKITNPAYAKTLGAVAADGPDAFYRGAIAEAIVAAAAD
MMAR_4920|M.marinum_M FLPGGRAPR-PGELFTFPDHADTLEKIAASTGAAFYRGELADKLEAHARA
MUL_0486|M.ulcerans_Agy99 FLPGGRAPK-PGELFTFPDHADTLEKIAASTGAAFYRGELADKLEAHARA
Mb0796c|M.bovis_AF2122/97 FMPGGRAPK-PGELFTFPDHAATLEKIAATNGEEFYRGELAAKLEAHSAA
Rv0773c|M.tuberculosis_H37Rv FMPGGRAPK-PGELFTFPDHAATLEKIAATNGEEFYRGELAAKLEAHSAA
MAV_0717|M.avium_104 FAPEGRAPR-PGERFRLPAHADTLEAIAASRGEAFYRGALAARVAEHAAA
MSMEG_1615|M.smegmatis_MC2_155 VFRPGGRMLATGEVLVQPALASTFAALRQQGPAAFYTGALADSMLAHLGK
Mvan_1330|M.vanbaalenii_PYR-1 --ALGDSAPAVGSRVPQPELAATIRRLARD-PEGFYTGEFAQRAVAALQA
. * . * * *: : ** * :*
Mflv_3716|M.gilvum_PYR-GCK PSGGRTPGLMTVEDLADYTVKQRDP-LCTPYRGKEICGMPPPSSGGIAVA
MAB_2788|M.abscessus_ATCC_1997 TSSGRTPSLMTTADLSGYTAKRRAA-LCTTYRDHEICGMPAPSSGGIAVA
MMAR_4920|M.marinum_M N-----DAALRASDLAAHRTDWVGT-ISTNYRDYTIHEIP-PNGQGIVAL
MUL_0486|M.ulcerans_Agy99 N-----DAALRASDLAAHRTDWVGT-ISTNYRDYTIHEIP-PNGQGIVAL
Mb0796c|M.bovis_AF2122/97 N-----GGVMRADDLAAHRVDWVDT-ITGTYRGYTIHQIP-PNGQGIVAL
Rv0773c|M.tuberculosis_H37Rv N-----GGVMRADDLAAHRVDWVDT-ITGTYRGYTIHQIP-PNGQGIVAL
MAV_0717|M.avium_104 N-----GGAMTADDLAAHRADWVET-ITGDYRGYTVHEIP-PNGHGIVAL
MSMEG_1615|M.smegmatis_MC2_155 H-----GSCLAAADFAEFTPEFTEP-LSARFGDLTVLTSP-PNTHGFAML
Mvan_1330|M.vanbaalenii_PYR-1 G-----GAPFSGDEWTAGAEVNPEPAITGRYAGAVVHQTP-LPTPGWMVL
. : : : . : : . : * *
Mflv_3716|M.gilvum_PYR-GCK ATLGMLERFPMADHAPTDVDLNGGRPSVMGVHLISEAERLAYADRDRYVA
MAB_2788|M.abscessus_ATCC_1997 ATLGILQNFPMASFRPTDIDLDGGKPTVDGVHYIAEAERLAYADRDKYVA
MMAR_4920|M.marinum_M IALGILDQFDMSCYPVDSADS---------VHLQIEALKLAFSDAQHQLA
MUL_0486|M.ulcerans_Agy99 IALGILDQFDMSCYPVDSADS---------VHLQIEALKLAFSDAQHQLA
Mb0796c|M.bovis_AF2122/97 IALGILEHFDMSSWSVDSAES---------VHVQIEALKLAFADAQACVA
Rv0773c|M.tuberculosis_H37Rv IALGILEHFDMSSWSVDSAES---------VHVQIEALKLAFADAQACVA
MAV_0717|M.avium_104 IALGILERFDMASLPVDSADS---------VHLQIEAVKLAFADAQAYLA
MSMEG_1615|M.smegmatis_MC2_155 RALRAIE-ERDVADPLGAGIG----------TLMR---IFHHGNVLRERR
Mvan_1330|M.vanbaalenii_PYR-1 QQAALCDGVVGFSGWLSAEAI----------DRLARAARLTFADRLALCA
: : ..:
Mflv_3716|M.gilvum_PYR-GCK DTDFVALPGGSPDTLLGNDYLAGRAALISPDRSMGTAEPGNFGPPTAPVP
MAB_2788|M.abscessus_ATCC_1997 DTDFVALPGNSPDTLLNPTYLAGRARLISGDTTMGVAKPGEFNIPASAAV
MMAR_4920|M.marinum_M DIDHMTVG---PDQLLDKEYLRGRAALIDLKQAKPASAG-----------
MUL_0486|M.ulcerans_Agy99 DIDHMTVG---PDQLLDKEYLRGRAALIDLKQAKPASAG-----------
Mb0796c|M.bovis_AF2122/97 DIDYMPVH---PKRLLDKEYLRQRATLIDPKRAMPAATG-----------
Rv0773c|M.tuberculosis_H37Rv DIDYMPVH---PKRLLDKEYLRQRATLIDPKRAMPAATG-----------
MAV_0717|M.avium_104 DIEHMPLR---PEHLLDTEYLERRAALIDPARAKPVSAG-----------
MSMEG_1615|M.smegmatis_MC2_155 LGDPRLSD------IDTHALVNGALGEVAELGKHPGPVL-----------
Mvan_1330|M.vanbaalenii_PYR-1 SDNDGSRY------VLTPDRIEAQRRDLDCGTEARGPVE-----------
: : : : .
Mflv_3716|M.gilvum_PYR-GCK PTPEHGTSHVSVVDRDGNAASLTTTVESAFGSFHMVDG--FLLNNQLTD-
MAB_2788|M.abscessus_ATCC_1997 STPEHGTSQVTVVDARGNAASLTTTVESAFGSFHMVDG--FFLNNQLTD-
MMAR_4920|M.marinum_M -TPKGGTIYLTAADADGLMVSMIQSNYMGFGSGVVVPGTGISLQNRGSG-
MUL_0486|M.ulcerans_Agy99 -TPKGGTIYLTAADADGLMVSMIQSNYMGFGSGVVVPGTGISLQNRGSG-
Mb0796c|M.bovis_AF2122/97 -IPRGGTVYLAAADAAGMMVSMIQSNYLGFGSGVVVPGTGISLHNRGSD-
Rv0773c|M.tuberculosis_H37Rv -IPRGGTVYLAAADAAGMMVSMIQSNYLGFGSGVVVPGTGISLHNRGSD-
MAV_0717|M.avium_104 -APAGGTVYLTAADAAGMMVSMIQSNYMGFGSGVVVPGTGISLQNRGAN-
MSMEG_1615|M.smegmatis_MC2_155 -VPHGDTVGVAAADSDGFVVSLIQSVYHAFGSGLIDPGTGVLFHNRGTS-
Mvan_1330|M.vanbaalenii_PYR-1 -VRAGDTTSTVVVDAEGRAVSFIHSLAFTFGAKFTVPGTGVILNNRLARG
.* ..* * .*: : **: * . ::*: :
Mflv_3716|M.gilvum_PYR-GCK FSAEPAGPDGAPVANRLEPGKRPRSTMAPTLIFDTSGPDRR--LYAVAGS
MAB_2788|M.abscessus_ATCC_1997 FSAEPVGKDGLPVANRLQPGKRPRSSMAPTLVFERAESGKRGALLLALGS
MMAR_4920|M.marinum_M FVATPGHP------NQVGPRKRPYHTIIPGFVTKDG------APVLSFGV
MUL_0486|M.ulcerans_Agy99 FVATPGHP------NQVGPRKRPYHTIIPGFVTKDG------APVLSFGV
Mb0796c|M.bovis_AF2122/97 FTVVPRHP------NRVGPRKRPYHTIIPGFVTRDG------APVMSFGV
Rv0773c|M.tuberculosis_H37Rv FTVVPRHP------NRVGPRKRPYHTIIPGFVTRDG------APVMSFGV
MAV_0717|M.avium_104 FTAGLGHP------NSVGPNKRPYHTIIPGFVTKGG------APVMSFGV
MSMEG_1615|M.smegmatis_MC2_155 FSLDPDSP------NVIAPRKRPAHTLMPALTTRDG------AVRHVLAT
Mvan_1330|M.vanbaalenii_PYR-1 AYLIPGHP------NEVAPRRKPLHTLNAWVVTDDAG-----ALLHVGNT
* : * ::* :: . . .
Mflv_3716|M.gilvum_PYR-GCK PGGSTIIQFVVKTVVGMLDWGLDPQQAVSMVDFGADNSPETNVGGEHPVI
MAB_2788|M.abscessus_ATCC_1997 PGGSVIIQFVVKTLVGILDWGLDPQQAVSMVDFGANNSPKTNVGGEHPSI
MMAR_4920|M.marinum_M MGAQMQPQGHVQMMVRIADYGQNPQAACDGPRFRWVQGLKVSC-------
MUL_0486|M.ulcerans_Agy99 MGAQMQPQGHVQMMVRIADYGQNPQAACDGPRFRWVQELKVSC-------
Mb0796c|M.bovis_AF2122/97 MGGMMQPQGHVQVLVRIADYGQNPQAACDGPRFRWVNGMRVSF-------
Rv0773c|M.tuberculosis_H37Rv MGGMMQPQGHVQVLVRIADYGQNPQAACDGPRFRWVNGMRVSF-------
MAV_0717|M.avium_104 MGGMMQPQGHVQVMVRIADHGQNPQAACDGPRFRWVQGTQVSC-------
MSMEG_1615|M.smegmatis_MC2_155 MGGQGQPQILTQVLLHAVAG-DSAQSAVSAPRAIAGGQVDG---ATADS-
Mvan_1330|M.vanbaalenii_PYR-1 PGGDGQVQWNMQLLSHVLDHGLDPAEAVSAPRFTVFPGSDADVVGSPDE-
*. * : : .. * .
Mflv_3716|M.gilvum_PYR-GCK DTADDGADDPLVRGLRELGHKVDLADQSSGLS---AIVRAGDGWVGGA-D
MAB_2788|M.abscessus_ATCC_1997 DARDNGADDPLIQRLRARGHIVDVADQSSGLS---ALVRRGPGWIGGA-D
MMAR_4920|M.marinum_M ---EKGFPPSTLDELRRRGHDLVTVEDYNEFGSCQAIWRLEHGYLAAS-D
MUL_0486|M.ulcerans_Agy99 ---EKGFPPSTLDELRRRGHDLVTVEDYNEFGSCQAIWRLEHGYLAGS-D
Mb0796c|M.bovis_AF2122/97 ---ENGFPDSTLDELRQRGHDLVAVADYSQFGSCQAIWRLDDGYLAAS-D
Rv0773c|M.tuberculosis_H37Rv ---ENGFPDSTLDELRQRGHDLVAVADYSQFGSCQAIWRLDDGYLAAS-D
MAV_0717|M.avium_104 ---ENGFPAATLDELRRRGHDLVAVDDYNQFGSCQAIWRMDTGYVAAS-D
MSMEG_1615|M.smegmatis_MC2_155 VVVEADLEAQARESLHASGLSMVEVPVHTEAMGQANVVFVDAGAMQAASD
Mvan_1330|M.vanbaalenii_PYR-1 LRVEQSLPAGVRRQLAAAGHRVVDQPALGGGGSAQLISVDERGVLAGAAD
: . * * : : * : .: *
Mflv_3716|M.gilvum_PYR-GCK PRREGAVMGDGDAPVS----
MAB_2788|M.abscessus_ATCC_1997 PRREGLVMGDTG--------
MMAR_4920|M.marinum_M PRRDGQAAAF----------
MUL_0486|M.ulcerans_Agy99 PRRDGQAAAF----------
Mb0796c|M.bovis_AF2122/97 PRRDGQAAAC----------
Rv0773c|M.tuberculosis_H37Rv PRRDGQAAAC----------
MAV_0717|M.avium_104 PRRDGQAAAF----------
MSMEG_1615|M.smegmatis_MC2_155 PRSDGAGMVAHYPRGPLTGG
Mvan_1330|M.vanbaalenii_PYR-1 PRQEGVALGVD---------
** :*