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VAVMWATRRTTTSALRVLLGLSLILTGCTARQDTPAAPPGPCDIVANGTPVSSDGGRSDDTAPETATGYR SDMTAVHTRSYAVATANPLATRAACEVLRDGGTAADALVTAQAVLGLVEPQSSGLGGGGFLLYYDAAAQS VQAFDGRETAPAAATENSLRWISDTDRTEPKPDARASGRSIGVPGIVAMLAQVHAEHGRTPWRDLFSPAV TLADDGFDVSARLAAAIAAAAPKLALDDDAAAYFLNADRTPKSAGTTLTNPAYAKTLGAVAADPEAFYTG DIARAIVASVTDPSGGRTPGLMTVEDLADYTVKQRDPLCTPYRGKEICGMPPPSSGGIAVAATLGMLERF PMADHAPTDVDLNGGRPSVMGVHLISEAERLAYADRDRYVADTDFVALPGGSPDTLLGNDYLAGRAALIS PDRSMGTAEPGNFGPPTAPVPPTPEHGTSHVSVVDRDGNAASLTTTVESAFGSFHMVDGFLLNNQLTDFS AEPAGPDGAPVANRLEPGKRPRSTMAPTLIFDTSGPDRRLYAVAGSPGGSTIIQFVVKTVVGMLDWGLDP QQAVSMVDFGADNSPETNVGGEHPVIDTADDGADDPLVRGLRELGHKVDLADQSSGLSAIVRAGDGWVGG ADPRREGAVMGDGDAPVS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3716 | - | - | 100% (648) | gamma-glutamyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2415 | ggtB | 0.0 | 69.87% (634) | gamma-glutamyltranspeptidase precursor GgtB |
| M. tuberculosis H37Rv | Rv2394 | ggtB | 0.0 | 69.87% (634) | gamma-glutamyltranspeptidase precursor GgtB |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2788 | - | 0.0 | 69.10% (644) | gamma-glutamyltranspeptidase (GgtB) |
| M. marinum M | MMAR_3713 | ggtB | 0.0 | 69.29% (635) | gamma-glutamyltranspeptidase precursor GgtB |
| M. avium 104 | MAV_0717 | ggt | 8e-51 | 32.09% (561) | gamma-glutamyltransferase |
| M. smegmatis MC2 155 | MSMEG_3076 | ggt | 0.0 | 74.45% (634) | gamma-glutamyltransferase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0486 | ggtA | 1e-33 | 30.44% (450) | bifunctional acylase, GgtA |
| M. vanbaalenii PYR-1 | Mvan_1330 | - | 1e-30 | 26.32% (570) | gamma-glutamyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0717|M.avium_104 --------------------------------------------------
MUL_0486|M.ulcerans_Agy99 --------------------------------------------------
Mflv_3716|M.gilvum_PYR-GCK MAVMWATRRTTTSALRVLLGLSLILTGCTA-RQDTPAAPPGPCDIVANGT
MSMEG_3076|M.smegmatis_MC2_155 MLIASGCSDGAERPRRPAPGPCEIVSNGTP-VPKTPESPP---------P
Mb2415|M.bovis_AF2122/97 MSVWLRAGALVAAVMLSLSGCGGFHAGAPS-TAGPCEIVPNGTPAPKT-P
Rv2394|M.tuberculosis_H37Rv MSVWLRAGALVAAVMLSLSGCGGFHAGAPS-TAGPCEIVPNGTPAPKT-P
MMAR_3713|M.marinum_M MTFVKRCGAVLAVAALALAGCGTTHVGAPN-SAGPCEIVPNGTPAPKTSV
MAB_2788|M.abscessus_ATCC_1997 MRALTRALAIASIALLASAGCAGDMTSRPGGAAEPCGITANGVPITKT-A
Mvan_1330|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0717|M.avium_104 ----------MNQPFGWDFPYAWPRKPVLADNVVCTSQPLAAQAGLRMLA
MUL_0486|M.ulcerans_Agy99 -----------------------------------------------MQR
Mflv_3716|M.gilvum_PYR-GCK PVSSDGGRSDDTAPETATGYRSDMTAVHTRSYAVATANPLATRAACEVLR
MSMEG_3076|M.smegmatis_MC2_155 PPGAPAGRDIATQPEVATGYRTDMTAVRTATYAVATANPLATEAACKVLR
Mb2415|M.bovis_AF2122/97 PATVPSSRNLATNPEIATGYRRDMTVVRTAHYAAATANPLATQVACRVLR
Rv2394|M.tuberculosis_H37Rv PATVPSSRNLATNPEIATGYRRDMTVVRTAHYAAATANPLATQVACRVLR
MMAR_3713|M.marinum_M AAAAPSSRNVATNPEIATGYRTDMTPVHTAHYSVSAANPLATQAACRVLR
MAB_2788|M.abscessus_ATCC_1997 ATQAATERNISTNPEVATGYRTGMTAVRTASYAAATANPLATQAACKVLR
Mvan_1330|M.vanbaalenii_PYR-1 ------------------MATAQRPPALSANAMVSSSHPAASLAGARVLA
:
MAV_0717|M.avium_104 EGGSAVDAAIATAITLTIVEPVSNGMGSDAFAIVWDGEKVHGLNASGRSP
MUL_0486|M.ulcerans_Agy99 SGG-----DLICRIRLALRLDLSVRMAAHAHPGRQ--RRVH-LTAAGRP-
Mflv_3716|M.gilvum_PYR-GCK DGGTAADALVTAQAVLGLVEPQSSGLGGGGFLLYYDAAAQSVQAFDGRET
MSMEG_3076|M.smegmatis_MC2_155 DGGTAADALITAQAVLGLVEPQASGLGGGGFLLYHDAATGAVRAFDGRET
Mb2415|M.bovis_AF2122/97 DGGTAADAVVAAQAVLGLVEPQSSGIGGGGYLVYFDARTGSVQAYDGREV
Rv2394|M.tuberculosis_H37Rv DGGTAADAVVAAQAVLGLVEPQSSGIGGGGYLVYFDARTGSVQAYDGREV
MMAR_3713|M.marinum_M DGGTAADAVVAAQAVLGLVEPQSSGIGGGGVLLYYDARTRSVQAYDGREV
MAB_2788|M.abscessus_ATCC_1997 DGGSAADALVAAQAVLGLVEPQSSGIGGGGFLVYYDAASGAVQTYDGREV
Mvan_1330|M.vanbaalenii_PYR-1 DGGNAIDATLAMAALTWLTLPGQCGIGGDAFAVVREPDGRVWTVNGSGYG
.** : : :.. . .
MAV_0717|M.avium_104 AAWTPEY-----------FGGNAVPVLGWNSVTVPGAVSAWTELHARFGK
MUL_0486|M.ulcerans_Agy99 -------------------SGSSDACRRRERRRRR----YRHRHHPHPGG
Mflv_3716|M.gilvum_PYR-GCK APAAATENSLRWISDTDRTEPKPDARASGRSIGVPGIVAMLAQVHAEHGR
MSMEG_3076|M.smegmatis_MC2_155 APAAATENYLRWISEADRTEPRPDARASGRSIGVPGIVRLLDVVHREYGK
Mb2415|M.bovis_AF2122/97 APAAATENYLRWVSDVDRSAPRPNARASGRSIGVPGILRMLEMVHNEHGR
Rv2394|M.tuberculosis_H37Rv APAAATENYLRWVSDVDRSAPRPNARASGRSIGVPGILRMLEMVHNEHGR
MMAR_3713|M.marinum_M APAAATENYMRWISDADHSAPRPDPRASGRSIGVPGILRMLEMVHNEHGT
MAB_2788|M.abscessus_ATCC_1997 APAAATENYLRWVDDADRTAPRPDVRSSGRSIGVPGILRMLYDVHAEHGA
Mvan_1330|M.vanbaalenii_PYR-1 PDGGTPEFY-------AAQGLSSIPLDGPLAVAVPGAVAALRALHLGGAT
. * .
MAV_0717|M.avium_104 LPFERLFAPAISYGRNGFPVSPVVAEQWVAQVPLFAGQPGFAEAFAPEGR
MUL_0486|M.ulcerans_Agy99 TGFQRLFGPAITYGRNGFLVSPKVSAQWQAQVALFADQPGFAEAFLPGGR
Mflv_3716|M.gilvum_PYR-GCK TPWRDLFSPAVTLADDGFDVSARLAAAIAAAAPKLALDDDAAAYFLNADR
MSMEG_3076|M.smegmatis_MC2_155 KAWRELFDPAVNLADRGFDISPRLAAALLDAAPQLRLDPEASAYFLNQDG
Mb2415|M.bovis_AF2122/97 TPWRDLFGPAVTLADGGFDISARMGAAISDAAPQLRDDPEARKYFLNPDG
Rv2394|M.tuberculosis_H37Rv TPWRDLFGPAVTLADGGFDISARMGAAISDAAPQLRDDPEARKYFLNPDG
MMAR_3713|M.marinum_M TPWRDLFSPAVALADNGFDISPRMAAAISDSAPQLGADPQARGYFLTPDG
MAB_2788|M.abscessus_ATCC_1997 APWRELFTPAVQLADDGFEISPRLAAAITDSAASLALDPEADLYLLNTDG
Mvan_1330|M.vanbaalenii_PYR-1 RELEQLWEPAARIAGDGLPCSARTAGDVVTALG----------------D
. *: ** . *: *. .
MAV_0717|M.avium_104 APR-PGERFRLPAHADTLEAIAASRGEAFYRGALAARVAEHAAAN-----
MUL_0486|M.ulcerans_Agy99 APK-PGELFTFPDHADTLEKIAASTGAAFYRGELADKLEAHARAN-----
Mflv_3716|M.gilvum_PYR-GCK TPKSAGTTLTNPAYAKTLGAVAAD-PEAFYTGDIARAIVASVTDPSGGRT
MSMEG_3076|M.smegmatis_MC2_155 TPKRVGTRLTNPAYAKTLGAIATDGADAFYTGDIARAIVAAAADTSGGRT
Mb2415|M.bovis_AF2122/97 SPKPAGTRLTNPAYSKTLSAIASAGANAFYSGDIAHDIVAAASDTSNGRT
Rv2394|M.tuberculosis_H37Rv SPKPAGTRLTNPAYSKTLSAIASAGANAFYSGDIAHDIVAAASDTSNGRT
MMAR_3713|M.marinum_M TPKAVGTRLTNPAYAKALSEIASAGASVFYTGDIAHDIVAAAGDTSGGRT
MAB_2788|M.abscessus_ATCC_1997 SAKPAGTKITNPAYAKTLGAVAADGPDAFYRGAIAEAIVAAAADTSSGRT
Mvan_1330|M.vanbaalenii_PYR-1 SAPAVGSRVPQPELAATIRRLARD-PEGFYTGEFAQRAVAALQAGG----
:. * . * : :: :* ** * :*
MAV_0717|M.avium_104 GGAMTADDLAAHRADWVETITGDYRGYTVHEIP-PNGHGIVALIALGILE
MUL_0486|M.ulcerans_Agy99 DAALRASDLAAHRTDWVGTISTNYRDYTIHEIP-PNGQGIVALIALGILD
Mflv_3716|M.gilvum_PYR-GCK PGLMTVEDLADYTVKQRDPLCTPYRGKEICGMPPPSSGGIAVAATLGMLE
MSMEG_3076|M.smegmatis_MC2_155 PSLLTENDLATYTVKTRDPLCTTYRGREICGMPPPSSGGIAVAATLGILE
Mb2415|M.bovis_AF2122/97 PGLLTIEDLAGYLAKRRQPLCTTYRGREICGMP--SSGGVAVAATLGILE
Rv2394|M.tuberculosis_H37Rv PGLLTIEDLAGYLAKRRQPLCTTYRGREICGMP--SSGGVAVAATLGILE
MMAR_3713|M.marinum_M PSLITLEDLSAYPAKKREPLCTTYRGRQICGMPTPSSGGVAVAATLGILE
MAB_2788|M.abscessus_ATCC_1997 PSLMTTADLSGYTAKRRAALCTTYRDHEICGMPAPSSGGIAVAATLGILQ
Mvan_1330|M.vanbaalenii_PYR-1 APFSGDEWTAGAEVNPEPAITGRYAGAVVHQTPLPTPGWMVLQQAALCDG
: .. .: * . : * . :. :
MAV_0717|M.avium_104 RFDMASLPVDSADS---------VHLQIEAVKLAFADAQAYLADIEHMPL
MUL_0486|M.ulcerans_Agy99 QFDMSCYPVDSADS---------VHLQIEALKLAFSDAQHQLADIDHMTV
Mflv_3716|M.gilvum_PYR-GCK RFPMADHAPTDVDLNGGRPSVMGVHLISEAERLAYADRDRYVADTDFVAL
MSMEG_3076|M.smegmatis_MC2_155 HFAMKQHRPTDLDRNGGHPTVMGVHLISEAERLAYADRDRYVADTDFVAL
Mb2415|M.bovis_AF2122/97 HFPMSDYAPSKVDLNGGRPTVMGVHLIAEAERLAYADRDQYIADVDFVQL
Rv2394|M.tuberculosis_H37Rv HFPMSDYAPSKVDLNGGRPTVMGVHLIAEAERLAYADRDQYIADVDFVRL
MMAR_3713|M.marinum_M HFPMSEYRPDNLDPNGGRPSVMGVHLVAEAERLAYADRDKYVADADFVPP
MAB_2788|M.abscessus_ATCC_1997 NFPMASFRPTDIDLDGGKPTVDGVHYIAEAERLAYADRDKYVADTDFVAL
Mvan_1330|M.vanbaalenii_PYR-1 VVGFSGWLS-----------AEAIDRLARAARLTFADRLALCASDN----
. : :. .* :*:::* *. :
MAV_0717|M.avium_104 R---PEHLLDTEYLERRAALIDPARAKPVSAG------------APAGGT
MUL_0486|M.ulcerans_Agy99 G---PDQLLDKEYLRGRAALIDLKQAKPASAG------------TPKGGT
Mflv_3716|M.gilvum_PYR-GCK PGGSPDTLLGNDYLAGRAALISPDRSMGTAEPGNFGPPTAPVPPTPEHGT
MSMEG_3076|M.smegmatis_MC2_155 PGGSPNTLLDSAYLTGRAALISEDRTMGTAQPGSFGPPVTAAP-VREHGT
Mb2415|M.bovis_AF2122/97 PGGSLTTLVDPGYLAARAALISPQHSMGSARPGDFGAPTAVAPPVPEHGT
Rv2394|M.tuberculosis_H37Rv PGGSLTTLVDPGYLAARAALISPQHSMGSARPGDFGAPTAVAPPVPEHGT
MMAR_3713|M.marinum_M PGGSLSTLVDPAYLAGRAALISPQHSMGTAKPGDFGLPTTIAAPVPEHGT
MAB_2788|M.abscessus_ATCC_1997 PGNSPDTLLNPTYLAGRARLISGDTTMGVAKPGEFNIPASAAVSTPEHGT
Mvan_1330|M.vanbaalenii_PYR-1 --------------DGSRYVLTPDRIEAQRRDLDCGTEARGPVEVRAGDT
:: . .*
MAV_0717|M.avium_104 VYLTAADAAGMMVSMIQSNYMGFGSGVVVPGTGISLQNRGA-NFTAGLGH
MUL_0486|M.ulcerans_Agy99 IYLTAADADGLMVSMIQSNYMGFGSGVVVPGTGISLQNRGS-GFVATPGH
Mflv_3716|M.gilvum_PYR-GCK SHVSVVDRDGNAASLTTTVESAFGSFHMVDG--FLLNNQLT-DFSAEPAG
MSMEG_3076|M.smegmatis_MC2_155 SQVSIIDSFGNAAALTTTVESAFGSFHMVDG--FLLNNQLT-DFSAEPVS
Mb2415|M.bovis_AF2122/97 SHLSVVDSYGNAATLTTTVESSFGSYHLVDG--FILNNQLS-DFSAEPHA
Rv2394|M.tuberculosis_H37Rv SHLSVVDSYGNAATLTTTVESSFGSYHLVDG--FILNNQLS-DFSAEPHA
MMAR_3713|M.marinum_M SHVSVVDSYGNAAALTTTVESAFGSFHMVDG--FLLNNQLS-DFNAQPYD
MAB_2788|M.abscessus_ATCC_1997 SQVTVVDARGNAASLTTTVESAFGSFHMVDG--FFLNNQLT-DFSAEPVG
Mvan_1330|M.vanbaalenii_PYR-1 TSTVVVDAEGRAVSFIHSLAFTFGAKFTVPGTGVILNNRLARGAYLIPGH
* * .:: : **: * * . *:*: : .
MAV_0717|M.avium_104 P------NSVGPNKRPYHTIIPGFVTKGG------APVMSFGVMGGMMQP
MUL_0486|M.ulcerans_Agy99 P------NQVGPRKRPYHTIIPGFVTKDG------APVLSFGVMGAQMQP
Mflv_3716|M.gilvum_PYR-GCK PDGAPVANRLEPGKRPRSTMAPTLIFDTS-GPDRR-LYAVAGSPGGSTII
MSMEG_3076|M.smegmatis_MC2_155 PEGTPIPNRVEPGKRPRSTMAPTLIFDHD-GGERGPLYAVLGSPGGSVII
Mb2415|M.bovis_AF2122/97 TDGSPVANRVEPGKRPRSSMAPTLVFDHS-SAGRGALYAVLGSPGGSMII
Rv2394|M.tuberculosis_H37Rv TDGSPVANRVEPGKRPRSSMAPTLVFDHS-SAGRGALYAVLGSPGGSMII
MMAR_3713|M.marinum_M SDGAPVANRIQPGKRPRSSMAPTFVFDGA-PAEHSSLYAVVGSPGGSTIV
MAB_2788|M.abscessus_ATCC_1997 KDGLPVANRLQPGKRPRSSMAPTLVFERAESGKRGALLLALGSPGGSVII
Mvan_1330|M.vanbaalenii_PYR-1 P------NEVAPRRKPLHTLNAWVVTDDA-----GALLHVGNTPGGDGQV
* : * ::* :: . .: . . *.
MAV_0717|M.avium_104 QGHVQVMVRIADHGQNPQAACDGPRFRWVQGTQVSCENGFP---------
MUL_0486|M.ulcerans_Agy99 QGHVQMMVRIADYGQNPQAACDGPRFRWVQELKVSCEKGFP---------
Mflv_3716|M.gilvum_PYR-GCK QFVVKTVVGMLDWGLDPQQAVSMVDFGADNSPETNVGGEHPVIDTADDGA
MSMEG_3076|M.smegmatis_MC2_155 QFVVKTVVGLLDWGLDPQQAVSMVDFGAANTPKTNVGGEHPNVDTSDNGD
Mb2415|M.bovis_AF2122/97 QFVVKTLVAMLDWGLNPQQAVSLVDFGAANSPHTNLGGENPEINTSDDGD
Rv2394|M.tuberculosis_H37Rv QFVVKTLVAMLDWGLNPQQAVSLVDFGAANSPHTNLGGENPEINTSDDGD
MMAR_3713|M.marinum_M QFVVKTLVAMLDWGLDPQQAVSAVDFGAANTPRTNVGGEHPDINTADNGA
MAB_2788|M.abscessus_ATCC_1997 QFVVKTLVGILDWGLDPQQAVSMVDFGANNSPKTNVGGEHPSIDARDNGA
Mvan_1330|M.vanbaalenii_PYR-1 QWNMQLLSHVLDHGLDPAEAVSAPRFTVFPGSDADVVGSPDELR-VEQSL
* :: : : * * :* * . * ..
MAV_0717|M.avium_104 -AATLDELRRRGHDLVAVDDYNQFGSCQAIWRMDTGYVA-ASDPRRDGQA
MUL_0486|M.ulcerans_Agy99 -PSTLDELRRRGHDLVTVEDYNEFGSCQAIWRLEHGYLA-GSDPRRDGQA
Mflv_3716|M.gilvum_PYR-GCK DDPLVRGLRELGHKVDLADQS---SGLSAIVRAGDGWVG-GADPRREGAV
MSMEG_3076|M.smegmatis_MC2_155 HDPLVRGLRRLGHDVNLDDQS---SGLSAIARTESGWIG-GADPRREGLV
Mb2415|M.bovis_AF2122/97 HDPLVQGLRALGHRVNLAEQS---SGLSAITRSEAGWAG-GADPRREGAV
Rv2394|M.tuberculosis_H37Rv HDPLVQGLRALGHRVNLAEQS---SGLSAITRSEAGWAG-GADPRREGAV
MMAR_3713|M.marinum_M HDPLVEGLRALGHQVNLADQS---SGLSAITRSKSGWTG-GADPRREGVV
MAB_2788|M.abscessus_ATCC_1997 DDPLIQRLRARGHIVDVADQS---SGLSALVRRGPGWIG-GADPRREGLV
Mvan_1330|M.vanbaalenii_PYR-1 PAGVRRQLAAAGHRVVDQPALGGGGSAQLISVDERGVLAGAADPRQEGVA
* ** : .. . : * . .:***::* .
MAV_0717|M.avium_104 AAF------
MUL_0486|M.ulcerans_Agy99 AAF------
Mflv_3716|M.gilvum_PYR-GCK MGDGDAPVS
MSMEG_3076|M.smegmatis_MC2_155 MGDPG----
Mb2415|M.bovis_AF2122/97 MGDDA----
Rv2394|M.tuberculosis_H37Rv MGDDA----
MMAR_3713|M.marinum_M MGDTS----
MAB_2788|M.abscessus_ATCC_1997 MGDTG----
Mvan_1330|M.vanbaalenii_PYR-1 LGVD-----
.