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QRSGGDLICRIRLALRLDLSVRMAAHAHPGRQRRVHLTAAGRPSGSSDACRRRERRRRRYRHRHHPHPGG TGFQRLFGPAITYGRNGFLVSPKVSAQWQAQVALFADQPGFAEAFLPGGRAPKPGELFTFPDHADTLEKI AASTGAAFYRGELADKLEAHARANDAALRASDLAAHRTDWVGTISTNYRDYTIHEIPPNGQGIVALIALG ILDQFDMSCYPVDSADSVHLQIEALKLAFSDAQHQLADIDHMTVGPDQLLDKEYLRGRAALIDLKQAKPA SAGTPKGGTIYLTAADADGLMVSMIQSNYMGFGSGVVVPGTGISLQNRGSGFVATPGHPNQVGPRKRPYH TIIPGFVTKDGAPVLSFGVMGAQMQPQGHVQMMVRIADYGQNPQAACDGPRFRWVQELKVSCEKGFPPST LDELRRRGHDLVTVEDYNEFGSCQAIWRLEHGYLAGSDPRRDGQAAAF*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_0486 | ggtA | - | 100% (469) | bifunctional acylase, GgtA |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0796c | ggtA | 0.0 | 76.43% (403) | bifunctional cephalosporin |
M. gilvum PYR-GCK | Mflv_3716 | - | 1e-33 | 30.44% (450) | gamma-glutamyltransferase |
M. tuberculosis H37Rv | Rv0773c | ggtA | 0.0 | 76.43% (403) | bifunctional cephalosporin |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_2788 | - | 4e-38 | 31.35% (453) | gamma-glutamyltranspeptidase (GgtB) |
M. marinum M | MMAR_4920 | ggtA | 0.0 | 97.28% (404) | bifunctional acylase, GgtA |
M. avium 104 | MAV_0717 | ggt | 1e-179 | 75.25% (404) | gamma-glutamyltransferase |
M. smegmatis MC2 155 | MSMEG_1615 | ggt | 2e-41 | 29.96% (454) | gamma-glutamyltranspeptidase |
M. thermoresistible (build 8) | - | - | - | - | - |
M. vanbaalenii PYR-1 | Mvan_1330 | - | 2e-27 | 28.93% (363) | gamma-glutamyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_3716|M.gilvum_PYR-GCK MAVMWATRRTTTSALRVLLGLSLILTGCTARQDTPAAPPGPCDIVANGTP MAB_2788|M.abscessus_ATCC_1997 ---MRALTRALAIASIALLASAGCAGDMTSR---PGGAAEPCGITANGVP MUL_0486|M.ulcerans_Agy99 -------------------------------------------------- MMAR_4920|M.marinum_M -------------------------------------------------- Mb0796c|M.bovis_AF2122/97 -------------------------------------------------- Rv0773c|M.tuberculosis_H37Rv -------------------------------------------------- MAV_0717|M.avium_104 -------------------------------------------------- MSMEG_1615|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1330|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_3716|M.gilvum_PYR-GCK VSSDGG------RSDDTAPETATGYRSDMTAVHTRSYAVATANPLATRAA MAB_2788|M.abscessus_ATCC_1997 ITKTAATQAATERNISTNPEVATGYRTGMTAVRTASYAAATANPLATQAA MUL_0486|M.ulcerans_Agy99 ---------MQRSGG---------------------DLICR--------- MMAR_4920|M.marinum_M ---------MTSSAGSASPFGWTFPYAWPHTPILAANAVCTSQPLAAQAG Mb0796c|M.bovis_AF2122/97 ------------------------------MPILATNVVCTSQPLAAQAG Rv0773c|M.tuberculosis_H37Rv ------------------------------MPILATNVVCTSQPLAAQAG MAV_0717|M.avium_104 ---------MNQPFG------WDFPYAWPRKPVLADNVVCTSQPLAAQAG MSMEG_1615|M.smegmatis_MC2_155 -------------------------------MSTFTGALASPHALATEAG Mvan_1330|M.vanbaalenii_PYR-1 -----------------------MATAQRPPALSANAMVSSSHPAASLAG . Mflv_3716|M.gilvum_PYR-GCK CEVLRDGGTAADALVTAQAVLGLVEPQSSGLGGGGFLLYYDAAAQSVQA- MAB_2788|M.abscessus_ATCC_1997 CKVLRDGGSAADALVAAQAVLGLVEPQSSGIGGGGFLVYYDAASGAVQT- MUL_0486|M.ulcerans_Agy99 ----------IRLALRLDLSVRMAAHAHPGR-----------QRRVHLT- MMAR_4920|M.marinum_M LRMLAEGGNAVDAAIATAITLTLVEPVSNGIGSDAFAIVWDGQQLHGLN- Mb0796c|M.bovis_AF2122/97 LRMLADGGNAVDAAVATAITLTVVEPVSNGIGSDAFSIVWDGQKLHGLN- Rv0773c|M.tuberculosis_H37Rv LRMLADGGNAVDAAVATAITLTVVEPVSNGIGSDAFSIVWDGQKLHGLN- MAV_0717|M.avium_104 LRMLAEGGSAVDAAIATAITLTIVEPVSNGMGSDAFAIVWDGEKVHGLN- MSMEG_1615|M.smegmatis_MC2_155 MAAFAEGGNAIDAAISAAAVLTVVYPHNVALGGDLIALVRTPDGIIRCVN Mvan_1330|M.vanbaalenii_PYR-1 ARVLADGGNAIDATLAMAALTWLTLPGQCGIGGDAFAVVREPDGRVWTVN : :. . Mflv_3716|M.gilvum_PYR-GCK FDGRETAPAAATENSLRWISDTDRTEPKPDARASGRSIGVPGIVAMLAQV MAB_2788|M.abscessus_ATCC_1997 YDGREVAPAAATENYLRWVDDADRTAPRPDVRSSGRSIGVPGILRMLYDV MUL_0486|M.ulcerans_Agy99 AAGRP--SGSSDACRR-----------RERRRRRYRHRHHP--------- MMAR_4920|M.marinum_M ASGRSPAAWTPEYFCG-----------KDVPILGWNSVTVPGAVSAWVDL Mb0796c|M.bovis_AF2122/97 ASGRSPSAWTPEYFGG-----------NAVPVLGWNSVTVPGAVSAWVEL Rv0773c|M.tuberculosis_H37Rv ASGRSPSAWTPEYFGG-----------NAVPVLGWNSVTVPGAVSAWVEL MAV_0717|M.avium_104 ASGRSPAAWTPEYFGG-----------NAVPVLGWNSVTVPGAVSAWTEL MSMEG_1615|M.smegmatis_MC2_155 ASGWSGAQATAERMRTRH--------GRSLPARHADSVTVPGGVRGWEAL Mvan_1330|M.vanbaalenii_PYR-1 GSGYGPDGGTPEFYAAQG--------LSSIPLDGPLAVAVPGAVAALRAL * :. * Mflv_3716|M.gilvum_PYR-GCK HAEHGRTPWRDLFSPAVTLADDGFDVSARLAAAIAAAAPKLALDDDAAAY MAB_2788|M.abscessus_ATCC_1997 HAEHGAAPWRELFTPAVQLADDGFEISPRLAAAITDSAASLALDPEADLY MUL_0486|M.ulcerans_Agy99 --HPGGTGFQRLFGPAITYGRNGFLVSPKVSAQWQAQVALFADQPGFAEA MMAR_4920|M.marinum_M HAKFGKLPFERLFGPAIAYGRNGFLVSPKVSAQWQAQVALFADQPGFAEA Mb0796c|M.bovis_AF2122/97 HARFGRLPFETLFEPAISYGRNGFLVSPTVAAQWAAQVPLFASQPGFADA Rv0773c|M.tuberculosis_H37Rv HARFGRLPFETLFEPAISYGRNGFLVSPTVAAQWAAQVPLFASQPGFADA MAV_0717|M.avium_104 HARFGKLPFERLFAPAISYGRNGFPVSPVVAEQWVAQVPLFAGQPGFAEA MSMEG_1615|M.smegmatis_MC2_155 RSLGCRISWAQTLAPAQRVAEAGVAVAKSLAHHIADPENADLAESEDFCR Mvan_1330|M.vanbaalenii_PYR-1 HLGGATRELEQLWEPAARIAGDGLPCSARTAGDVVT-------------- ** . *. : : Mflv_3716|M.gilvum_PYR-GCK FLNADRTPKSAGTTLTNPAYAKTLGAVAAD-PEAFYTGDIARAIVASVTD MAB_2788|M.abscessus_ATCC_1997 LLNTDGSAKPAGTKITNPAYAKTLGAVAADGPDAFYRGAIAEAIVAAAAD MUL_0486|M.ulcerans_Agy99 FLPGGRAPK-PGELFTFPDHADTLEKIAASTGAAFYRGELADKLEAHARA MMAR_4920|M.marinum_M FLPGGRAPR-PGELFTFPDHADTLEKIAASTGAAFYRGELADKLEAHARA Mb0796c|M.bovis_AF2122/97 FMPGGRAPK-PGELFTFPDHAATLEKIAATNGEEFYRGELAAKLEAHSAA Rv0773c|M.tuberculosis_H37Rv FMPGGRAPK-PGELFTFPDHAATLEKIAATNGEEFYRGELAAKLEAHSAA MAV_0717|M.avium_104 FAPEGRAPR-PGERFRLPAHADTLEAIAASRGEAFYRGALAARVAEHAAA MSMEG_1615|M.smegmatis_MC2_155 VFRPGGRMLATGEVLVQPALASTFAALRQQGPAAFYTGALADSMLAHLGK Mvan_1330|M.vanbaalenii_PYR-1 --ALGDSAPAVGSRVPQPELAATIRRLARD-PEGFYTGEFAQRAVAALQA . * . * * *: : ** * :* Mflv_3716|M.gilvum_PYR-GCK PSGGRTPGLMTVEDLADYTVKQRDP-LCTPYRGKEICGMPPPSSGGIAVA MAB_2788|M.abscessus_ATCC_1997 TSSGRTPSLMTTADLSGYTAKRRAA-LCTTYRDHEICGMPAPSSGGIAVA MUL_0486|M.ulcerans_Agy99 N-----DAALRASDLAAHRTDWVGT-ISTNYRDYTIHEIP-PNGQGIVAL MMAR_4920|M.marinum_M N-----DAALRASDLAAHRTDWVGT-ISTNYRDYTIHEIP-PNGQGIVAL Mb0796c|M.bovis_AF2122/97 N-----GGVMRADDLAAHRVDWVDT-ITGTYRGYTIHQIP-PNGQGIVAL Rv0773c|M.tuberculosis_H37Rv N-----GGVMRADDLAAHRVDWVDT-ITGTYRGYTIHQIP-PNGQGIVAL MAV_0717|M.avium_104 N-----GGAMTADDLAAHRADWVET-ITGDYRGYTVHEIP-PNGHGIVAL MSMEG_1615|M.smegmatis_MC2_155 H-----GSCLAAADFAEFTPEFTEP-LSARFGDLTVLTSP-PNTHGFAML Mvan_1330|M.vanbaalenii_PYR-1 G-----GAPFSGDEWTAGAEVNPEPAITGRYAGAVVHQTP-LPTPGWMVL . : : : . : : . : * * Mflv_3716|M.gilvum_PYR-GCK ATLGMLERFPMADHAPTDVDLNGGRPSVMGVHLISEAERLAYADRDRYVA MAB_2788|M.abscessus_ATCC_1997 ATLGILQNFPMASFRPTDIDLDGGKPTVDGVHYIAEAERLAYADRDKYVA MUL_0486|M.ulcerans_Agy99 IALGILDQFDMSCYPVDSADS---------VHLQIEALKLAFSDAQHQLA MMAR_4920|M.marinum_M IALGILDQFDMSCYPVDSADS---------VHLQIEALKLAFSDAQHQLA Mb0796c|M.bovis_AF2122/97 IALGILEHFDMSSWSVDSAES---------VHVQIEALKLAFADAQACVA Rv0773c|M.tuberculosis_H37Rv IALGILEHFDMSSWSVDSAES---------VHVQIEALKLAFADAQACVA MAV_0717|M.avium_104 IALGILERFDMASLPVDSADS---------VHLQIEAVKLAFADAQAYLA MSMEG_1615|M.smegmatis_MC2_155 RALRAIE-ERDVADPLGAGIG----------TLMR---IFHHGNVLRERR Mvan_1330|M.vanbaalenii_PYR-1 QQAALCDGVVGFSGWLSAEAI----------DRLARAARLTFADRLALCA : : ..: Mflv_3716|M.gilvum_PYR-GCK DTDFVALPGGSPDTLLGNDYLAGRAALISPDRSMGTAEPGNFGPPTAPVP MAB_2788|M.abscessus_ATCC_1997 DTDFVALPGNSPDTLLNPTYLAGRARLISGDTTMGVAKPGEFNIPASAAV MUL_0486|M.ulcerans_Agy99 DIDHMTVG---PDQLLDKEYLRGRAALIDLKQAKPASAG----------- MMAR_4920|M.marinum_M DIDHMTVG---PDQLLDKEYLRGRAALIDLKQAKPASAG----------- Mb0796c|M.bovis_AF2122/97 DIDYMPVH---PKRLLDKEYLRQRATLIDPKRAMPAATG----------- Rv0773c|M.tuberculosis_H37Rv DIDYMPVH---PKRLLDKEYLRQRATLIDPKRAMPAATG----------- MAV_0717|M.avium_104 DIEHMPLR---PEHLLDTEYLERRAALIDPARAKPVSAG----------- MSMEG_1615|M.smegmatis_MC2_155 LGDPRLSD------IDTHALVNGALGEVAELGKHPGPVL----------- Mvan_1330|M.vanbaalenii_PYR-1 SDNDGSRY------VLTPDRIEAQRRDLDCGTEARGPVE----------- : : : : . Mflv_3716|M.gilvum_PYR-GCK PTPEHGTSHVSVVDRDGNAASLTTTVESAFGSFHMVDG--FLLNNQLTD- MAB_2788|M.abscessus_ATCC_1997 STPEHGTSQVTVVDARGNAASLTTTVESAFGSFHMVDG--FFLNNQLTD- MUL_0486|M.ulcerans_Agy99 -TPKGGTIYLTAADADGLMVSMIQSNYMGFGSGVVVPGTGISLQNRGSG- MMAR_4920|M.marinum_M -TPKGGTIYLTAADADGLMVSMIQSNYMGFGSGVVVPGTGISLQNRGSG- Mb0796c|M.bovis_AF2122/97 -IPRGGTVYLAAADAAGMMVSMIQSNYLGFGSGVVVPGTGISLHNRGSD- Rv0773c|M.tuberculosis_H37Rv -IPRGGTVYLAAADAAGMMVSMIQSNYLGFGSGVVVPGTGISLHNRGSD- MAV_0717|M.avium_104 -APAGGTVYLTAADAAGMMVSMIQSNYMGFGSGVVVPGTGISLQNRGAN- MSMEG_1615|M.smegmatis_MC2_155 -VPHGDTVGVAAADSDGFVVSLIQSVYHAFGSGLIDPGTGVLFHNRGTS- Mvan_1330|M.vanbaalenii_PYR-1 -VRAGDTTSTVVVDAEGRAVSFIHSLAFTFGAKFTVPGTGVILNNRLARG .* ..* * .*: : **: * . ::*: : Mflv_3716|M.gilvum_PYR-GCK FSAEPAGPDGAPVANRLEPGKRPRSTMAPTLIFDTSGPDRR--LYAVAGS MAB_2788|M.abscessus_ATCC_1997 FSAEPVGKDGLPVANRLQPGKRPRSSMAPTLVFERAESGKRGALLLALGS MUL_0486|M.ulcerans_Agy99 FVATPGHP------NQVGPRKRPYHTIIPGFVTKDG------APVLSFGV MMAR_4920|M.marinum_M FVATPGHP------NQVGPRKRPYHTIIPGFVTKDG------APVLSFGV Mb0796c|M.bovis_AF2122/97 FTVVPRHP------NRVGPRKRPYHTIIPGFVTRDG------APVMSFGV Rv0773c|M.tuberculosis_H37Rv FTVVPRHP------NRVGPRKRPYHTIIPGFVTRDG------APVMSFGV MAV_0717|M.avium_104 FTAGLGHP------NSVGPNKRPYHTIIPGFVTKGG------APVMSFGV MSMEG_1615|M.smegmatis_MC2_155 FSLDPDSP------NVIAPRKRPAHTLMPALTTRDG------AVRHVLAT Mvan_1330|M.vanbaalenii_PYR-1 AYLIPGHP------NEVAPRRKPLHTLNAWVVTDDAG-----ALLHVGNT * : * ::* :: . . . Mflv_3716|M.gilvum_PYR-GCK PGGSTIIQFVVKTVVGMLDWGLDPQQAVSMVDFGADNSPETNVGGEHPVI MAB_2788|M.abscessus_ATCC_1997 PGGSVIIQFVVKTLVGILDWGLDPQQAVSMVDFGANNSPKTNVGGEHPSI MUL_0486|M.ulcerans_Agy99 MGAQMQPQGHVQMMVRIADYGQNPQAACDGPRFRWVQELKVSC------- MMAR_4920|M.marinum_M MGAQMQPQGHVQMMVRIADYGQNPQAACDGPRFRWVQGLKVSC------- Mb0796c|M.bovis_AF2122/97 MGGMMQPQGHVQVLVRIADYGQNPQAACDGPRFRWVNGMRVSF------- Rv0773c|M.tuberculosis_H37Rv MGGMMQPQGHVQVLVRIADYGQNPQAACDGPRFRWVNGMRVSF------- MAV_0717|M.avium_104 MGGMMQPQGHVQVMVRIADHGQNPQAACDGPRFRWVQGTQVSC------- MSMEG_1615|M.smegmatis_MC2_155 MGGQGQPQILTQVLLHAVAG-DSAQSAVSAPRAIAGGQVDG---ATADS- Mvan_1330|M.vanbaalenii_PYR-1 PGGDGQVQWNMQLLSHVLDHGLDPAEAVSAPRFTVFPGSDADVVGSPDE- *. * : : .. * . Mflv_3716|M.gilvum_PYR-GCK DTADDGADDPLVRGLRELGHKVDLADQSSGLS---AIVRAGDGWVGGA-D MAB_2788|M.abscessus_ATCC_1997 DARDNGADDPLIQRLRARGHIVDVADQSSGLS---ALVRRGPGWIGGA-D MUL_0486|M.ulcerans_Agy99 ---EKGFPPSTLDELRRRGHDLVTVEDYNEFGSCQAIWRLEHGYLAGS-D MMAR_4920|M.marinum_M ---EKGFPPSTLDELRRRGHDLVTVEDYNEFGSCQAIWRLEHGYLAAS-D Mb0796c|M.bovis_AF2122/97 ---ENGFPDSTLDELRQRGHDLVAVADYSQFGSCQAIWRLDDGYLAAS-D Rv0773c|M.tuberculosis_H37Rv ---ENGFPDSTLDELRQRGHDLVAVADYSQFGSCQAIWRLDDGYLAAS-D MAV_0717|M.avium_104 ---ENGFPAATLDELRRRGHDLVAVDDYNQFGSCQAIWRMDTGYVAAS-D MSMEG_1615|M.smegmatis_MC2_155 VVVEADLEAQARESLHASGLSMVEVPVHTEAMGQANVVFVDAGAMQAASD Mvan_1330|M.vanbaalenii_PYR-1 LRVEQSLPAGVRRQLAAAGHRVVDQPALGGGGSAQLISVDERGVLAGAAD : . * * : : * : .: * Mflv_3716|M.gilvum_PYR-GCK PRREGAVMGDGDAPVS---- MAB_2788|M.abscessus_ATCC_1997 PRREGLVMGDTG-------- MUL_0486|M.ulcerans_Agy99 PRRDGQAAAF---------- MMAR_4920|M.marinum_M PRRDGQAAAF---------- Mb0796c|M.bovis_AF2122/97 PRRDGQAAAC---------- Rv0773c|M.tuberculosis_H37Rv PRRDGQAAAC---------- MAV_0717|M.avium_104 PRRDGQAAAF---------- MSMEG_1615|M.smegmatis_MC2_155 PRSDGAGMVAHYPRGPLTGG Mvan_1330|M.vanbaalenii_PYR-1 PRQEGVALGVD--------- ** :*